Standout Papers

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabin... 1995 2026 2005 2015 2.3k
  1. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors (1995)
    Raphael Mechoulam, Shimon Ben‐Shabat et al. Biochemical Pharmacology

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Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB2 cannabinoid, as potential ligands for the cannabinoid receptors
1999
Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa‐induced dyskinesias
2003
Occlusion of the presynaptic action of cannabinoids in rat substantia nigra pars reticulata by cadmium
1998
Cannabinoids: potential anticancer agents
2003
Central effects of the cannabinoid receptor agonist WIN55212‐2 on respiratory and cardiovascular regulation in anaesthetised rats
2004
Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain
1997
Levels, Metabolism, and Pharmacological Activity of Anandamide in CB1 Cannabinoid Receptor Knockout Mice
2000
Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented Combination of Potency and Selectivity
2004
Cross‐tolerance between delta‐9‐tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212‐2 and anandamide
1993
Characterization of the Diarylether Sulfonylester (−)-(R)-3-(2-Hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate (BAY 38-7271) as a Potent Cannabinoid Receptor Agonist with Neuroprotective Properties
2002
An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
1998
The endocannabinoid system: function in survival of the embryo, the newborn and the neuron
2002
Pulmonary actions of anandamide, an endogenous cannabinoid receptor agonist, in guinea pigs
1998
Synergistic efects of opioid and cannabinoid antagonists on food intake
2001
Detection of an Endogenous Cannabimimetic Molecule, 2-Arachidonoylglycerol, and Cannabinoid CB1 Receptor mRNA in Human Vascular Cells: Is 2-Arachidonoylglycerol a Possible Vasomodulator?
1998
The Central Cannabinoid Receptor Inactivation Suppresses Endocrine Reproductive Functions
2001
Cannabinoid receptor systems: therapeutic targets for tumour intervention
2003
Mutational analysis and molecular modelling of the antagonist SR 144528 binding site on the human cannabinoid CB2 receptor
2000
Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a “CB3” receptor
2003
Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock
1997 Nature
Cannabinoid CB1 receptors are localized primarily on cholecystokinin-containing GABAergic interneurons in the rat hippocampal formation
1999
Rapid Glucocorticoid-Mediated Endocannabinoid Release and Opposing Regulation of Glutamate and γ-Aminobutyric Acid Inputs to Hypothalamic Magnocellular Neurons
2005
Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats
2005
Selective activation of cannabinoid CB2 receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation
2003
Suppression of noxious stimulus-evoked expression of fos protein-like immunoreactivity in rat spinal cord by a selective cannabinoid agonist
1996
Modulation of peristalsis by cannabinoid CB1 ligands in the isolated guinea‐pig ileum
2000
Cannabinoids: a real prospect for pain relief
2002
Fatty-Acid Amide Hydrolase Is Expressed in the Mouse Uterus and Embryo during the Periimplantation Period1
1999
Hypothesis: cannabinoid therapy for the treatment of gliomas?
