Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling
2009
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
2013
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome
2011
Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate
2015
Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia
2014
Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation
2010
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1
2010
Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer
2014
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
Mutation Analysis of Isocitrate Dehydrogenase in Acute Lymphoblastic Leukemia
2012
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
2010
Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
2013
Cancer-associated Isocitrate Dehydrogenase Mutations Inactivate NADPH-dependent Reductive Carboxylation
2012
Aspartate Rescues S-phase Arrest Caused by Suppression of Glutamine Utilization in KRas-driven Cancer Cells
2016
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
2011 Nature
Fatty Acid Labeling from Glutamine in Hypoxia Can Be Explained by Isotope Exchange without Net Reductive Isocitrate Dehydrogenase (IDH) Flux
2013
In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation
2013
Hallmarks of Cancer: The Next Generation
2011 Standout
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer
2014 Nobel
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: clinical evidence for leukemogenic collaboration with JAK2V617F
2011
Lactate promotes glutamine uptake and metabolism in oxidative cancer cells
2015
Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects
2014
Oncogenic K‐Ras decouples glucose and glutamine metabolism to support cancer cell growth
2011
ErbB2 Activation Upregulates Glutaminase 1 Expression Which Promotes Breast Cancer Cell Proliferation
2013
Cancer Cell Metabolism
2011
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
2010
MYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent Mechanisms
2010
Alterations of metabolic genes and metabolites in cancer
2012
Cross-talk between ER and HER2 regulates c-MYC-mediated glutamine metabolism in aromatase inhibitor resistant breast cancer cells
2015
Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
2012
Reductive carboxylation supports growth in tumour cells with defective mitochondria
2011 Nature
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
2011 Standout
MYC on the Path to Cancer
2012 Standout
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
2012
IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms
2010
Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling
2014
IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo
2011
A lymphoblast model for IDH2 gain-of-function activity in d-2-hydroxyglutaric aciduria type II: Novel avenues for biochemical and therapeutic studies
2011
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
2012 Standout
Glutaminase activity determines cytotoxicity of l-asparaginases on most leukemia cell lines
2015
p53 and metabolism
2009
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Cancer-associated IDH mutations: biomarker and therapeutic opportunities
2010
The Potential for Isocitrate Dehydrogenase Mutations to Produce 2-Hydroxyglutarate Depends on Allele Specificity and Subcellular Compartmentalization
2012
Autophagy and the Integrated Stress Response
2010 Standout
Metabolic Regulation of Epigenetics
2012
Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic Study of 277 patients
2011
Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress
2015
Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells
2016
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
2016 Nature
Revisiting the TCA cycle: signaling to tumor formation
2011
Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
2013
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress
2013
IDH mutations in glioma and acute myeloid leukemia
2010
IDH mutation status impact on in vivo hypoxia biomarkers expression: new insights from a clinical, nuclear imaging and immunohistochemical study in 33 glioma patients
2011
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
Glutaminolysis Activates Rag-mTORC1 Signaling
2012
Glutamine and cancer: cell biology, physiology, and clinical opportunities
2013
Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State
2012
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer
2014
Acetate Dependence of Tumors
2014
Targeting glutamine metabolism in myeloproliferative neoplasms
2015
Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation
2015
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases
2018
Otto Warburg's contributions to current concepts of cancer metabolism
2011 Standout
The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4
2013
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
2013 Nature
The multifaceted roles of fatty acid synthesis in cancer
2016
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
2011
Hypoxia-Inducible Factors: Master Regulators of Cancer Progression
2016 StandoutNobel
SIRT5 regulation of ammonia-induced autophagy and mitophagy
2015
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
2009
Links between metabolism and cancer
2012
Comparative Evaluation of 18F-Labeled Glutamic Acid and Glutamine as Tumor Metabolic Imaging Agents
2012
Quiescent Fibroblasts Exhibit High Metabolic Activity
2010
Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation
2012
Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport
2014
IDH mutations in acute myeloid leukemia
2012
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia
2015
Clinical Implications of Novel Mutations in Epigenetic Modifiers in AML
2011
IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis
2010
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Impact of MYC in regulation of tumor cell metabolism
2014
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
Control of glutamine metabolism by the tumor suppressor Rb
2013
Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling
2016
The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type
2012 Nobel
Famine versus feast: understanding the metabolism of tumors in vivo
2015
Rethinking the Regulation of Cellular Metabolism
2011
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Regulation of cancer cell metabolism
2011 Standout
Glutaminolysis and Transferrin Regulate Ferroptosis
2015 Standout
Tumor suppressors and cell metabolism: a recipe for cancer growth
2009
L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
2017
Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress
2015
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Analysis of glutamine dependency in non-small cell lung cancer
2012
IDH mutation impairs histone demethylation and results in a block to cell differentiation
2012 Nature
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Glutamine Synthetase Is a Genetic Determinant of Cell Type–Specific Glutamine Independence in Breast Epithelia
2011
Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells
2009
ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy
2010
Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism
2017 Nature
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
2010
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex
2012
Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆
2009
Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation
2017
Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion
2014
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
2015
5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy
2015
New cancer targets emerging from studies of the Von Hippel‐Lindau tumor suppressor protein
2010 StandoutNobel
Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis
2009
Akt and c-Myc Differentially Activate Cellular Metabolic Programs and Prime Cells to Bioenergetic Inhibition
2009
Mitochondrial TCA cycle metabolites control physiology and disease
2020 Standout
The Hallmarks of Aging
2013 Standout
Induction of sarcomas by mutant IDH2
2013
Histone 3 Lysine 9 Trimethylation Is Differentially Associated With Isocitrate Dehydrogenase Mutations in Oligodendrogliomas and High-Grade Astrocytomas
2013
MYC-induced reprogramming of glutamine catabolism supports optimal virus replication
2015
DNA Methylation, Isocitrate Dehydrogenase Mutation, and Survival in Glioma
2010
Identification of additional IDH mutations associated with oncometabolite R(−)-2-hydroxyglutarate production
2011
Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target
2013
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
2012 Nature
Vemurafenib resistance reprograms melanoma cells towards glutamine dependence
2015
Hypoxia Induces Production of L-2-Hydroxyglutarate
2015
Autophagy
2012
Mitochondria and cancer
2012 Standout
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Latent KSHV Infected Endothelial Cells Are Glutamine Addicted and Require Glutaminolysis for Survival
2015
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
2017
Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
2013
Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth
2014
Redox control of glutamine utilization in cancer
2014
Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer
2016
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
2013 Nature
IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma
2011
Effects of hypoxia and HIFs on cancer metabolism
2012
2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP+-Dependent Isocitrate Dehydrogenase Mutations
2011
Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
2012
The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases
2011 StandoutNobel
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
2014
Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC
2012
Clues from cell metabolism
2010 StandoutNatureNobel
Coactivator SRC-2–dependent metabolic reprogramming mediates prostate cancer survival and metastasis
2015
Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism
2010
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
2011 Standout
Hominoid-specific enzyme GLUD2 promotes growth of IDH1 R132H glioma
2014
Targeting glutamine transport to suppress melanoma cell growth
2014
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
2015
Regulation of mammalian nucleotide metabolism and biosynthesis
2015
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
Fundamentals of cancer metabolism
2016 Standout
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
2011
Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d -2-Hydroxyglutarate
2014
Determination of Glutamate Dehydrogenase Activity and Its Kinetics in Mouse Tissues using Metabolic Mapping (Quantitative Enzyme Histochemistry)
2014
Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development
2016 StandoutNobel
Ammonia-induced autophagy is independent of ULK1/ULK2 kinases
2011
Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation
2015
Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
2016
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value
2010
PKM2 Tyrosine Phosphorylation and Glutamine Metabolism Signal a Different View of the Warburg Effect
2009
Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells
2014
Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy
2010
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
RUNX1Mutations in Acute Myeloid Leukemia: Results From a Comprehensive Genetic and Clinical Analysis From the AML Study Group
2011
Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch
2016
A comparative study of short‐ and long‐TE 1H MRS at 3 T for in vivo detection of 2‐hydroxyglutarate in brain tumors
2013
MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism
2015
Cancer Genome Landscapes
2013 StandoutScience
Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2
2015
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach
2015
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells
2011
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Hypoxia. 2. Hypoxia regulates cellular metabolism
2010
Progress in understanding 2‐hydroxyglutaric acidurias
2012
Amino Acid Transporters in Cancer and Their Relevance to “Glutamine Addiction”: Novel Targets for the Design of a New Class of Anticancer Drugs
2015
MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
2009
TET2 Mutations in Acute Myeloid Leukemia (AML): Results From a Comprehensive Genetic and Clinical Analysis of the AML Study Group
2012
Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism
2012
IDH mutations in Primary Myelofibrosis Predict Leukemic Transformation and Shortened Survival: Clinical Evidence for Leukemogenic Collaboration with JAK2V617F
2011
Glutamine Metabolism Is Essential for Human Cytomegalovirus Infection
2009
p63 regulates glutaminase 2 expression
2013
Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
2015
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Frequent Mutation of Isocitrate Dehydrogenase(IDH)1andIDH2in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping
2011
Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism
2010
Mitochondrial Energetics and Therapeutics
2010
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo
2015
The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes
2010 Science
Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells
2014
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
2010
Works of David R. Wise being referenced
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
2008 Standout
Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival
2008
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
2010 Standout
PET Imaging of Glutaminolysis in Tumors by 18F-(2S,4R)4-Fluoroglutamine
2011
ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation
2012
Glutamine addiction: a new therapeutic target in cancer
2010
Synthesis of Optically Pure 4-Fluoro-Glutamines as Potential Metabolic Imaging Agents for Tumors
2010
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
2011