Standout Papers
Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
c-Jun NH2-Terminal Kinase 1 Is a Critical Regulator for the Development of Gastric Cancer in Mice
2008
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
2007 StandoutNobel
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis
1999
Gadd45β promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling
2008
The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307
2000
The p38 MAPK stress pathway as a tumor suppressor or more?
2008
JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species
2004
A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis
2003
The Reelin Receptor ApoER2 Recruits JNK-interacting Proteins-1 and -2
2000
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
The JNK signal transduction pathway
2002
C–Jun–N–Terminal Kinase Drives Cyclin D1 Expression and Proliferation During Liver Regeneration
2003
Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis
2002
pp60v- Induction of Cyclin D1 Requires Collaborative Interactions between the Extracellular Signal-regulated Kinase, p38, and Jun Kinase Pathways
1999
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
Signal integration by JNK and p38 MAPK pathways in cancer development
2009 Standout
Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
1999
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
2003
Functional roles of non-coding Y RNAs
2015
AP-1: a double-edged sword in tumorigenesis
2003 Standout
Mechanism of p38 MAP kinase activation in vivo
2003
Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
1999
Chemical Genetic Analysis of the Time Course of Signal Transduction by JNK
2006
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
2006 StandoutNatureNobel
Inhibition of hypoxia/reoxygenation-induced apoptosis by an antisense oligonucleotide targeted to JNK1 in human kidney cells
2000
Arrestins Block G Protein-coupled Receptor-mediated Apoptosis
2004
Sequential Activation of Signaling Pathways during Innate Immune Responses in Drosophila
2002
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
1998
Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways
2009 StandoutNobel
Ro’s Role in RNA Reconnaissance
2005 StandoutNobel
Role of mitogen-activated protein kinase kinase 4 in cancer
2007
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical Importance
2005
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
1999
Distinct Roles for JNK1 and JNK2 in Regulating JNK Activity and c-Jun-Dependent Cell Proliferation
2004
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Crystal structure of JNK3: a kinase implicated in neuronal apoptosis
1998
Membrane vesicles as conveyors of immune responses
2009 Standout
The c-jun kinase/stress-activated pathway: Regulation, function and role in human disease
2007
Regulation of the immune response by stress‐activated protein kinases
2009
Analysis of pharmacologic inhibitors of Jun N-terminal kinases
2001
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy
2005 Standout
A selective small‐molecule inhibitor of c‐Jun N‐terminal kinase 1
2009
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
A central role for JNK in obesity and insulin resistance
2002 StandoutNature
JNK signalling modulates intestinal homeostasis and tumourigenesis in mice
2009
Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening
2003
Four deaths and a funeral: from caspases to alternative mechanisms
2001 Standout
Regulation of c-Myc through Phosphorylation at Ser-62 and Ser-71 by c-Jun N-Terminal Kinase
1999
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
2001
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
2000 Standout
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3(Mkk3)-deficient mice
1999
p38 MAP-Kinases pathway regulation, function and role in human diseases
2007
The immune response of Drosophila
2003 StandoutNatureNobel
JNK2 Is a Positive Regulator of the cJun Transcription Factor
2006
Oncomirs — microRNAs with a role in cancer
2006 Standout
Survival signaling mediated by c-Jun NH2-terminal kinase in transformed B lymphoblasts
2002
Identifying the MAGUK Protein Carma-1 as a Central Regulator of Humoral Immune Responses and Atopy by Genome-Wide Mouse Mutagenesis
2003
Dendritic cell regulation of TH1-TH2 development
2000
A TRP Channel that Senses Cold Stimuli and Menthol
2002 StandoutNobel
NF-κB in cancer: a marked target
2003
Signals involved in thymocyte positive and negative selection
1999
The Evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death
2000
Th1 and Th2 cells
2001
The miRNA-Processing Enzyme Dicer Is Essential for the Morphogenesis and Maintenance of Hair Follicles
2006
Hypersusceptibility to Vesicular Stomatitis Virus Infection in Dicer1-Deficient Mice Is Due to Impaired miR24 and miR93 Expression
2007 StandoutNobel
The functional contrariety of JNK
2007
Mammalian MAP kinase signalling cascades
2001 StandoutNature
T-cell regulation by CD28 and CTLA-4
2001
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development
1999
Requirement for p38α in Erythropoietin Expression
2000
Neuronal Cell Death
1998
Revealing the world of RNA interference
2004 StandoutNatureNobel
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
A Family of Stress-Inducible GADD45-like Proteins Mediate Activation of the Stress-Responsive MTK1/MEKK4 MAPKKK
1998
New Insights into the Control of MAP Kinase Pathways
1999
The Ro 60�kDa autoantigen: insights into cellular function and role in autoimmunity
2004
c-Jun NH2-Terminal Kinase 1 Plays a Critical Role in Intestinal Homeostasis and Tumor Suppression
2007
MAP-kinase signaling pathways in T cells
2001
Induction of Hepatitis by JNK-Mediated Expression of TNF-α
2009
Cancer-related inflammation
2008 StandoutNature
The Mixed Lineage Kinase DLK Utilizes MKK7 and Not MKK4 as Substrate
1999
c-Jun N-terminal kinases as potential therapeutic targets
2007
Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
2007 StandoutNobel
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
The JNK signal transduction pathway
2007
NF-κB at the crossroads of life and death
2002 Standout
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
A conserved motif of vertebrate Y RNAs essential for chromosomal DNA replication
2009
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation
2000
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Structural Insights into RNA Quality Control: The Ro Autoantigen Binds Misfolded RNAs via Its Central Cavity
2005
A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons
1999
p38α, but not p38β, inhibits the phosphorylation and presence of c-FLIPS in DISC to potentiate Fas-mediated caspase-8 activation and type I apoptotic signaling
2004
The Stress Kinase Mitogen-Activated Protein Kinase Kinase (Mkk)7 Is a Negative Regulator of Antigen Receptor and Growth Factor Receptor–Induced Proliferation in Hematopoietic Cells
2001 StandoutNobel
Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.
