Citation Impact
Citing Papers
Formation and properties of C1‐inhibitor polymers
1995
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
Affinity mass spectrometry from a tailored porous silicon surfaceElectronic supplementary information (ESI) available: synthesis and characterization of new compounds, experimental details. See http://www.rsc.org/suppdata/cc/b4/b408200a/
2004
Structural Mechanisms for Domain Movements in Proteins
1994
Activation of Store-Operated Ca2+ Current in Xenopus Oocytes Requires SNAP-25 but Not a Diffusible Messenger
1999 StandoutNobel
Structural aspects of serpin inhibition
1994 Nobel
Characterization of the Binding of Different Conformational Forms of Plasminogen Activator Inhibitor-1 to Vitronectin
1997
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion
1993 StandoutNobel
Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1
1998
Cation–π interactions in ligand recognition and catalysis
2002
Serpin-Protease Complexes Are Trapped as Stable Acyl-Enzyme Intermediates
1995
Structural and Functional Analysis of the Plasminogen Activator Inhibitor-1 Binding Motif in the Somatomedin B Domain of Vitronectin
1996
The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions
1994
NMR structure of the mouse prion protein domain PrP(121–231)
1996 StandoutNatureNobel
Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor
2016
Crystal structure of an uncleaved α1‐antitrypsin reveals the conformation of its inhibitory reactive loop
1995
Plasminogen‐activator inhibitor type 2 (PAI‐2) is a spontaneously polymerising SERPIN
1993
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
1997 Standout
The Axonally Secreted Serine Proteinase Inhibitor, Neuroserpin, Inhibits Plasminogen Activators and Plasmin but Not Thrombin
1998
Potent and Selective Inhibitors of Glutathione S-Transferase Omega 1 That Impair Cancer Drug Resistance
2011
Structural basis for serpin inhibitor activity
1995
Role of the Catalytic Serine in the Interactions of Serine Proteinases with Protein Inhibitors of the Serpin Family
1995
Structural and biochemical studies of retroviral proteases
2000
Modeling of serpin-protease complexes: Antithrombin-thrombin, α1-antitrypsin (358Met→Arg)-thrombin, α1-antitrypsin (358Met→Arg)-trypsin, and antitrypsin-elastase
1996
Kinetics versus Thermodynamics in Protein Folding
1994 StandoutNobel
A Fluorescent Probe Study of Plasminogen Activator Inhibitor-1
1995
Preparation and Characterization of Latent α1-Antitrypsin
1995
Cleavage of Rabaptin-5 blocks endosome fusion during apoptosis
1997
The structural puzzle of how serpin serine proteinase inhibitors work
1996
The structure of active serpin 1K from Manduca sexta
1999
Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function
2000
Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1
1995
The chemistry of scrapie infection: implications of the ‘ice 9’ metaphor
1995
Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis
1997
Stopped Flow Fluorescence Energy Transfer Measurement of the Rate Constants Describing the Reversible Formation and the Irreversible Rearrangement of the Elastase-α1-Proteinase Inhibitor Complex
1998
Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation
2000
The Large Subunit of the DNA Replication Complex C (DSEB/RF-C140) Cleaved and Inactivated by Caspase-3 (CPP32/YAMA) during Fas-induced Apoptosis
1997
Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins
1994 StandoutNobel
Evidence for the extent of insertion of the active site loop of intact .alpha.1 proteinase inhibitor in .beta.-sheet A
1992 Nobel
Topology of the Stable Serpin-Protease Complexes Revealed by an Autoantibody That Fails to React with the Monomeric Conformers of Antithrombin
1999
Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis
1997
Engineering Plasminogen Activator Inhibitor 1 Mutants with Increased Functional Stability
1994
The large subunit of replication factor C is a substrate for caspase-3 invitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis
1997
A cryo-electron microscopic study of ribosome-bound termination factor RF2
2003 StandoutNatureNobel
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Serpin α1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy
1996
Protein folding in the landscape perspective: Chevron plots and non-arrhenius kinetics
1998
Sequential activation of three distinct ICE‐like activities in Fas‐ligated Jurkat cells
1996
UCSF Chimera—A visualization system for exploratory research and analysis
2004 Standout
Structural Clues to Prion Replication
1994 StandoutScienceNobel
The karyogamy gene KAR2 and novel proteins are required for ER-membrane fusion
1994 StandoutNobel
A 2.1 Å resolution structure of an uncleaved α1-antitrypsin shows variability of the reactive center and other loops11Edited by R. Huber
2001
Helix D Elongation and Allosteric Activation of Antithrombin
2002
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
The native strains in the hydrophobic core and flexible reactive loop of a serine protease inhibitor: crystal structure of an uncleaved α1-antitrypsin at 2.7 å
1996
Effects of mutations in the hinge region of serpins
1993
Importance of the Hinge Region between α-Helix F and the Main Part of Serpins, Based upon Identification of the Epitope of Plasminogen Activator Inhibitor Type 1 Neutralizing Antibodies
2000
Identification of centerin: a novel human germinal center B cell-restricted serpin
2000
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
1998
Rho GTPases and signaling networks
1997 Standout
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Partitioning of Serpin-Proteinase Reactions between Stable Inhibition and Substrate Cleavage Is Regulated by the Rate of Serpin Reactive Center Loop Insertion into β-Sheet A
2000
Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype
2002
The structure of a Michaelis serpin-protease complex.
