Standout Papers
Citation Impact
Citing Papers
Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors
2009 Science
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins
2006
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance
2014 StandoutNobel
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
2010 StandoutScience
Neuroanatomical evidence for segregation of nerve fibers conveying light touch and pain sensation in Eimer’s organ of the mole
2006 StandoutNobel
Transposition-Driven Genomic Heterogeneity in the Drosophila Brain
2013 StandoutScienceNobel
Regulation of NMDA receptors by cyclin-dependent kinase-5
2001
Gating the Selectivity Filter in ClC Chloride Channels
2003 StandoutScienceNobel
Sleep Drives Metabolite Clearance from the Adult Brain
2013 StandoutScience
Transcriptional regulation of the GluR2 gene: Neural-specific expression, multiple promoters, and regulatory elements
1998
Developmental Expression of Ca2+-Permeable AMPA Receptors Underlies Depolarization-Induced Long-Term Depression at Mossy Fiber–CA3 Pyramid Synapses
2007
Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum
2009
Modulation of non‐NMDA receptor gating by auxiliary subunits
2014
Structure and Mechanism of Kainate Receptor Modulation by Anions
2007
A Role for Extracellular Na+in the Channel Gating of Native and Recombinant Kainate Receptors
2003
Subtype selectivity and flexibility of ionotropic glutamate receptors upon antagonist ligand binding
2006
Molecular Mechanism of AMPA Receptor Modulation by TARP/Stargazin
2017
Neuropharmacology of AMPA and kainate receptors
1998
Developmental and activity- dependent regulation of kainate receptors at thalamocortical synapses
1999 Nature
Kainate receptors: Pharmacology, function and therapeutic potential
2008
Lectin-Induced Inhibition of Desensitization of the Kainate Receptor GluR6 Depends on the Activation State and Can Be Mediated by a Single Native or Ectopic N-Linked Carbohydrate Side Chain
1999
Radial symmetry in a chimeric glutamate receptor pore
2014
Identification of C-terminal domain residues involved in protein kinase A-mediated potentiation of kainate receptor subtype 6
2007
Control of rat GluR6 glutamate receptor open probability by protein kinase A and calcineurin
1997
A Transmembrane Accessory Subunit that Modulates Kainate-Type Glutamate Receptors
2009
Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine
2009
Interface Interactions Modulating Desensitization of the Kainate-Selective Ionotropic Glutamate Receptor Subunit GluR6
2006
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Domain organization and function in GluK2 subtype kainate receptors
2010
Block of Kainate Receptor Desensitization Uncovers a Key Trafficking Checkpoint
2006
Ionotropic and metabotropic glutamate receptor structure and pharmacology
2005
Molecular Determinants Responsible for Differences in Desensitization Kinetics of AMPA Receptor Splice Variants
2004
Coassembly of Two GluR6 Kainate Receptor Splice Variants within a Functional Protein Complex
2005
Functional Assembly of AMPA and Kainate Receptors Is Mediated by Several Discrete Protein-Protein Interactions
2001
Q/R Site Editing Controls Kainate Receptor Inhibition by Membrane Fatty Acids
2005
Engineering a high-affinity allosteric binding site for divalent cations in kainate receptors
2008
An Endoplasmic Reticulum Retention Signal Located in the Extracellular Amino-terminal Domain of the NR2A Subunit of N-Methyl-d-aspartate Receptors
2009
Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles
2013
Glutamate Receptor Trafficking: Endoplasmic Reticulum Quality Control Involves Ligand Binding and Receptor Function
2005
Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions
2009
Molecular Basis of Kainate Receptor Modulation by Sodium
2008
Crystal Structures of the Kainate Receptor GluR5 Ligand Binding Core Dimer with Novel GluR5-Selective Antagonists
2006
N-Glycosylation Is Not a Prerequisite for Glutamate Receptor Function but Is Essential for Lectin Modulation
1997
A Point Mutation in the Glutamate Binding Site Blocks Desensitization of AMPA Receptors
1998
Amino-Acid Residues Involved in Glutamate Receptor 6 Kainate Receptor Gating and Desensitization
2003
Amino acid substitutions in the pore of rat glutamate receptors at sites influencing block by polyamines
1999
Structural basis of kainate subtype glutamate receptor desensitization
2016 Nature
Structural mechanism of glutamate receptor activation and desensitization
2014 Nature
Mutations to the Kainate Receptor Subunit GluR6 Binding Pocket That Selectively Affect Domoate Binding
2008
The Serine Protease Plasmin Cleaves the Amino-terminal Domain of the NR2A Subunit to Relieve Zinc Inhibition of the N-Methyl-d-aspartate Receptors
2009
A Nondesensitizing Kainate Receptor Point Mutant
2009
Intracellular Domains of NR2 Alter Calcium-Dependent Inactivation of N-Methyl-d-aspartate Receptors
2002
Structure–activity analysis of a novel NR2C/NR2D‐preferring NMDA receptor antagonist: 1‐(phenanthrene‐2‐carbonyl) piperazine‐2,3‐dicarboxylic acid
2004
Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex
2008
Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors1The first two authors contributed equally to this work.1
2001
Binding of spermine and ifenprodil to a purified, soluble regulatory domain of theN‐methyl‐d‐aspartate receptor
2008
Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation
2009
Glutamate receptor ion channels
2005 Standout
N-Methyl-d-aspartate (NMDA) Receptor Subunit NR1 Forms the Substrate for Oligomeric Assembly of the NMDA Receptor
2007
Gating motions underlie AMPA receptor secretion from the endoplasmic reticulum
2008
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
2010 Standout
Functional diversity of recombinant human AMPA type glutamate receptors: possible implications for selective vulnerability of motor neurons
2001
Emotion Enhances Learning via Norepinephrine Regulation of AMPA-Receptor Trafficking
2007
Stargazin Reduces Desensitization and Slows Deactivation of the AMPA-Type Glutamate Receptors
2005
Protons Trap NR1/NR2B NMDA Receptors in a Nonconducting State
2005
Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state
2001
Amyloid beta peptides and glutamatergic synaptic dysregulation
2007
Inhibition of Glutamate Receptor 2 Translation by a Polymorphic Repeat Sequence in the 5′-Untranslated Leaders
2004
NMDA receptors in clinical neurology: excitatory times ahead
2008
Structural basis of long-term potentiation in single dendritic spines
2004 StandoutNature
Structural biology of glutamate receptor ion channel complexes
2016
Regulation of NR1/NR2C N-Methyl-D-aspartate (NMDA) Receptors by Phosphorylation*
2006
Staggering of Subunits in NMDAR Channels
2002
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia
2005 Nature
Structural aspects of AMPA receptor activation, desensitization and deactivation
2007
Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed inXenopus laevisoocytes
2007
Effects of theLurcherMutation on GluR1 Desensitization and Activation Kinetics
2004
3-Hydroxypyridazine 1-oxides as carboxylate bioisosteres: A new series of subtype-selective AMPA receptor agonists
2006
Pharmacological characterization, localization, and regulation of ionotropic glutamate receptors in skate horizontal cells
2009
Functional architecture of the nicotinic acetylcholine receptor: A prototype of ligand-gated ion channels
1993
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Gating Reaction Mechanisms for NMDA Receptor Channels
2005
The δ2 ‘ionotropic’ glutamate receptor functions as a non‐ionotropic receptor to control cerebellar synaptic plasticity
2007
Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor
2006
The Stoichiometry of AMPA Receptors and TARPs Varies by Neuronal Cell Type
2009
Modulation of the Dimer Interface at Ionotropic Glutamate-Like Receptor δ2 by d-Serine and Extracellular Calcium
2009
The Interaction between Stargazin and PSD-95 Regulates AMPA Receptor Surface Trafficking
2007
Astrocytic control of synaptic NMDA receptors
2007
20-Oxo-5β-Pregnan-3α-yl Sulfate Is a Use-Dependent NMDA Receptor Inhibitor
2005
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
Neuroprotection by the NR3A Subunit of the NMDA Receptor
2009
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
AMPA Receptor Trafficking at Excitatory Synapses
2003
Prostaglandin E2‐induced sensitization of bradykinin‐evoked responses in rat dorsal root ganglion neurons is mediated by cAMP‐dependent protein kinase A
2000
PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
2003
Interaction of the M4 Segment with Other Transmembrane Segments Is Required for Surface Expression of Mammalian α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors
2011
The Quaternary Structure of a Calcium-Permeable AMPA Receptor: Conservation of Shape and Symmetry across Functionally Distinct Subunit Assemblies
2008
Exposure to novel environment is characterized by an interaction of D1/NMDA receptors underlined by phosphorylation of the NMDA and AMPA receptor subunits and activation of ERK1/2 signaling, leading to epigenetic changes and gene expression in rat hippocampus
2011
Crystal structure and mechanism of a calcium-gated potassium channel
2002 StandoutNatureNobel
AMPA Receptor Binding Cleft Mutations That Alter Affinity, Efficacy, and Recovery from Desensitization
2005
2005
The Transmembrane Domain Mediates Tetramerization of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors
2016
Allosteric regulation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptors by thiocyanate and cyclothiazide at a common modulatory site distinct from that of 2,3-benzodiazepines
1998
Characterization of the Ligand-binding Domains of Glutamate Receptor (GluR)-B and GluR-D Subunits Expressed in as Periplasmic Proteins
1996
The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain
2007
Inducible and Reversible Enhancement of Learning, Memory, and Long-Term Potentiation by Genetic Inhibition of Calcineurin
2001 Nobel
GluR6/KA2 Kainate Receptors Mediate Slow-Deactivating Currents
2008
Tweaking Agonist Efficacy at N-Methyl-d-aspartate Receptors by Site-Directed Mutagenesis