2001
C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation
2001
Spatial, temporal and subcellular localization of islet‐brain 1 (IB1), a homologue of JIP‐1, in mouse brain
2000
MEK kinase 1 gene disruption alters cell migration and c-Jun NH 2 -terminal kinase regulation but does not cause a measurable defect in NF-κB activation
2000
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
2001 Standout
Neurotrophins: Roles in Neuronal Development and Function
2001 Standout
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
2003 StandoutNobel
Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4
1999
JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms
2002
c-Jun NH2-Terminal Kinase Inhibits Targeting of the Protein Phosphatase Calcineurin to NFATc1
2000
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
1999 Standout
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
Generation and Characterization of p38β (MAPK11) Gene-Targeted Mice
2005
Neural Science
2000 StandoutNobel
Ro60 and Y RNAs: structure, functions, and roles in autoimmunity
2019
JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway
1999
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
2001
Disturbance of Tumor Necrosis Factor Alpha-Mediated Beta Interferon Signaling in Cervical Carcinoma Cells
2002 StandoutNobel
Exosomes with Immune Modulatory Features Are Present in Human Breast Milk
2007 Standout
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
2002 StandoutScience
Linking JNK signaling to NF-κB: a key to survival
2004
Molecular Mechanisms RegulatinG Th1 Immune Responses
2003
Requirement of JNK2 for Scavenger Receptor A-Mediated Foam Cell Formation in Atherogenesis
2004 Science
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
1999 Standout
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
2001 StandoutNobel
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
1999 Standout
Why YRNAs? About Versatile RNAs and Their Functions
2013
Reactive Oxygen Species (ROS), Troublemakers between Nuclear Factor-κB (NF-κB) and c-Jun NH2-terminal Kinase (JNK)
2004
BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G2/M
1999
Functional Requirement of Noncoding Y RNAs for Human Chromosomal DNA Replication
2006
Spinophilin regulates the formation and function of dendritic spines
2000
Dicer function is essential for lung epithelium morphogenesis
2006
Suppression of p53-dependent senescence by the JNK signal transduction pathway
2007
Macrophages Induce Invasiveness of Epithelial Cancer Cells Via NF-κB and JNK
2005
Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase
2004
Inhibition of c-Jun N-Terminal Kinase 2 Expression Suppresses Growth and Induces Apoptosis of Human Tumor Cells in a p53-Dependent Manner
2000
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
2001 Standout
Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death
1999
The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins
1999
Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.
2002
Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3
2000
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer
2005
Works of Derek Yang being referenced
The Ro Autoantigen Binds Misfolded U2 Small Nuclear RNAs and Assists Mammalian Cell Survival after UV Irradiation
2003
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
1997 Nature
JNK is required for effector T-cell function but not for T-cell activation
2000 Nature
The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development
1999
DENDRITIC CELL-DERIVED EXOSOMES CONTAINING MILK FAT GLOBULE EPIDERMAL GROWTH FACTOR-FACTOR VIII ATTENUATE PROINFLAMMATORY RESPONSES IN SEPSIS
2006
Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2
1998
Dicer Is Required for Embryonic Angiogenesis during Mouse Development
2004
The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes
1998
A critical role of neural-specific JNK3 for ischemic apoptosis
2003
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
2000 StandoutScience
A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen
2003
JNK1 Is Required for T Cell-Mediated Immunity AgainstLeishmania majorInfection
2000
Regulation of c-Jun NH2-terminal Kinase ( Jnk) Gene Expression during T Cell Activation
2000
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression
1999
Defective T Cell Differentiation in the Absence of Jnk1
1998 Science