Citation Impact
Citing Papers
Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
2010 StandoutScience
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Regulators of PP2C Phosphatase Activity Function as Abscisic Acid Sensors
2009 StandoutScience
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
A G Protein-Coupled Receptor Is a Plasma Membrane Receptor for the Plant Hormone Abscisic Acid
2007 Science
The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist
2008 StandoutScience
Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for Difficult-to-Treat depression
2003
Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated
2000
Cortisol Circadian Rhythm Alterations in Psychotic Major Depression
2006
Density and distribution of excitatory amino acid receptors in the developing human fetal brain: A quantitative autoradiographic study
1992
Metyrapone as Additive Treatment in Major Depression
2004
The Corticosteroid Receptor Hypothesis of Depression
2000 Standout
MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex
1997
Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease
1998
Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function
1998 Standout
Corticotropin Releasing Factor Receptor 1–Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development
1998
Antiglucocorticoid drugs in the treatment of depression
2001
Molecular Neurobiology of Glutamate Receptors
1992
Stromal fibroblasts in cancer initiation and progression
2004 StandoutNature
Blockade of CRF1 or V1b receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression
2003
Corticotropin-Releasing Factor in Brain: A Role in Activation, Arousal, and Affect Regulation
2004
Stabilization of the Human β2-Adrenergic Receptor TM4–TM3–TM5 Helix Interface by Mutagenesis of Glu1223.41, A Critical Residue in GPCR Structure
2007
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
2001 StandoutNature
Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery
2006
Glutamate uptake
2001 Standout
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
New directions in the development of antidepressants: the interface of neurobiology and psychiatry
2002
Dynamics of receptor/G protein coupling in living cells
2005
Glucocorticoid and mineralocorticoid receptor mRNA expression in squirrel monkey brain
2000
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
2001 StandoutNature
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
1995 StandoutNature
The high affinity uptake system for excitatory amino acids in the brain
1994
Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia
2004
Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress
2003
Immunocytochemical localization of serotonin1A receptors in the rat central nervous system
1996
A synaptic model of memory: long-term potentiation in the hippocampus
1993 StandoutNature
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
2005 StandoutNature
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
2013 Standout
Toll-like receptors in the induction of the innate immune response
2000 StandoutNature
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
2001
The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety
1999
Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture
2003
Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR
2003
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Stress and the brain: from adaptation to disease
2005 Standout
Cytokine, Sickness Behavior, and Depression
2009
Genetic Selection For Coping Style Predicts Stressor Susceptibility
2003
The acute effects of corticosteroids on cognition: integration of animal and human model studies
1997
Discovering Endophenotypes for Major Depression
2004
Psychobiological Mechanisms of Resilience and Vulnerability: Implications for Successful Adaptation to Extreme Stress
2004
Oxytocin increases trust in humans
2005 StandoutNature
The evolving role of lipid rafts and caveolae in G protein‐coupled receptor signaling: implications for molecular pharmacology
2004
Conformational complexity of G-protein-coupled receptors
2007 StandoutNobel
Origin and physiological roles of inflammation
2008 StandoutNature
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Ligand-Independent Adenosine A2B Receptor Constitutive Activity as a Promoter of Prostate Cancer Cell Proliferation
2016
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Interleukin 1 receptor accessory protein (IL-1RAcP) is necessary for centrally mediated neuroendocrine and immune responses to IL-1β
2000
Interindividual differences in the levels of the glutamate transporters GLAST and GLT, but no clear correlation with Alzheimer's disease
1999
The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease
2004
Structure and dynamics of the M3 muscarinic acetylcholine receptor
2012 StandoutNatureNobel
Leptin and the regulation of body weight in mammals
1998 StandoutNature
Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
2002 StandoutNature
The Constitutive Activity of the Human Muscarinic M3 Receptor Unmasks Differences in the Pharmacology of Anticholinergics
2009
The molecular neurobiology of depression
2008 StandoutNature
Trends in the Development of New Antidepressants. Is there a Light at the End of the Tunnel?