2005
Regulation of mitogen‐activated protein kinases by glutamate receptors
2006
Atomistic mechanism for the activation and desensitization of an AMPA-subtype glutamate receptor
2011
Characterization of the Binding Site for a Novel Class of Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonists
2000
Regulatory mechanisms of AMPA receptors in synaptic plasticity
2007
Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin
1998 StandoutNobel
Regulation of AMPA receptors during synaptic plasticity
2002
Activation of recombinant NR1/NR2C NMDA receptors
2008
Assembly and Stoichiometry of the AMPA Receptor and Transmembrane AMPA Receptor Regulatory Protein Complex
2010
Mechanisms for Activation and Antagonism of an AMPA-Sensitive Glutamate Receptor
2000
The Expanding Social Network of Ionotropic Glutamate Receptors: TARPs and Other Transmembrane Auxiliary Subunits
2011
Pharmacology of δ2 Glutamate Receptors: Effects of Pentamidine and Protons
2003
Regulation of Synaptic Strength and AMPA Receptor Subunit Composition by PICK1
2004
Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors
2003
Glutamate receptors in the mammalian central nervous system
1998
Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors
2016
Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation
2003
Structural Features of the Glutamate Binding Site in Recombinant NR1/NR2A N-Methyl-D-aspartate Receptors Determined by Site-Directed Mutagenesis and Molecular Modeling
2005
Pharmacological Characterization of Glycine-Activated Currents in HEK 293 Cells Expressing N-Methyl-D-aspartate NR1 and NR3 Subunits
2007
Two Families of TARP Isoforms that Have Distinct Effects on the Kinetic Properties of AMPA Receptors and Synaptic Currents
2007
Permeant Ion Effects on External Mg2+Block of NR1/2D NMDA Receptors
2006
Stargazin attenuates intracellular polyamine block of calcium-permeable AMPA receptors
2007
Relating NMDA Receptor Function to Receptor Subunit Composition: Limitations of the Pharmacological Approach
2006
Allosteric modulators of NR2B‐containing NMDA receptors: molecular mechanisms and therapeutic potential
2009
Design of antagonists for NMDA and AMPA receptors
2005
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
Changes in Agonist Concentration Dependence That Are a Function of Duration of Exposure SuggestN-Methyl-d-aspartate Receptor Nonsaturation during Synaptic Stimulation
2001
Subunit‐specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles
2005
Stereocontrolled Synthesis and Pharmacological Evaluation of Azetidine‐2,3‐Dicarboxylic Acids at NMDA Receptors
2008
Mechanism of glutamate receptor desensitization
2002 Nature
Organic blockers escape from trapping in the AMPA receptor channels by leaking into the cytoplasm
2007
AMPA Receptor Ligand Binding Domain Mobility Revealed by Functional Cross Linking
2009
Distinct NMDA Receptors Provide Differential Modes of Transmission at Mossy Fiber-Interneuron Synapses
2002
An analysis of philanthotoxin block for recombinant rat GluR6(Q) glutamate receptor channels
1998
Molecular Dynamics Simulation for All
2018 Standout
Kinetic properties of human AMPA‐type glutamate receptors expressed in HEK293 cells
2003
Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-d-aspartate receptors
2009
Xenopus laevis Oocytes Endogenously Express All Subunits of the Ionotropic Glutamate Receptor Family
2009
Gating Modes in AMPA Receptors
2010
Block of AMPA Receptor Desensitization by a Point Mutation outside the Ligand-Binding Domain
2004
Interdomain Interactions in AMPA and Kainate Receptors Regulate Affinity for Glutamate
2006
Phosphorylation‐dependent interactions of α‐Actinin‐1/IQGAP1 with the AMPA receptor subunit GluR4
2005
Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors
2007
Stargazin (TARP γ-2) Is Required for Compartment-Specific AMPA Receptor Trafficking and Synaptic Plasticity in Cerebellar Stellate Cells
2011
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
Structural Basis of Inward Rectification
2002 StandoutNobel
Coupling of Energy Metabolism and Synaptic Transmission at the Transcriptional Level: Role of Nuclear Respiratory Factor 1 in Regulating both CytochromecOxidase and NMDA Glutamate Receptor Subunit Genes
2009
Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression
2004
Coupled Control of Desensitization and Gating by the Ligand Binding Domain of Glutamate Receptors
2012
Nuclear respiratory factor 1 co‐regulates AMPA glutamate receptor subunit 2 and cytochrome c oxidase: tight coupling of glutamatergic transmission and energy metabolism in neurons
2009
Allosteric control of an ionotropic glutamate receptor with an optical switch
2005
Revisiting the Postulated “Unitary Glutamate Receptor”: Electrophysiological and Pharmacological Analysis in Two Heterologous Expression Systems Fails to Detect Evidence for Its Existence
2005
Structural Rearrangements of NR1/NR2A NMDA Receptors during Allosteric Inhibition
2008
Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus
2005
NMDA receptor function: subunit composition versus spatial distribution