2004
A Predominant Role for Inhibition of the Adenylate Cyclase/Protein Kinase A Pathway in ERK Activation by Cannabinoid Receptor 1 in N1E-115 Neuroblastoma Cells
2003
Pharmacology of cannabinoid CB1 and CB2 receptors
1997
Locomotor activity and occupancy of brain cannabinoid CB1 receptors by the antagonist/inverse agonist AM281
2000
The cannabinoid agonist Win55,212-2 inhibits calcium channels by receptor-mediated and direct pathways in cultured rat hippocampal neurons
1998
Cannabinoids in Multiple Sclerosis
2004
Cannabinoid receptors and the regulation of immune response
2000
Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): what we still do not know
2012
Local pressure application of cannabinoid agonists increases spontaneous activity of rat substantia nigra pars reticulata neurons without affecting response to iontophoretically-applied GABA
1996
CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents
2004
Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism
1994
Down-regulation of cannabinoid receptor agonist-stimulated [ ]GTPγS binding in synaptic plasma membrane from chronic ethanol exposed mouse
1999
Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity
2002
Correlation between cannabinoid mediated effects on paired pulse depression and induction of long term potentiation in the rat hippocampal slice
1998
Adverse effects of cannabis
1998
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
2003 Nature
Differential CB1 and CB2 cannabinoid receptor-inotropic response of rat isolated atria: Endogenous signal transduction pathways
2005
Transacylase‐Mediated and Phosphodiesterase‐Mediated Synthesis ofN‐Arachidonoylethanolamine, an Endogenous Cannabinoid‐Receptor Ligand, in Rat Brain Microsomes
1996
CB2 cannabinoid receptor mediation of antinociception
2006
Alzheimer's Disease
2010 Standout
Ceramide: a new second messenger of cannabinoid action
2001
Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
1998
Antihyperalgesic effects of spinal cannabinoids
1998
Cannabinoid receptor-mediated inhibition of dopamine release in the retina
1996
The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
2005
An endocannabinoid mechanism for stress-induced analgesia
2005 Nature
An examination of the central sites of action of cannabinoid-induced antinociception in the rat
1995
Blockade of Effects of Smoked Marijuana by the CB1-Selective Cannabinoid Receptor Antagonist SR141716
2001
Involvement of cannabinoids in the cardioprotection induced by lipopolysaccharide
2001
Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents
1993 Nobel
The molecular logic of endocannabinoid signalling
2003 Standout
The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway
2006
Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
2004 StandoutNobel
Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles
1992
Identification of cannabinoid receptors in cultures of rat cerebellar granule cells
1993
Vasodilator actions of abnormal‐cannabidiol in rat isolated small mesenteric artery
2003
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002 StandoutNobel
Cannabinoids in the treatment of glaucoma
2002
Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice
2006
Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes
2006
The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function
2003 Standout
Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor‐independent mechanism
2005
An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice
2003
Analysis of the respiratory effects of cannabinoids in rats
2003
Cannabinoid receptors and their ligands
2002
Evaluation of CB1 Receptor Knockout Mice in the Morris Water Maze
2002
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease
2003
Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin‐like activity
2000
Role of the endogenous cannabinoid system as a modulator of dopamine transmission: Implications for Parkinson’s disease and schizophrenia
2001
Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
2004
THE ACTIVATION OF CANNABINOID RECEPTORS IN STRIATONIGRAL GABAERGIC NEURONS INHIBITED GABA UPTAKE
1997
Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals
1997
Effects of topical anandamides on intraocular pressure in normotensive rabbits
1996
Anandamide: some like it hot
2001
Comparison of cannabinoid binding sites in guinea‐pig forebrain and small intestine
1998
De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis
2002
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
2001 Nature
CB2 cannabinoid receptor-mediated peripheral antinociception
2001
