Citation Impact
Citing Papers
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth
2008
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
New trends in photobiology
1991
Interstitial fluid pressure in cervical carcinoma
1998
Cell mechanics and the cytoskeleton
2010 StandoutNature
Pathways mediating VEGF-independent tumor angiogenesis
2009
Molecular imaging in drug development
2008 Standout
Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment
2007
A view on drug resistance in cancer
2019 StandoutNature
Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts
1996
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure
2004
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors
2010
In vitroandin vivophase II metabolism of combretastatin A-4: Evidence for the formation of a sulphate conjugate metabolite
2009
Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness
2000
Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation
2000
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
2012 Standout
Contribution of Transient Blood Flow to Tumour Hypoxia in Mice
1995
Combination effect of AC‐7700, a novel combretastatin A‐4 derivative, and cisplatin against murine and human tumors in vivo
2003
Drug penetration in solid tumours
2006 Standout
Proliferation and hypoxia in human squamous cell carcinoma of the cervix: First report of combined immunohistochemical assays
1997
Imaging in the era of molecular oncology
2008 StandoutNature
Tumor angiogenesis: past, present and the near future
2000
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
2008
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Involvement of endothelial progenitor cells in tumor vascularization
2010
Synthesis of Phenanthrenes and Polycyclic Heteroarenes by Transition‐Metal Catalyzed Cycloisomerization Reactions
2004
Temporal changes in pO2 of R3230Ac tumors in fischer-344 rats
1998
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Rapid Chemotherapy-Induced Acute Endothelial Progenitor Cell Mobilization: Implications for Antiangiogenic Drugs as Chemosensitizing Agents
2008
Disrupting tumour blood vessels
2005
Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
1997
Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: tools or decorations?
2008
Intermittent Blood Flow in Solid Tumours – an under-appreciated Source of ‘drug Resistance’
2001
Balancing efficacy of and host immune responses to cancer therapy: the yin and yang effects
2016
Angiogenesis in cancer and other diseases
2000 StandoutNature
A New Weapon for Attacking Tumor Blood Vessels
2008 StandoutNobel
Vincristine revisited
1999
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
Tumor acidity, ion trapping and chemotherapeutics
2003
Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization
2007
Mechanisms of resistance to antiangiogenesis therapy
2010
Assessing responses to cancer therapy using molecular imaging
2006
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
2003
Combined suicide gene therapy for pancreatic peritoneal carcinomatosis using BGTC liposomes
2003
Illuminating the metastatic process
2007
Tirapazamine causes vascular dysfunction in HCT-116 tumour xenografts
2006
Angiogenesis in life, disease and medicine
2005 StandoutNature
Expression of the Hypoxia-Inducible and Tumor-Associated Carbonic Anhydrases in Ductal Carcinoma in Situ of the Breast
2001 StandoutNobel
Immunity, Inflammation, and Cancer
2010 Standout
The biology of the combretastatins as tumour vascular targeting agents
2002
The pathobiology of mucositis
2004 Standout
Keynote address: The influence of microenvironmental factors on the activity of radiation and drugs
1991
Uncertainty in the niches that maintain haematopoietic stem cells
2008
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
Hypoxia‐induced resistance to doxorubicin and methotrexate in human melanoma cell lines in vitro
1994
New approaches for imaging tumour responses to treatment
2008
Relativistic effects in homogeneous gold catalysis
2007 StandoutNature
The multifaceted circulating endothelial cell in cancer: towards marker and target identification
2006
Stem cells in tumor angiogenesis
2010
Measurement of Hypoxia in Vivo Using A 2-Nitromidazole (NITP)
1997
Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
2006
Vascular architecture, hypoxia, and proliferation in first-generation xenografts of human head-and-neck squamous cell carcinomas
2002
High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis
2014 StandoutNobel
Microtubule-binding agents: a dynamic field of cancer therapeutics
2010 Standout
Elusive Identities and Overlapping Phenotypes of Proangiogenic Myeloid Cells in Tumors
2010
Microenvironmental regulation of metastasis
2008 Standout
Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11
2003
Intermittent blood flow in the KHT sarcoma--flow cytometry studies using Hoechst 33342
1990
SR 4233 (Tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours
1993
Microtubules as a target for anticancer drugs
2004 Standout
Non-invasive determination of tumor oxygen tension and local variation with growth
1994
Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide]
1995
Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
2010
In vivo labelling with halogenated pyrimidines of squamous cell carcinomas and adjacent non‐involved mucosa of head and neck region
1995
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
2001 Standout
Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications
2007
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Tumour Hypoxia: The Picture Has Changed in the 1990s
1994
Molecular and cellular biomarkers for angiogenesis in clinical oncology
2007
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Modes of resistance to anti-angiogenic therapy
2008 Standout
Drug and radiation resistance in spheroids: cell contact and kinetics
1994
Studies in catalytic C–H amination involving nitrene C–H insertion
2010
Angiogenesis as a therapeutic target
2005 StandoutNature
Tumor Angiogenesis
2008 Standout
A prospective phase I–II trial of the cyclooxygenase-2 inhibitor celecoxib in patients with carcinoma of the cervix with biomarker assessment of the tumor microenvironment
2006
FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?