2006
Polyamine-dependent facilitation of postsynaptic AMPA receptors counteracts paired-pulse depression
1999 Nature
Extracellular Interactions between GluR2 and N-Cadherin in Spine Regulation
2007
The chemical biology of clinically tolerated NMDA receptor antagonists
2006
Crystal structure and association behaviour of the GluR2 amino‐terminal domain
2009
Visually Driven Modulation of Glutamatergic Synaptic Transmission Is Mediated by the Regulation of Intracellular Polyamines
2002
PICK1 and Phosphorylation of the Glutamate Receptor 2 (GluR2) AMPA Receptor Subunit Regulates GluR2 Recycling after NMDA Receptor-Induced Internalization
2007
NMDA Receptor NR2 Subunit Dependence of the Slow Component of Magnesium Unblock
2006
Structural landscape of isolated agonist-binding domains from single AMPA receptors
2011
Conformational restriction blocks glutamate receptor desensitization
2006
Four Different Subunits Are Essential for Expressing the Synaptic Glutamate Receptor at Neuromuscular Junctions ofDrosophila
2005
Amantadine Inhibits NMDA Receptors by Accelerating Channel Closure during Channel Block
2005
A Novel Conus Snail Polypeptide Causes Excitotoxicity by Blocking Desensitization of AMPA Receptors
2009
Developmental Changes in AMPA and Kainate Receptor-Mediated Quantal Transmission at Thalamocortical Synapses in the Barrel Cortex
2005
Apparent Homomeric NR1 Currents Observed in Xenopus Oocytes are Caused by an Endogenous NR2 Subunit
2007
Mg2+Imparts NMDA Receptor Subtype Selectivity to the Alzheimer's Drug Memantine
2009
Phosphorylation of the AMPA Receptor GluR1 Subunit Is Required for Synaptic Plasticity and Retention of Spatial Memory
2003
Molecular Determinants of Glycine-Independent Desensitization of NR1/NR2A Receptors
2005
Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
2003
Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors
2005
Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function
2015
Superactivation of AMPA receptors by auxiliary proteins
2016
The Activation Gate and Gating Mechanism of the NMDA Receptor
2008
Desensitization of NMDA Receptor Channels Is Modulated by Glutamate Agonists
2001
N-Terminal Domains in the NR2 Subunit Control Desensitization of NMDA Receptors
1998
N1-Dansyl-Spermine and N1-(n-Octanesulfonyl)-Spermine, Novel Glutamate Receptor Antagonists: Block and Permeation ofN-Methyl-d-Aspartate Receptors
1997
Competitive AMPA receptor antagonists
2006
Maximum likelihood fitting of single channel NMDA activity with a mechanism composed of independent dimers of subunits
2005
PDZ Proteins Interacting with C-Terminal GluR2/3 Are Involved in a PKC-Dependent Regulation of AMPA Receptors at Hippocampal Synapses
2000
Site within N-Methyl-D-aspartate Receptor Pore Modulates Channel Gating
2004
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Memantine binding to a superficial site on NMDA receptors contributes to partial trapping
2009
Crystal Structure of the GluR2 Amino-Terminal Domain Provides Insights into the Architecture and Assembly of Ionotropic Glutamate Receptors
2009
Differential binding properties of [3H]dextrorphan and [3H]MK-801 in heterologously expressed NMDA receptors
2005
Translational regulation of GluR2 mRNAs in rat hippocampus by alternative 3′ untranslated regions
2009
Molecular Dynamics Simulations of the Ligand-Binding Domain of the Ionotropic Glutamate Receptor GluR2
2002
Enhancement of NMDA receptor‐mediated currents by light in rat neurones in vitro
2000
Different Domains of the AMPA Receptor Direct Stargazin-mediated Trafficking and Stargazin-mediated Modulation of Kinetics
2006
The Selective Activation of the Glutamate Receptor GluR5 by ATPA Is Controlled by Serine 741
2003
Mechanisms of Modal Activation of GluA3 Receptors
2011
Control of Glutamate Receptor 2 (GluR2) Translational Initiation by Its Alternative 3′ Untranslated Regions
2009
Tyrosine Phosphorylation and Regulation of the AMPA Receptor by Src Family Tyrosine Kinases
2004
Mechanism of Partial Agonism at NMDA Receptors for a Conformationally Restricted Glutamate Analog
2005
The Role of the GluR2 Subunit in AMPA Receptor Function and Synaptic Plasticity
2007
Neto1 Is a Novel CUB-Domain NMDA Receptor–Interacting Protein Required for Synaptic Plasticity and Learning
2009
Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
2006
An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder
2008
Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2
2005
Molecular Mechanism of AMPA Receptor Noncompetitive Antagonism
2005
Subtype-dependence of N-methyl-d-aspartate receptor modulation by pregnenolone sulfate
2005
Structure and gating of the glutamate receptor ion channel
2004
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
Differential Regulation of Ionotropic Glutamate Receptors
2006
Novel Protein Kinase A-Dependent Long-Term Depression of Excitatory Synapses
2002
Three-dimensional structure of an AMPA receptor without associated stargazin/TARP proteins
2006
Protein Kinase Cγ Associates Directly with the GluR4 α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate Receptor Subunit