Direct inhibition by cannabinoids of human 5‐HT3A receptors: probable involvement of an allosteric modulatory site
2002
Endocannabinoids and related fatty acid derivatives in pain modulation
2002
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Localisation of cannabinoid CB1 receptor immunoreactivity in the guinea pig and rat myenteric plexus
2002
Antinociceptive actions of cannabinoids following intraventricular administration in rats
1993
The non-psychotropic cannabinoid (+)-(3S,4S)-7-hydroxy-Δ6-tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) attenuates receptor-mediated neurotoxicity in primary cultures of rat forebrain
1993
Lack of response suppression follows repeated ventral tegmental cannabinoid administration: an in vitro electrophysiological study
2000
Further evidence for the presence of cannabinoid CB1 receptors in guinea‐pig small intestine
1996
Some highlights of research on the effects of caudate nucleus lesions over the past 200 years
2008
Endocannabinoid-Mediated Control of Synaptic Transmission
2009
Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes
2004
Neuromodulatory role of the endocannabinoid signaling system in alcoholism: an overview
2002
Role of endocannabinoid system in mental diseases
2004
Ligand Binding and Modulation of Cyclic AMP Levels Depend on the Chemical Nature of Residue 192 of the Human Cannabinoid Receptor 1
1998
Effects of anandamide on cannabinoid receptors in rat brain membranes
1994
Stereochemical effects of 11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor
1990
Reversal of Δ9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine
2002
Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
2005
The effects of cannabinoids on the brain
1999
Cannabinoids inhibit excitatory neurotransmission in the substantia nigra pars reticulata
2000
Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system
2003
The endocannabinoid signalling system: Biochemical aspects
2005
Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats
1995
Role of the highly conserved Asp‐Arg‐Tyr motif in signal transduction of the CB2 cannabinoid receptor
2000
Endocannabinoids — at the crossroads between the gut microbiota and host metabolism
2015
Endocannabinoid system and opioid addiction: Behavioural aspects
2005
Anandamide transport: A critical review
2005
Effects of SR141716A, a central cannabinoid receptor antagonist, on food-maintained responding
2000
Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development
2000
(—)-Δ9-Tetrahydrocannabinol Antagonizes the Peripheral Cannabinoid Receptor-mediated Inhibition of Adenylyl Cyclase
1996
Endocannabinoids and liver disease – review
2005
Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death
2003
Endocannabinoids in the regulation of appetite and body weight
2005
The CB1 Cannabinoid Receptor of Astrocytes Is Coupled to Sphingomyelin Hydrolysis through the Adaptor Protein Fan
2001
Presynaptic Specificity of Endocannabinoid Signaling in the Hippocampus
2001
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry
2014 StandoutNobel
Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia
2004
O‐1057, a potent water‐soluble cannabinoid receptor agonist with antinociceptive properties
2000
Endogenous cannabinoids mediate hypotension after experimental myocardial infarction
2001
Identification and characterisation of a novel splice variant of the human CB1 receptor
2004
The Super-Cooling Agent Icilin Reveals a Mechanism of Coincidence Detection by a Temperature-Sensitive TRP Channel
2004 StandoutNobel
Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice
2005
THE CANNABINOID AGONIST HU 210 MODIFIES RAT BEHAVIOURAL RESPONSES TO NOVELTY AND STRESS
2000
Inhibition of the cAMP signaling cascade via cannabinoid receptors: a putative mechanism of immune modulation by cannabinoid compounds
1998
The peripheral sympathetic nervous system is the major target of cannabinoids in eliciting cardiovascular depression
2003
Cannabinoid modulation of sensory neurotransmission via cannabinoid and vanilloid receptors: Roles in regulation of cardiovascular function
2002
Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomach
2002
The fatty acid amide hydrolase (FAAH)
2000
Appetite suppression and weight loss after the cannabinoid antagonist SR 141716
1998
Endocannabinoid system and stress and anxiety responses
2005
Striatal Cannabinoid CB1 Receptor mRNA Expression Is Decreased in the Reserpine-Treated Rat Model of Parkinson's Disease
2001
Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1
2004
Examination of the effect of the cannabinoid receptor agonist, CP 55,940, on electrically evoked transmitter release from rat brain slices
