Standout Papers
Citation Impact
Citing Papers
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System
1993
CRY, a Drosophila Clock and Light-Regulated Cryptochrome, Is a Major Contributor to Circadian Rhythm Resetting and Photosensitivity
1998 StandoutNobel
CYCLE Is a Second bHLH-PAS Clock Protein Essential for Circadian Rhythmicity and Transcription of Drosophila period and timeless
1998 StandoutNobel
A Mucin-type O-Glycosyltransferase Modulates Cell Adhesion during Drosophila Development
2008
In Vivo Regulation of the IκB Homologue cactus during the Immune Response of Drosophila
1998 StandoutNobel
Direct and continuous assessment by cells of their position in a morphogen gradient
1995 StandoutNatureNobel
Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation
1999
Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA
1999
The inducible transcription activator NF-κB: regulation by distinct protein subunits
1991
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Identification of a signal for rapid export of proteins from the nucleus
1995 StandoutNobel
Conservation of peptide acceptor preferences between Drosophila and mammalian polypeptide-GalNAc transferase ortholog pairs
2008
How proteins enter the nucleus
1991
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs
1990 Nature
The clip-domain family of serine proteinases in arthropods
2000
DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide
1991
Glycopeptide-preferring Polypeptide GalNAc Transferase 10 (ppGalNAc T10), Involved in Mucin-type O-Glycosylation, Has a Unique GalNAc-O-Ser/Thr-binding Site in Its Catalytic Domain Not Found in ppGalNAc T1 or T2
2009 StandoutNobel
Krapfen/dMyd88 is required for the establishment of dorsoventral pattern in the Drosophila embryo
2003 Nobel
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos
1997 StandoutNobel
Mutational analysis of the Drosophila snake protease: an essential role for domains within the proenzyme polypeptide chain.
1994
A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless
1998 StandoutNobel
decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo
1992
The Rel Protein DIF Mediates the Antifungal but Not the Antibacterial Host Defense in Drosophila
2000 StandoutNobel
p73 and p63 Are Homotetramers Capable of Weak Heterotypic Interactions with Each Other but Not with p53
1999
The dynamic disulphide relay of quiescin sulphydryl oxidase
2012 StandoutNatureNobel
The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in drosophila
1991
IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: A new member of the IκB family
1992
A UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase Is Required for Epithelial Tube Formation
2006
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
1996 StandoutNobel
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
A single population of olfactory sensory neurons mediates an innate avoidance behaviour in Drosophila
2004 StandoutNatureNobel
Direct and Long-Range Action of a Wingless Morphogen Gradient
1996
Conditional modification of behavior inDrosophilaby targeted expression of a temperature‐sensitiveshibireallele in defined neurons
2001
A serpin mutant links Toll activation to melanization in the host defence of Drosophila
2002
2 Dorsal—Ventral Pattern Formation in the Drosophila Embryo: The Role of Zygotically Active Genes
1991
Activin signalling and response to a morphogen gradient
1994 StandoutNatureNobel
A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
1999
Molecular genetics of Drosophila immunity
1994
Control of cell lineage-specific development and transcription by bHLH-PAS proteins
1998
The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein 1
1991
The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila
1989
The human PDI family: Versatility packed into a single fold
2007
Cactus-independent regulation of Dorsal nuclear import by the ventral signal
2000
Differentially Timed Extracellular Signals Synchronize Pacemaker Neuron Clocks
2014
The immune response of Drosophila
2003 StandoutNatureNobel
Weckle Is a Zinc Finger Adaptor of the Toll Pathway in Dorsoventral Patterning of the Drosophila Embryo
2006
The drosophila gastrulation gene concertina encodes a Gα-like protein
1991 StandoutNobel
Twin of I-POU: A two amino acid difference in the I-POU homeodomain distinguishes an activator from an inhibitor of transcription
1992
Spatially localized rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis
1993 StandoutNobel
Control of development and immunity by Rel transcription factors in Drosophila
1999
The polarity of the dorsoventral axis in the drosophila embryo is defined by an extracellular signal
1991
Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen
1993
Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum
2002 StandoutNobel
Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins
1992
Dorsoventral Axis Formation in the Drosophila Embryo—Shaping and Transducing a Morphogen Gradient
2005
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections
2007 StandoutNobel
Dif, a dorsal-related gene that mediates an immune response in Drosophila
1993
staufen, a gene required to localize maternal RNAs in the Drosophila egg
1991 StandoutNobel
Signal transduction by a protease cascade
1999
The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo
1994
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal
1990 Nobel
Homeodomain-DNA recognition
1994 StandoutNobel
Problems and paradigms: Morphogens and pattern formation
1997
Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product
1991
Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity
1992 StandoutNobel
Dorsal-ventral polarity in the Drosophila embryo
1993
Regulated nuclear import of Rel proteins in the Drosophila immune response
1998 Nature
Identification of Common and Unique Peptide Substrate Preferences for the UDP-GalNAc:Polypeptide α-N-acetylgalactosaminyltransferases T1 and T2 Derived from Oriented Random Peptide Substrates
2006
pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo
1993
Dorsoventral pattern formation in Drosophila: signal transduction and nuclear targeting
1991
skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo
1992
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates
1992 StandoutNobel
Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo.
