Citation Impact
Citing Papers
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
2004 Standout
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
2005 StandoutScience
TOR Signaling in Growth and Metabolism
2006 Standout
Promoter Choice Determines Splice Site Selection in Protocadherin α and γ Pre-mRNA Splicing
2002 StandoutNobel
Mismatch Repair-dependent Iterative Excision at Irreparable O6-Methylguanine Lesions in Human Nuclear Extracts
2006 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis
1999
High levels of chromosome instability in polyploids of Saccharomyces cerevisiae
1990
Base-excision repair of oxidative DNA damage
2007 StandoutNature
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
2002 Nature
Pancreatic cancer
2004 Standout
Stromal fibroblasts in cancer initiation and progression
2004 StandoutNature
The Tuberous Sclerosis Complex
2006 Standout
Distribution of repetitive DNA sequences in eubacteria and application to finerpriting of bacterial enomes
1991 Standout
Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vλ repertoire
1999 StandoutNobel
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
2004 StandoutNobel
DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2
1997 Standout
A truncated isoform of Ca2+/calmodulin‐dependent protein kinase II expressed in human islets of Langerhans may result from trans‐splicing
1997
SMAD genes in juvenile polyposis
1999
Lung Cancer
2008 Standout
Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
2006
Genetics of hereditary colorectal cancer
2005
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation
1995
The mini-driver model of polygenic cancer evolution
2015 StandoutNobel
From developmental disorder to heritable cancer: it's all in the BMP/TGF-β family
2003
Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way
2004
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
1998 StandoutNobel
PTEN: One Gene, Many Syndromes
2003
The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization
2006
A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 ( SMAD4)
2004 Standout
The genetics of FAP and FAP-like syndromes
2006
Role of the retinoblastoma protein in the pathogenesis of human cancer.
1997 StandoutNobel
Cancer genes and the pathways they control
2004 Standout
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
2001
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
2003 Standout
Regulation of cancer cell metabolism
2011 Standout
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
Phosphorylation and Functional Inactivation of TSC2 by Erk
2005 Standout
mTOR: from growth signal integration to cancer, diabetes and ageing
2010 Standout
Genetic instability in colorectal cancers
1997 StandoutNature
Tuberous sclerosis
2008 Standout
Germline and Somatic Mutations of the STK11/LKB1 Peutz-Jeghers Gene in Pancreatic and Biliary Cancers
1999
Hereditary Colorectal Cancer
2003 Standout
LKB1; linking cell structure and tumor suppression
2008
Genetic predisposition to colorectal cancer
2004
Evidence That Lymphangiomyomatosis Is Caused by TSC2 Mutations: Chromosome 16p13 Loss of Heterozygosity in Angiomyolipomas and Lymph Nodes from Women with Lymphangiomyomatosis
1998
TGFβ in Cancer
2008 Standout
Assembly and extension of yeast artificial chromosomes to build up a large locus
1996
Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase
1998
Role of Transforming Growth Factor-beta Signaling in Cancer
2000
The LKB1 tumor suppressor negatively regulates mTOR signaling
2004
Abnormalities of the RB1 and DCC tumor suppressor genes: Uncommon in human pancreatic adenocarcinoma
1995
Fibroblasts in cancer
2006 Standout
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
LKB1, a protein kinase regulating cell proliferation and polarity
2003
Cancer-related inflammation
2008 StandoutNature
Wnt signalling in stem cells and cancer
2005 StandoutNature
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
Hamartomatous Polyposis Syndromes: Molecular Genetics, Neoplastic Risk, and Surveillance Recommendations
2001
LKB1 — A master tumour suppressor of the small intestine and beyond
2002
Rho GTPases and Regulation of Hematopoietic Stem Cell Localization
2008
HIF activation identifies early lesions in VHL kidneys
2002 StandoutNobel
Nonfilamentous C. albicans Mutants Are Avirulent
1997 Standout
Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes
2004 StandoutNobel
Genetics of Pancreatic Cancer
1998
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity
2008 StandoutNobel
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
1999 Standout
In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients
1997 StandoutNobel
De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine
2004 Science
Morphogenesis in Candida Albicans
1985
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
A Candida albicans dispersed, repeated gene family and its epidemiologic applications.
1988
CHASING THE CANCER DEMON
2000
Signal Transduction by the TGF-β Superfamily
2002 StandoutScience
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
2007 StandoutNobel
The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex
2015
A survey of phenotypic features in juvenile polyposis.
1998
Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans
1993
LKB1 protein expression in the evolution of glandular neoplasia of the lung.
2003
Genetics of Cowden syndrome: through the looking glass of oncology.
1998
Growth suppression by Lkb1 is mediated by a G 1 cell cycle arrest
1999
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
2009 StandoutScience
TGF-β and cancer
2005
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER
2004
The two faces of transforming growth factor β in carcinogenesis
2003 Standout
Works of David Markie being referenced
Screening SMAD1 , SMAD2 , SMAD3 , and SMAD5 for germline mutations in juvenile polyposis syndrome
1999
PCR-based detection of two MspI Polymorphic sites at D18S8
1991
New vector for transfer of yeast artificial chromosomes to mammalian cells
1993
Mitotic recombination of yeast artificial chromosomes
1992
A somatic cell hybrid panel for regional mapping of human chromosome 18
1992
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis
1997
The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours
2000
Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases
1998
Instability of Candida albicans hybrids
1985
Genetic mapping of hereditary mixed polyposis syndrome to chromosome 6q.
1996
Isolation and morphological characterization of a mycelial mutant of Candida albicans
1986
Two-Hybrid Reporter Vectors for Gap Repair Cloning
2005
Recombination analysis of naturally diploid Candida albicans
1982
Complementation analysis of resistance to 5-fluorocytosine in Candida albicans
1986