Standout Papers
Citation Impact
Citing Papers
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
Principles for designing proteins with cavities formed by curved β sheets
2017 StandoutScienceNobel
Substrate polypeptide presents a load on the apical domains of the chaperonin GroEL
2004
Complete Replication of Hepatitis C Virus in Cell Culture
2005 StandoutScienceNobel
De novo design of self-assembling helical protein filaments
2018 StandoutScienceNobel
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
2020 StandoutScienceNobel
Four-component protein nanocages designed by programmed symmetry breaking
2024 StandoutNatureNobel
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Structures of the RNA-guided surveillance complex from a bacterial immune system
2011 StandoutNatureNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Elucidating the medium-resolution structure of ribosomal particles: an interplay between electron cryo-microscopy and X-ray crystallography
1999 StandoutNobel
MgATP binding to the nucleotide‐binding domains of the eukaryotic cytoplasmic chaperonin induces conformational changes in the putative substrate‐binding domains
1998
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Multiple cycles of global unfolding of GroEL-bound cyclophilin A evidenced by NMR
1997 StandoutNobel
Cooperativity in the Thermosome
2005
High-resolution single-particle orientation refinement based on spectrally self-adapting common lines
2009
Residues in chaperonin GroEL required for polypeptide binding and release
1994 Nature
Review: A Structural View of the GroE Chaperone Cycle
2001
Use of organic cosmotropic solutes to crystallize flexible proteins: application to T7 RNA polymerase and its complex with the inhibitor T7 lysozyme
1997 StandoutNobel
Exploring the Structural Dynamics of the E.coli Chaperonin GroEL Using Translation-libration-screw Crystallographic Refinement of Intermediate States
2004
The Origins and Consequences of Asymmetry in the Chaperonin Reaction Cycle
1995
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
Structure of unliganded HIV-1 reverse transcriptase at 2.7 å resolution: implications of conformational changes for polymerization and inhibition mechanisms
1996
Automated segmentation of molecular subunits in electron cryomicroscopy density maps
2006
Multiple States of a Nucleotide-Bound Group 2 Chaperonin
2008
The crystal structure of the asymmetric GroEL–GroES–(ADP)7 chaperonin complex
1997 Nature
Structure and function of the GroE chaperone
2002
A dynamic model for the allosteric mechanism of GroEL 1 1Edited by A. Fersht
2000
Closing the Folding Chamber of the Eukaryotic Chaperonin Requires the Transition State of ATP Hydrolysis
2003
Specificity in chaperonin-mediated protein folding
1995 Nature
1.7 Å structure of the stabilized REIv mutant T39K. Application of local NCS restraints
1999
The dynamic disulphide relay of quiescin sulphydryl oxidase
2012 StandoutNatureNobel
GroEL/GroES: Structure and Function of a Two-Stroke Folding Machine
1998
Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Å Resolution
2000 StandoutNobel
Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit
2013 StandoutNatureNobel
The crystal structure of the GroES co-chaperonin at 2.8 Å resolution
1996 NatureNobel
The Hsp70 and Hsp60 Chaperone Machines
1998 Standout
Crystal Structures of the Group II Chaperonin from Thermococcus strain KS-1: Steric Hindrance by the Substituted Amino Acid, and Inter-subunit Rearrangement between Two Crystal Forms
2003
A short history ofSHELX
2007 Standout
Optimal description of a protein structure in terms of multiple groups undergoing TLS motion
2006
Evolution of a designed protein assembly encapsulating its own RNA genome
2017 StandoutNatureNobel
Nested cooperativity and salt dependence of the ATPase activity of the archaeal chaperonin Mm‐cpn
2003
Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes
1998 StandoutNobel
Nested cooperativity in the ATPase activity of the oligomeric chaperonin GroEL
1995
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
Nested allosteric interactions in the cytoplasmic chaperonin containing TCP‐1
2001
Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase
1995
Not your average density
1997
GroEL-Mediated Protein Folding: Making the Impossible, Possible
2006
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
Structure of Taq polymerase with DNA at the polymerase active site
1996 StandoutNatureNobel
An Expanded Conformation of Single-Ring GroEL-GroES Complex Encapsulates an 86 kDa Substrate
2006
The Disordered Mobile Loop of GroES Folds into a Defined β-Hairpin upon Binding GroEL
2001
NMR analysis of a 900K GroEL–GroES complex
2002 StandoutNatureNobel
Crystal Structures of a Group II Chaperonin Reveal the Open and Closed States Associated with the Protein Folding Cycle
2010
Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT
2008
Structures of DNA and RNA polymerases and their interactions with nucleic acid substrates
1995
Automated molecular microscopy: The new Leginon system
2005 Standout
Conformational Changes in the GroEL Oligomer during the Functional Cycle
1997
Molecular chaperones in cellular protein folding
1996 StandoutNature
ATP-Bound States of GroEL Captured by Cryo-Electron Microscopy
2001
The 'sequential allosteric ring' mechanism in the eukaryotic chaperonin-assisted folding of actin and tubulin
2001
Action of the Chaperonin GroEL/ES on a Non-native Substrate Observed with Single-Molecule FRET
2010 StandoutNobel
Refolding of Bovine Mitochondrial Rhodanese by Chaperonins GroEL and GroES
2003
Crystal Structure of the Thermosome, the Archaeal Chaperonin and Homolog of CCT
1998
Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors
1995
3D reconstruction of the ATP-bound form of CCT reveals the asymmetric folding conformation of a type II chaperonin.
