Standout Papers
Citation Impact
Citing Papers
Drosophila melanogaster Is a Genetically Tractable Model Host for Mycobacterium marinum
2003
Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae
2002
Induction of Ectopic Eyes by Targeted Expression of the eyeless Gene in Drosophila
1995 Science
The Homeobox Gene Caudal Regulates Constitutive Local Expression of Antimicrobial Peptide Genes in Drosophila Epithelia
2003
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
Two Proteases Defining a Melanization Cascade in the Immune System of Drosophila
2006
A Ubiquitin-Proteasome Pathway Represses the Drosophila Immune Deficiency Signaling Cascade
2002
Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila
2003
Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster
2003
The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. VII. Characterization of the region around the snail and cactus loci.
1990
A community effect in animal development
1988 StandoutNatureNobel
A Drosophila IκB kinase complex required for Relish cleavage and antibacterial immunity
2000
Hemolymph‐dependent and ‐independent responses in Drosophila immune tissue
2004
Wnt Signals and Frizzled Activity Orient Anterior-Posterior Axon Outgrowth in C. elegans
2006
WntD is a feedback inhibitor of Dorsal/NF-κB in Drosophila development and immunity
2005 Nature
Maternal-effect mutations altering the anterior-posterior pattern of the Drosophila embryo
1986 StandoutNobel
Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation Movements
2003
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
Localized requirement for torso-like expression in follicle cells for development of terminal anlagen of the Drosophila embryo
1990 StandoutNatureNobel
The clip-domain family of serine proteinases in arthropods
2000
Drosophila immunity: two paths to NF-κB
2001
GAL4 system in drosophila: A fly geneticist's swiss army knife
2002
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos
1997 StandoutNobel
A family of proteins related to Spätzle, the toll receptor ligand, are encoded in the Drosophila genome
2001
The Rel Protein DIF Mediates the Antifungal but Not the Antibacterial Host Defense in Drosophila
2000 StandoutNobel
Molecular Analysis of EMS-Induced frizzled Mutations in Drosophila melanogaster
1996
Sensing and signaling during infection in Drosophila
2004 StandoutNobel
Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice
2007 StandoutNobel
Toll signaling: the enigma variations
2000
Evolution of enzyme cascades from embryonic development to blood coagulation
2002
Functional Dissection of an Innate Immune Response by a Genome-Wide RNAi Screen
2004
Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections
2001 StandoutNobel
Gram-negative Bacteria-binding Protein, a Pattern Recognition Receptor for Lipopolysaccharide and β-1,3-Glucan That Mediates the Signaling for the Induction of Innate Immune Genes in Drosophila melanogaster Cells
2000
Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling
2003 StandoutNobel
Role of Drosophila IKKγ in a Toll-independent antibacterial immune response
2000 StandoutNobel
Molecular structure of frizzled, a Drosophila tissue polarity gene.
1990
The Toll and Imd pathways are the major regulators of the immune response in Drosophila
2002
In Vivo RNA Interference Analysis Reveals an Unexpected Role for GNBP1 in the Defense against Gram-positive Bacterial Infection in Drosophila Adults
2004
NF-κB signaling pathways in mammalian and insect innate immunity
2001
The product of the Drosophila gene vasa is very similar to eukaryotic initiation factor-4A
1988 Nature
The Drosophila Inhibitor of Apoptosis (IAP) DIAP2 Is Dispensable for Cell Survival, Required for the Innate Immune Response to Gram-negative Bacterial Infection, and Can Be Negatively Regulated by the Reaper/Hid/Grim Family of IAP-binding Apoptosis Inducers
2006
New insights into Drosophila larval haemocyte functions through genome-wide analysis
2005
Toll-like receptors in the induction of the innate immune response
2000 StandoutNature
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
2007 StandoutNature
A Model of Bacterial Intestinal Infections in Drosophila melanogaster
2007 StandoutNobel
A Drosophila Pattern Recognition Receptor Contains a Peptidoglycan Docking Groove and Unusual L,D-Carboxypeptidase Activity
2004 Nobel
Peptidomic and proteomic analyses of the systemic immune response of Drosophila
2004 StandoutNobel
The role of RhoA in tissue polarity and Frizzled signalling
1997 Nature
Drosophila immunity: paths and patterns
2003
Drosophila innate immunity: an evolutionary perspective
2002 StandoutNobel
Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3
1995 StandoutNatureNobel
The immune response of Drosophila
2003 StandoutNatureNobel
First, trap your enhancer
1991
The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila
2008 StandoutNobel
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Bacterial recognition and signalling by the Drosophila IMD pathway
2005
Toll receptors in innate immunity
2001 StandoutNobel
The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development
1992 StandoutNobel
Drosophila Immunity: A Large-Scale In Vivo RNAi Screen Identifies Five Serine Proteases Required for Toll Activation
2006
Drosophila Immune Deficiency (IMD) Is a Death Domain Protein that Activates Antibacterial Defense and Can Promote Apoptosis
2001 StandoutNobel
The Drosophila gene torso encodes a putative receptor tyrosine kinase
1989 StandoutNatureNobel
A new member of the frizzled family from Drosophila functions as a Wingless receptor
1996 Nature
Dorsoventral Axis Formation in the Drosophila Embryo—Shaping and Transducing a Morphogen Gradient
2005
Immune Activation of NF-κB and JNK Requires Drosophila TAK1
2003
Tehao functions in the Toll pathway in Drosophila melanogaster : possible roles in development and innate immunity
2001
An Immune-Responsive Serpin Regulates the Melanization Cascade in Drosophila
2002
Targeting of TAK1 by the NF-κB protein Relish regulates the JNK-mediated immune response in Drosophila
2004
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections
2007 StandoutNobel
Function of torso in determining the terminal anlagen of the Drosophila embryo
1988 StandoutNatureNobel
Genetic resistance to viral infection: the molecular cloning of a Drosophila gene that restricts infection by the rhabdovirus sigma.