2004
Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
2002
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Pathogen Recognition and Innate Immunity
2006 Standout
NEUROENDOCRINE PERSPECTIVES ON SOCIAL ATTACHMENT AND LOVE
1998
Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor
2001
The immunopathogenesis of sepsis
2002 StandoutNature
Expression and localization of p80 and p68 interleukin-1 receptor proteins in the brain of adult mice
1999
Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide
1996 Science
G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology
2004
Growth factor involvement in progression of prostate cancer
1998
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*
1999
Urocortin, But Not Urocortin II, Protects Cultured Hippocampal Neurons from Oxidative and Excitotoxic Cell Death via Corticotropin-Releasing Hormone Receptor Type I
2002
Negative Selection during the Peripheral Immune Response to Antigen
2000
Long-term exposure to high corticosterone levels attenuates serotonin responses in rat hippocampal CA1 neurons
1999
A prolactin-releasing peptide in the brain
1998 Nature
Memory--a Century of Consolidation
2000 StandoutScience
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.
1996 StandoutNobel
Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart.
1995
Growth factor involvement in progression of prostate cancer.
1998
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes
2006 StandoutNobel
The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products
2000
Angst and the amygdala
2006
Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease
1997 StandoutNobel
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors
2001
Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain
1999 StandoutScience
Glucocorticoid receptor overexpression in forebrain: A mouse model of increased emotional lability
2004
Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein
1997 StandoutScience
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
Leptin affects food intake via CRF-receptor-mediated pathways
1998
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
2001 Standout
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
2009 StandoutNobel
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
Serotonin receptor knockouts: A moody subject
1998 StandoutNobel
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
1999 StandoutNature
Gut hormone PYY3-36 physiologically inhibits food intake
2002 StandoutNature
Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice
2000
Psychological Stress Increases Hippocampal Mineralocorticoid Receptor Levels: Involvement of Corticotropin-Releasing Hormone
2001
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
1999
Neurotransmitter Transporters: Regulators of Function and Functional Regulation
1998
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
2000 StandoutScience
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
2012 StandoutNobel
CRF and CRF Receptors: Role in Stress Responsivity and Other Behaviors
2004
Works of Derek Chalmers being referenced
Corticotrophin-releasing factor receptors: from molecular biology to drug design
1996
The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist
1997
Rat homolog of mouse interleukin-1 receptor accessory protein: cloning, localization and modulation studies
1996
Steroid-growth factor interaction in human prostate cancer. 1. Short-term effects of transforming growth factors on growth of human prostate cancer cells
1994
Characterization of Corticotropin‐releasing Factor Receptor Subtypesa
1996
Regulation of Hippocampal 5-HT1A Receptor Gene Expression by Dexamethasone
1994
Global analysis of G‐protein‐coupled receptor signaling in human tissues
2003
The use of constitutively active GPCRs in drug discovery and functional genomics
2002
Regulation of Serotonin1A, Glucocorticoid, and Mineralocorticoid Receptor in Rat and Human Hippocampus: Implications for the Neurobiology of Depression
1998
Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2)
1996
Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms
1997
Ligand Specific Up-Regulation of a Renilla reniformis Luciferase-Tagged, Structurally Unstable Muscarinic M3 Chimeric G Protein-Coupled Receptor
2003
Regulation of 5‐HT Receptors and the Hypothalamic‐Pituitary‐Adrenal Axis
1997
Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior
1997
Cloning and expression of the A2a adenosine receptor from guinea pig brain
1994
Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus
1991
Serotonin transporter mRNA in rat brain is regulated by classical antidepressants
1994
Comparative anatomical distribution of 5-HT1A receptor mRNA and 5-HT1A binding in rat brain — a combined in situ hybridisation/in vitro receptor autoradiographic study
1991
Corticotropin releasing factor binding protein (CRF-BP) is expressed in neuronal and astrocytic cells
1995
Glucocorticoid regulation of hippocampal oxytocin receptor binding
1994
Generation and Analysis of Constitutively Active and Physically Destabilized Mutants of the Human β1-Adrenoceptor
2002
Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain.
1995
CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues.
1995
Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders.
1996
GCR1 , the putative Arabidopsis G protein-coupled receptor gene is cell cycle-regulated, and its overexpression abolishes seed dormancy and shortens time to flowering
2002
Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type.
1990