Citation Impact
Citing Papers
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
2006
Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells
2019 StandoutNobel
Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
2004 StandoutScience
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
2020 StandoutNobel
Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
2004 Science
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
2004 StandoutScience
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
2008
Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import
2004
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Regulation of Insulin Secretion by SIRT4, a Mitochondrial ADP-ribosyltransferase
2007
Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis
2021
Sirtuins as regulators of metabolism and healthspan
2012 Standout
Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression
2003
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
2008
Physiological functions of the HECT family of ubiquitin ligases
2009
The Plasticity of Aging: Insights from Long-Lived Mutants
2005
Nuclear Trapping of the Forkhead Transcription Factor FoxO1 via Sirt-dependent Deacetylation Promotes Expression of Glucogenetic Genes
2005
Caenorhabditis elegans HCF-1 Functions in Longevity Maintenance as a DAF-16 Regulator
2008
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation
2003
Individual histone deacetylases in Drosophila modulate transcription of distinct genes
2005
The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway
2005
SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
2007
Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis
2010
Mechanism of Human SIRT1 Activation by Resveratrol
2005
The interaction between FOXO and SIRT1: tipping the balance towards survival
2004
Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
2005
Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1
2002
Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde
2002
Paradigms and pitfalls of yeast longevity research
2002
A systematic RNAi screen for longevity genes in C. elegans
2005 StandoutNobel
Lysine‐63‐linked ubiquitination is required for endolysosomal degradation of class I molecules
2006
Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
2010
Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State
2003
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Epigenetic regulation of aging stem cells
2011
Sirtuin 1 in lipid metabolism and obesity
2011
The Sir2 family of protein deacetylases
2005
The chemical basis of ferroptosis
2019
Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity
2021
HDAC6 is a microtubule-associated deacetylase
2002 StandoutNature
SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α
2005
DBC1 is a negative regulator of SIRT1
2008 Nature
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
2022 Standout
Hypoxia-responsive transcription factors
2005
STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta
2003
SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons
2008
Sirtuins, Aging, and Medicine
2011
E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation
2006
Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification
2008
Oxidant signals and oxidative stress
2003
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
2007
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1
2007
Axis of ageing: telomeres, p53 and mitochondria
2012
Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses
2005
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
2002
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
2003 Nature
Transcriptional targets of sirtuins in the coordination of mammalian physiology
2008
Mitochondrial longevity pathways
2010
SIRT2 Regulates Adipocyte Differentiation through FoxO1 Acetylation/Deacetylation
2007
Tissue-specific regulation of SIRT1 by calorie restriction
2008
Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics
2005
Mammalian Base Excision Repair: the Forgotten Archangel
2013
p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington’s Disease
2005
Mitochondria, Oxidants, and Aging
2005 Standout
Negative regulation of inflammation by SIRT1
2012
The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity
2021
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
2005
PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis
2022
PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis
2021
Acetylation and deacetylation of non-histone proteins
2005
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
The emerging roles of forkhead box (Fox) proteins in cancer
2007
A coming-of-age story: activation-induced cytidine deaminase turns 10
2009
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
2011
Co-ordination of base excision repair and genome stability
2013
SIRT1: recent lessons from mouse models
2010
Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase
2005
Evidence for Bidentate Substrate Binding as the Basis for the K48 Linkage Specificity of Otubain 1
2009
Divorcing ARF and p53: an unsettled case
2006
Recent progress in the biology and physiology of sirtuins
2009 Nature
Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma
2019
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
2005
Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
2010
FOXO4 Is Acetylated upon Peroxide Stress and Deacetylated by the Longevity Protein hSir2
2004
Toward a unified theory of caloric restriction and longevity regulation
2005
Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
2009
AMP-activated protein kinase and its downstream transcriptional pathways
2010
A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response
2006
The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase
2003
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
2005
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53
2007
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Origin and physiological roles of inflammation
2008 StandoutNature
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
2004 StandoutNature
How does calorie restriction work?
