Citation Impact
Citing Papers
Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor–modified T cells
2014
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Toxicities of chimeric antigen receptor T cells: recognition and management
2016
mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer
2015
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
2013 Science
Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
2013
Requirement of bic/microRNA-155 for Normal Immune Function
2007 StandoutScience
Recognition of a Ubiquitous Self Antigen by Prostate Cancer-Infiltrating CD8 + T Lymphocytes
2008 StandoutScienceNobel
The Basic Principles of Chimeric Antigen Receptor Design
2013
T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells
2016
CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date
2016
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity
2014
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Vitiligo-Like Depigmentation in Patients With Stage III-IV Melanoma Receiving Immunotherapy and Its Association With Survival: A Systematic Review and Meta-Analysis
2015
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Critical Role of O-Linked β-N-Acetylglucosamine Transferase in Prostate Cancer Invasion, Angiogenesis, and Metastasis
2012
CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells
2015
Proceedings from the National Cancer Institute’s Second International Workshop on the Biology, Prevention, and Treatment of Relapse after Hematopoietic Stem Cell Transplantation: Part III. Prevention and Treatment of Relapse after Allogeneic Transplantation
2013
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR
2012
Anoikis mechanisms
2001
Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia
2013 Standout
Post-translational modification of p53 protein in response to ionizing radiation analyzed by mass spectrometry
2000
Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas
2017
A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity
2020
mRNA vaccines — a new era in vaccinology
2018 StandoutNobel
Rewiring human cellular input–output using modular extracellular sensors
2016
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
2015
Adoptive T Cell Transfer for Cancer Immunotherapy in the Era of Synthetic Biology
2013
Changes in Metabolic Chemical Reporter Structure Yield a Selective Probe of O-GlcNAc Modification
2014
Cytokine release syndrome in cancer immunotherapy with chimeric antigen receptor engineered T cells
2013
The Human T Cell Response to Melanoma Antigens
2006
Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression
2014
Toll-like receptors and cancer
2008
Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery
2015
Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors
2015
Adoptive immunotherapy for cancer: harnessing the T cell response
2012
Extensive Crosstalk between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling
2012
Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses
2018
Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
2015 Standout
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
Metazoan MicroRNAs
2018 Standout
Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells
2018
Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
2017 StandoutNobel
CTLA-4 blockade increases antigen-specific CD8+ T cells in prevaccinated patients with melanoma: three cases
2011 StandoutNobel
Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors
2013
Immunity, Inflammation, and Cancer
2010 Standout
Engineering CAR-T cells: Design concepts
2015
Emerging Biological Principles of Metastasis
2017 Standout
Antigens for cancer immunotherapy
2008
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells
2012
The pharmacology of second-generation chimeric antigen receptors
2015
Cancer immunotherapy comes of age
2011 StandoutNature
Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor
2018
A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects
2018
Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity
2013
Fully human CD19-specific chimeric antigen receptors for T-cell therapy
2017
Mechanisms of switching on p53: a role for covalent modification?
1999
Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes
2003 Standout
AKT/PKB Signaling: Navigating the Network
2017 Standout
Driving CAR T-cells forward
2016
Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
2014 Standout
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
2014 Standout
New Cell Sources for T Cell Engineering and Adoptive Immunotherapy
2015
Integrins
2002 Standout
Prospects for adoptive immunotherapy of pancreatic cancer using chimeric antigen receptor-engineered T-cells
2015
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
2001 Standout
CD95's deadly mission in the immune system
2000 Nature
mRNA Cancer Vaccines
2016
Chimeric antigen receptor T-cell therapies for lymphoma
2017
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
2020 Standout
Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for Glioma
2012
Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma
2012
Adoptive Immunotherapy for Cancer or Viruses
2014
Remote control of therapeutic T cells through a small molecule–gated chimeric receptor
2015 Science
Acute Myeloid Leukemia
2015 Standout
Current concepts in the diagnosis and management of cytokine release syndrome
2014 Standout
Adoptive cell transfer as personalized immunotherapy for human cancer
2015 StandoutScience
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
Integrated NY-ESO-1 antibody and CD8+T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
2011 StandoutNobel
Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection
2014
Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1
2011
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade
2018 Standout
Immune Tolerance After Delivery of Dying Cells to Dendritic Cells In Situ
2002 StandoutNobel
Cytokine Storm
2020 Standout
Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia
2018 Standout
Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis
2015
A Biogenesis Step Upstream of Microprocessor Controls miR-17∼92 Expression
2015
Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation
2015
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
Chimeric Antigen Receptor Therapy
2018 Standout
Worldwide emergence of resistance to antifungal drugs challenges human health and food security
2018 StandoutScience
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
Dendritic cell maturation by innate lymphocytes
2005 StandoutNobel
Toxicities of Immunotherapy for the Practitioner
2015
Surfing the p53 network
2000 StandoutNature
Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor–expressing T cells
2015
Going viral: chimeric antigen receptor T‐cell therapy for hematological malignancies
2014
T cells expressing an anti–B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma
2016
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.
1996
Neoantigens in cancer immunotherapy
2015 StandoutScience
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
Tolerogenic Dendritic Cells
2003 StandoutNobel
An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines
2002
CAR T cell immunotherapy for human cancer
2018 StandoutScience
Crbn I391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice
2018
Exploiting the curative potential of adoptive T‐cell therapy for cancer
2013
Immunotherapy of non-Hodgkin’s lymphoma with a defined ratio of CD8 + and CD4 + CD19-specific chimeric antigen receptor–modified T cells
2016
A Population of Murine γδ T Cells That Recognize an Inducible MHC Class Ib Molecule
2000 Science
De novo design of protein logic gates
2020 StandoutScienceNobel
N‐Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen‐Presenting Cells through Dectin‐1 and Dectin‐2
2018 StandoutNobel
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Works of David Spaner being referenced
Clinical Efficacy of Lenalidomide in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia: Results of a Phase II Study
2006
Phosphorylation of p53 protein in response to ionizing radiation occurs at multiple sites in both normal and DNA-PK deficient cells
1999
Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia
2006
Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia
2010
Cytotoxic T Lymphocyte Reactivity to gp100, MelanA/MART-1, and Tyrosinase, in HLA-A2-Positive Vitiligo Patients
2003
A central role for IL-2 in fate determination of mature T cells—I: role in determining the Th1/Th2 profile in primary T cell cultures
2001
Gamma delta T cells differentiate into a functional but nonproliferative state during a normal immune response.
1993 Nobel
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells
2011
Antigen-presenting cells for naive transgenic gamma delta T cells. Potent activation by activated alpha beta T cells.
1995
Comprehensive Lipidomics Analysis of Bioactive Lipids in Complex Regulatory Networks
2010
The miR-17-92 cluster expands multipotent hematopoietic progenitors whereas imbalanced expression of its individual oncogenic miRNAs promotes leukemia in mice
2012
Amplification of virus-induced antimelanoma T-cell reactivity by high-dose interferon-alpha2b: implications for cancer vaccines.
2003
A Role for Perforin in Activation-Induced T Cell Death In Vivo: Increased Expansion of Allogeneic Perforin-Deficient T Cells in SCID mice
1999
Enhanced viral and tumor immunity with intranodal injection of canary pox viruses expressing the melanoma antigen, gp100
2006
Epidermal growth factor induces cell cycle arrest and apoptosis of squamous carcinoma cells through reduction of cell adhesion
2000