Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
The Allelic Context of the C797S Mutation Acquired upon Treatment with Third-Generation EGFR Inhibitors Impacts Sensitivity to Subsequent Treatment Strategies
2015
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
2019 StandoutNobel
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
2006
Structural Alerts, Reactive Metabolites, and Protein Covalent Binding: How Reliable Are These Attributes as Predictors of Drug Toxicity?
2009
Vascularized and functional human liver from an iPSC-derived organ bud transplant
2013 StandoutNature
First synthesis of 1,2,3-triazolo-linked (1,6)-α-d -oligomannoses (triazolomannoses) by iterative Cu(i )-catalyzed alkyne–azide cycloaddition
2006
Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites
2010
The biology and management of non-small cell lung cancer
2018 StandoutNature
Advances in synthetic approach to and antifungal activity of triazoles
2011
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
2010 Standout
PharmGKB summary
2010
Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks
2012
Catalysis for fluorination and trifluoromethylation
2011 StandoutNature
Fluorine in Medicinal Chemistry
2015
A redox-mediated Kemp eliminase
2017
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
2014 StandoutNature
Organocatalytic Asymmetric Hydrolysis of Epoxides
2014 StandoutNobel
Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2
2009
Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
2011
Complex reactions catalyzed by cytochrome P450 enzymes
2006
The ChEMBL database in 2017
2016 Standout
Triazole: the Keystone in Glycosylated Molecular Architectures Constructed by a Click Reaction
2007
A bioluminescent assay for monoamine oxidase activity
2006
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode α-carbonic anhydrases
2009
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
2013 Standout
Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies
2015
Cyclisation versus 1,1‐Carboboration: Reactions of B(C6F5)3 with Propargyl Amides
2013
Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors
2010
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry
2014 StandoutNobel
A direct continuous fluorometric turn-on assay for monoamine oxidase B and its inhibitor-screening based on the abnormal fluorescent behavior of silole
2010
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
Fluorine in medicinal chemistry
2007 Standout
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
The M06 suite of density functionals for main group thermochemistry, thermochemical kinetics, noncovalent interactions, excited states, and transition elements: two new functionals and systematic testing of four M06-class functionals and 12 other functionals
2007 Standout
Targeted Covalent Inhibitors for Drug Design
2016
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub
2017 StandoutNobel
A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design
2015
Non‐Covalent Aggregation of Discrete Metallo‐Supramolecular Helicates into Higher Assemblies by Aromatic Pathways: Structural and Chemical Studies of New Aniline‐Based Neutral Metal(II ) Dihelicates
2005
SuFEx Chemistry of Thionyl Tetrafluoride (SOF4) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates
2018 StandoutNobel
PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS
2015
Cytochromes P450 Catalyze Both Steps of the Major Pathway of Clopidogrel Bioactivation, whereas Paraoxonase Catalyzes the Formation of a Minor Thiol Metabolite Isomer
2011
Carnitine Palmitoyltransferase (CPT) Modulators: A Medicinal Chemistry Perspective on 35 Years of Research
2011
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Precise Modulation of CO2 Sorption in Ti8Ce2–Oxo Clusters: Elucidating Lewis Acidity of the Ce Metal Sites and Structural Flexibility
2024 StandoutNobel
New Bioluminogenic Substrates for Monoamine Oxidase Assays
2006
Metabolism-guided drug design
2012
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
2019 StandoutNobel
The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
2015
Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
2015 Standout
Azine Activation via Silylium Catalysis
2021 StandoutNobel
The broadening reach of frustrated Lewis pair chemistry
2016 StandoutScience
“Click Chemistry” Inspired Synthesis of pseudo-Oligosaccharides and Amino Acid Glycoconjugates
2005
The Essential Roles of Chemistry in High-Throughput Screening Triage
2014
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Docking-Based Virtual Screening of Covalently Binding Ligands: An Orthogonal Lead Discovery Approach
