Citation Impact
Citing Papers
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
2005 StandoutNobel
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate
1997 Standout
Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast
1995 StandoutNobel
Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin
1993 StandoutNatureNobel
Peroxovanadium compounds: Biolgoical actions and mechanism of insulin-mimesis
1995
Involvement of the Pleckstrin Homology Domain in the Insulin-stimulated Activation of Protein Kinase B
1998
Identification of a signal for rapid export of proteins from the nucleus
1995 StandoutNobel
Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase
1991 Standout
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
1997 StandoutNatureNobel
Signalling through the lipid products of phosphoinositide-3-OH kinase
1997 Nature
CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development
1994
A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains
1997
The Src Homology 2 (SH2) Domain of SH2-containing Inositol Phosphatase (SHIP) Is Essential for Tyrosine Phosphorylation of SHIP, Its Association with Shc, and Its Induction of Apoptosis
1997
The Inositol Phosphatase SHIP Inhibits Akt/PKB Activation in B Cells
1998
SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk
1998
The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function
1999
Regulation of Phosphatidylinositol 3,4,5-Trisphosphate 5′-Phosphatase Activity by Insulin
1996
Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor
1998
Primary Structure, Tissue Distribution, and Expression of Mouse Phosphoinositide-dependent Protein Kinase-1, a Protein Kinase That Phosphorylates and Activates Protein Kinase Cζ
1999
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
2006 StandoutNatureNobel
Oncoprotein Networks
1997
Inhibitory Pathways Triggered by ITIM-Containing Receptors
1999
Cellular survival: a play in three Akts
1999 Standout
Targeted disruption ofSHIPleads to hemopoietic perturbations, lung pathology, and a shortened life span
1998
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans
1999 StandoutNobel
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
1997 Standout
The Hallmarks of Cancer
2000 Standout
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
1998 StandoutNobel
PI3K: Downstream AKTion Blocks Apoptosis
1997 Standout
Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling
2009
Activation of phospholipase Cgamma by PI 3-kinase-induced PH domain-mediated membrane targeting
1998
Enhancement of Memory-Related Long-Term Facilitation by ApAF, a Novel Transcription Factor that Acts Downstream from Both CREB1 and CREB2
2000 StandoutNobel
SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival
1999
Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change
1995 StandoutNobel
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
1999
Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane
2001
High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity
1997
Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins
1995 StandoutNatureNobel
Role of Translocation in the Activation and Function of Protein Kinase B
1997
cAMP stimulates protein kinase B in a Wortmannin‐insensitive manner
1997
Protein phosphatases
1995
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase
1994 StandoutNobel
cAMP-Dependent Regulation of Gene Transcription by cAMP Response Element-Binding Protein and cAMP Response Element Modulator
1995
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold
1995 StandoutNobel
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Mechanism of activation and function of protein kinase B
1998
Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells
2001 StandoutNobel
AKT/PKB Signaling: Navigating the Network
2017 Standout
CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation
1998 StandoutNobel
Deletion of SHIP or SHP-1 Reveals Two Distinct Pathways for Inhibitory Signaling
1997
A Tripartite Protein Complex with the Potential to Couple Synaptic Vesicle Exocytosis to Cell Adhesion in Brain
1998 StandoutNobel
Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ
1997
Mechanisms and consequences of activation of protein kinase B/Akt
1998
Protein tyrosine phosphatases take off
1995
The RasGAP-Binding Protein p62dok Is a Mediator of Inhibitory FcγRIIB Signals in B Cells
2000
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
1993
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
Reactive oxygen species mediate phorbol ester-regulated tyrosine phosphorylation and phospholipase A2 activation: potentiation by vanadate
1993
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
1999 Standout
The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.
1995 StandoutNobel
Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt
1997
clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans
1998 StandoutNobel
Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons
1998
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
1997
Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B
1997 Science
PER Protein Interactions and Temperature Compensation of a Circadian Clock in Drosophila
1995 StandoutScienceNobel
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
1999
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
2000 StandoutScienceNobel
cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase.
1991 StandoutNobel
The cellular transcription factor CREB corresponds to activating transcription factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43.
1990
Activated Phosphatidylinositol 3-Kinase and Akt Kinase Promote Survival of Superior Cervical Neurons
1997
Transformation of Chicken Cells by the Gene Encoding the Catalytic Subunit of PI 3-Kinase
1997 Science
Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain.
1994
Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice.
1991 StandoutNobel
CREB: a Ca 2+ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases
1991 Science
The T-Cell Receptor Regulates Akt (Protein Kinase B) via a Pathway Involving Rac1 and Phosphatidylinositide 3-Kinase
2000
Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B α
1998
Walden-Inversion-Enforced Transition-State Stabilization in a Protein Tyrosine Phosphatase
1998
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
1997 Standout
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice
2002 StandoutNobel
The Solution Structure and Dynamics of the Pleckstrin Homology Domain of G Protein-coupled Receptor Kinase 2 (β-Adrenergic Receptor Kinase 1)
1998
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
2001 StandoutNobel
Purification and characterization of a protein tyrosine phosphatase containing SH2 domains.
1993 Nobel
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation
1997
Interleukin 3-dependent survival by the Akt protein kinase
1997 Nobel
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Insulin signal transduction through protein kinase cascades
1998
Akt Signaling--Linking Membrane Events to Life and Death Decisions
1997 Science
The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation.
1994
A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression.
1994
A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication.
1996 StandoutNobel
Enhancement by hypoxia of human erythropoietin gene transcription in vitro.
1990
Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis
2000 Science
Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.
1991 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Seeing the Machinery of Live Cells
1998 StandoutScienceNobel
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
1994 StandoutNatureNobel
Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element
1997
Protein-tyrosine phosphatases.
1994
Works of David Pot being referenced
Sequential dephosphorylation of a multiply phosphorylated insulin receptor peptide by protein tyrosine phosphatases
1992
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
1996
A thousand and two protein tyrosine phosphatases
1992
Active site labeling of a receptor-like protein tyrosine phosphatase.
1992
In vitro transcription directed from the somatostatin promoter is dependent upon a purified 43-kDa DNA-binding protein.
1989
Purification and Characterization of a 43-kDa Transcription Factor Required for Rat Somatostatin Gene Expression
1989
Three sequence-specific DNA-protein complexes are formed with the same promoter element essential for expression of the rat somatostatin gene.
1988
Cloning, bacterial expression, purification, and characterization of the cytoplasmic domain of rat LAR, a receptor-like protein tyrosine phosphatase.
1991
A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain
1997