2003
Two mechanisms of action of the adamantane derivative IEM‐1460 at human AMPA‐type glutamate receptors
2005
Structure of a glutamate-receptor ligand-binding core in complex with kainate
1998 Nature
Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, γ-5
2009
Structure of the zinc‐bound amino‐terminal domain of the NMDA receptor NR2B subunit
2009
Constitutively active and G-protein coupled inward rectifier K+ channels: Kir2.0 and Kir3.0
2007
Subtypes of NMDA receptors in new‐born rat hippocampal granule cells
2002
Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating
2017
Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity
2004
Stargazin modulates AMPA receptor gating and trafficking by distinct domains
2005 Nature
The Hypothalamic Neuropeptide Melanin-Concentrating Hormone Acts in the Nucleus Accumbens to Modulate Feeding Behavior and Forced-Swim Performance
2005
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Subunit-Specific Agonist Activity at NR2A-, NR2B-, NR2C-, and NR2D-Containing N-Methyl-d-aspartate Glutamate Receptors
2007
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
2003
Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape ‘superslow’ afterburst EPSC in rat hippocampus
2004
Autoinactivation of Neuronal AMPA Receptors via Glutamate-Regulated TARP Interaction
2009
Control of NMDA Receptor Function by the NR2 Subunit Amino-Terminal Domain
2009
Fast and Slow Voltage-Dependent Dynamics of Magnesium Block in the NMDA Receptor: The Asymmetric Trapping Block Model
2004
The Free Energy Landscapes Governing Conformational Changes in a Glutamate Receptor Ligand-Binding Domain
2007
Comparative Studies of Anthraquinone- and Anthracene-Tetraamines as Blockers of N-Methyl-d-aspartate Receptors
2006
The contributions of GluR2 to allosteric modulation of AMPA receptors
2000
LTP and LTD
2004 Standout
Common Binding Site for Externally and Internally Applied AMPA Receptor Channel Blockers
2009
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
2000 Nature
Dual Palmitoylation of NR2 Subunits Regulates NMDA Receptor Trafficking
2009
Structural and Single-Channel Results Indicate That the Rates of Ligand Binding Domain Closing and Opening Directly Impact AMPA Receptor Gating
2008
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Genetic Evidence for a Role for Protein Kinase A in the Maintenance of Sleep and Thalamocortical Oscillations
2010
Activation of NR1/NR2B NMDA receptors
2003
Structural Determinants of d-Cycloserine Efficacy at the NR1/NR2C NMDA Receptors
2010
Stable synaptic retention of serine-880-phosphorylated GluR2 in hippocampal neurons
2008
Mechanism of differential control of NMDA receptor activity by NR2 subunits
2009 Nature
On the role of NR3A in human NMDA receptors
2007
Proteolysis of the N-Methyl-d-Aspartate Receptor by Calpain in Situ
2002
Interaction of hydrogen sulfide with ion channels
2010
Pathway-Specific Trafficking of Native AMPARs by In Vivo Experience
2006
Regulation of Synaptic Strength by Protein Phosphatase 1
2001
The Outer Pore of the Glutamate Receptor Channel Has 2-Fold Rotational Symmetry
2004
Kainate receptors
2006
Zinc inhibition of rat NR1/NR2AN‐methyl‐d ‐aspartate receptors
2007
Partial Agonism and Antagonism of the Ionotropic Glutamate Receptor iGLuR5
2007
Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro
2001
Activity of the rat GluR4 promoter in transfected cortical neurons and glia
2003
Equilibrium Constants for (R)-[(S)-1-(4-Bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic Acid (NVP-AAM077) Acting at Recombinant NR1/NR2A and NR1/NR2B N-Methyl-d-aspartate Receptors: Implications for Studies of Synaptic Transmission
2006
The Role of Intracellular Sodium in the Regulation of NMDA-Receptor-Mediated Channel Activity and Toxicity
2005
The involvement of the NMDA receptor d-serine/glycine site in the pathophysiology and treatment of schizophrenia
2009
Enhanced LTP in Mice Deficient in the AMPA Receptor GluR2
1996
Modulation by permeant ions of Mg2+ inhibition of NMDA‐activated whole‐cell currents in rat cortical neurons
2002
Generation of neuronal variability and complexity
2006 Nature
Cdk5 Regulates the Phosphorylation of Tyrosine 1472 NR2B and the Surface Expression of NMDA Receptors
2008
Mutation of a glutamate receptor motif reveals its role in gating and δ2 receptor channel properties
2000
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
2007 Standout
Molecular Dynamics Simulations of the Ligand-binding Domain of an N-Methyl-d-aspartate Receptor
2006
Structural basis for partial agonist action at ionotropic glutamate receptors
2003
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
2009 Nature
Structure and function of AMPA receptors
2003
Stargazin Modulation of AMPA Receptors
2016
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
2017 StandoutNobel
The macro- and microarchitectures of the ligand-binding domain of glutamate receptors
1998
Allosteric interactions between cyclothiazide and AMPA/kainate receptor antagonists
1996