2013
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes
2016 StandoutNobel
Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy
2019
Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate
2013 StandoutNobel
Constituents in Kava Extracts Potentially Involved in Hepatotoxicity: A Review
2011
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
2020 StandoutNobel
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
Recent advances towards sulfur (VI) fluoride exchange (SuFEx) click chemistry
2018
Bacterial Topoisomerase Inhibitors: Quinolone and Pyridone Antibacterial Agents
2005
Emerging Targets in Photopharmacology
2016 StandoutNobel
Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
2013 Standout
Palladium‐Catalyzed Fluorosulfonylvinylation of Organic Iodides
2017 StandoutNobel
Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications
2007
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Chemistry: Chemical con artists foil drug discovery
2014 StandoutNature
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space
2016
The Essential Medicinal Chemistry of Curcumin
2017 Standout
Design and synthesis of fluconazole/bile acid conjugate using click reaction
2006
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States
2011
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
2023 StandoutNobel
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope
2017 StandoutNobel
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Cytochrome P450 and Chemical Toxicology
2007
Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
2012 Standout
Works of Deepak Dalvie being referenced
Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance
2013
Cytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics
2016
Pharmacokinetics and Metabolism of 2-Aminothiazoles with Antiprion Activity in Mice
2013 Nobel
Use of a Multistaged Time-Dependent Inhibition Assay to Assess the Impact of Intestinal Metabolism on Drug-Drug Interaction Potential
2011
On the Diversity of Oxidative Bioactivation Reactions on Nitrogen- Containing Xenobiotics
2002
Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals
2003
Identification of primary and sequential bioactivation pathways of carbamazepine in human liver microsomes using liquid chromatography/tandem mass spectrometry
2007
A Comprehensive Listing of Bioactivation Pathways of Organic Functional Groups
2005
Comparison of In Vitro Metabolism of Ticlopidine by Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4
2010
Drug discovery for a new generation of covalent drugs
2012
Identification of a Novel Glutathione Conjugate of Flutamide in Incubations with Human Liver Microsomes
2007
Pharmacokinetics and metabolism of single oral doses of trovafloxacin
1998
Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
2007
Bioactivation of Flutamide Metabolites by Human Liver Microsomes
2008
IN VITRO METABOLISM STUDIES ON THE ISOXAZOLE RING SCISSION IN THE ANTI-INFLAMMATORY AGENT LEFLUNOMIDE TO ITS ACTIVE α-CYANOENOL METABOLITE A771726: MECHANISTIC SIMILARITIES WITH THE CYTOCHROME P450-CATALYZED DEHYDRATION OF ALDOXIMES
2003
Identification of Novel Substrates for Human Cytochrome P450 2J2
2009
CHARACTERIZATION OF NOVEL DIHYDROTHIENOPYRIDINIUM AND THIENOPYRIDINIUM METABOLITES OF TICLOPIDINE IN VITRO: ROLE OF PEROXIDASES, CYTOCHROMES P450, AND MONOAMINE OXIDASES
2004
IN VITRO METABOLIC ACTIVATION OF THIABENDAZOLE VIA 5-HYDROXYTHIABENDAZOLE: IDENTIFICATION OF A GLUTATHIONE CONJUGATE OF 5-HYDROXYTHIABENDAZOLE
2006
Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings
2002
Bioactivation of Lumiracoxib by Peroxidases and Human Liver Microsomes: Identification of Multiple Quinone Imine Intermediates and GSH Adducts
2008
Synthesis of 4‐(2‐chloroethyl)‐2,3‐dihydro[1,4]oxazino[2,3‐b]quinoline and 4‐(2‐chloroethyl)2,3‐dihydropyrido[2,3‐b][1,4]oxazine
1993
Interactions of Nitrogen-Containing Xenobiotics with Monoamine Oxidase (MAO) Isozymes A and B: SAR Studies on MAO Substrates and Inhibitors
2001
Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery
2010
Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites
2009
NADPH-Dependent Covalent Binding of [3H]Paroxetine to Human Liver Microsomes and S-9 Fractions: Identification of an Electrophilic Quinone Metabolite of Paroxetine
2007
Effect of Intestinal Glucuronidation in Limiting Hepatic Exposure and Bioactivation of Raloxifene in Humans and Rats
2008
MECHANISM-BASED INACTIVATION OF HUMAN RECOMBINANT P450 2C9 BY THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG SUPROFEN
2003
A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes
2014