Citation Impact
Citing Papers
Complement and microglia mediate early synapse loss in Alzheimer mouse models
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A Gene Network Regulating Lysosomal Biogenesis and Function
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Sleep Drives Metabolite Clearance from the Adult Brain
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Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide.
1996
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
1998 StandoutNature
Inflammation and Alzheimer's disease
2000 Standout
Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain
1995
Apoptosis in the nervous system
2000 StandoutNature
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature
2011
Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport
2004 StandoutNobel
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
2002 StandoutNature
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase
2003
Direct Interaction of Alzheimer's Disease-related Presenilin 1 with Armadillo Protein p0071
1999 StandoutNobel
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
2000 StandoutNature
NMR studies of amyloid .beta.-peptides: proton assignments, secondary structure, and mechanism of an .alpha.-helix .fwdarw. .beta.-sheet conversion for a homologous, 28-residue, N-terminal fragment
1992
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 Standout
Atomic structures of amyloid cross-β spines reveal varied steric zippers
2007 StandoutNature
Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function
1999
Alzheimer's disease: a cell biological perspective
1992 Science
Identification of a penta- and hexapeptide of islet amyloid polypeptide (IAPP) with amyloidogenic and cytotoxic properties
2000
Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP
2005
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Aggregation of Secreted Amyloid β-Protein into Sodium Dodecyl Sulfate-stable Oligomers in Cell Culture
1995
Amyloid fibril formation requires a chemically discriminating nucleation event: studies of an amyloidogenic sequence from the bacterial protein OsmB
1992
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
Inflammation and Alzheimer's disease pathogenesis
1996
Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome
2002
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Prion Protein Isoforms, a Convergence of Biological and Structural Investigations
1995 StandoutNobel
Structure of the cross-β spine of amyloid-like fibrils
2005 StandoutNature
Structural and functional features of central nervous system lymphatic vessels
2015 StandoutNature
Distinct Early Folding and Aggregation Properties of Alzheimer Amyloid-β Peptides Aβ40 and Aβ42
2006
Amyloid β-peptide polymerization studied using fluorescence correlation spectroscopy
1999
NMR studies in aqueous solution fail to identify significant conformational differences between the monomeric forms of two Alzheimer peptides with widely different plaque‐competence, Aβ(1–40)ox and Aβ(1–42)ox
2001 StandoutNobel
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau
1998
In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity
1991
Structural and kinetic features of amyloid β-protein fibrillogenesis
1998
Arrest of -Amyloid Fibril Formation by a Pentapeptide Ligand
1996
Common mechanisms of amyloid oligomer pathogenesis in degenerative disease
2006
Endogenous β-amyloid production in presenilin-deficient embryonic mouse fibroblasts
2001
[18] Quantification of β-sheet amyloid fibril structures with thioflavin T
1999 Standout
Non-A.beta. Component of Alzheimer's Disease Amyloid (NAC) is Amyloidogenic
1995
The Toxicity of the Alzheimer's β-Amyloid Peptide Correlates with a Distinct Fiber Morphology
1997
The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
1993 Standout
Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling
1998
Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation
1998
Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF
1993
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Lysosomal Activation Is a Compensatory Response Against Protein Accumulation and Associated Synaptopathogenesis—An Approach for Slowing Alzheimer Disease?