1997
Evidence for novel cannabinoid receptors
2005
Formation and inactivation of endogenous cannabinoid anandamide in central neurons
1994 StandoutNature
Assessment of cannabinoid induced gene changes: tolerance and neuroprotection
2002
Functional consequences of the acute administration of the cannabinoid receptor antagonist, SR141716A, in cannabinoid-naive and -tolerant animals: a quantitative 2-[14C]deoxyglucose study
2003
Endocannabinoids and the gut
2002
Cannabidiol: An Overview of Some Pharmacological Aspects
2002
Cannabinoid-induced antinociception is mediated by a spinalα2-noradrenergic mechanism
1991
Synthesis and Characterization of NESS 0327: A Novel Putative Antagonist of the CB1 Cannabinoid Receptor
2003
A random walk through a cannabis field
1991
Marijuana, immunity and infection
1998
Differential effects of anandamide on acetylcholine release in the guinea‐pig ileum mediated via vanilloid and non‐CB1 cannabinoid receptors
2001
Arachidonoylserotonin and Other Novel Inhibitors of Fatty Acid Amide Hydrolase
1998
Cannabis, cannabinoids and reproduction
2003
Anandamide amidohydrolase reacting with 2‐arachidonoylglycerol, another cannabinoid receptor ligand
1998
Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas deferens and the myenteric plexus preparation of guinea‐pig small intestine
1992
2-arachidonyl-glycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1
2000
Increased cannabinoid CB1 receptor binding and activation of GTP‐binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP‐treated marmosets
2001
Neuropharmacology and therapeutic potential of cannabinoids
2000
Cannabinoids and neuroinflammation
2004
Δ9-tetrahydrocannabinol and anandamide enhance the ability of muscimol to induce catalepsy in the globus pallidus of rats
1993
Cannabinoids and the expanded endocannabinoid system in neurological disorders
2019
Cannabinoid Receptor Agonist Efficacy for Stimulating [35S]GTPγS Binding to Rat Cerebellar Membranes Correlates with Agonist-induced Decreases in GDP Affinity
1998
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
2001
Anti-Ischemia Activity of HU-211, a Non-Psychotropic Synthetic Cannabinoid
1994
Anandamide‐induced mobilization of cytosolic Ca2+ in endothelial cells
1999
The ligand that came from within
2001
The quest for a vascular endothelial cannabinoid receptor
2002
Therapeutic Potential of Cannabinoids in CNS Disease
2003
Endocannabinoid control of food intake and energy balance
2005
Synthesis and Characterization of Potent and Selective Agonists of the Neuronal Cannabinoid Receptor (CB1)
1999
The Difference between the CB1 and CB2Cannabinoid Receptors at Position 5.46 Is Crucial for the Selectivity of WIN55212-2 for CB2
1999
Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation.
1992
Δ9-Tetrahydrocannabinol Acts as a Partial Agonist to Modulate Glutamatergic Synaptic Transmission between Rat Hippocampal Neurons in Culture
1999
The endocannabinoid system links gut microbiota to adipogenesis
2010
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
2002
The endocannabinoid system drives neural progenitor proliferation
2005
Cannabinoid Inhibition of the Processing of Intact Lysozyme by Macrophages: Evidence for CB2 Receptor Participation
1999
Functional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibition
1997 Science
CANNABINOID RECEPTORS AND THEIR ENDOGENOUS AGONISTS
1998
Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid.
2002
Role of cyclic AMP in the actions of cannabinoid receptors
1996
Cannabis: pharmacology and toxicology in animals and humans
1996
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
2003
The Cannabinoid System and Cytokine Network
2000
The therapeutic potential of the cannabinoids in neuroprotection
2002
Cannabis: pharmacology and toxicology in animals and humans
1996
Endogenous cannabinoids and appetite.
2001
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
2005
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
2000
CB1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction
2003
The neurobiology and evolution of cannabinoid signalling
2001
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice
1999 StandoutScience
In Vitro and in Vivo Pharmacological Characterization of JTE-907, a Novel Selective Ligand for Cannabinoid CB2 Receptor
2001
Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide
1998
Systemic and portal hemodynamic effects of anandamide
2001
Occurrence and Biosynthesis of Endogenous Cannabinoid Precursor,N-Arachidonoyl Phosphatidylethanolamine, in Rat Brain
1997
Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide.
