Citation Impact
Citing Papers
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
2002 StandoutScienceNobel
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for Difficult-to-Treat depression
2003
Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus?
2009
Interaction of the Grb10 Adapter Protein with the Raf1 and MEK1 Kinases
1998
MST/MLK2, a Member of the Mixed Lineage Kinase Family, Directly Phosphorylates and Activates SEK1, an Activator of c-Jun N-terminal Kinase/Stress-activated Protein Kinase
1997
Identification and Characterization of an IκB Kinase
1997
New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades
2001 StandoutNobel
MAPKs: new JNK expands the group
1994
From molecular to modular cell biology
1999 StandoutNatureNobel
IKAP is a scaffold protein of the IκB kinase complex
1998 Nature
Antidepressant-Like Effects of the Corticotropin-Releasing Factor 1 Receptor Antagonist, SSR125543, and the Vasopressin 1b Receptor Antagonist, SSR149415, in a DRL-72 s Schedule in the Rat
2006
Nerve Growth Factor-mediated Activation of the Mitogen-activated Protein (MAP) Kinase Cascade Involves a Signaling Complex Containing B-Raf and HSP90
1996
Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein
1997
Psychobiology and molecular genetics of resilience
2009
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway
1997
Contribution of the ERK5/MEK5 Pathway to Ras/Raf Signaling and Growth Control
1999
Intrinsic disorder in scaffold proteins: Getting more from less
2008
Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gβγ complex underlies activation of the yeast pheromone response pathway
1998
The N-terminal ERK-binding Site of MEK1 Is Required for Efficient Feedback Phosphorylation by ERK2 in Vitro and ERK Activation in Vivo
1999
Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptors
2002
'Location, location, location': activation and targeting of MAP kinases by G protein-coupled receptors
2003
Molecular Characterization of Ste20p, a Potential Mitogen-activated Protein or Extracellular Signal-regulated Kinase Kinase (MEK) Kinase Kinase from Saccharomyces cerevisiae
1995
MEKK1 Binds Directly to the c-Jun N-terminal Kinases/Stress-activated Protein Kinases
1997
A walk-through of the yeast mating pheromone response pathway
2004
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Mating in Saccharomyces cerevisiae: The Role of the Pheromone Signal Transduction Pathway in the Chemotropic Response to Pheromone
1997 StandoutNobel
Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity
1995
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine
1995 Standout
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior
2007
Protein Kinase A Anchoring
1997
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension
1998
A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade
1997 Nature
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
2013 Standout
Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK
1998
NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain
1997
A Conserved Docking Site in MEKs Mediates High-affinity Binding to MAP Kinases and Cooperates with a Scaffold Protein to Enhance Signal Transmission
2001
Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation
2005
Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals
1998
Brain growth, life history, and cognition in primate and human evolution
2004
Signal transduction and growth control in yeast
1995
Mechanistic Studies of the Dual Phosphorylation of Mitogen-activated Protein Kinase
1997
Functional binding between Gβ and the LIM domain of Ste5 is required to activate the MEKK Ste11
1998
AKAPs: from structure to function
1999
Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling
1995 Standout
Membrane Fusion
2003 StandoutNobel
The MEK1 Proline-rich Insert Is Required for Efficient Activation of the Mitogen-activated Protein Kinases ERK1 and ERK2 in Mammalian Cells
1998
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Stress and the brain: from adaptation to disease
2005 Standout
MAP kinase pathways
1999
Dynamics and organization of MAP kinase signal pathways
1995
Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase
1999
Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration
2001
Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins
1995 StandoutNobel
Discovering Endophenotypes for Major Depression
2004
How can we realize the promise of personalized antidepressant medicines?
2008
KSR modulates signal propagation within the MAPK cascade.
1996
Antidepressant actions of the exercise-regulated gene VGF
2007
Major Depressive Disorder
2008 Standout
The protein kinase KSR interacts with 14-3-3 protein and Raf
1997
HTLV-I Tax Protein Binds to MEKK1 to Stimulate IκB Kinase Activity and NF-κB Activation
1998
MAP kinase pathways in yeast: For mating and more
1995
Expanding roles for β-arrestins as scaffolds and adapters in GPCR signaling and trafficking
2001 StandoutNobel
Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma
2002
New Insights into the Control of MAP Kinase Pathways
1999
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Signal transduction by MAP kinase cascades in budding yeast
1998
MAP Kinases with Distinct Inhibitory Functions Impart Signaling Specificity during Yeast Differentiation
1997
Nuclear Shuttling of Yeast Scaffold Ste5 Is Required for Its Recruitment to the Plasma Membrane and Activation of the Mating MAPK Cascade
1999
Glucocorticoid antagonists in neuropsychotic disorders
2008
CLIP170-like tip1p Spatially Organizes Microtubular Dynamics in Fission Yeast
2000 StandoutNobel
The molecular neurobiology of depression
2008 StandoutNature
Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3
1996
Stress and adult neurogenesis
2006
A novel MAP-kinase kinase from Candida albicans
1997
Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade
1996
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
Signal transduction: hanging on a scaffold
2000
Purification of a 12,020-Dalton Protein That Enhances the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase
1995
A walk-through of the yeast mating pheromone response pathway
2004
An open label trial of C-1073 (mifepristone) for psychotic major depression*
2002
Signaling in the Yeast Pheromone Response Pathway: Specific and High-Affinity Interaction of the Mitogen-Activated Protein (MAP) Kinases Kss1 and Fus3 with the Upstream MAP Kinase Kinase Ste7
1996
Interactions between the Ankyrin Repeat-Containing Protein Akr1p and the Pheromone Response Pathway inSaccharomyces cerevisiae
1996
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
2004 StandoutNobel
MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase.