Subunit‐specific mechanisms and proton sensitivity of NMDA receptor channel block
2007
Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors
2005
The Structure of a Mixed GluR2 Ligand-binding Core Dimer in Complex with (S)-Glutamate and the Antagonist (S)-NS1209
2006
Identification of the Amino Acid Subsets Accounting for the Ligand Binding Specificity of a Glutamate Receptor
1996
Glutamate Receptor Gating
2004
Evolutionary Conserved Role for TARPs in the Gating of Glutamate Receptors and Tuning of Synaptic Function
2008
The molecular neurobiology of depression
2008 StandoutNature
Roles of the N-terminal Domain on the Function and Quaternary Structure of the Ionotropic Glutamate Receptor
2005
Modeling of the Pore Domain of the GLUR1 Channel: Homology with K+ Channel and Binding of Channel Blockers
2002
The Relationship between Agonist Potency and AMPA Receptor Kinetics
2006
Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity
2009 Standout
Activity Patterns Govern Synapse-Specific AMPA Receptor Trafficking between Deliverable and Synaptic Pools
2009
NR3A Modulates the Outer Vestibule of the “NMDA” Receptor Channel
2006
Extracellular Vestibule Determinants of Ca2+ Influx in Ca2+‐Permeable AMPA Receptor Channels
2003
Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons
1997
Synaptic AMPA receptor composition in development, plasticity and disease
2016
Molecular Determinants of Proton-Sensitive N-Methyl-d-aspartate Receptor Gating
2003
Subcellular segregation of distinct heteromeric NMDA glutamate receptors in the striatum
2003
AKAP signalling complexes: focal points in space and time
2004
Facilitation of currents through rat Ca2+‐permeable AMPA receptor channels by activity‐dependent relief from polyamine block
1998
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes
2005 StandoutNatureNobel
Developmental Changes in NMDA Neurotoxicity Reflect Developmental Changes in Subunit Composition of NMDA Receptors
2006
Heteromeric AMPA Receptors Assemble with a Preferred Subunit Stoichiometry and Spatial Arrangement
2001
Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtype
2000 Nature
pH-Dependent Inhibition of Kainate Receptors by Zinc
2008
Pharmacological Implications of Two Distinct Mechanisms of Interaction of Memantine with N-Methyl-d-aspartate-Gated Channels
2005
Stargazin promotes closure of the AMPA receptor ligand-binding domain
2014
Developmental changes in synaptic AMPA and NMDA receptor distribution and AMPA receptor subunit composition in living hippocampal neurons.
2000
A Developmental Switch of AMPA Receptor Subunits in Neocortical Pyramidal Neurons
2002
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
2012 Standout
Distinct Synaptic and Extrasynaptic NMDA Receptors in Developing Cerebellar Granule Neurons
1999
Interactions of polyamines with ion channels
1997
Ca 2+ /calmodulin-kinase II enhances channel conductance of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors
1999
Regulation of Kinetic Properties of GluR2 AMPA Receptor Channels by Alternative Splicing
2000
Different Mechanisms of Ca2+ Transport in NMDA and Ca2+-permeable AMPA Glutamate Receptor Channels
1998 Nobel
Mapping the Binding Site of the Neuroprotectant Ifenprodil on NMDA Receptors
2002
Mechanism of Irk1 Channel Block by Intracellular Polyamines
2000
Circular permutation and receptor insertion within green fluorescent proteins
1999 StandoutNobel
Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2
2005
Neuronal activity regulates protein and gene expressions of GluR2 in postnatal rat visual cortical neurons in culture
2003
The multifaceted subunit interfaces of ionotropic glutamate receptors
2014
Specific Assembly with the NMDA Receptor 3B Subunit Controls Surface Expression and Calcium Permeability of NMDA Receptors
2003
FM1-43 Dye Behaves as a Permeant Blocker of the Hair-Cell Mechanotransducer Channel
2001
Assembly with the NR1 Subunit Is Required for Surface Expression of NR3A-Containing NMDA Receptors
2001
Postsynaptic Application of a Peptide Inhibitor of cAMP-Dependent Protein Kinase Blocks Expression of Long-Lasting Synaptic Potentiation in Hippocampal Neurons
2003
NR2B and NR2D Subunits Coassemble in Cerebellar Golgi Cells to Form a Distinct NMDA Receptor Subtype Restricted to Extrasynaptic Sites
2003
Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain
2017
Differential Dependence on GluR2 Expression of Three Characteristic Features of AMPA Receptors
1997
Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12
2000
Ischemic Insults Derepress the Gene Silencer REST in Neurons Destined to Die
2003
The Lurcher Mutation Identifies δ2 as an AMPA/Kainate Receptor-Like Channel That Is Potentiated by Ca2+
2000
Transcriptional Regulation of the GluR2 Gene: Neural-Specific Expression, Multiple Promoters, and Regulatory Elements
1998
Structure and organization of heteromeric AMPA-type glutamate receptors
2016 Science
Structure of an agonist-bound ionotropic glutamate receptor
2014 Science
RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release
2011 StandoutScienceNobel
Long-Term Potentiation--A Decade of Progress?
