Citation Impact
Citing Papers
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
A small-molecule switch for Golgi sulfotransferases
2004 StandoutNobel
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
2006 StandoutNobel
Copper-free click chemistry in living animals
2010 StandoutNobel
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia
1994 Nature
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Structural Basis for Gating and Activation of RyR1
2016 StandoutNobel
Destabilization of the complete protein secondary structure on binding to the chaperone GroEL
1994 StandoutNatureNobel
Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes
1990
Small-molecule displacement of a cryptic degron causes conditional protein degradation
2011
Chemical genetics: tailoring tools for cell biology
2003
Dynamic Covalent Chemistry
2002 StandoutNobel
Microarrays of cells expressing defined cDNAs
2001 Nature
1,4‐Pentenyne as a Five‐Carbon Synthon for Efficient and Selective Syntheses of Natural Products Containing 2,4‐Dimethyl‐1‐penten‐1,5‐ylidene and Related Moieties by Means of Zr‐Catalyzed Carboalumination of Alkynes and Alkenes
2007 StandoutNobel
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
1995 StandoutNature
Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin
1998 StandoutNobel
Two distinct forms of peptidylprolyl-cis-trans-isomerase are expressed separately in periplasmic and cytoplasmic compartments of Escherichia coli cells
1991
Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus
1991
Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein
1994
BCL-2 family proteins: changing partners in the dance towards death
2017
Peptidomimetics derived from natural products
1993
Molecular cloning and overexpression of the human FK506-binding protein FKBP
1990 Nature
Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway
1999 StandoutNobel
Conditional Protein Alleles Using Knockin Mice and a Chemical Inducer of Dimerization
2003
Mechanism of TGFβ receptor inhibition by FKBP12
1997
The karyogamy gene KAR2 and novel proteins are required for ER-membrane fusion
1994 StandoutNobel
Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy
1991 StandoutNatureNobel
Protein folding in the cell
1992 StandoutNature
The mechanism of action of cyclosporin A and FK506
1992 Standout
Suppression of B cell activation by cyclosporin A, FK506 and rapamycin
1990
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
1992 Nature
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Splicing factor SF3b as a target of the antitumor natural product pladienolide
2007
The cyclophilin homolog ninaA is a tissue-specific integral membrane protein required for the proper synthesis of a subset of Drosophila rhodopsins
1991
Inositol trisphosphate and calcium signalling
1993 StandoutNature
How Chemoproteomics Can Enable Drug Discovery and Development
2012
Cyclosporin A—cyclophilin complex formation A model based on X‐ray and NMR data
1992 StandoutNobel
Solution structure of the major binding protein for the immunosuppressant FK506
1991 Nature
Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A
1997
Revealing the world of RNA interference
2004 StandoutNatureNobel
Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp
1999 StandoutNatureNobel
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
1991 Standout
Human and Escherichia coli cyclophilins: sensitivity to inhibition by the immunosuppressant cyclosporin A correlates with a specific tryptophan residue
1991
The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGFβ Family Type I Receptors
1996
Calcineurin
1999
Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: One in the presence and one in the absence of CsA
1991
Crystallisation and preliminary X‐ray diffraction studies of cyclophilin‐tetrapeptide and cyclophilin‐cyclosporin complexes
1990
A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
2000 StandoutNature
Isolation and sequence of an FK506-binding protein from N. crassa which catalyses protein folding
1990 Nature
Sympathetic Neural Mechanisms of Cyclosporine-Induced Hypertension*
1996
Immunophilins in the Nervous System
1998
Oligomerization of immunoglobulin G heavy and light chains in vitro. A cell-free assay to study the assembly of the endoplasmic reticulum.
1993
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
A selective role of calcineurin Aα in synaptic depotentiation in hippocampus
1999 StandoutNobel
Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.
1990
Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesis.
1990
A three-hybrid system for detecting small ligand–protein receptor interactions
1996
Catalytic Asymmetric Reductive Amination of Aldehydes via Dynamic Kinetic Resolution
2006 StandoutNobel
S-cyclophilin. New member of the cyclophilin family associated with the secretory pathway
1991
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
Catalysis of protein folding by cyclophilins from different species
1991
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C
1995 StandoutScienceNobel
Molecular Modeling Studies of the DNA−Topoisomerase I Ternary Cleavable Complex with Camptothecin
1998 StandoutNobel
Total synthesis of FK-506. Part 1: Construction of the C16–C34 fragment
1997
The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.
1990
Protein folding
1990
Apoptosis in the Pathogenesis and Treatment of Disease
1995 StandoutScience
The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain.
1991 StandoutNobel
The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.
1992
Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand
1990 Science
High-affinity FKBP-12 ligands derived from (R)-(−)-carvone. Synthesis and evaluation of FK506 pyranose ring replacements
1995
Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites.
1995 StandoutNobel
Synthesis and structure-activity relationships of macrocyclic FKBP ligands
1994
A novel secreted cyclophilin-like protein (SCYLP)
1991
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae.
