Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Transforming Growth Factor-β Signaling–Deficient Fibroblasts Enhance Hepatocyte Growth Factor Signaling in Mammary Carcinoma Cells to Promote Scattering and Invasion
2008
Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver
2010
Combined Total Genome Loss of Heterozygosity Scan of Breast Cancer Stroma and Epithelium Reveals Multiplicity of Stromal Targets
2004
Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
2011
Fate-determining mechanisms in epithelial–myofibroblast transition: major inhibitory role for Smad3
2010
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis
2009
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Cell Contact–dependent Regulation of Epithelial–Myofibroblast Transition via the Rho-Rho Kinase-Phospho-Myosin Pathway
2007
Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer
2008
TGF-β Signaling in Myeloid Cells Is Required for Tumor Metastasis
2013
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney
2006
Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts
2012
Sorafenib ameliorates bleomycin-induced pulmonary fibrosis: potential roles in the inhibition of epithelial–mesenchymal transition and fibroblast activation
2013
Hallmarks of Cancer: The Next Generation
2011 Standout
Inflammation and EMT: an alliance towards organ fibrosis and cancer progression
2009
Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease
2015
Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression
2010
SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion
2007
Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy
2002
Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection
2008
Bone Marrow–Derived Cells Do Not Contribute Significantly to Collagen I Synthesis in a Murine Model of Renal Fibrosis
2006 StandoutNobel
Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
2003
Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN
2005
Resident vascular progenitor cells: An emerging role for non-terminally differentiated vessel-resident cells in vascular biology
2008
Epithelial-mesenchymal transition and its implications for fibrosis
2003 Standout
Stromal fibroblasts in cancer initiation and progression
2004 StandoutNature
A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth
2009
Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition
2008
Epithelial-to-mesenchymal transition confers resistance to apoptosis in three murine mammary epithelial cell lines
2006
Oncogenic roles of EMT-inducing transcription factors
2014
Amelioration of Radiation-induced Fibrosis
2004
Cellular and molecular mechanisms of fibrosis
2007 Standout
Friends or foes — bipolar effects of the tumour stroma in cancer
2004
Development of TGF-β signalling inhibitors for cancer therapy
2004
Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis
2003
Bone marrow–derived progenitor cells in pulmonary fibrosis
2004
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Autophagy Is a Component of Epithelial Cell Fate in Obstructive Uropathy
2010
Molecular mechanisms of epithelial–mesenchymal transition
2014 Standout
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
2005 Standout
The tumor microenvironment is a dominant force in multidrug resistance
2012
Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways
2008
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
2006 Nature
Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer
2005
Transforming Growth Factor-β Signaling in Immunity and Cancer
2019 Standout
Wound repair and regeneration
2008 StandoutNature
Cancer Metastasis: Building a Framework
2006 Standout
TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment
2017
Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model
2010
Hepatocytes Do Not Undergo Epithelial-Mesenchymal Transition in Liver Fibrosis in Mice
2009
Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
2006
Cellular pathophysiology of ischemic acute kidney injury
2011 Standout
Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment
2014
Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis
2012
Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP- and HGF-mediated signaling networks
2005
Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis
2008
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state
2014
The biology and function of fibroblasts in cancer
2016 Standout
The evolution of the cancer niche during multistage carcinogenesis
2013
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes
2012 Nature
Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs?
2008
Modelling glandular epithelial cancers in three-dimensional cultures
2005
TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease
2007 Standout
Aberrant Wnt/β-Catenin Pathway Activation in Idiopathic Pulmonary Fibrosis
2003
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
2014 StandoutNature
The Role of Tubular Epithelial-Mesenchymal Transition in Progressive Kidney Disease
2007
Complex networks orchestrate epithelial–mesenchymal transitions
2006 Standout
BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury
2003
Intrinsic Epithelial Cells Repair the Kidney after Injury
2008
TGFβ: the molecular Jekyll and Hyde of cancer
2006
Twist: A Regulator of Epithelial-Mesenchymal Transition in Lung Fibrosis
2009
Cancer-associated fibroblasts and tumor growth – bystanders turning into key players
2009
Isolation of rare circulating tumour cells in cancer patients by microchip technology
2007 StandoutNature
The Role of Stromal Myofibroblast and Extracellular Matrix in Tumor Angiogenesis
2011
TGF-β and epithelial-to-mesenchymal transitions
2005
Cellular and molecular mechanisms of renal fibrosis
2011 Standout
The impact of tumor stroma on drug response in breast cancer
2014
Hallmarks of cancer: Interactions with the tumor stroma
2010
The role of EMT in renal fibrosis
2011
Intrarenal cells, not bone marrow–derived cells, are the major source for regeneration in postischemic kidney
2005
Fibroblast-mediated drug resistance in cancer
2013
TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression
2010
Early Epithelial Phenotypic Changes Predict Graft Fibrosis
2008
Differentiation plasticity regulated by TGF-β family proteins in development and disease
2007
Loss of TGFβ Signaling Destabilizes Homeostasis and Promotes Squamous Cell Carcinomas in Stratified Epithelia
2007
Emergence of the Phosphoinositide 3-Kinase-Akt- Mammalian Target of Rapamycin Axis in Transforming Growth Factor-β-Induced Epithelial-Mesenchymal Transition
2010
Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology
2006 Standout
PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment
2009
Genetic Labeling Does Not Detect Epithelial-to-Mesenchymal Transition of Cholangiocytes in Liver Fibrosis in Mice
2010
Essential role for Smad3 in angiotensin II‐induced tubular epithelial–mesenchymal transition
2010
Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis
2009
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Localisation and phenotypical characterisation of collagen-producing cells in TGF-β1-induced renal interstitial fibrosis
2003
Normal and Pathologic Soft Tissue Remodeling: Role of the Myofibroblast, with Special Emphasis on Liver and Kidney Fibrosis
2003
Bone Morphogenic Protein-7 Induces Mesenchymal to Epithelial Transition in Adult Renal Fibroblasts and Facilitates Regeneration of Injured Kidney
2005
The Role of the Microenvironment in Mammary Gland Development and Cancer
2010
TGF-β1 Signaling and Tissue Fibrosis
2017
New Insights into the Regulation of Epithelial–Mesenchymal Transition and Tissue Fibrosis
2012
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
2011
Angiogenesis in life, disease and medicine
2005 StandoutNature
Cancer as an overhealing wound: an old hypothesis revisited
2008 Standout
Low-Dose Paclitaxel Ameliorates Pulmonary Fibrosis by Suppressing TGF-β1/Smad3 Pathway via miR-140 Upregulation
2013
Immunity, Inflammation, and Cancer
2010 Standout
The role of CXC chemokines in pulmonary fibrosis
2007
Epithelial to Mesenchymal Transition in Renal Fibrogenesis
2004
Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction
2003
Regenerative activity of the lung after epithelial injury
2012
Induction of Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells by Transforming Growth Factor-β1
2005
Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV‐Cripto‐1 transgenic mice
2004
Migrating cancer stem cells — an integrated concept of malignant tumour progression
2005
Involvement of matrix metalloproteinase-2 in the development of renal interstitial fibrosis in mouse obstructive nephropathy
2012
Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation
2015
Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury
2014
Gr‐1+CD11b+ cells are responsible for tumor promoting effect of TGF‐β in breast cancer progression
2012
Fibroblasts as architects of cancer pathogenesis
2012
EMT: 2016
2016 Standout
Heart repair by reprogramming non-myocytes with cardiac transcription factors
2012 Nature
A stromal address code defined by fibroblasts
2004
LKB1; linking cell structure and tumor suppression
2008
TGFβ in Cancer
2008 Standout
Epithelial-to-mesenchymal transition of peritoneal mesothelial cells is regulated by an ERK/NF-κB/Snail1 pathway
2008
Fibroblasts Derive from Hepatocytes in Liver Fibrosis via Epithelial to Mesenchymal Transition
2007
Integrity of Cell-Cell Contacts Is a Critical Regulator of TGF-β1-Induced Epithelial-to-Myofibroblast Transition
2004
Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting
2008
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
2007 StandoutNatureNobel
Smad3 is key to TGF-β-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis
2005
Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
2011
Alport's Syndrome, Goodpasture's Syndrome, and Type IV Collagen
2003
Transient Overexpression of TGF-β1 Induces Epithelial Mesenchymal Transition in the Rodent Peritoneum
2004
Transforming Growth Factor-β1 Induces an Epithelial-to-Mesenchymal Transition State in Mouse Hepatocytes in Vitro
2007
Inflammation and Cancer: Is the Link as Simple as We Think?
