Citation Impact
Citing Papers
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Discovery and engineering of enhanced SUMO protease enzymes
2018 StandoutNobel
Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7
2008
The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains
1988 StandoutScience
Shared genetic susceptibility of Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus: contributions of HLA and haptoglobin
1991
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition
2010 Standout
Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility
1991 Nature
Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1
2005
The Uteroplacental Prolactin Family and Pregnancy1
1998
Alternative splicing in individual aplysia neurons generates neuropeptide diversity
1987 StandoutNobel
Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates
2006
A genome-wide search for human type 1 diabetes susceptibility genes
1994 Nature
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
2001 StandoutNature
Modification in reverse: the SUMO proteases
2007
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
2007 Standout
Characterization of a Family of Nucleolar SUMO-specific Proteases with Preference for SUMO-2 or SUMO-3
2006
SUMO
2005 Standout
Structure and Analysis of a Complex between SUMO and Ubc9 Illustrates Features of a Conserved E2-Ubl Interaction
2007
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
1994 StandoutScience
Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
1997
Global and societal implications of the diabetes epidemic
2001 StandoutNature
Small Ubiquitin-like Modifier (SUMO) Recognition of a SUMO Binding Motif
2005
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
Genetics of Type 2 diabetes
2005
HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
1987 StandoutNature
Atherosclerosis
2000 StandoutNature
The epidemiology and natural history of niddm–lessons from the South Pacific
1990
Concepts in sumoylation: a decade on
2007
SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?
2004
Genetic Control of Diabetes Progression
1997
Local and Systemic Effects of Intradermal Recombinant Interferon-γ in Patients with Lepromatous Leprosy
1986 StandoutNobel
Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis.
1986
Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).
1993 Standout
Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells
1984
HLA DR antigens and susceptibility to insulin-dependent diabetes mellitus.
1984
HLA-DO polymorphism associated with resistance to type I diabetes detected with monoclonal antibodies, isoelectric point differences, and restriction fragment length polymorphism.
1986
Overexpression of beta 2-microglobulin in transgenic mouse islet beta cells results in defective insulin secretion.
1991 StandoutNobel
The application of targeted mass spectrometry‐based strategies to the detection and localization of post‐translational modifications
2014
Cachectin and tumour necrosis factor as two sides of the same biological coin
1986 StandoutNatureNobel
Analysis of the regions flanking the human insulin gene and sequence of an Alu family member
1980
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Sumoylation dynamics during keratinocyte differentiation
2006
Comparison of DR β1 alleles from diabetic and normal individuals
1987
Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage
1984 StandoutScienceNobel
A history of the human fetal globin gene duplication
1981 StandoutNobel
Locus of the α-Chain of the T-Cell Receptor Is Split by Chromosome Translocation in T-Cell Leukemias
1985 Science
Regulation of transmembrane signaling by receptor phosphorylation
1987 StandoutNobel
Molecular cloning of a polymorphic DNA endonuclease fragment associates insulin-dependent diabetes mellitus with HLA-DQ.
1987
Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice
1998 Standout
Cell type-specific enhancer element associated with a mouse MHC gene, Eβ
1984 StandoutNatureNobel
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization
1982
Molecular analysis of a chromosomal translocation, t(9;14)(p13;q32), in a diffuse large-cell lymphoma cell line expressing the Ki-1 antigen.
1990 StandoutNobel
A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus.
1985
Polymorphisms of a human variable heavy chain gene show linkage with constant heavy chain genes.
1984 StandoutNobel
Both alpha and beta chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains.
1984
A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway.
1988
A truncated immunoglobulin epsilon pseudogene is found in gorilla and man but not in chimpanzee.
1985 StandoutNobel
Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor.
1995 StandoutNobel
Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes
1983 Nature
Nucleocytoplasmic Shuttling Modulates Activity and Ubiquitination-Dependent Turnover of SUMO-Specific Protease 2
2006
Cloning and expression of murine immune interferon cDNA.
1983
Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II
1986 StandoutNatureNobel
Polymorphic DNA region adjacent to the 5' end of the human insulin gene.
1981
DR2+ haplotypes in insulin-dependent diabetes: Analysis of DNA restriction fragment length polymorphisms
1986
Ancient DNA: extraction, characterization, molecular cloning, and enzymatic amplification.
1989 StandoutNobel
Chromosomal Locations of the Murine T-Cell Receptor Alpha-Chain Gene and the T-Cell Gamma Gene
1985 StandoutScienceNobel
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Isolation and characterization of the human prolactin gene.
1984
Cachectin: More Than a Tumor Necrosis Factor
1987 StandoutNobel
Genetic aspects of arteriosclerosis.
1986
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour
1983 StandoutNatureNobel
Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc
1984 StandoutNatureNobel
Characterization of an up-stream promoter directing extrapituitary expression of the human prolactin gene.
1994
Essential Role of Insulin in Transcription of the Rat 25,000 Molecular Weight Casein Gene
1984 Science
Pharmacokinetics, single-dose tolerance, and biological activity of recombinant gamma-interferon in cancer patients.
1985
Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.
1984 StandoutNobel
The structure of SENP1–SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing
2006
Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization
1985
Differential activity of maternally and paternally derived chromosome regions in mice
1985 StandoutNature
Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter
1986 StandoutNatureNobel
Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: studies of the HLA class II loci.
