Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
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Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection
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IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice.
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C/EBPβ Gene Inactivation Causes Both Impaired and Enhanced Gene Expression and Inverse Regulation of IL-12 p40 and p35 mRNAs in Macrophages
2002
The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death
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Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
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Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
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Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
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A Neurotrophic Model for Stress-Related Mood Disorders
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Expression of Epstein-Barr Virus-Induced Gene 3, an Interleukin-12 p40-Related Molecule, throughout Human Pregnancy
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Regulation and function of mTOR signalling in T cell fate decisions
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Mechanisms and Functional Implications of Adult Neurogenesis
2008 Standout
Pilocarpine-Induced Seizures Cause Selective Time-Dependent Changes to Adult-Generated Hippocampal Dentate Granule Cells
2007
Stress proteins, infection, and immune surveillance
1989
Inhibition of neurogenesis interferes with hippocampus‐dependent memory function
2006
Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
2016
An optogenetic toolbox designed for primates
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Persistent CREB Phosphorylation with Protection of Hippocampal CA1 Pyramidal Neurons Following Temporary Occlusion of the Middle Cerebral Artery in the Rat
2000
Interleukin-12 and the regulation of innate resistance and adaptive immunity
2003 Standout
Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain
2003
CD4+ T-cell subsets in autoimmunity
1997
Regulatory T Cells
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Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
2009
Adeno-associated virus vectors for gene therapy: more pros than cons?
2000
Synergistic Regulation of the Human Interleukin-12 p40 Promoter by NFκB and Ets Transcription Factors in Epstein-Barr Virus-transformed B Cells and Macrophages
1998
Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
2002
Interleukin-12 in anti-tumor immunity and immunotherapy
2002
Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease
2003
Function and Regulation of CREB Family Transcription Factors in the Nervous System
2002 Standout
Structure and chromosomal location of the mouse interleukin‐12 p35 and p40 subunit genes
1996
Defects in enteric innervation and kidney development in mice lacking GDNF
1996 StandoutNature
Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions
1996
Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain
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The Science of Stroke: Mechanisms in Search of Treatments
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Adult neurogenesis and functional plasticity in neuronal circuits
2006
Localization of Glial Cell Line‐derived Neurotrophic Factor (GDNF) mRNA in Embryonic Rat by In Situ Hybridization
1996
Expression monitoring by hybridization to high-density oligonucleotide arrays
1996 Standout
Decoding NMDA Receptor Signaling: Identification of Genomic Programs Specifying Neuronal Survival and Death
2007
Wnt signalling regulates adult hippocampal neurogenesis
2005 Nature
Rheumatoid Arthritis
1990
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior
2007
Parkinson's disease
2009 Standout
Interleukin-18: A Novel Cytokine That Augments Both Innate and Acquired Immunity
1998
Large‐scale neurocognitive networks and distributed processing for attention, language, and memory
1990 Standout
Disease resistant, NOD-related strains reveal checkpoints of immunoregulation in the pancreas
2001
Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.
1998
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-activating Polypeptide Inhibit Interleukin-12 Transcription by Regulating Nuclear Factor κB and Ets Activation
1999
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
2013 Standout
Evolution of a designed protein assembly encapsulating its own RNA genome
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Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation
2005
Induction of interferon-γ production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation
1999
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
2002
DIFFERENTIAL RESPONSE OF THE MURINE IL-12 p35 GENE TO LIPOPOLYSACCHARIDE COMPARED WITH INTERFERON-GAMMA AND CD40 LIGATION
2001
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
2007
Interleukin-12 Induces Tyrosine Phosphorylation of an 85-kDa Protein Associated with the Interleukin-12 Receptor β1 Subunit
1998
Genes Induced in Programmed Cell Death of Neuronal PC12 Cells and Developing Sympathetic Neuronsin Vivo
1997
Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: effects on stress hormone levels and adult hippocampal neurogenesis
2002
Taking dendritic cells into medicine
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Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo
1999
Partial Normalization of Serum Brain-Derived Neurotrophic Factor in Remitted Patients after a Major Depressive Episode
2005
Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice
1995
Atherosclerosis — An Inflammatory Disease
1999 Standout