1999 StandoutScience
Knockdown of AMPA Receptor GluR2 Expression Causes Delayed Neurodegeneration and Increases Damage by Sublethal Ischemia in Hippocampal CA1 and CA3 Neurons
1999
Auxiliary proteins promote modal gating ofAMPA ‐ and kainate‐type glutamate receptors
2014
Regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit
2007
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes
2006 StandoutNobel
INWARD RECTIFIER POTASSIUM CHANNELS
1997
Molecular organization of the postsynaptic specialization
2001
Ischemic preconditioning acts upstream of GluR2 down-regulation to afford neuroprotection in the hippocampal CA1
2002
Glutamate receptor pores
2014
Surface Expression of GluR-D AMPA Receptor Is Dependent on an Interaction between Its C-Terminal Domain and a 4.1 Protein
2003
Selective Activation Induced Cleavage of the NR2B Subunit by Calpain
2003
Synapse-Associated Protein 97 Selectively Associates with a Subset of AMPA Receptors Early in their Biosynthetic Pathway
2001
Subunit-specific Contribution of Pore-forming Domains to NMDA Receptor Channel Structure and Gating
2007
Amino Acid Substitutions in the Pore Helix of GluR6 Control Inhibition by Membrane Fatty Acids
2008
Subunit-Dependent Modulation of Kainate Receptors by Extracellular Protons and Polyamines
2003
A steroid modulatory domain on NR2B controlsN-methyl-d -aspartate receptor proton sensitivity
2004
Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice
2000 StandoutNobel
Architecture of fully occupied GluA2 AMPA receptor–TARP complex elucidated by cryo-EM
2016 Nature
The role of AMPA receptor-mediated excitotoxicity in ALS: Is deficient RNA editing to blame?
2009
Conserved SOL-1 proteins regulate ionotropic glutamate receptor desensitization
2006
The Cell Biology of Synaptic Plasticity: AMPA Receptor Trafficking
2007
AMPA Receptor Flip/Flop Mutants Affecting Deactivation, Desensitization, and Modulation by Cyclothiazide, Aniracetam, and Thiocyanate
1996
Conantokin-Br fromConus brettinghamiand Selectivity Determinants for the NR2D Subunit of the NMDA Receptor
2009
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Cocaine-induced potentiation of synaptic strength in dopamine neurons: Behavioral correlates in GluRA(–/–) mice
2004
Probing the Function, Conformational Plasticity, and Dimer−Dimer Contacts of the GluR2 Ligand-Binding Core: Studies of 5-Substituted Willardiines and GluR2 S1S2 in the Crystal,
2003
Functional Characterization of Tet-AMPA [Tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic Acid] Analogues at Ionotropic Glutamate Receptors GluR1−GluR4. The Molecular Basis for the Functional Selectivity Profile of 2-Bn-Tet-AMPA
2007
Bruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release
2006 StandoutScienceNobel
How AMPA Receptor Desensitization Depends on Receptor Occupancy
2003
Rapid Synthesis and Synaptic Insertion of GluR2 for mGluR-LTD in the Ventral Tegmental Area
2007 Science
Functional Insights from Glutamate Receptor Ion Channel Structures
2012
Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters
2008 StandoutNobel
Developmental Profile of the Changing Properties of NMDA Receptors at Cerebellar Mossy Fiber–Granule Cell Synapses
2000
Structure and gating of tetrameric glutamate receptors
2013
Studies of NMDA Receptor Function and Stoichiometry with Truncated and Tandem Subunits
2003
Subunit Interactions and AMPA Receptor Desensitization
2001
Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+Modulation of the NMDA Receptor
2001
Transcription of the chickenGrin1gene is regulated by the activity of SP3 and NRSF in undifferentiated cells and neurons
2008
Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression
2001
Channel-Lining Residues of the AMPA Receptor M2 Segment: Structural Environment of the Q/R Site and Identification of the Selectivity Filter
2001 Nobel
Identification of a New Endogenous Metabolite and the Characterization of Its Protein Interactions through an Immobilization Approach
2008 StandoutNobel
Overexpression of a glutamate receptor (GluR2) ligand binding domain in Escherichia coli : Application of a novel protein folding screen
1997
Correlating AMPA Receptor Activation and Cleft Closure across Subunits: Crystal Structures of the GluR4 Ligand-Binding Domain in Complex with Full and Partial Agonists
2008
Characterization of the Binding Site for a Novel Class of Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonists
2000
A Subtype-Selective, Use-Dependent Inhibitor of Native AMPA Receptors
2007
Developmental Changes in Synaptic AMPA and NMDA Receptor Distribution and AMPA Receptor Subunit Composition in Living Hippocampal Neurons
2000
A Novel Allosteric Potentiator of AMPA Receptors: 4-[2-(Phenylsulfonylamino)ethylthio]-2,6-Difluoro-Phenoxyacetamide
1997
Enantiomeric Propanolamines as selectiveN-Methyl-d -aspartate 2B Receptor Antagonists
2008
Redox cycling and kinetic analysis of single molecules of solution-phase nitrite reductase
2011 StandoutNobel
N-Hydroxypyrazolyl Glycine Derivatives as SelectiveN-Methyl-d -aspartic Acid Receptor Ligands