1995
AKR1Encodes a Candidate Effector of the Gβγ Complex in theSaccharomyces cerevisiaePheromone Response Pathway and Contributes to Control of both Cell Shape and Signal Transduction
1996 StandoutNobel
Pheromone Response in Yeast: Association of Bem1p with Proteins of the MAP Kinase Cascade and Actin
1995 Science
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
1999 StandoutNobel
Characterization of Fus3 Localization: Active Fus3 Localizes in Complexes of Varying Size and Specific Activity
1999
Osmotic Activation of the HOG MAPK Pathway via Ste11p MAPKKK: Scaffold Role of Pbs2p MAPKK
1997 Science
Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2
1995 Science
Two distinct classes of Ran-binding sites on the nucleoporin Nup-358
1999 StandoutNobel
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
2003 StandoutNobel
A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation
1998 Science
Transcriptional neoteny in the human brain
2009 StandoutNobel
MAP Kinase Pathways in the Yeast Saccharomyces cerevisiae
1998
Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice
2002 StandoutNobel
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
2001 Standout
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
2000 StandoutScienceNobel
Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.
1996 StandoutNobel
Identification of a Motif in the Carboxyl Terminus of β-Arrestin2 Responsible for Activation of JNK3
2001 StandoutNobel
Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth.
1994
Signaling Through Scaffold, Anchoring, and Adaptor Proteins
1997 StandoutScience
Kinase Suppressor of Ras Forms a Multiprotein Signaling Complex and Modulates MEK Localization
1999
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
1999 Standout
The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
2002 StandoutNobel
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
Cell Signaling in Space and Time: Where Proteins Come Together and When They’re Apart
2009 Science
MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade
1998 Science
Dynamic Localization of Fus3 Mitogen-Activated Protein Kinase Is Necessary To Evoke Appropriate Responses and Avoid Cytotoxic Effects
2010
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor
2005 StandoutNobel
JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway
1999
Association of the Yeast Pheromone Response G Protein βγ Subunits with the Map Kinase Scaffold Ste5p
1995 Science
The UNC-14 protein required for axonal elongation and guidance in Caenorhabditis elegans interacts with the serine/threonine kinase UNC-51.
1997
Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity
1997
Regulation of Myosin Phosphatase by a Specific Interaction with cGMP- Dependent Protein Kinase Iα
1999 Science
Rewiring MAP Kinase Pathways Using Alternative Scaffold Assembly Mechanisms
2003 Science
The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm.
1995
The proliferation of MAP kinase signaling pathways in yeast
1995
Location, Location, Location: Membrane Targeting Directed by PX Domains
2001 Science
Spatiotemporal dynamics of guanosine 3′,5′-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator
2001 StandoutNobel
ZDS1 and ZDS2, Genes Whose Products May Regulate Cdc42p in Saccharomyces cerevisiae
1996
Ste5 RING-H2 Domain: Role in Ste4-Promoted Oligomerization for Yeast Pheromone Signaling
1997 Science
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
1999 Standout
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
2001 StandoutNobel
More on target with protein phosphorylation: conferring specificity by location.
1996
Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A
1998
Rapid metabolic evolution in human prefrontal cortex
2011 StandoutNobel
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.
1996
Pheromone Signalling in Saccharomyces cerevisiae Requires the Small GTP-Binding Protein Cdc42p and Its Activator CDC24
1995
A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway
1997 Science
The Osmoregulatory Pathway Represses Mating Pathway Activity in Saccharomyces cerevisiae: Isolation of a FUS3 Mutant That Is Insensitive to the Repression Mechanism
1996
Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction
1996
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
The Ste5p scaffold
2001
Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae.
1995
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Signal Transduction through MAP Kinase Cascades
1998 Standout
Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.
1995
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties
2000
Regulation of Cell Polarity by Microtubules in Fission Yeast
1998 StandoutNobel
Light Deprivation Induces Depression-Like Behavior and Suppresses Neurogenesis in Diurnal Mongolian Gerbil (Meriones unguiculatus)
2010
De novo design of protein logic gates
2020 StandoutScienceNobel
Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3
2000
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference
2003 StandoutNobel
Identification of fission yeast nuclear markers using random polypeptide fusions with green fluorescent protein
1996 StandoutNobel
Works of David M. Lyons being referenced
Neuroendocrine aspects of hypercortisolism in major depression
2003
Prospective Investigation of Stress Inoculation in Young Monkeys
2004
Frustrative nonreward and pituitary–adrenal activity in squirrel monkeys
2000
Experience-dependent asymmetric variation in primate prefrontal morphology
2002
Application of microarray technology in primate behavioral neuroscience research
2006
Early Life Stress and Inherited Variation in Monkey Hippocampal Volumes
2001
Glucocorticoid and mineralocorticoid receptor mRNA expression in squirrel monkey brain
2000
Social stress-related behavior affects hippocampal cell proliferation in mice
2006
Stress inoculation‐induced indications of resilience in monkeys
2007
Fus3p and Kss1p Control G1 Arrest in Saccharomyces cerevisiae Through a Balance of Distinct Arrest and Proliferative Functions That Operate in Parallel With Far1p
1999
Stress, Depression, and Inherited Variation in Primate Hippocampal and Prefrontal Brain Development
2025
Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae
1994
The SH3-Domain Protein Bem1 Coordinates Mitogen-Activated Protein Kinase Cascade Activation with Cell Cycle Control in Saccharomyces cerevisiae
1996
Stress-induced changes in primate prefrontal profiles of gene expression
2007
Stress-Level Cortisol Treatment Impairs Inhibitory Control of Behavior in Monkeys
2000