1995
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
1994 Standout
Exogenous Anandamide Protects Rat Brain against Acute Neuronal InjuryIn Vivo
2001
Bioisosterism:  A Rational Approach in Drug Design
1996
Cannabinoid Suppression of Noxious Heat-Evoked Activity in Wide Dynamic Range Neurons in the Lumbar Dorsal Horn of the Rat
1999
Δ-9-Tetrahydrocannabinol Enhances Breast Cancer Growth and Metastasis by Suppression of the Antitumor Immune Response
2005
Structure−Activity Relationships of Pyrazole Derivatives as Cannabinoid Receptor Antagonists
1999
Presynaptic Cannabinoid Sensitivity Is a Major Determinant of Depolarization-Induced Retrograde Suppression at Hippocampal Synapses
2002
G Protein-coupled Endothelial Receptor for Atypical Cannabinoid Ligands Modulates a Ca2+-dependent K+ Current
2003
Role of a Conserved Lysine Residue in the Peripheral Cannabinoid Receptor (CB2): Evidence for Subtype Specificity
1999
The CB1 Cannabinoid Receptor of Astrocytes Is Coupled to Sphingomyelin Hydrolysis through the Adaptor Protein Fan
2001
Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172
2004
Effects of Cannabinoid Receptor Agonist and Antagonist Ligands on Production of Inflammatory Cytokines and Anti-Inflammatory Interleukin-10 in Endotoxemic Mice
2000
Single-Crystal Structure of a Covalent Organic Framework
2013 StandoutNobel
N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo
2000
Delta-9-tetrahydrocannabinol effects in schizophrenia: Implications for cognition, psychosis, and addiction
2005
The Central Cannabinoid Receptor (CB1) Mediates Inhibition of Nitric Oxide Production by Rat Microglial Cells
1999
Role of Endogenous Cannabinoids in Synaptic Signaling
2003
Azido‐ and Isothiocyanato‐Substituted Aryl Pyrazoles Bind Covalently to the CB1 Cannabinoid Receptor and Impair Signal Transduction
2000
Structural Requirements for Binding of Anandamide-Type Compounds to the Brain Cannabinoid Receptor
1997
Mesenteric Vasodilation Mediated by Endothelial Anandamide Receptors
1999
Head Group Analogs of Arachidonylethanolamide, the Endogenous Cannabinoid Ligand
1996
Cannabinoid Analgesia as a Potential New Therapeutic Option in the Treatment of Chronic Pain
2006
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
Central and Peripheral Signaling Mechanisms Involved in Endocannabinoid Regulation of Feeding: A Perspective on the Munchies
2005
Microinjection of a cannabinoid receptor antagonist into the NTS increases baroreflex duration in dogs
2003
Recent Developments in Isocyanide Based Multicomponent Reactions in Applied Chemistry
2005 Standout
Cannabinoid receptor agonists inhibit depolarization‐induced calcium influx in cerebellar granule neurons
2001
Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation1
2000
Novel Analogues of Arachidonylethanolamide (Anandamide):  Affinities for the CB1 and CB2 Cannabinoid Receptors and Metabolic Stability
1998
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB 1 receptor
2001
Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase
2003
A novel pseudo four-component reaction: unexpected formation of densely functionalized pyrroles
2004
LY320135, a Novel Cannabinoid CB1 Receptor Antagonist, Unmasks Coupling of the CB1 Receptor to Stimulation of cAMP Accumulation
1998
Reversal of Dopamine D2Receptor Responses by an Anandamide Transport Inhibitor
2000
Cloning and Pharmacological Characterization of the Rat CB2 Cannabinoid Receptor
2000
Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ 1 Opioid Receptor Mechanism
1997 Science
Platelet‐ and macrophage‐derived endogenous cannabinoids are involved in endotoxin‐induced hypotension
1998
Ultrastructural Localization of the CB1 Cannabinoid Receptor in μ-Opioid Receptor Patches of the Rat Caudate Putamen Nucleus
2001
Substrate Specificity and Stereoselectivity of Rat Brain Microsomal Anandamide Amidohydrolase
1999
Inhibitory effects of cannabinoid CB 1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis
2003
Effects of Chronic Treatment with Δ9-Tetrahydrocannabinol on Cannabinoid-Stimulated [35S]GTPγS Autoradiography in Rat Brain
1996
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis
2003
Mechanism of Cannabinoid Effects on Long-Term Potentiation and Depression in Hippocampal CA1 Neurons
1999
CB1 cannabinoid receptors are involved in neuroprotection via NF-κB inhibition
2005
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
1998
Reticular Synthesis of Microporous and Mesoporous 2D Covalent Organic Frameworks
2007 StandoutNobel
Endocannabinoid 2-Arachidonyl Glycerol Is a Full Agonist through Human Type 2 Cannabinoid Receptor: Antagonism by Anandamide
2000
Storage of Hydrogen, Methane, and Carbon Dioxide in Highly Porous Covalent Organic Frameworks for Clean Energy Applications
2009 StandoutNobel
Inhibition of tumor angiogenesis by cannabinoids
2003
Effects of Cannabinoids on Sympathetic and Parasympathetic Neuroeffector Transmission in the Rabbit Heart
2001
Drug Abuse: Hedonic Homeostatic Dysregulation
1997 StandoutScience
Functional CB1 cannabinoid receptors in human vascular endothelial cells
2000
Cannabinoids and Neuroprotection in Global and Focal Cerebral Ischemia and in Neuronal Cultures
1999
Cannabinoid receptor agonists and antagonists
1998
Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration
2001
Suppression of Noxious Stimulus-Evoked Activity in the Ventral Posterolateral Nucleus of the Thalamus by a Cannabinoid Agonist: Correlation between Electrophysiological and Antinociceptive Effects
1996
Cannabinol Derivatives:  Binding to Cannabinoid Receptors and Inhibition of Adenylylcyclase
1997
The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons.