2008
Drug Delivery and Transport to Solid Tumors
2003
Drug Resistance and the Solid Tumor Microenvironment
2007 Standout
Detection and Characterization of Tumor Hypoxia Using pO 2 Histography
2007
Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors
2015 StandoutNobel
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer.
2001 StandoutNobel
Direct Assessment of Drug Penetration into Tissue Using a Novel Application of Three-Dimensional Cell Culture
2004
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber.
1992
Measurement of Tumor Oxygenation: A Comparison between Polarographic Needle Electrodes and a Time-Resolved Luminescence-Based Optical Sensor
1997
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.
1998
A Perspective on Cancer Cell Metastasis
2011 StandoutScience
Pathophysiologic Effects of Vascular-Targeting Agents and the Implications for Combination with Conventional Therapies
2006
Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
2007
CXCL12 (SDF1α)-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies?
2011
Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics
2006
Measuring Tumor Hypoxia.
1996
Longevity of Pimonidazole Adducts in Spontaneous Canine Tumors as an Estimate of Hypoxic Cell Lifetime
1997
Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer
2014 StandoutNobel
Preconditioning of the Tumor Vasculature and Tumor Cells by Intermittent Hypoxia: Implications for Anticancer Therapies
2006
The cell transmembrane pH gradient in tumors enhances cytotoxicity of specific weak acid chemotherapeutics.
2001
Measuring tumor hypoxia
1996
Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
Novel A-Ring and B-Ring Modified Combretastatin A-4 (CA-4) Analogues Endowed with Interesting Cytotoxic Activity
2008
Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent.
2003
Microenvironment-induced cancer metastasis
2000
Multistage nanoparticle delivery system for deep penetration into tumor tissue
2011 StandoutNobel
Carbogen-induced changes in rat mammary tumour oxygenation reported by near infrared spectroscopy
1999
Cancer Genome Landscapes
2013 StandoutScience
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
1997 StandoutNobel
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
2005 StandoutScience
Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
2021 StandoutNobel
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.
2000
Two-Photon Absorbing Nanocrystal Sensors for Ratiometric Detection of Oxygen
2009 StandoutNobel
Reversible Photochemical Control of Singlet Oxygen Generation Using Diarylethene Photochromic Switches
2014 StandoutNobel
Roles for Growth Factors in Cancer Progression
2010
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
Quantum dot/antibody conjugates for in vivo cytometric imaging in mice
2015 StandoutNobel
The tumor vascular targeting agent combretastatin A–4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells
2002
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
The Microenvironment Effect on the Generation of Reactive Oxygen Species by Pd−Bacteriopheophorbide
2005
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
2009 StandoutScience
Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis.
1995
Cell selection from a murine tumour using the fluorescent probe Hoechst 33342
1985
Endothelin-1 Is a Critical Mediator of Myogenic Tone in Tumor Arterioles
2004
Effect of p53 Status on Tumor Response to Antiangiogenic Therapy
2002 Science
Review of methods used to study oxygen transport at the microcirculatory level
2000
Works of David J. Chaplin being referenced
Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents
2009
ZD6126: a novel vascular-targeting agent that causes selective destruction of tumor vasculature.