1985
Prolactin: Structure, Function, and Regulation of Secretion
2000 Standout
Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin.
1984
Genetic Dissection of Complex Traits
1994 StandoutScience
Analysis of a break in chromosome 14 mapping to the region of the immunoglobulin heavy chain locus.
1983
Developmental coordination of α-amylase and psp gene expression during mouse parotid gland differentiation is controlled posttranscriptionally
1986
DR5-Associated DC molecules carry three different allospecificities
1985
Induction of human beta-interferon synthesis with poly(rI . rC) in mouse cells transfected with cloned cDNA plasmids.
1982
The class II molecules of the human and murine major histocompatibility complex
1984
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes.
1990 StandoutNobel
Coordinate modulation of transfected HSV thymidine kinase and human globin genes
1983 StandoutNobel
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
2000 StandoutNobel
Insulin regulation of protein phosphorylation in isolated rat liver nuclear envelopes: potential relationship to mRNA metabolism.
1983
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
HLA and Disease 1982 ‐ A Survey
1983
Controlled transcription of a human α-interferon gene introduced into mouse L cells
1982 Nature
The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling
1985
Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse.
1987
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
1987 Standout
Identification of a polymorphic variant associated with HLA-DQw3 and characterized by specific restriction sites within the DQ beta-chain gene.
1985
Regulated expression of an extrachromosomal human beta-interferon gene in mouse cells.
1982
Interleukin 2 (IL2) is assigned to human chromosome 4
1984
A Macrophage Factor Inhibits Adipocyte Gene Expression: An in Vitro Model of Cachexia
1985 StandoutScienceNobel
Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region
1996 StandoutScience
Characterization of an HLA DR beta pseudogene.
1985
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
1987 Standout
The regulated expression of β-globin genes introduced into mouse erythroleukemia cells
1983 StandoutNobel
Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene.
1983
HLA-DR2-associated Dw subtypes correlate with RFLP clusters: most DR2 IDDM patients belong to one of these clusters
1986
Localization of the human insulin gene to the distal end of the short arm of chromosome 11.
1981
A family study of the association between insulin dependent diabetes mellitus, autoantibodies and the HLA system
1984
Immunoglobulin heavy chain genes in humans are located on chromosome 14
1981
Chemical Glycoproteomics
2016 StandoutNobel
Cloning and sequence analysis of the human major histocompatibility complex gene DC-3 beta.
1984
Works of David Owerbach being referenced
Genetics of diabetes in Nauru: Effects of foreign admixture, HLA antigens and the insulin-gene-linked polymorphism
1983
A M55V Polymorphism in a Novel SUMO Gene (SUMO-4) Differentially Activates Heat Shock Transcription Factors and Is Associated with Susceptibility to Type I Diabetes Mellitus
2004
A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation
2005
Pancreatic Islet-Acinar Cell Interaction: Amylase Messenger RNA Levels Are Determined By Insulin
1981 Science
Genes for Growth Hormone, Chorionic Somatomammotropin, and Growth Hormone-Like Gene on Chromosome 17 in Humans
1980 Science
The insulin gene is located on chromosome 11 in humans
1980 Nature
HLA-D region β-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individuals
1983 Nature
Human class II major histocompatibility antigen β-chains are derived from at least three loci
1983 Nature
The Search for IDDM Susceptibility Genes: The Next Generation
1996
The proopiocortin (adrenocorticotropin/?-lipotropin) gene is located on chromosome 2 in humans
1981
Detection of HLA-D/DR-related DNA polymorphism in HLA-D homozygous typing cells.
1983
Susceptibility to Insulin-dependent Diabetes Defined by Restriction Enzyme Polymorphism of HLA-D Region Genomic DNA
1984
Leukocyte and fibroblast interferon genes are located on human chromosome 9.
1981
The HOXD8 Locus (2q31) is Linked to Type I Diabetes: Interaction with Chromosome 6 and 11 Disease Susceptibility Genes
1995
The Prolactin Gene Is Located on Chromosome 6 iIn Humans
1981 Science
Diabetes mellitus, atherosclerosis, and the 5′ flanking polymorphism of the human insulin gene
1986
Characterization of three HLA-DR beta genes isolated from an HLA-DR 3/4 insulin-dependent diabetic patient
1986
Identification of an HLA-DQ beta-chain related genomic sequence associated with insulin-dependent diabetes.
1985
Multigenic Basis for Type I Diabetes: Association of HRAS1 Polymorphism With HLA-DR3,DQw2/DR4,DQw8
1990
Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs.
1994
INHERITANCE OF A PAROTID SECRETORY PROTEIN IN MICE AND ITS USE IN DETERMINING SALIVARY AMYLASE QUANTITATIVE VARIANTS
1980
Restriction Fragment Length Polymorphism of the Insulin Gene in Diabetes Mellitus
1982
The Insulin Gene Is Located on the Short Arm of Chromosome 11 in Humans
1981
POSSIBLE ASSOCIATION BETWEEN DNA SEQUENCES FLANKING THE INSULIN GENE AND ATHEROSCLEROSIS
1982