1996
Brain Regional Distribution of Endocannabinoids: Implications for Their Biosynthesis and Biological Function
1999
VR1-Mediated Depressor Effects During High-Salt Intake
2005
Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol‐induced dopamine release in the nucleus accumbens
2003
HU-308: A specific agonist for CB 2 , a peripheral cannabinoid receptor
1999
Endocannabinoid Signaling in the Brain
2002 Science
STRUCTURE AND FUNCTION OF FATTY ACID AMIDE HYDROLASE
2005
Neuronal localization of cannabinoid receptors and second messengers in mutant mouse cerebellum
1991
Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice
2003
Novel Pyrazole Cannabinoids: Insights into CB1Receptor Recognition and Activation
2001
The Science of Marijuana
2007
Determination and characterization of a cannabinoid receptor in rat brain.
1988 Standout
Cannabinoids and the gastrointestinal tract
2001
Endocannabinoids and Neuroprotection
2002
Structure activity relationships of tetrahydrocannabinol analogues on human cannabinoid receptors
1996
Covalent Organic Frameworks as Exceptional Hydrogen Storage Materials
2008 StandoutNobel
Cannabinoid receptor localization in brain.
1990 Standout
Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-α inhibitor and an effective neuroprotectant
1997
An Aromatic Microdomain at the Cannabinoid CB1 Receptor Constitutes an Agonist/Inverse Agonist Binding Region
2003
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
2011 StandoutNobel
The Cannabinoid 1 Receptor Antagonist, AM251, Prolongs the Survival of Rats with Severe Acute Pancreatitis
2005
Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor.
2001
Cannabinoid Receptors Can Activate and Inhibit G Protein-Coupled Inwardly Rectifying Potassium Channels in a Xenopus Oocyte Expression System
1999
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
1992 StandoutScience
Pharmacology of cannabinoids.
2004
The cannabinoid system and immune modulation
2003
Cannabinoid Receptor Agonists Inhibit Glutamatergic Synaptic Transmission in Rat Hippocampal Cultures
1996
Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons
1999 Standout
Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
2004
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
1991 Standout
Crystalline Covalent Organic Frameworks with Hydrazone Linkages
2011 StandoutNobel
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
Jekyll and Hyde: Two Faces of Cannabinoid Signaling in Male and Female Fertility
2006
CANNABINOID RECEPTORS AS THERAPEUTIC TARGETS
2005
SR 144528, an Antagonist for the Peripheral Cannabinoid Receptor that Behaves as an Inverse Agonist
1999
Cannabinoids Promote Oligodendrocyte Progenitor Survival: Involvement of Cannabinoid Receptors and Phosphatidylinositol-3 Kinase/Akt Signaling
2002
Cannabinoids Protect Cells from Oxidative Cell Death: A Receptor-Independent Mechanism
2000
Facile Synthesis of a Highly Crystalline, Covalently Linked Porous Boronate Network
2006
The Third Transmembrane Helix of the Cannabinoid Receptor Plays a Role in the Selectivity of Aminoalkylindoles for CB2, Peripheral Cannabinoid Receptor
1999
Differential Expression of Cannabinoid Receptors in the Human Colon: Cannabinoids Promote Epithelial Wound Healing
2005
Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells.