2005
Modulated expression of WFDC1 during carcinogenesis and cellular senescence
2008
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
2015 Nature
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
2015 StandoutNature
Potential approaches to reverse or repair renal fibrosis
2014
Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment
2015
Sheep, wolf, or werewolf: Cancer stem cells and the epithelial-to-mesenchymal transition
2013
Scar wars: mapping the fate of epithelial–mesenchymal–myofibroblast transition
2011
Origin and function of myofibroblasts in kidney fibrosis
2013
New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis
2009
Biomarkers for epithelial-mesenchymal transitions
2009 Standout
Inflammation-Mediated Genetic and Epigenetic Alterations Drive Cancer Development in the Neighboring Epithelium upon Stromal Abrogation of TGF-β Signaling
2013
Idiopathic pulmonary fibrosis
2011 Standout
Fibroblasts in cancer
2006 Standout
LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer
2014
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
2007
Plasticity, Nuclear Diapause, and a Requiem for the Terminal Differentiation of Epithelia
2007
Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys
2005
Cancer-related inflammation
2008 StandoutNature
Cancer as an evolutionary and ecological process
2006 Standout
Co-evolution of tumor cells and their microenvironment
2008
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
TGF-β-induced epithelial to mesenchymal transition
2009 Standout
Mechanisms of Disease: fibroblasts—a new look at an old problem
2006
Microenvironmental Regulators of Tissue Structure and Function Also Regulate Tumor Induction and Progression: The Role of Extracellular Matrix and Its Degrading Enzymes
2005
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
2007 StandoutNature
Epithelial–mesenchymal transitions in development and pathologies
2003
Tumors as Organs: Complex Tissues that Interface with the Entire Organism
2010
Angiogenesis as a therapeutic target
2005 StandoutNature
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
2011 StandoutNature
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
2007 Standout
miR-200b Precursor Can Ameliorate Renal Tubulointerstitial Fibrosis
2010
The cancer genome
2009 StandoutNature
Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
2012
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
Molecular characterization of the tumor microenvironment in breast cancer
2004
Targeted cancer therapy
2004 Nature
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
2009
VEGF-A and Tenascin-C produced by S100A4 + stromal cells are important for metastatic colonization
2011
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner
2010
Twist Relates to Tubular Epithelial-Mesenchymal Transition and Interstitial Fibrogenesis in the Obstructed Kidney
2007
Epithelial-mesenchymal transition
2005
Mechanisms of Pulmonary Fibrosis
2004
The Fallacy of Epithelial Mesenchymal Transition in Neoplasia
2005
Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL −/− clear cell renal carcinoma
2017 StandoutNobel
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity
2009 StandoutNobel
Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
2015 StandoutNobel
A Perspective on Cancer Cell Metastasis
2011 StandoutScience
Tumor–Stroma Interaction: Revealing Fibroblast-Secreted Exosomes as Potent Regulators of Wnt-Planar Cell Polarity Signaling in Cancer Metastasis
2013
Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
2003
STAT‐3 contributes to pulmonary fibrosis through epithelial injury and fibroblast‐myofibroblast differentiation
2015
Transforming Growth Factor β Receptor Type II Inactivation Induces the Malignant Transformation of Intestinal Neoplasms Initiated by Apc Mutation
2006
Suppression of Tumor Development and Metastasis Formation in Mice Lacking the S100A4(mts1) Gene
2005
Cellular Mechanisms of Tissue Fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis
2012
Pathological Ventricular Remodeling
2013
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
The Versatile Role of microRNA-30a in Human Cancer
2017 Standout
Fibrosis — A Common Pathway to Organ Injury and Failure
2015 Standout
Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis
2016 StandoutNobel
Fibroblast differentiation of bone marrow‐derived cells during wound repair
2005
Fibroblast heterogeneity in the cancer wound
2014
Obstructive nephropathy and renal fibrosis
2002
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling
2012
Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis
2011
LIV-1 enhances the aggressive phenotype through the induction of epithelial to mesenchymal transition in human pancreatic carcinoma cells
2009
Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis
2003
Epithelial-mesenchymal transition and its implications for fibrosis
2003 Standout
Resolved
2010
The role of epithelial-to-mesenchymal transition in renal fibrosis
2004
Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models
2003
TGF-β and cancer
2005
Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis
2011
Central role for Rho in TGF-β1-induced α-smooth muscle actin expression during epithelial-mesenchymal transition
2003
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
2006
Of Extracellular Matrix, Scaffolds, and Signaling: Tissue Architecture Regulates Development, Homeostasis, and Cancer
2006
Activation of fibroblasts in cancer stroma
2010
Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy
2002
The epithelial–mesenchymal transition: new insights in signaling, development, and disease
2006 Standout
Works of David Plieth being referenced
TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
2004 Science
Evidence that fibroblasts derive from epithelium during tissue fibrosis
2002 Standout
Antibodies against macrophages that overlap in specificity with fibroblasts
2005
Contribution of Epithelial-derived Fibroblasts to Bleomycin-induced Lung Fibrosis
2009
Conditional Abatement of Tissue Fibrosis Using Nucleoside Analogs to Selectively Corrupt DNA Replication in Transgenic Fibroblasts
2001
EGFR Signaling Promotes TGFβ-Dependent Renal Fibrosis
2011
A proximal activator of transcription in epithelial-mesenchymal transition
2007
Characterization of Fibroblast-specific Protein 1 in Pulmonary Fibrosis
2004
Evidence that fibroblasts derive from epithelium during tissue fibrosis
2002 Standout
The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis.
2003
Epithelial-mesenchymal transitions and the intersecting cell fate of fibroblasts and metastatic cancer cells.
2003
Evidence that fibroblasts derive from epithelium during tissue fibrosis
2002