AAV‐mediated delivery of BDNF augments neurogenesis in the normal and quinolinic acid‐lesioned adult rat brain
2007
GDNF signalling through the Ret receptor tyrosine kinase
1996 StandoutNature
Alzheimer's Disease
2010 Standout
GDNF is an age-specific survival factor for sensory and autonomic neurons
1995
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial
2008
The Acid-Activated Ion Channel ASIC Contributes to Synaptic Plasticity, Learning, and Memory
2002
CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal
2000
Central functions of neuropeptide Y in mood and anxiety disorders
2011
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Stereotaxic gene delivery in the rodent brain
2006
Functional recovery in parkinsonian monkeys treated with GDNF
1996 Nature
Interleukin‐12 and B7.1 co‐stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors
1996
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
1996 Nature
Persistent phosphorylation of cyclic amp responsive element-binding protein and activating transcription factor-2 transcription factors following transient cerebral ischemia in rat brain
1999
Renal agenesis and the absence of enteric neurons in mice lacking GDNF
1996 StandoutNature
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
The molecular neurobiology of depression
2008 StandoutNature
Stress and adult neurogenesis
2006
Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system
1999
Optogenetics in Neural Systems
2011 Standout
Oligomeric Amyloid Decreases Basal Levels of Brain-Derived Neurotrophic factor (BDNF) mRNA via Specific Downregulation of BDNF Transcripts IV and V in Differentiated Human Neuroblastoma Cells
2007
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways
2006
Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist
1995
Depression of Synaptic Transmission by Vascular Endothelial Growth Factor in Adult Rat Hippocampus and Evidence for Increased Efficacy after Chronic Seizures
2005
Mycobacterium tuberculosis CDC1551 Induces a More Vigorous Host Response In Vivo and In Vitro, But Is Not More Virulent Than Other Clinical Isolates
1999
Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity
2013 StandoutScienceNobel
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes
2005 StandoutNobel
Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons.
1995
Localization of Phosphorylated cAMP Response Element-Binding Protein in Immature Neurons of Adult Hippocampus
2002
The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo
2011 StandoutNobel
Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes
1995
Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration.
1995
Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70
2000 StandoutNobel
CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
1998 StandoutNobel
1997
Interferon-γ–Dependent Inducible Expression of the Human Interleukin-12 p35 Gene in Monocytes Initiates From a TATA-Containing Promoter Distinct From the CpG-Rich Promoter Active in Epstein-Barr Virus-Transformed Lymphoblastoid Cells
1998
A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits
1996
Cutting Edge: IL-12 and IL-18 Differentially Regulate the Transcriptional Activity of the Human IFN-γ Promoter in Primary CD4+ T Lymphocytes
1998
Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells
1997
Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site
1995
Interleukin-12–Activated Natural Killer Cells Recognize B7 Costimulatory Molecules on Tumor Cells and Autologous Dendritic Cells
1998
Roles of Interleukin-12 and Gamma Interferon in MurineChlamydia pneumoniaeInfection
2000
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.
1995
Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.
1994
Role of Interleukin-12 in Primary Influenza Virus Infection
1998
Nonviral Vectors for Gene Delivery
2008 Standout
Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.
1993
Induction of Interleukin-1 Associated with Compensatory Dopaminergic Sprouting in the Denervated Striatum of Young Mice: Model of Aging and Neurodegenerative Disease
1998
Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
1998 StandoutNobel
Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells
2002 StandoutNobel
Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins
1997
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.
1993 Standout
Heat shock protein 70-associated peptides elicit specific cancer immunity.
1993
Superior Protection against Malaria and Melanoma Metastases by a C-glycoside Analogue of the Natural Killer T Cell Ligand α-Galactosylceramide
2003
Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
1993 StandoutScience
Disparate Intracellular Processing of Human IL-12 Preprotein Subunits: Atypical Processing of the P35 Signal Peptide
2000
Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.
1995
IL-12 Is Dysregulated in Macrophages from IRF-1 and IRF-2 Knockout Mice
1999
Double-knockout mice for α- and β-synucleins: Effect on synaptic functions
2004 StandoutNobel
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.
1995
Expression of Murine IL-12 Is Regulated by Translational Control of the p35 Subunit
1999
A high-light sensitivity optical neural silencer: development, and application to optogenetic control of nonhuman primate cortex
2011
Expression and Function of IL-12 and IL-18 Receptors on Human Tonsillar B Cells
2000
MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence
2003 StandoutNobel
Molecular Mechanisms of the Induction of IL-12 and Its Inhibition by IL-10
1998
Regulation of IL-12 p40 Promoter Activity in Primary Human Monocytes: Roles of NF-κB, CCAAT/Enhancer-Binding Protein β, and PU.1 and Identification of a Novel Repressor Element (GA-12) That Responds to IL-4 and Prostaglandin E2
2001
Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.