2003
Inhibition of Aβ fibril formation and Aβ-induced cytotoxicity by senile plaque-associated proteins
2000
LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms
2004
Amyloid β-Protein Fibrillogenesis
1997
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex
1998
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
2005 StandoutNature
A Biotechnological Method Provides Access to Aggregation Competent Monomeric Alzheimer's 1–42 Residue Amyloid Peptide
1995
Structural and Dynamic Features of Alzheimer's Aβ Peptide in Amyloid Fibrils Studied by Site-directed Spin Labeling
2002
Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis
2006
Solution structures of micelle-bound amyloid β-(1-40) and β-(1-42) peptides of Alzheimer’s disease 1 1Edited by P. E. Wright
1999
The role of microglia in amyloid clearance from the AD brain
2010
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
1999 StandoutNature
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
In pursuit of the molecular structure of amyloid plaque: new technology provides unexpected and critical information
1992
Polyclonals to β-amyloid(1–42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum
1994
Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons
1995
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor
1993 Science
The toxicity in vitro of β-amyloid protein
1995
Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
1992 StandoutNature
Prion-inducing domain 2–114 of yeast Sup35 protein transforms in vitro into amyloid-like filaments
1997 StandoutNobel
A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation
2003
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
1996 StandoutScience
An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants
1994 StandoutScience
INFLAMMATION AND ALZHEIMERS DISEASE
2000
Solution Structure of Amyloid β-Peptide(1−40) in a Water−Micelle Environment. Is the Membrane-Spanning Domain Where We Think It Is?,
1998
Apoptosis in the Pathogenesis and Treatment of Disease
1995 StandoutScience
A Century of Alzheimer's Disease
2006 StandoutScience
An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease
1997 Nature
3D structure of Alzheimer's amyloid-β(1–42) fibrils
2005 Standout
Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging.
1994
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
1997 StandoutScience
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation.
2003
A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.
1994
Calcium and neuronal injury in Alzheimer's disease. Contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise.
1994
MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES
1999
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-beta by cathepsin D
1994
Intracellular metalloprotease activity controls intraneuronal Aβ aggregation and limits secretion of Aβ via exosomes
2018
Calcium and Neuronal Injury in Alzheimer's Disease
1994
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
Transthyretin sequesters amyloid beta protein and prevents amyloid formation.
1994
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
2004 StandoutNobel
Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses.
1993
Deposition of Monomeric, Not Oligomeric, Aβ Mediates Growth of Alzheimer's Disease Amyloid Plaques in Human Brain Preparations
1999
Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes
2003 StandoutScience
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Propagating structure of Alzheimer’s β-amyloid (10–35) is parallel β-sheet with residues in exact register
1998
Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path
1998
Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.
1993
The 3D profile method for identifying fibril-forming segments of proteins
2006 StandoutNobel
On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants.
1996
Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis
2006
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
1996 StandoutNature
From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles
2011 Standout
Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing
1992 StandoutScience
Inhibitors of Amyloid Toxicity Based on β-sheet Packing of Aβ40 and Aβ42
2006
Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
2003 StandoutScience
MODELS OF AMYLOID SEEDING IN ALZHEIMER'S DISEASE AND SCRAPIE: Mechanistic Truths and Physiological Consequences of the Time-Dependent Solubility of Amyloid Proteins
1997
Characterization of New Polyclonal Antibodies Specific for 40 and 42 Amino Acid-Long Amyloid β Peptides: Their Use to Examine the Cell Biology of Presenilins and the Immunohistochemistry of Sporadic Alzheimer’s Disease and Cerebral Amyloid Angiopathy Cases
1997
Self-Assembly of β-Amyloid 42 Is Retarded by Small Molecular Ligands at the Stage of Structural Intermediates
2000 StandoutNobel
Amyloid Fibril Formation by Aβ16-22, a Seven-Residue Fragment of the Alzheimer's β-Amyloid Peptide, and Structural Characterization by Solid State NMR
2000
Surfactant properties of Alzheimer's A beta peptides and the mechanism of amyloid aggregation.
1994
Synthetic peptides corresponding to different mutated regions of the amyloid gene in familial Creutzfeldt-Jakob disease show enhanced in vitro formation of morphologically different amyloid fibrils.
1993 Nobel
Works of Debra Burdick being referenced
Intracellular Aβ1-42 Aggregates Stimulate the Accumulation of Stable, Insoluble Amyloidogenic Fragments of the Amyloid Precursor Protein in Transfected Cells
1995
Cultured Rat Microglia Express C1q and Receptor for C1q: Implications for Amyloid Effects on Microglia
1995
Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, Aβ1–42, in differentiated PC12 cells
1997
beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.
1994
Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.
1992
Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor
2003