Citation Impact
Citing Papers
Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions
2013 StandoutNobel
BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity
2008
Controlling Macromolecular Topology with Genetically Encoded SpyTag–SpyCatcher Chemistry
2013 StandoutNobel
Ubiquitin Ligases: Structure, Function, and Regulation
2017
Ubiquitin-binding domains
2006
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)
2010
Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis
2013
Breast cancer
2019 Standout
A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases
2019
A Human Ubiquitin Conjugating Enzyme (E2)-HECT E3 Ligase Structure-function Screen
2012
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases
2012
Ubiquitin-binding domains — from structures to functions
2009
Ubiquitylation of the amino terminus of Myc by SCFβ-TrCP antagonizes SCFFbw7-mediated turnover
2010
Autophagy in infection, inflammation and immunity
2013 Standout
Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation
2007
MYC on the Path to Cancer
2012 Standout
Necroptosis and its role in inflammation
2015 StandoutNature
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
2010 Standout
RSUME, a Small RWD-Containing Protein, Enhances SUMO Conjugation and Stabilizes HIF-1α during Hypoxia
2007
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition
2010 Standout
E2–c-Cbl Recognition Is Necessary but not Sufficient for Ubiquitination Activity
2008
Building ubiquitin chains: E2 enzymes at work
2009
Biochemical and Structural Characterization of the Ubiquitin-Conjugating Enzyme UBE2W Reveals the Formation of a Noncovalent Homodimer
2013
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation
2008
Ube2w and Ataxin-3 Coordinately Regulate the Ubiquitin Ligase CHIP
2011
Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7–Atg3 and Atg7–Atg10 structures
2012
c‐IAP1 and UbcH5 promote K11‐linked polyubiquitination of RIP1 in TNF signalling
2010
HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency
2011
Regulation of Ubiquitin Chain Initiation to Control the Timing of Substrate Degradation
2011
PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
2010 Standout
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
2015 Standout
Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
2012
Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects
2020 Standout
TRIM5 Suppresses Cross-Species Transmission of a Primate Immunodeficiency Virus and Selects for Emergence of Resistant Variants in the New Species
2010
Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment
2008
UBE2W Interacts with FANCL and Regulates the Monoubiquitination of Fanconi Anemia Protein FANCD2
2011
Designed proteins induce the formation of nanocage-containing extracellular vesicles
2016 Nature
A compendium of proteins that interact with HIF-1α
2017 StandoutNobel
TRIM5α and Species Tropism of HIV/SIV
2012
The machinery of macroautophagy
2013 Standout
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
2009 Nature
The Mdm2 RING domain C‐terminus is required for supramolecular assembly and ubiquitin ligase activity
2006
Structure and Analysis of a Complex between SUMO and Ubc9 Illustrates Features of a Conserved E2-Ubl Interaction
2007
Inflammation and tumor progression: signaling pathways and targeted intervention
2021 Standout
Modulation of K11-Linkage Formation by Variable Loop Residues within UbcH5A
2011
The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy
2007 StandoutNobel
BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer
2012
Massively parallel determination and modeling of endonuclease substrate specificity
2014 StandoutNobel
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
BRCA1 and its toolbox for the maintenance of genome integrity
2009
Breaking the chains: structure and function of the deubiquitinases
2009 Standout
Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex
2011
The E2 Ubiquitin-conjugating Enzymes Direct Polyubiquitination to Preferred Lysines
2010
NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly
2020 Nature
MX2 is an interferon-induced inhibitor of HIV-1 infection
2013 StandoutNatureNobel
The Ubiquitin-conjugating Enzyme (E2) Ube2w Ubiquitinates the N Terminus of Substrates
2013
Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation
2008
Mechanism of p53 stabilization by ATM after DNA damage
2010
Unique Requirement for ESCRT Factors in Flavivirus Particle Formation on the Endoplasmic Reticulum
2016
Priming and Extending: A UbcH5/Cdc34 E2 Handoff Mechanism for Polyubiquitination on a SCF Substrate
