Standout Papers
Citation Impact
Citing Papers
Binding of small molecules to an adaptive protein–protein interface
2003
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Ca2+ Regulates Reactive Oxygen Species Production and pH during Mechanosensing in Arabidopsis Roots
2009
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
PIEZO ion channel is required for root mechanotransduction in Arabidopsis thaliana
2021 StandoutNobel
Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases
2012 StandoutNobel
Fragment-based lead discovery
2004
A view on drug resistance in cancer
2019 StandoutNature
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Detection of Ligands from a Dynamic Combinatorial Library by X‐ray Crystallography
2003
The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
1997
Massively parallel manipulation of single cells and microparticles using optical images
2005 StandoutNature
Modular click chemistry libraries for functional screens using a diazotizing reagent
2019 StandoutNatureNobel
Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis
2017
Inhibition of the complete set of mammalian secreted phospholipases A2 by indole analogues
2004
Reprogramming of human somatic cells to pluripotency with defined factors
2007 StandoutNature
Capillary electrophoresis of biological particles: Viruses, bacteria, and eukaryotic cells
2004
Probing the β2 Adrenoceptor Binding Site with Catechol Reveals Differences in Binding and Activation by Agonists and Partial Agonists
2005 StandoutNobel
2003
New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases
2011 StandoutNobel
Immunogenicity of induced pluripotent stem cells
2011 StandoutNature
Iterative In Situ Click Chemistry Creates Antibody‐like Protein‐Capture Agents
2009 StandoutNobel
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
New Approaches and Therapeutics Targeting Apoptosis in Disease
2005
2,3,7,8-Tetrachlorodibezo-p-dioxin exposure and prostate cancer: a meta-analysis of cohort studies
2014
Environmental exposures and prostate cancer
2012
Fragment-based lead discovery: a chemical update
2006
In situ click chemistry: probing the binding landscapes of biological molecules
2010
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
2004 Standout
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group
2004
GlcNAc 2-Epimerase Can Serve a Catabolic Role in Sialic Acid Metabolism
2003 StandoutNobel
Design of new secreted phospholipase A2 inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor
2010
Synthesis and Characterization of 5′-p-fluorosulfonylbenzoyl-2′ (or 3′)-(biotinyl)adenosine as an Activity-Based Probe for Protein Kinases
2006
A ROCK inhibitor permits survival of dissociated human embryonic stem cells
2007 Standout
Cerebral organoids model human brain development and microcephaly
2013 StandoutNature
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
2009 Standout
Inhibitors of HIV‐1 Protease by Using In Situ Click Chemistry
2006 StandoutNobel
Making drugs on proteins: site-directed ligand discovery for fragment-based lead assembly
2004
1 Caspase Inhibitors as Anti-inflammatory and Antiapoptotic Agents
2002
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry
2014 StandoutNobel
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
Design of new potent and selective secretory phospholipase A2 inhibitors. 6-Synthesis, structure–activity relationships and molecular modelling of 1-substituted-4-[4,5-dihydro-1,2,4-(4H)-oxadiazol-5-one-3-yl(methyl)]-functionalized aryl piperazin/one/dione derivatives
2010
Fragment-based lead discovery: leads by design
2005
In Situ Click Chemistry: Enzyme‐Generated Inhibitors of Carbonic Anhydrase II
2004 StandoutNobel
The Receptor-like Kinase FERONIA Is Required for Mechanical Signal Transduction in Arabidopsis Seedlings
2014
Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase
2016 StandoutNobel
EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals
2015 Standout
Plasma Organochlorines and Subsequent Risk of Prostate Cancer in Japanese Men: A Nested Case–Control Study
2009
Discovery of a New Phosphotyrosine Mimetic for PTP1B Using Breakaway Tethering
2003
New insights into the kinetic target-guided synthesis of protein ligands
2015
In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications
2004 StandoutNobel
Nuclear pore complex contains a family of glycoproteins that includes p62: glycosylation through a previously unidentified cellular pathway.
1987 StandoutNobel
Identification and characterization of a nuclear pore complex protein
1986 StandoutNobel
Protein‐Templated Fragment Ligations—From Molecular Recognition to Drug Discovery
2017
In Situ Click Chemistry: Enzyme‐Generated Inhibitors of Carbonic Anhydrase II
2004 StandoutNobel
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Docking and scoring in virtual screening for drug discovery: methods and applications
2004 Standout
CML24 is Involved in Root Mechanoresponses and Cortical Microtubule Orientation in Arabidopsis
2011
Substrate Activity Screening: A Fragment-Based Method for the Rapid Identification of Nonpeptidic Protease Inhibitors
2005
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template
2012 StandoutNobel
A Specific Mechanism of Nonspecific Inhibition
2003 Standout
Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
2013 StandoutNobel
A chemical approach for identifying O -GlcNAc-modified proteins in cells
2003 StandoutNobel
Catalytic Stereoselective Synthesis of Diverse Oxindoles and Spirooxindoles from Isatins
2012
Organogenesis in a dish: Modeling development and disease using organoid technologies
2014 StandoutScience
Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc.
1984
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells
2012 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
Molecular Docking and 3D-QSAR CoMFA Studies on Indole Inhibitors of GIIA Secreted Phospholipase A2
2010
Interfacial Enzymology: The Secreted Phospholipase A2-Paradigm
2001
Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase
2000 StandoutScience
In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors
2005 StandoutNobel
Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides
2005 StandoutNobel
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
2011 Standout
Nitrated Confined Imidodiphosphates Enable a Catalytic Asymmetric Oxa-Pictet–Spengler Reaction
2016 StandoutNobel
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
2009 StandoutScience
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Agent Orange as a risk factor for high‐grade prostate cancer
2013
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
2011 Standout
Chemical Glycoproteomics
2016 StandoutNobel
Works of Dennis Lee being referenced
A substrate combinatorial array for caspases
1999
In situ assembly of enzyme inhibitors using extended tethering
2003
Expression, Purification, and Characterization of an Enzymatically Active Truncated Human Rho-Kinase I (ROCK I) Domain Expressed in Sf-9 Insect Cells
2006
Genome‐wide identification of touch‐ and darkness‐regulated Arabidopsis genes: a focus on calmodulin‐like and XTH genes
2004
Agent Orange exposure, Vietnam War veterans, and the risk of prostate cancer
2008
Identification of potent and novel small-Molecule inhibitors of caspase-3
2003
Capillary zone electrophoresis of a recombinant adenovirus
2000
Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design
2002
Incorporation of galactose into galactosyltransferase
1977
Apoptosis in polycystic kidney disease: involvement of caspases
2000
Identification of a Selective Nonpeptide Antagonist of the Anaphylatoxin C3a Receptor That Demonstrates Antiinflammatory Activity in Animal Models
2001
High-Resolution X-ray Crystallography Reveals Precise Binding Interactions between Human Nonpancreatic Secreted Phospholipase A2 and a Highly Potent Inhibitor (FPL67047XX)
1996
Potent, Selective and Orally Bioavailable Dihydropyrimidine Inhibitors of Rho Kinase (ROCK1) as Potential Therapeutic Agents for Cardiovascular Diseases
2008
Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges
2005
2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis
1995
Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7
2001