2001
Heterologous Expression of Three Plant Serpins with Distinct Inhibitory Specificities
1996
Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1·95Å resolution
1992
A spring-loaded mechanism for the conformational change of influenza hemagglutinin
1993
Chemical Proteomics with Sulfonyl Fluoride Probes Reveals Selective Labeling of Functional Tyrosines in Glutathione Transferases
2013
Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells
1998
Purified native subunits of bacterial luciferase are active in the bioluminescence reaction but fail to assemble into the .alpha..beta. structure
1993
The structure of a serpin–protease complex revealed by intramolecular distance measurements using donor–donor energy migration and mapping of interaction sites
2000
Characterization of a Human α1-Antitrypsin Variant That Is as Stable as Ovalbumin
1998
Inactivation of Plasminogen Activator Inhibitor-1 by Specific Proteolysis with Stromelysin-1 (MMP-3)
2000
What do dysfunctional serpins tell us about molecular mobility and disease?
1995
C1 inhibitor hinge region mutations produce dysfunction by different mechanisms
1992
DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis
1997 Standout
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability to probe its latency transition
2022
Actin cleavage in various tumor cells is not a critical requirement for executing apoptosis
1998
Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide
1998
Translational activation of the lck proto-oncogene
1988 StandoutNatureNobel
Inhibitory conformation of the reactive loop of α1-antitrypsin
1996
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Specific Cleavage of α-Fodrin during Fas- and Tumor Necrosis Factor-induced Apoptosis Is Mediated by an Interleukin-1β-converting Enzyme/Ced-3 Protease Distinct from the Poly(ADP-ribose) Polymerase Protease
1996
Caspase-3-mediated Cleavage of Protein Kinase C θ in Induction of Apoptosis
1997
A surprising simplicity to protein folding
2000 StandoutNatureNobel
Formation of the Covalent Chymotrypsin·Antichymotrypsin Complex Involves No Large-scale Movement of the Enzyme
2001
Processing and Activation of Pro-Interleukin-16 by Caspase-3
1998
Plasminogen Activator Inhibitor-1 Contains a Cryptic High Affinity Binding Site for the Low Density Lipoprotein Receptor-related Protein
1998
Natural protein proteinase inhibitors and their interaction with proteinases
1992 Nobel
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
1995 StandoutNobel
Proteolytic cleavage of Ras GTPase-activating protein during apoptosis
1998
Prion (PrPSc)-specific epitope defined by a monoclonal antibody
1997 StandoutNatureNobel
A 2.6 å structure of a serpin polymer and implications for conformational disease 1 1Edited by R. Huber
1999
Wild-type α1-antitrypsin is in the canonical inhibitory conformation
1998
Bypassing the kinetic trap of serpin protein folding by loop extension
2000
Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop
1994
Significance of secondary structure predictions on the reactive center loop region of seprins: a model for the folding of serpins into a metastable state
1996
Evolution of the C 30 Carotenoid Synthase CrtM for Function in a C 40 Pathway
2002 StandoutNobel
Bacterial toxins: cellular mechanisms of action
1984
Molecular Targets for AIDS Therapy
1990 Science
Serpin Structure, Mechanism, and Function
2002 Standout
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Functional rafts in cell membranes
1997 StandoutNature
Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation
1997 StandoutNobel
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Dismantling Cell–Cell Contacts during Apoptosis Is Coupled to a Caspase-dependent Proteolytic Cleavage of β-Catenin
1997
Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function
2000
Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.
1994 StandoutNobel
Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2
1997 Science
The catabolism of intact, reactive centre-cleaved and proteinase-complexed C1 inhibitor in the guinea pig
1996
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.