1994
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
IL-12 Is Required to Maintain a Th1 Response DuringLeishmania majorInfection
2000
Programmed cell death and AIDS: significance of T-cell apoptosis in pathogenic and nonpathogenic primate lentiviral infections.
1994 StandoutNobel
Glycolipid α-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice
2006 StandoutNobel
Expansion of Functional NK Cells in Multiple Tissue Compartments of Mice Treated with Flt3-Ligand: Implications for Anti-Cancer and Anti-Viral Therapy
1998
Macrophages as effector cells in interleukin 12-induced T cell-dependent tumor rejection.
2002
Recognition of Self Antigens by Skin-Derived T Cells with Invariant γδ Antigen Receptors
1991 StandoutScienceNobel
Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice
1998
B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.
1994
Ischemic Cell Death in Brain Neurons
1999 Standout
Interleukin 12: A key modulator of immune function
1994
Interferon-γ–Dependent Inducible Expression of the Human Interleukin-12 p35 Gene in Monocytes Initiates From a TATA-Containing Promoter Distinct From the CpG-Rich Promoter Active in Epstein-Barr Virus-Transformed Lymphoblastoid Cells
1998
Multifactorial Nature of Human Immunodeficiency Virus Disease: Implications for Therapy
1993 Science
Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.
1996
Requirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors
1997 Science
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.
1993
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.
1996
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.
1993
Regulation of interleukin-12 production in antigen-presenting cells
2001
Antitumor and antimetastatic activity of interleukin 12 against murine tumors.
1993
The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major
1994 Science
Neural Computing in Cancer Drug Development: Predicting Mechanism of Action
1992 StandoutScienceNobel
Large-scale analysis of the human and mouse transcriptomes
2002 StandoutNobel
Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.
1994
Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-β in ANA-1 cells
1998
IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes.
1998
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
C-Rel Regulates Interleukin 12 P70 Expression in Cd8+ Dendritic Cells by Specifically Inducing p35 Gene Transcription
2001
Regulation of Nuclear Gamma Interferon Gene Expression by Interleukin 12 (IL-12) and IL-2 Represents a Novel Form of Posttranscriptional Control
2002
NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines
1999 Standout
A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
1996
Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production.
1995
Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12
1998
Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.
1988
CREB Phosphorylation Promotes Nerve Cell Survival
1999
Biosynthesis and Posttranslational Regulation of Human IL-12
2000
Works of Deborah Young being referenced
Efficient Gene Delivery and Selective Transduction of Glial Cells in the Mammalian Brain by AAV Serotypes Isolated From Nonhuman Primates
2009
A novel role of circadian transcription factor DBP in hippocampal plasticity
2005
Stress proteins may provide a link between the immune response to infection and autoimmunity
1989
Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury?
1993
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial
2007
AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats
2004
Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective
1999
Differential regulation by MK801 of immediate-early genes, brain-derived neurotrophic factor and trk receptor mRNA induced by a kindling after-discharge
1998
Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus
1997
Peroral gene therapy of lactose intolerance using an adeno-associated virus vector
1998
Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
1995 Nature
Brain-derived neurotrophic factor is reduced in Alzheimer's disease
1997
Neuronal death and survival in two models of hypoxic-ischemic brain damage
1999
AAV-Mediated gene delivery of BDNF or GDNF is neuroprotective in a model of huntington disease
2004
Differential Actions of NPY on Seizure Modulation via Y1 and Y2 Receptors: Evidence from Receptor Knockout Mice
2006
MK-801 sensitizes rats to pilocarpine induced limbic seizures and status epilepticus
1993
Non-NMDA glutamate receptors are involved in the maintenance of status epilepticus
1993
Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes
2001
Induction of clusterin in the immature brain following a hypoxic-ischemic injury
1996
VEGF links hippocampal activity with neurogenesis, learning and memory
2004
Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms
1994
Interleukin-12 Stimulates B Cell Growth by Inducing IFN-γ
1996
mTOR — beyond transplantation
2005
Do c-Jun, c-Fos, and amyloid precursor protein play a role in neuronal death or survival?
1998
Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients.
1992
Differential expression of inducible transcription factors in basal ganglia neurons
1995
Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF.
1992
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.
1991
An Oral Vaccine Against NMDAR1 with Efficacy in Experimental Stroke and Epilepsy
2000 Science
T lymphocytes respond to solid-phase antigen: a novel approach to the molecular analysis of cellular immunity.
1986
Brain norepinephrine depleting lesions selectively enhance behavioral responsiveness to novelty
1984
Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.
1992
Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
1991
Raised serum IgG and IgA antibodies to mycobacterial antigens in rheumatoid arthritis.
1989