1993
Dominant and recessive alleles of the Drosophila easter gene are point mutations at conserved sites in the serine protease catalytic domain
1990
Nuclear protein localization
1991
Mechanisms of Signal Transduction to the Cell Nucleus
1990
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
Kap104p: A Karyopherin Involved in the Nuclear Transport of Messenger RNA Binding Proteins
1996 StandoutScienceNobel
Activation of the easter zymogen is regulated by five other genes to define dorsal-ventral polarity in the Drosophila embryo
1992
The Drosophila membrane receptor Toll can function to promote cellular adhesion.
1990
Interactions of a Rel protein with its inhibitor.
1995
In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish
2008 StandoutScienceNobel
Cactus protein degradation mediates Drosophila dorsal-ventral signaling.
1995
Specificity of Rel-Inhibitor Interactions in Drosophila Embryos
1995
The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo
1992 StandoutNobel
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo
2000
The Drosophila Atypical Protein Kinase C-Ref(2)P Complex Constitutes a Conserved Module for Signaling in the Toll Pathway
2002
A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo
1994
An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo
1993
A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-kappa B.
1993
The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen.
1991
A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway
1996
Amino acids conserved in interleukin-1 receptors (IL-1Rs) and the Drosophila toll protein are essential for IL-1R signal transduction.
1992
A Spätzle-Processing Enzyme Required for Toll Signaling Activation in Drosophila Innate Immunity
2006
Localized enhancement and repression of the activity of the TGF-P family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo
1992
The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos.
1991
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Molecular organization of the decapentaplegic gene in Drosophila melanogaster.
1990
Role of Glycosylation in Development
2004
vRel is an inactive member of the Rel family of transcriptional activating proteins
1991
cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos
1991 StandoutNobel
Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila.
1995 StandoutNobel
The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product
1990
An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators
1997
In vivo self-association of the Drosophila rel-protein dorsal.
1992
Determination of the embryonic axes of Drosophila*
1991 StandoutNobel
The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain.
1990
Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal–ventral pattern formation
1991
Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.
1991
DrosophilaWntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo
2005
Cell shape changes during gastrulation in Drosophila
1990
Establishment of the Mesoderm-Neuroectoderm Boundary in the Drosophila Embryo
1991 Science
Functional analysis of the Drosophila twist promoter reveals a dorsal-binding ventral activator region.
1991
Dissociation of the dorsal-cactus complex and phosphorylation of the dorsal protein correlate with the nuclear localization of dorsal.
1993
Disulfide cross-linking in crude embryonic lysates reveals three complexes of the Drosophila morphogen dorsal and its inhibitor cactus.
1994 StandoutNobel
Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region
2001
Multiple pathways in nuclear transport: the import of U2 snRNP occurs by a novel kinetic pathway.
1991
The Dorsal-related immunity factor (Dif) can define the dorsal-ventral axis of polarity in the Drosophila embryo
1998
Altered mitotic domains reveal fate map changes in Drosophila embryos mutant for zygotic dorsoventral patterning genes
1992 StandoutNobel
Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.
1991
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
1994 StandoutNatureNobel
The control of cell fate along the dorsal-ventral axis of the Drosophila embryo
1991 StandoutNobel
A multimeric complex and the nuclear targeting of the Drosophila Rel protein Dorsal
1997
Circadian neuron feedback controls the Drosophila sleep–activity profile
2016 StandoutNatureNobel
Morphogen gradient interpretation
2001 StandoutNatureNobel
The functional domains of the Drosophila morphogen dorsal: evidence from the analysis of mutants.
1992 StandoutNobel
Role of Peptide Sequence and Neighboring Residue Glycosylation on the Substrate Specificity of the Uridine 5'-Diphosphate−α-N-acetylgalactosamine:Polypeptide N-acetylgalactosaminyl Transferases T1 and T2: Kinetic Modeling of the Porcine and Canine Submaxillary Gland Mucin Tandem Repeats
2004
Works of David Stein being referenced
Establishment of dorsal-ventral and terminal pattern in the Drosophila embryo
1991
Functional Characterization and Expression Analysis of Members of the UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase Family from Drosophila melanogaster
2003
A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila
1996 Nobel
Spatially Restricted Expression of pipe in the Drosophila Egg Chamber Defines Embryonic Dorsal–Ventral Polarity
1998
The cAMP-dependent Protein Kinase Site (Ser312) Enhances Dorsal Nuclear Import through Facilitating Nuclear Localization Sequence/Importin Interaction
1998
A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo
1989 StandoutNobel
A Biochemical and Biological Analysis of Myc Superfamily Interactions
1997
Separable and redundant regulatory determinants in Cactus mediate its dorsal group dependent degradation
2001
Windbeutel is required for function and correct subcellular localization of the Drosophila patterning protein Pipe
2000
DrosophilaPipe protein activity in the ovary and the embryonic salivary gland does not require heparan sulfate glycosaminoglycans
2005
Investigating the function of follicular subpopulations during Drosophila oogenesis through hormone-dependent enhancer-targeted cell ablation
2000