1993 Standout
Serpin reactive center loop mobility is required for inhibitor function but not for enzyme recognition.
1994
Localization of vitronectin binding domain in plasminogen activator inhibitor-1.
1994
Proposed three-dimensional structure for the cellular prion protein.
1994 StandoutNobel
Caspases Mediate Tumor Necrosis Factor-–Induced Neutrophil Apoptosis and Downregulation of Reactive Oxygen Production
1999
A genome-wide analysis of immune responses in Drosophila
2001 StandoutNobel
Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution
2005 StandoutNobel
Molecular evolution of plasminogen activator inhibitor-1 functional stability.
1995
Biological implications of a 3 å structure of dimeric antithrombin
1994
Single amino acid substitutions of alpha 1-antitrypsin that confer enhancement in thermal stability
1994
Caspases Mediate Tumor Necrosis Factor-–Induced Neutrophil Apoptosis and Downregulation of Reactive Oxygen Production
1999
Inactive conformation of the serpin α1-antichymotrypsin indicates two-stage insertion of the reactive loop: Implications for inhibitory function and conformational disease
2000
Membrane receptors for bacterial toxins
1983
The serpin superfamily of proteinase inhibitors: structure, function, and regulation.
1994
Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity
1996 StandoutScienceNobel
Enzymatic Chemistry of Cyclopropane, Epoxide, and Aziridine Biosynthesis
2011
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
PROTEOLYTIC ACTIVITIES THAT MEDIATE APOPTOSIS
1998
Prion Diseases and the BSE Crisis
1997 StandoutScienceNobel
Structure-Based Strategies for Drug Design and Discovery
1992 Science
Evolution of a Pathway to Novel Long-Chain Carotenoids
2004 StandoutNobel
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
2004 StandoutNobel
NMR solution structure of the human prion protein
2000 StandoutNobel
Proteolytic Activation of Protein Kinase C δ by an ICE/CED 3-like Protease Induces Characteristics of Apoptosis
1996
MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis
1998
Binding of urokinase-type plasminogen activator–plasminogen activator inhibitor-1 complex to the endocytosis receptors α2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves basic residues in the inhibitor
1998
Caspases: the executioners of apoptosis
1997 Standout
The necrotic Gene in Drosophila Corresponds to One of a Cluster of Three Serpin Transcripts Mapping at 43A1.2
2000
Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform
1997 StandoutNobel
Caspase Cleavage of Keratin 18 and Reorganization of Intermediate Filaments during Epithelial Cell Apoptosis
1997
Mitochondria and Apoptosis
1998 StandoutScience
Structure of the recombinant full-length hamster prion protein PrP(29–231): The N terminus is highly flexible
1997 StandoutNobel
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains
1996 StandoutNobel
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
1999 Standout
Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)
1994
Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene
1987
BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases
1996
Kinetically Controlled Folding of the Serpin Plasminogen Activator Inhibitor 1
1996
Three-Dimensional Structure of Cholera Toxin Penetrating a Lipid Membrane
1988 StandoutScienceNobel
Recombinant Squalene Synthase. A Mechanism for the Rearrangement of Presqualene Diphosphate to Squalene
2002
Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor.
1994
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Involvement of caspase-dependent activation of cytosolic phospholipase A2in tumor necrosis factor-induced apoptosis
1997
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Recombinant Squalene Synthase. Synthesis of Non-Head-to-Tail Isoprenoids in the Absence of NADPH
2002
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of Dennis E. Danley being referenced
Crystal Structure of Human Squalene Synthase
2000
Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases
2000
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
2000
Expression of human plasminogen activator inhibitor type-1 (PAI-1) in Escherichia coli as a soluble protein comprised of active and latent forms. Isolation and crystallization of latent PAI-1
1990
Preliminary x‐ray analysis of crystals of plasminogen activator inhibitor‐1
1991
Structural basis of latency in plasminogen activator inhibitor-1
1992 Nature
X-ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes
1989 Nature
D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis
1996
Activation of Human Liver Glycogen Phosphorylase by Alteration of the Secondary Structure and Packing of the Catalytic Core
2000
Codominant translational mutants of Chinese hamster ovary cells selected with diphtheria toxin
1979
In vitro biosynthesis of diphthamide, studied with mutant Chinese hamster ovary cells resistant to diphtheria toxin.
1984
Posttranslational modification of elongation factor 2 in diphtheria-toxin-resistant mutants of CHO-K1 cells.
1980