1992
Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN
2003
Cannabinoids as Novel Anti-Inflammatory Drugs
2009
Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and independent
2002
Preparation of iodine-123 labeled AM251: A potential SPECT radioligand for the brain cannabinoid CB1 receptor
1996
ENDOCANNABINOID-MEDIATED SYNAPTIC PLASTICITY IN THE CNS
2006
Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations
2008 StandoutScience
Vascular targets for cannabinoids: animal and human studies
2013
Dysregulated Cannabinoid Signaling Disrupts Uterine Receptivity for Embryo Implantation
2001
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
1999
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice
2002
Plant, Synthetic, and Endogenous Cannabinoids in Medicine
2005
Tetrahydrocannabinol and endocannabinoids in feeding and appetite
2002
Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration
2003
Reticular Synthesis of Covalent Organic Borosilicate Frameworks
2008 StandoutNobel
Evidence for a New G Protein-Coupled Cannabinoid Receptor in Mouse Brain
2001
A beneficial aspect of a CB1 cannabinoid receptor antagonist: SR141716A is a potent inhibitor of macrophage infection by the intracellular pathogen Brucella suis
2000
N-arachidonoyll-serine, an endocannabinoid-like brain constituent with vasodilatory properties
2006
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
2003
The Endocannabinoid System and the Brain
2012
Characterization of the acute endocrine actions of (−)-11-hydroxy-Δ8-tetrahydrocannabinol-dimethylheptyl (HU-210), a potent synthetic cannabinoid in rats
1998
Endogenous cannabinoids and appetite
2001
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1receptor coupling to Gq/11G proteins
2005
Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors
2004
Endocannabinoids Acting at Cannabinoid-1 Receptors Regulate Cardiovascular Function in Hypertension
2004
A Crystalline Imine-Linked 3-D Porous Covalent Organic Framework
2009 StandoutNobel
Endocannabinoids and Vascular Function
2000
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
2001
SR141716A is an inverse agonist at the human cannabinoid CB1 receptor
1997
A role for endocannabinoids in the generation of parkinsonism and levodopa‐induced dyskinesia in MPTP‐lesioned non‐human primate models of Parkinson's disease
2005
2-Arachidonoylglycerol
2004
Mechanism of action of cannabinoids: how it may lead to treatment of cachexia, emesis, and pain.
2006
Identification of the role of endogenous cannabinoids in pain modulation: strategies and pitfalls
2000
Mechanisms of Cannabinoid-Receptor–Mediated Inhibition of Synaptic Transmission in Cultured Hippocampal Pyramidal Neurons
1999
Up‐regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation
2006
Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones.
1992
Hypoactivity of the Spinal Cannabinoid System Results in NMDA-Dependent Hyperalgesia
1998
Anandamide-Induced Depressor Effect in Spontaneously Hypertensive Rats
2003
Involvement of Cannabinoid Receptors in the Intraocular Pressure-Lowering Effects of WIN55212-2
2000
Structural determinants for recognition and translocation by the anandamide transporter
1999
Effects of cannabinoids on prefrontal neuronal responses to ventral tegmental area stimulation
2001
Cardiovascular Effects of Anandamide in Anesthetized and Conscious Normotensive and Hypertensive Rats
1997
Multiple Functions of Endocannabinoid Signaling in the Brain
2012
A new strategy to block tumor growth by inhibiting endocannabinoid inactivation
2004
Mutation of a Highly Conserved Aspartate Residue in the Second Transmembrane Domain of the Cannabinoid Receptors, CB1 and CB2, Disrupts G-Protein Coupling
1998

Works of David M. Compton being referenced

Modeling the Cannabinoid Receptor: A Three-Dimensional Quantitative Structure-Activity Analysis
1991
Pharmacology and stereoselectivity of structurally novel cannabinoids in mice.
1988
Characterization of the lipophilicity of natural and synthetic analogs of delta 9-tetrahydrocannabinol and its relationship to pharmacological potency.
1990
Evaluation of cannabinoid receptor binding and in vivo activities for anandamide analogs.
1995
Cannabinoid-Induced Hypotension and Bradycardia in Rats Is Mediated by CB1-Like Cannabinoid Receptors
1997
Assessment of Anandamide Interaction with the Cannabinoid Brain Receptor: SR 141716A Antagonism Studies in Mice and Autoradiographic Analysis of Receptor Binding in Rat Brain
1998
Are memories for stimulus–stimulus associations or stimulus–response associations responsible for serial-pattern learning in rats?
