Citation Impact
Citing Papers
Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells
2019 StandoutNobel
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The DNA-damage response in human biology and disease
2009 StandoutNature
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
2004
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Human cancers express mutator phenotypes: origin, consequences and targeting
2011
Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids
1999
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
2005 StandoutNature
Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors
1996
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
2020 Standout
[2] Fluorimetric assays of proteolytic enzymes
1995
The Cathepsin B Inhibitor z-FA.fmk Inhibits Cytokine Production in Macrophages Stimulated by Lipopolysaccharide
2001
Proteolytic Activity of Human Osteoclast Cathepsin K
1996
Peptidyl O-acyl hydroxamates: Potent new inactivators of cathepsin B
1988
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation
2007
Proteasome inhibitors: from research tools to drug candidates
2001
Enterococcus faecalis produces extracellular superoxide and hydrogen peroxide that damages colonic epithelial cell DNA
2002
Dipeptide vinyl sulfones suitable for intracellular inhibition of dipeptidyl peptidase I
2001
Synthetic Inhibitors of Elastase
1994
Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot–peptide conjugates
2006
Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: insights on safety, target validation, and mechanism of action
1999
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
1996 StandoutNature
Proteasome Inhibitors: Complex Tools for a Complex Enzyme
2002
Synthesis and activity of pyrrolidinyl- and thiazolidinyl-dipeptide derivatives as inhibitors of the Tc80 prolyl oligopeptidase from Trypanosoma cruzi
2000
Environmental and chemical carcinogenesis
2004
A Continuous Spectrophotometric Assay for P450 BM-3, a Fatty Acid Hydroxylating Enzyme, and Its Mutant F87A
1999
Lack of Proteasome Active Site Allostery as Revealed by Subunit-Specific Inhibitors
2001
Crystal Structure of HslUV Complexed with a Vinyl Sulfone Inhibitor: Corroboration of a Proposed Mechanism of Allosteric Activation of HslV by HslU
2002
Human Cathepsin F
1998
Active Site-directed Inhibitors of Rhodococcus 20 S Proteasome
1997
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
Peptidyl fluoromethyl ketones as inhibitors of cathepsin B
1992
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. Part 7: Structure–Activity Studies of Bicyclic 2-Pyridone-Containing Peptidomimetics
2002
Cysteine proteases of parasitic organisms
2002
Probing Structural Determinants Distal to the Site of Hydrolysis that Control Substrate Specificity of the 20S Proteasome
2002 Nobel
Peptidyl (acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases
1991
Localization of Rat Cathepsin K in Osteoclasts and Resorption Pits: Inhibition of Bone Resorption and Cathepsin K-Activity by Peptidyl Vinyl Sulfones
1999
[48] N,O-Diacyl hydroxamates as selective and irreversible inhibitors of cysteine proteinases
1994
The Crystal Structure of Human Cathepsin F and Its Implications for the Development of Novel Immunomodulators
2002
Protein degradation and protection against misfolded or damaged proteins
2003 StandoutNature
Computational Design of an Unnatural Amino Acid Dependent Metalloprotein with Atomic Level Accuracy
2013 StandoutNobel
Recent Developments in Inhibiting Cysteine and Serine Proteases
1990
Isolation and quantification of fluoroacetate in rat tissues, following dosing of Z-Phe-Ala-CH2-F, a peptidyl fluoromethyl ketone protease inhibitor
1997
Cysteinyl Proteinases and Their Selective Inactivation
1990
Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
2000
Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes
2007
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation
2000
Causes and consequences of aneuploidy in cancer
2012
Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex
1997
Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes
1998
Homology Modeling of Falcipain-2: Validation,De NovoLigand Design and Synthesis of Novel Inhibitors
2002
Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools
2000
Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor
2006
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14
2001
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1998 StandoutNature
The role of senescent cells in ageing
2014 StandoutNature
Clonal evolution in cancer
2012 StandoutNature
[47] Peptidyl (Acyloxy)methanes as quiescent affinity labels for cysteine proteinases
1994
Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain
2001
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
Microbial P450 enzymes in biotechnology
2004
Calpain inhibitors based on the quiescent affinity label concept: high rates of calpain inactivation with leaving groups derived from N-hydroxy peptide coupling reagents
2000
Genetics and biology of pancreatic ductal adenocarcinoma
2006
Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitors
1999
Tumorigenesis and the angiogenic switch
2003 Standout
The cancer genome
2009 StandoutNature
A target within the target: probing cruzain’s P1′ site to define structural determinants for the Chagas’ disease protease
2000
Towards subunit-specific proteasome inhibitors: synthesis and evaluation of peptide α', β'-epoxyketones
1999
Protease inhibitors targeting coronavirus and filovirus entry
2015
Bimodal Inhibition of Caspase-1 by Aryloxymethyl and Acyloxymethyl Ketones
1998
Mechanism-Based Profiling of Enzyme Families
2006
Relative Rates of Michael Reactions of 2‘-(Phenethyl)thiol with Vinyl Sulfones, Vinyl Sulfonate Esters, and Vinyl Sulfonamides Relevant to Vinyl Sulfonyl Cysteine Protease Inhibitors
2003
Proliferation of aneuploid human cells is limited by a p53-dependent mechanism
2010
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Inhibition of serine proteases by peptidyl fluoromethyl ketones
1986
Specific and efficient peptide substrates for assaying the proteolytic activity of prostate-specific antigen.