1991
Conformational Analysis of the cis‐ and trans‐Isomers of FK506 by NMR and Molecular Dynamics
1991
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
1991 StandoutScience
Structure of the FKBP12-Rapamycin Complex Interacting with Binding Domain of Human FRAP
1996 Science
The immunophilins
1994
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
2010 StandoutNobel
FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins.
1991
Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.
1995 StandoutNobel
Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription.
1991
Biologically active Phytophthora mating hormone prepared by catalytic asymmetric total synthesis
2008 StandoutNobel
Design, synthesis and X-ray crystallographic studies of novel FKBP-12 ligands
1995
Complete 15 N and 1 H NMR assignments for the amino-terminal domain of the phage 434 repressor in the urea-unfolded form
1992 StandoutNobel
Boron Reagents in Process Chemistry: Excellent Tools for Selective Reductions
2006
A Total Synthesis of FK-5061
1996
Overproduction and dissection of proteins by the expression-cassette polymerase chain reaction.
1990
Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin.
1990
Cyclosporine- and FK506-induced sympathetic activation correlates with calcineurin-mediated inhibition of T-cell signaling.
1993
Control of Memory Formation Through Regulated Expression of a CaMKII Transgene
1996 StandoutScienceNobel
Total Synthesis of Immunosuppressants: Unified Strategies Exploiting Dithiane Couplings and σ-Bond Olefin Constructions
1998
Stereoselective Organic Synthesis via Dynamic Kinetic Resolution
1995 StandoutNobel
Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands
1991 Science
Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings
2000 StandoutNobel
Charged surface residues of FKBP12 participate in formation of the FKBP12-FK506-calcineurin complex.
1992
Der Stand der Totalsynthese zu Beginn des 21. Jahrhunderts
2000
Specific Affinity Extraction Method for Small Molecule-Binding Proteins
2006
Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13.
1991
Solution Structure of FKBP, a Rotamase Enzyme and Receptor for FK506 and Rapamycin
1991 Science
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.
1995 StandoutNobel
Peptidyl‐Prolyl cis/trans Isomerases and Their Effectors
1994
Rapamycin Sensitivity in Saccharomyces cerevisiae Is Mediated by a Peptidyl-Prolyl cis-trans Isomerase Related to Human FK506-Binding Protein
1991
Structure-Based Design of Novel, Urea-Containing FKBP12 Inhibitors
1996
Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein.
1991
PRIM: Proximity imaging of green fluorescent protein-tagged polypeptides
1998 StandoutNobel
Atomic Structure of FKBP-FK506, an Immunophilin-Immunosuppressant Complex
1991 Science
Proline‐Derived N‐Sulfonylcarboxamides: Readily Available, Highly Enantioselective and Versatile Catalysts for Direct Aldol Reactions
2004
Isotope-Edited NMR of Cyclosporin a Bound to Cyclophilin: Evidence for a Trans 9,10 Amide Bond
1990 Science
Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?
1991
Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.
1991
Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen
1997
Multiple event activation of a generic prodrug trigger by antibody catalysis
1999 StandoutNobel
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Asymmetric Enamine Catalysis
2007 StandoutNobel
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
The use of HIV-1 protease structure in inhibitor design
1992
Inhibition of FKBP Rotamase Activity by Immunosuppressant FK506: Twisted Amide Surrogate
1990 Science
Effects of Rapamycin on Ryanodine Receptor/Ca 2+ -Release Channels From Cardiac Muscle
1996
The target of rapamycin (TOR) proteins
2001
Receptor-Induced Conformation Change of the Immunosuppressant Cyclosporin A
1991 StandoutScienceNobel
Synthesis of Zaragozic Acid A/Squalestatin S1
1995
Peptidyl prolyl cis-trans isomerase activity of cyclophilin A in functional homo-oligomeric receptor expression
1997
Chemical Glycoproteomics
2016 StandoutNobel
Drug Delivery Systems. 2. Camptothecin 20-O-Poly(ethylene glycol) Ester Transport Forms
1996
Works of David Uehling being referenced
A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase
1989 Nature
Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup
2011
Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I
1995
Synthesis, Topoisomerase I Inhibitory Activity, and in Vivo Evaluation of 11-Azacamptothecin Analogs
1995
Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors
2013
Small molecules reveal an alternative mechanism of Bax activation
2016
Total synthesis of FK506 and an FKBP probe reagent, [C(8),C(9)-13C2]-FK506
1990
Synthesis and Evaluation of Potent and Selective β3 Adrenergic Receptor Agonists Containing Acylsulfonamide, Sulfonylsulfonamide, and Sulfonylurea Carboxylic Acid Isosteres
2001
Studies relating to the synthesis of the immunosuppressive agent FK-506: application of the two-directional chain synthesis strategy to the pyranose moiety
1989
Studies of the immunosuppressive agent FK-506: synthesis of an advanced intermediate
1989