1999
Mechanism of folding chamber closure in a group II chaperonin
2010 StandoutNatureNobel
Mechanism of GroEL action: Productive release of polypeptide from a sequestered position under groes
1995
Gene Duplication and the Evolution of Group II Chaperonins: Implications for Structure and Function
2001
Transient Kinetic Analysis of ATP-induced Allosteric Transitions in the Eukaryotic Chaperonin containing TCP-1
2003
BeF Stops the Chaperonin Cycle of GroEL-GroES and Generates a Complex with Double Folding Chambers
2004
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
2002 StandoutNatureNobel
A 11.5 Å single particle reconstruction of GroEL using EMAN
2001
Protein folding in the central cavity of the GroEL–GroES chaperonin complex
1996 Nature
A surprising simplicity to protein folding
2000 StandoutNatureNobel
Molecular Mechanism of Protein Folding in the Cell
2011 StandoutNobel
Multivalent Binding of Nonnative Substrate Proteins by the Chaperonin GroEL
2000
[11] Construction of single-ring and two-ring hybrid versions of bacterial chaperonin GroEL
1998
Novel Insights into Hepatitis C Virus Replication and Persistence
2004
The Chaperonin ATPase Cycle: Mechanism of Allosteric Switching and Movements of Substrate-Binding Domains in GroEL
1996
Characterization of the Active Intermediate of a GroEL–GroES-Mediated Protein Folding Reaction
1996
Structural changes in GroEL effected by binding a denatured protein substrate 1 1Edited by W. Baumeister
2001
Dual Function of Protein Confinement in Chaperonin-Assisted Protein Folding
2001
Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 å resolution
1995
De Novo Backbone Trace of GroEL from Single Particle Electron Cryomicroscopy
2008
Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin
2010
A Reversible, Unidirectional Molecular Rotary Motor Driven by Chemical Energy
2005 StandoutScienceNobel
Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius
1999 Nobel
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
3V: cavity, channel and cleft volume calculator and extractor
2010
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Asymmetrical Interaction of GroEL and GroES in the ATPase Cycle of Assisted Protein Folding
1995 Science
Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning
2015 StandoutScienceNobel
Probing the Sequence of Conformationally Induced Polarity Changes in the Molecular Chaperonin GroEL with Fluorescence Spectroscopy
2005 StandoutNobel
The Structural Basis of Ribosome Activity in Peptide Bond Synthesis
2000 StandoutScienceNobel
Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance
1998 StandoutScience
Sensing cooperativity in ATP hydrolysis for single multisubunit enzymes in solution
2011 StandoutNobel
Mechanism of chaperonin action: GroES binding and release can drive GroEL-mediated protein folding in the absence of ATP hydrolysis.
1996
The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity
1998 StandoutScienceNobel
Interplay of structure and disorder in cochaperonin mobile loops.
1996
Chaperonin-Mediated Protein Folding
2001
Toward Intelligent Molecular Machines: Directed Motions of Biological and Artificial Molecules and Assemblies
2005
3′-Azido-3′-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes
1998
Nucleotide-dependent protein folding in the type II chaperonin from the mesophilic archaeon Methanococcus maripaludis
2003
Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors
2004 StandoutNobel
STRUCTURE AND FUNCTION IN GroEL-MEDIATED PROTEIN FOLDING
1998
Folding of Newly Translated Proteins In Vivo: The Role of Molecular Chaperones
2001
Chaperone rings in protein folding and degradation
1999
Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase
2002 StandoutScienceNobel
Functional Significance of Symmetrical Versus Asymmetrical GroEL-GroES Chaperonin Complexes
1995 Science
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle
2011 StandoutNobel
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of D.C. Boisvert being referenced
Comparison of three different crystal forms shows HIV-1 reverse transcriptase displays an internal swivel motion
1994 StandoutNobel
The 2.4 Å crystal structure of the bacterial chaperonin GroEL complexed with ATPγS
1996
The crystal structure of the bacterial chaperonln GroEL at 2.8 Å
1994 Nature
Structural Basis for GroEL-assisted Protein Folding from the Crystal Structure of (GroEL-KMgATP)14 at 2.0Å Resolution
2003
The 2.4 A crystal structure of the bacterial chaperonin GroEL complex with ATPγS
1996