1997
Genetic instability and darwinian selection in tumours
1999
De Novo-Designed Enzymes as Small-Molecule-Regulated Fluorescence Imaging Tags and Fluorescent Reporters
2014 StandoutNobel
γ‐Synuclein and the progression of cancer
2007
Enantioselective α-Hydroxylation of 2-Arylacetic Acid Derivatives and Buspirone Catalyzed by Engineered Cytochrome P450 BM-3
2006 StandoutNobel
Comparison of Efficacies of Cysteine Protease Inhibitors against Five Strains of Plasmodium falciparum
2001
Vinyl Sulfonate Esters and Vinyl Sulfonamides: Potent, Irreversible Inhibitors of Cysteine Proteases
1998
THE GREEN FLUORESCENT PROTEIN
1998 StandoutNobel
Visible Light‐Mediated Metal‐Free Synthesis of Vinyl Sulfones from Aryl Sulfinates
2015
Cysteine Proteases and Their Inhibitors
1997
Genetic instability and darwinian selection in tumours
1999
Aryl Vinyl Sulfonates and Sulfones as Active Site-Directed and Mechanism-Based Probes for Protein Tyrosine Phosphatases
2008
Structural basis of the action of thermolysin and related zinc peptidases
1988
Carbon-13 NMR characterization of the papain adduct formed by peptidyl acyloxy-, aryloxy-, and chloromethyl ketone irreversible inhibitors
1992
A Strategy for the Selective Imaging of Glycans Using Caged Metabolic Precursors
2010 StandoutNobel
Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target
1999
Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases
1992
Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.
1987 StandoutNobel
Crystal structure of human cathepsin S
1998
Whole chromosome loss is promoted by telomere dysfunction in primary cells
2010
Mass spectrometry-based proteomics
2003 StandoutNature
Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis.
2001
Covalent modification of the active site threonine of proteasomal β subunits and theEscherichia colihomolog HslV by a new class of inhibitors
1997
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
Design, Synthesis and Evaluation of d-Homophenylalanyl Epoxysuccinate Inhibitors of the Trypanosomal Cysteine Protease Cruzain
2000
The synthesis of lysylfluoromethanes and their properties as inhibitors of trypsin, plasmin and cathepsin B
1987
Identification of Selective, Nonpeptidic Nitrile Inhibitors of Cathepsin S Using the Substrate Activity Screening Method
2006
THE LYSOSOMAL CYSTEINE PROTEASES
1999
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Protease Inhibitors: Current Status and Future Prospects
2000
The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B
1989
Synthesis and properties of peptidyl derivatives of arginylfluoromethanes
1988
Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin.
1986
Epoxomicin, a potent and selective proteasome inhibitor, exhibitsin vivoantiinflammatory activity
1999
A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides
2004
Two-Photon Absorbing Nanocrystal Sensors for Ratiometric Detection of Oxygen
2009 StandoutNobel
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans
2013 StandoutNobel
The synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteinases and cysteine proteinases
1986
Carcinogen-specific induction of genetic instability
2001
Development of Peptidomimetics with a Vinyl Sulfone Warhead as Irreversible Falcipain-2 Inhibitors
2008
Visible‐Light Photocatalysis: Does It Make a Difference in Organic Synthesis?
2018 Standout
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Mechanisms underlying losses of heterozygosity in human colorectal cancers
2001
Compact Biocompatible Quantum Dots Functionalized for Cellular Imaging
2008 StandoutNobel
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Synthesis and In Vitro Studies of Novel Pyrimidinyl Peptidomimetics as Potential Antimalarial Therapeutic Agents
2002
Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors
1998
Cancers Exhibit a Mutator Phenotype: Clinical Implications
2008
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Vinyl Sulfones: Inhibitors of SrtA, a Transpeptidase Required for Cell Wall Protein Anchoring and Virulence in Staphylococcus aureus
2004
Recent advances in the development of human rhinovirus 3C protease inhibitors
2001
Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues
2011 StandoutNobel
Works of David Rasnick being referenced
Cysteine protease activity is up-regulated in inflamed ankle joints of rats with adjuvant-induced arthritis and decreases with in vivo administration of a vinyl sulfone cysteine protease inhibitor
2001
Aneuploidy Precedes and Segregates with Chemical Carcinogenesis
2000
Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors
1995
Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase.
1991
A direct, highly sensitive assay for cytochrome P-450 catalyzed O-deethylation using a novel coumarin analog
1988
Aneuploidy theory explains tumor formation, the absence of immune surveillance, and the failure of chemotherapy
2002
Aneuploidy, the somatic mutation that makes cancer a species of its own
2000
Genetic instability of cancer cells is proportional to their degree of aneuploidy
1998
Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors
1996
How aneuploidy may cause cancer and genetic instability.
2000
Aneuploidy vs. gene mutation hypothesis of cancer: Recent study claims mutation but is found to support aneuploidy
2000
How aneuploidy affects metabolic control and causes cancer
1999
Small synthetic inhibitors of cysteine proteases
1996
Cysteine proteinase activity in arthritic rat knee joints and the effects of a selective systemic inhibitor, Z-Phe-AlaCH2F.
1988
Active site directed irreversible inhibition of thermolysin
1978
Cytochemical and biochemical evidence of cathepsin B in malignant, transformed and normal breast epithelial cells
1987
Clostridium histolyticum collagenase: development of new thio ester, fluorogenic, and depsipeptide substrates and new inhibitors
1985
Visualization of time-dependent inactivation of human tumor cathepsin B isozymes by a peptidyl fluoromethyl ketone using a fluorescent print technique.
1988
Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L
1996
Synthesis of peptide fluoromethyl ketones and the inhibition of human cathepsin B
1985