Citation Impact
Citing Papers
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4
1993
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation
2003 StandoutNobel
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
MOLECULAR AND GENETIC INSIGHTS INTO T CELL ANTIGEN RECEPTOR STRUCTURE AND FUNCTION
1991
CDK inhibitors: positive and negative regulators of G1-phase progression
1999 Standout
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase
1995 StandoutNobel
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
The p21Cip1 and p27Kip1 CDK `inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
1999
The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.
1997
A cyclin associated with the CDK-activating kinase MO15
1994 Nature
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.
1995
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells
2009
Isolation and Function of Human Dendritic Cells
1994
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
1994 Standout
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
The Hallmarks of Cancer
2000 Standout
Direct lineage conversions: unnatural but useful?
2011
Developmental regulation of MHC class II transport in mouse dendritic cells
1997 StandoutNatureNobel
Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK
1994 StandoutNobel
Essential role for ZAP-70 in both positive and negative selection of thymocytes
1995 Nature
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
1999 StandoutNobel
Protein kinase regulation: insights from crystal structure analysis
1994
Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
1994
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
CD 69 expression during selection and maturation of CD4+8+ thymocytes
1993
The Xenopus Cdc6 Protein Is Essential for the Initiation of a Single Round of DNA Replication in Cell-Free Extracts
1996
Dynamics of Diacylglycerol Kinase ζ Translocation in Living T-cells
2002
The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways
1991
Signal transduction by lymphocyte antigen receptors
1994 Standout
A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase
1994
Differential Interaction of the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1 with Cyclin A-Cdk2 and Cyclin D2-Cdk4
1997
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
1995 Nature
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Isolation of mutant T lymphocytes with defects in capacitative calcium entry
1995
Crystal structure of cyclin-dependent kinase 2
1993 Nature
A light-entrainment mechanism for the Drosophila circadian clock
1996 StandoutNatureNobel
Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms
2002
The Cdt1 protein is required to license DNA for replication in fission yeast
2000 StandoutNatureNobel
Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation
1994
A Spontaneously Arising Mutation in the DLAARN Motif of Murine ZAP-70 Abrogates Kinase Activity and Arrests Thymocyte Development
1997
Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
1992
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
1999 StandoutNobel
A brain-specific activator of cyclin-dependent kinase 5
1994 StandoutNatureNobel
Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway
1990 Nature
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
1993 Nature
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
1994 Standout
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
1994 Standout
Activation of the various cyclin/cdc2 protein kinases
1993
Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex
1994 StandoutNobel
Thymocyte development is normal in CTLA-4-deficient mice
1997 StandoutNobel
Study of the cell cycle-dependent assembly of the DNA pre-replication centres in Xenopus egg extracts.
1994
Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes
1998
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.
1992
Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro.
1993
Quantitation of Transcription and Clonal Selection of Single Living Cells with β-Lactamase as Reporter
1998 StandoutScienceNobel
Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.
1996
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
1999 StandoutNobel
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.
1991
Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb
1997
clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans
1998 StandoutNobel
Rescue of Signaling by a Chimeric Protein Containing the Cytoplasmic Domain of CD45
1993 Science
D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells
1994
Temporal phosphorylation of the Drosophila period protein.
1994 StandoutNobel
Cell-Free Degradation of p27kip1, a G1 Cyclin-Dependent Kinase Inhibitor, Is Dependent on CDK2 Activity and the Proteasome
1999
T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1
1991
Cancer Cell Cycles
1996 StandoutScience
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
1995 Standout
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero
1998 StandoutNobel
Molecular cloning of a murine N-acetylgalactosamine transferase cDNA that determines expression of the T lymphocyte-specific CT oligosaccharide differentiation antigen.
1994
Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins.
1993
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.
1995
Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.
1990
Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene
1997 StandoutNobel
Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.
1996
Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors.
1995
Analysis of the Schizosaccharomyces pombe cyclin puc1: evidence for a role in cell cycle exit
1994 StandoutNobel
The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.
1993 StandoutNobel
Repression of p27kip1 Synthesis by Platelet-Derived Growth Factor in BALB/c 3T3 Cells
1996
Differential regulation of E2F transactivation by cyclin/cdk2 complexes.
1994
The retinoblastoma protein and cell cycle control
1995 Standout
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Disruption of retinoblastoma protein function by coexpression of its C pocket fragment.
1995
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
1997 Standout
Formation and Activation of a Cyclin E-cdk2 Complex During the G 1 Phase of the Human Cell Cycle
1992 Science
CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15.
1993
Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice.
1995 StandoutNobel
Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to Eag and cyclic nucleotide-gated channels
1997 StandoutNobel
Study of the higher eukaryotic gene function CDK2 using fission yeast
1994 StandoutNobel
Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein.
1994
D-type cyclin-dependent kinase activity in mammalian cells.
1994
A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes.
1993
The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.
1996
Cyclin D1 Is Dispensable for G1 Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity
1995
A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication.
1996 StandoutNobel
Activation of tyrosine kinase p60fyn following T cell antigen receptor cross-linking.
1992
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation.
1995 StandoutNobel
Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-β
1993 Science
Assembly of cyclin D-dependent kinase and titration of p27 Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
1998
A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation
2000
Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.
1994
Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits.
1992 StandoutNobel
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
1994 Standout
Works of Dev M. Desai being referenced
Stimulation of the phosphatidyl-inositol pathway can induce T-cell activation
1990 Nature
A transfected human muscarinic receptor fails to substitute for the T cell antigen receptor complex in CD2-initiated signal transduction
1990
The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction
1994
Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase
1993
Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation.
1994
Signal Transduction by the T Cell Antigen Receptor
1989
Function of a Heterologous Muscarinic Receptor in T Cell Antigen Receptor Signal Transduction Mutants
1989
Activation of human cyclin-dependent kinases in vitro.
1992
The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation.
1994