2003
SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
2010
Mitochondrial sirtuins
2010
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
2008 Nature
Identification of Conserved Pathways of DNA-Damage Response and Radiation Protection by Genome-Wide RNAi
2006
MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells
2021
Targeting ferroptosis as a vulnerability in cancer
2022 Standout
Negative regulation of the deacetylase SIRT1 by DBC1
2008 Nature
SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
2008
USP10 Regulates p53 Localization and Stability by Deubiquitinating p53
2010
DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
2010
β-Arrestin and Mdm2 Mediate IGF-1 Receptor-stimulated ERK Activation and Cell Cycle Progression
2007 StandoutNobel
Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?
2011
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
2006 Standout
SMK-1, an Essential Regulator of DAF-16-Mediated Longevity
2006
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
Sirtuins: Sir2-related NAD-dependent protein deacetylases.
2004
The Hallmarks of Aging
2013 Standout
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
2005 StandoutNature
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
2004 Standout
Ferroptosis, radiotherapy, and combination therapeutic strategies
2021
PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans
2001
SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells
2006
Active Regulator of SIRT1 Cooperates with SIRT1 and Facilitates Suppression of p53 Activity
2007
A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition
2010
Back to the Future with Ubiquitin
2004
The Ubiquitin-Specific Protease Usp4 Regulates the Cell Surface Level of the A2a Receptor
2005
MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans
2002 StandoutNobel
SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
2009
Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
2011
Global quantification of mammalian gene expression control
2011 StandoutNature
JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity
2009
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
2003 StandoutNature
Involvement of the Histone Deacetylase SIRT1 in Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF)-interacting Protein 2-mediated Transcriptional Repression
2003
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
2020 Standout
Post-translational modification of p53 in tumorigenesis
2004
Signalling via the hypoxia-inducible factor-1α requires multiple posttranslational modifications
2004
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
2001 Standout
SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
2010
Energy-stress-mediated AMPK activation inhibits ferroptosis
2020
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
2005 Standout
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
2003
An Efficient Nonviral Method to Generate Integration-Free Human-Induced Pluripotent Stem Cells from Cord Blood and Peripheral Blood Cells
2012 StandoutNobel
The Biochemistry of Sirtuins
2006
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
2012
On Acetyl-CoA as a Gauge of Cellular Metabolic State
2011
Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1
2009 Science
Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex
2013 StandoutNobel
Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features
2006
Acetylation of the C Terminus of Ku70 by CBP and PCAF Controls Bax-Mediated Apoptosis
2004
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
miR-34a repression of SIRT1 regulates apoptosis
2008
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Diversity in the Sir2 family of protein deacetylases
2004
Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway
2004 Science
Mammalian Sirtuins: Biological Insights and Disease Relevance
2010 Standout
The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis
2002
Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells
2017
Recent Progress in Ferroptosis Inducers for Cancer Therapy
2019
The Metabolic Underpinnings of Ferroptosis
2020
Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53
2019
A comprehensive method for detecting ubiquitinated substrates using TR-TUBE
2015
Linking chromatin function with metabolic networks: Sir2 family of NAD+-dependent deacetylases
2003
Trapping a transition state in a computationally designed protein bottle
2015 StandoutScienceNobel
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
The Sir2 Family of Protein Deacetylases
2004
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
2020
Hyperglycemia Regulates Hypoxia-Inducible Factor-1α Protein Stability and Function
2004
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
SIRT2 Suppresses Adipocyte Differentiation by Deacetylating FOXO1 and Enhancing FOXO1's Repressive Interaction with PPARγ
2008
Genetics and the Specificity of the Aging Process
2003 Science
Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
2009 StandoutNobel
The Ubiquitin Code
2012 Standout
Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice
2009 StandoutNobel
Identification of a small molecule inhibitor of Sir2p
2001
Protein structure prediction for the male-specific region of the human Y chromosome
2004 StandoutNobel
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Sirtuins — novel therapeutic targets to treat age-associated diseases
2008
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
2008
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
The Structural Basis of Sirtuin Substrate Affinity,
2006
Dynamic FoxO transcription factors
2007
Works of Delin Chen being referenced
ARF-BP1/Mule Is a Critical Mediator of the ARF Tumor Suppressor
2005
ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway
2019
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
2002 Nature
iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
2021
NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression
2017
Deacetylation of p53 modulates its effect on cell growth and apoptosis
2000 Nature
Direct Interactions between HIF-1α and Mdm2 Modulate p53 Function
2003
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
2001 Standout
Mammalian SIRT1 Represses Forkhead Transcription Factors
2004
Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2
2003 Science