2008
The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses
2001 StandoutScienceNobel
Postsynaptic glutamate receptor δ family contributes to presynaptic terminal differentiation and establishment of synaptic transmission
2009
Synapse-Associated Protein-97 Isoform-Specific Regulation of Surface AMPA Receptors and Synaptic Function in Cultured Neurons
2003
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
Cutting Edge: Granzyme B Proteolysis of a Neuronal Glutamate Receptor Generates an Autoantigen and Is Modulated by Glycosylation
2001
DRPEER: A Motif in the Extracellular Vestibule Conferring High Ca2+Flux Rates in NMDA Receptor Channels
2002
Single-Channel Properties of Recombinant AMPA Receptors Depend on RNA Editing, Splice Variation, and Subunit Composition
1997
Glutamate Receptor Subunit 2 Serine 880 Phosphorylation Modulates Synaptic Transmission and Mediates Plasticity in CA1 Pyramidal Cells
2003
Molecular determinants of coordinated proton and zinc inhibition of N- methyl- d -aspartate NR1/NR2A receptors
2000
Activation Kinetics of AMPA Receptor Channels Reveal the Number of Functional Agonist Binding Sites
1998
Growth Factor-Induced Transcription of GluR1 Increases Functional AMPA Receptor Density in Glial Progenitor Cells
1997
Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes
2003
GluR3 Flip and Flop: Differences in Channel Opening Kinetics
2007
Probing of NMDA Channels with Fast Blockers
1999
Identification of Amino Acid Residues in GluR1 Responsible for Ligand Binding and Desensitization
2001
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission
2003 StandoutNobel
Subtype-Dependence of NMDA Receptor Channel Open Probability
1999
SOL-1 is an auxiliary subunit that modulates the gating of GLR-1 glutamate receptors inCaenorhabditis elegans
2006
Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid
2005
Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors
2008
Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation
2005 StandoutNobel
A Tetrazolyl-Substituted Subtype-Selective AMPA Receptor Agonist
2007
Structural Similarities between Glutamate Receptor Channels and K+ Channels Examined by Scanning Mutagenesis
2001
Brominated 7-hydroxycoumarin-4-ylmethyls: Photolabile protecting groups with biologically useful cross-sections for two photon photolysis
1999 StandoutNobel
Mechanisms of Antagonism of the GluR2 AMPA Receptor: Structure and Dynamics of the Complex of Two Willardiine Antagonists with the Glutamate Binding Domain
2009
Works of Derek Bowie being referenced
Permeation and block of rat glur6 glutamate receptor channels by internal and external polyamines
1997
Activity-Dependent Modulation of Glutamate Receptors by Polyamines
1998
External anions and cations distinguish between AMPA and kainate receptor gating mechanisms
2002
Concanavalin‐A reports agonist‐induced conformational changes in the intact GluR6 kainate receptor
2006
Functional Stoichiometry of Glutamate Receptor Desensitization
2002
Kainate receptor pore‐forming and auxiliary subunits regulate channel block by a novel mechanism
2015
Ion‐dependent gating of kainate receptors
2009
Interaction of 5-bromowillardiine with non-NMDA receptors expressed in Xenopus laevis oocytes injected with chick brain mRNA
1991
Cations But Not Anions Regulate the Responsiveness of Kainate Receptors
2011
Crosslinking the ligand‐binding domain dimer interface locks kainate receptors out of the main open state
2013
Defining the structural relationship between kainate-receptor deactivation and desensitization
2013
External Ions Are Coactivators of Kainate Receptors
2006
Ionotropic Glutamate Receptors & CNS Disorders
2008
Allosteric Regulation and Spatial Distribution of Kainate Receptors Bound to Ancillary Proteins
2003
Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block
1995
Interplay between expressed non-NMDA receptors and endogenous calcium-activated chloride currents in Xenopus laevis oocytes
1993
Thiocyanate ions selectively antagonize AMPA‐evoked responses in Xenopus laevis oocytes microinjected with rat brain mRNA
1993
Structural determinants of allosteric regulation in alternatively spliced AMPA receptors
1995
Light triggers expression of philanthotoxin‐insensitive Ca2+‐permeable AMPA receptors in the developing rat retina
2007
Redefining the classification of AMPA‐selective ionotropic glutamate receptors
2011
Na+/Cl- Dipole Couples Agonist Binding to Kainate Receptor Activation
2007
Subpopulations of neonatal rat sensory neurons express functional neurotransmitter receptors which elevate intracellular calcium
1994
Transmembrane AMPA receptor regulatory protein regulation of competitive antagonism: a problem of interpretation
2011
Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation
2015
Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes
2016
Control of GluR1 AMPA Receptor Function by cAMP-Dependent Protein Kinase
2000
The Glutamate Receptor Ion Channels
1999 Standout
The glutamate receptor ion channels.
1999