2001
A rational search for the separation of psychoactivity and analgesia in cannabinoids
1991
Pharmacological and behavioral evaluation of alkylated anandamide analogs
1995
Evaluation of Agonist-antagonist Properties of Nitrogen Mustard and Cyano Derivatives of Δ 8 -Tetrahydrocannabinol
1996
Canabis Dependence and Tolerance Production
1990
5'-Azido-.DELTA.8-THC: a novel photoaffinity label for the cannabinoid receptor
1992
Stereochemical effects of 11-OH-Δ8-THC-dimethylheptyl in mice and dogs
1989
Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE)
2003
Agonist-antagonist characterization of 6′-cyanohex-2′-yne-Δ8-tetrahydrocannabinol in two isolated tissue preparations
1996
Synthesis and pharmacological evaluation of ether and related analogs of .DELTA.8-, .DELTA.9-, and .DELTA.9,11-tetrahydrocannabinol
1991
Behavior strategy learning in rat: effects of lesions of the dorsal striatum or dorsal hippocampus
2004
Pharmacological evaluation of water soluble cannabinoids and related analogs
1990
Synthesis and Pharmacological Properties of 11-Hydroxy-3-(1',1'-dimethylheptyl)hexahydrocannabinol: A High Affinity Cannabinoid Agonist
1994
A novel class of potent tetrahydrocannabinols (THCS): 2′-YNE-Δ8- and Δ9-THCS
1995
Synthesis and pharmacological evaluation of amino, azido, and nitrogen mustard analogs of 10-substituted cannabidiol and 11- or 12-substituted .DELTA.8-tetrahydrocannabinol
1990
Synthesis, pharmacology, and molecular modeling of novel 4-alkyloxy indole derivatives related to cannabimimetic aminoalkyl indoles (AAIs)
1997
Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs
1991
Pharmacological evaluation of halogenated Δ8-THC analogs
1991
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
1995 Standout
The Flexible Use of Multiple Cue Relationships in Spatial Navigation: A Comparison of Water Maze Performance Following Hippocampal, Medial Septal, Prefrontal Cortex, or Posterior Parietal Cortex Lesions
1997
Pharmacological evaluation of iodo and nitro analogs of Δ8-THC and Δ9-THC
1993
Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents.
1992
The Effect of the Enzyme Inhibitor Phenylmethylsulfonyl Fluoride on the Pharmacological Effect of Anandamide in the Mouse Model of Cannabimimetic Activity
1997
Development of cross-tolerance between delta 9-tetrahydrocannabinol, CP 55,940 and WIN 55,212.
1994
Pharmacological evaluation of agonistic and antagonistic activity of cannabinoids.
1987
Synthesis and Pharmacological Comparison of Dimethylheptyl and Pentyl Analogs of Anandamide
1997
Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.
1993
Investigation of the role of the phenolic hydroxyl in cannabinoid activity.
1990
In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity.
1996
Side chain methyl analogues of Δ8-THC
1997
Structure-Activity Relationships of Indole- and Pyrrole-Derived Cannabinoids
1998
The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.
1994
Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol.
1992
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
1999
Synthesis and Pharmacology of a Very Potent Cannabinoid Lacking a Phenolic Hydroxyl with High Affinity for the CB2 Receptor
1996
Importance of the C-1 Substituent in Classical Cannabinoids to CB2 Receptor Selectivity:  Synthesis and Characterization of a Series of O,2-Propano-Δ8-tetrahydrocannabinol Analogs
1997
Cannabinoid-induced hypotension and bradycardia in rats mediated by CB1-like cannabinoid receptors.
1997
Synthesis and pharmacological evaluation of mercapto and thioacetyl analogues of cannabidiol and Δ8-tetrahydrocannabinol
1989
Design, Synthesis and Pharmacology of Cannabimimetic Indoles
1994
Synthesis and pharmacology of (R)- and (5)-4′-hydroxy-Δ9-tetrahydrocannabinols
1997
1-Alkyl-3-(1-naphthoyl)pyrroles: A new class of cannabinoid
1995
Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.
1996
Rankless by CCL
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