2002
Determinants of anti-vascular action by combretastatin A-4 phosphate: role of nitric oxide
2000
The effects of hyperoxic and hypercarbic gases on tumour blood flow
1999
The effect of hypoxia and low pH on the cytotoxicity of chlorambucil
1992
Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry
1996
Vascular response of tumour and normal tissues to endothelin-1 following antagonism of ETA and ETB receptors in anaesthetised rats
1997
Schedule dependence of combretastatin A4 phosphate in transplanted and spontaneous tumour models
2002
The comparative effects of the NOS inhibitor, nω-nitro-l-arginine, and the haemoxygenase inhibitor, zinc protoporphyrin IX, on tumour blood flow
1998
The use of fluorescent probes to identify regions of transient perfusion in murine tumors
1989
Tumour Radiosensitization by High-Oxygen–Content Gases: Influence of the Carbon Dioxide Content of the Inspired Gas on pO2, Microcirculatory Function and Radiosensitivity
1998
Vinca alkaloids: Anti-vascular effects in a murine tumour
1993
Effect of angiotensin II on intermittent tumour blood flow and acute hypoxia in the murine SCCVII carcinoma
1991
Tumour response to hypercapnia and hyperoxia monitored by FLOOD magnetic resonance imaging
1999
Anti—vascular approaches to solid tumour therapy: Evaluation of vinblastine and flavone acetic acid
1995
Potentiation of the tumor cytotoxicity of melphalan by vasodilating drugs
1989
Nitric oxide production by tumour tissue: impact on the response to photodynamic therapy
2000
Involvement of Oxygen Free Radicals in Ischaemia-Reperfusion Injury to Murine Turnours: Role of Nitric Oxide
1998
Transient perfusion and radiosensitizing effect after nicotinamide, carbogen, and perflubron emulsion administration
1996
Vascular‐targeting therapies for treatment of malignant disease
2004
Microenvironmental control of gene expression: Implications for tumor angiogenesis, progression, and metastasis
1998
Tumor blood flow changes induced by chemical modifiers of radiation response
1992
Relationship between radiobiological hypoxia in tumors and electrode measurements of tumor oxygenation
1994
Ischaemia induced cell death in tumors: Importance of temperature and pH
1994
Nicotinamide, Fluosol DA and Carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vivo
1991
The development of combretastatin A4 phosphate as a vascular targeting agent
2002
Improvement in human tumour oxygenation with carbogen of varying carbon dioxide concentrations
1999
Chapter 45 Cell Sorting with Hoechst or Carbocyanine Dyes as Perfmion Probes in Spheroids and Tumors
1990
The use of blood flow modifiers to improve the treatment response of solid tumors
1991
The radiation response of KHT sarcomas following nicotinamide treatment and carbogen breathing
1994
Combretastatin family member OXI4503 induces tumor vascular collapse through the induction of endothelial apoptosis
2004
Thein vivointeraction between flavone acetic acid and hyperthermia
1996
Modification of tumor blood flow: Current status and future directions
1998
Combretastatin A4 phosphate: background and current clinical status
2004
Hydralazine-Induced Tumor Hypoxia: A Potential Target for Cancer Chemotherapy
1989
Modification of blood flow in the HSN tumour and normal tissues of the rat by the endothelin ETB receptor agonist, IRL 1620
1999
Effects of novel and conventional anti-cancer agents on human endothelial permeability: influence of tumour secreted factors.
1997
Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues.
1999
Evidence for intermittent radiobiological hypoxia in experimental tumour systems.
1989
Acute hypoxia in tumors: Implications for modifiers of radiation effects
1986
OXI 4503 a novel vascular targeting agent: Effects on bloodflow and antitumor activity in comparison to Combretastatin A-4 phosphate
2002
Low-dose metronomic cyclophosphamide combined with vascular disrupting therapy induces potent antitumor activity in preclinical human tumor xenograft models
2009
Radiosensitizationin Vivo: A Study with an Homologous Series of 2-nitroimidazoles
1983
Cytotoxicity of rsu 1069 in spheroids and murine tumors
1987
Anti-vascular approaches to solid tumour therapy: evaluation of combretastatin A4 phosphate.
1999
The first international conference on vascular targeting: meeting overview.
2003
Inhibition of intracellular pH control and relationship to cytotoxicity of chlorambucil and vinblastine.
1996
The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death
2007
Therapy-Induced Acute Recruitment of Circulating Endothelial Progenitor Cells to Tumors
2006 Science
Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.
2001
Tumour vasculature as a target for cancer therapy.
1999
Radiosensitization by Nicotinamide in Vivo: A Greater Enhancement of Tumor Damage Compared to That of Normal Tissues
1987
Phase I Trial of the Antivascular Agent Combretastatin A4 Phosphate on a 5-Day Schedule to Patients With Cancer: Magnetic Resonance Imaging Evidence for Altered Tumor Blood Flow
2003
Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo.
2001
Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4.
1998
The susceptibility of tumors to the antivascular drug combretastatin A4 phosphate correlates with vascular permeability.
2001
Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503
2002
Ischemia reperfusion injury in tumors: the role of oxygen radicals and nitric oxide.
1995
The effect of hydralazine on the tumor cytotoxicity of the hypoxic cell cytotoxin RSU-1069: Evidence for therapeutic gain
1987
Tumor radiosensitization by nicotinamide: a result of improved perfusion and oxygenation.
1989
Targeting gene therapy to cancer: a review.
1997
Tumor Radiosensitization by Nicotinamide: A Result of Improved Perfusion and Oxygenation
1989
Intermittent blood flow in a murine tumor: radiobiological effects.
1987