2010
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
2020 Standout
Intrinsic disorder drives N-terminal ubiquitination by Ube2w
2014 StandoutNobel
Structural Basis of Atg8 Activation by a Homodimeric E1, Atg7
2011 StandoutNobel
Inhibition of HIV-1 Particle Assembly by 2′,3′-Cyclic-Nucleotide 3′-Phosphodiesterase
2012 StandoutNobel
PROTAC targeted protein degraders: the past is prologue
2022 Standout
Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinity
2007 Nature
Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling
2010
Ubiquitin signalling in DNA replication and repair
2010
TRIM5 is an innate immune sensor for the retrovirus capsid lattice
2011 Nature
Evaluation of a Diffusion-Driven Mechanism for Substrate Ubiquitination by the SCF-Cdc34 Ubiquitin Ligase Complex
2006
Identification of Interferon-Stimulated Genes with Antiretroviral Activity
2016 StandoutNobel
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Cancer-related inflammation
2008 StandoutNature
Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1
2017
ROS and the DNA damage response in cancer
2018 Standout
Structural Insights into Atg10-Mediated Formation of the Autophagy-Essential Atg12-Atg5 Conjugate
2012 StandoutNobel
Structure of a SUMO-binding-motif Mimic Bound to Smt3p–Ubc9p: Conservation of a Non-covalent Ubiquitin-like Protein–E2 Complex as a Platform for Selective Interactions within a SUMO Pathway
2007
Certain Pairs of Ubiquitin-conjugating Enzymes (E2s) and Ubiquitin-Protein Ligases (E3s) Synthesize Nondegradable Forked Ubiquitin Chains Containing All Possible Isopeptide Linkages
2007
Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin‐3
2009
UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids
2011 Nature
Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes
2008
Structural basis for specific recognition of Lys 63‐linked polyubiquitin chains by tandem UIMs of RAP80
2009
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis
2012 Nature
Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas
2010 StandoutScience
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
2009 Standout
IgG Subclasses and Allotypes: From Structure to Effector Functions
2014 Standout
Oxygen homeostasis
2009 StandoutNobel
CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila
2012 StandoutNobel
Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs
2009
Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI
2008
Atypical ubiquitin chains: new molecular signals
2008
Polyubiquitination by HECT E3s and the Determinants of Chain Type Specificity
2009
Structure of the Atg12–Atg5 conjugate reveals a platform for stimulating Atg8–PE conjugation
2012 StandoutNobel
Hepatitis C virus infects rhesus macaque hepatocytes and simianized mice
2015 StandoutNobel
E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6
2011
UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex
2010
Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex
2013 StandoutNobel
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
The ubiquitin landscape at DNA double-strand breaks
2009
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
E2s: structurally economical and functionally replete
2010
RING Domain E3 Ubiquitin Ligases
2009 Standout
Structural insight into HIV-1 capsid recognition by rhesus TRIM5α
2012
Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2
2009
Recognition of the HIV Capsid by the TRIM5α Restriction Factor Is Mediated by a Subset of Pre-Existing Conformations of the TRIM5α SPRY Domain
2014
Structural Insights into the Conformation and Oligomerization of E2∼Ubiquitin Conjugates
2012
The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension
2012
Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions
2012
The Ubiquitin Code
2012 Standout
Structural Mechanisms Underlying Posttranslational Modification by Ubiquitin-Like Proteins
2007
Ube2W conjugates ubiquitin to α-amino groups of protein N-termini
2013
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
Works of Devin E. Christensen being referenced
2015
Attenuated protein expression vectors for use in siRNA rescue experiments
2012
A UbcH5/Ubiquitin Noncovalent Complex Is Required for Processive BRCA1-Directed Ubiquitination
2006
Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3‐dependent protein ubiquitination
2009
E2–BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages
2007
Biochemical Characterization of a Recombinant TRIM5α Protein That Restricts Human Immunodeficiency Virus Type 1 Replication
2008