1989
Peptidoglycan recognition protein (PGRP)‐LE and PGRP‐LC act synergistically in Drosophila immunity
2004
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Tip of another iceberg: Drosophila serpins
2005
Downregulation of the Drosophila Immune Response by Peptidoglycan-Recognition Proteins SC1 and SC2
2006 StandoutNobel
Revealing the world of RNA interference
2004 StandoutNatureNobel
Toll-like receptors: critical proteins linking innate and acquired immunity
2001 Standout
Peptidoglycan Recognition Proteins Involved in 1,3-β-D-Glucan-dependent Prophenoloxidase Activation System of Insect
2004
The evolution and genetics of innate immunity
2001 StandoutNobel
JNK Signaling Pathway Is Required for Efficient Wound Healing in Drosophila
2002
Sensing infection in Drosophila: Toll and beyond
2004 StandoutNobel
The road to Toll
2004
Downregulation of lipopolysaccharide response in drosophila by negative crosstalk between the AP1 and NF-κB signaling modules
2005
The role of Toll-like receptors in host defense against microbial infection
2001
Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen
1989 StandoutNatureNobel
A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophila Tissue Polarity Gene frizzled
1996
Tissue and stage-specific expression of the Tolls in Drosophila embryos
2002 StandoutNobel
Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway
1998
Antifungal defense in drosophila
2007 StandoutNobel
Proteomic Analysis of the Systemic Immune Response of Drosophila
2003
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
How Drosophila combats microbial infection: a model to study innate immunity and host–pathogen interactions
2002
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
The Role of Ubiquitination in Drosophila Innate Immunity
2005
Critical evaluation of the role of the Toll‐like receptor 18‐Wheeler in the host defense of Drosophila
2002
The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence.
1991 StandoutNobel
Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays
2001
Serpin Structure, Mechanism, and Function
2002 Standout
Tissue-Specific Inducible Expression of Antimicrobial Peptide Genes in Drosophila Surface Epithelia
2000 StandoutNobel
A proteomic approach for the analysis of instantly released wound and immune proteins in Drosophila melanogaster hemolymph
2004
The Toll pathway is important for an antiviral response in Drosophila
2005
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis
2012 StandoutNobel
Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid
1986 StandoutNatureNobel
Pathway Specificity by the Bifunctional Receptor Frizzled Is Determined by Affinity for Wingless
2000
Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues.
1992
A genome-wide analysis of immune responses in Drosophila
2001 StandoutNobel
A Spätzle-Processing Enzyme Required for Toll Signaling Activation in Drosophila Innate Immunity
2006
Caspar, a suppressor of antibacterial immunity in Drosophila
2006
Drosophila Immunity: Genes on the Third Chromosome Required for the Response to Bacterial Infection
2001
dishevelled is a component of the frizzled signaling pathway in Drosophila
1995
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
abdA expression in Drosophila embryos.
1990
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Immune-Deficient Drosophila melanogaster: A Model for the Innate Immune Response to Human Fungal Pathogens
2004
Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila
1999
Determination of Anteroposterior Polarity in Drosophila
1987 StandoutScienceNobel
Multimerization and interaction of Toll and Spätzle in Drosophila
2004
dishevelled is required during wingless signaling to establish both cell polarity and cell identity
1994
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
The Drosophila Inhibitor of Apoptosis Protein DIAP2 Functions in Innate Immunity and Is Essential To Resist Gram-Negative Bacterial Infection
2006
Toll and IMD Pathways Synergistically Activate an Innate Immune Response in Drosophila melanogaster
2007
The Host Defense of Drosophila melanogaster
2007 StandoutNobel
Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity.
1990 StandoutNobel
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor
2005
The Mating of a Fly
1994 StandoutScienceNobel
Innate Immune Recognition
2002 Standout
RNAi in C. elegans : Soaking in the Genome Sequence
1998 StandoutScienceNobel
Drosophila : The Genetics of Innate Immune Recognition and Response
2004
The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein.
1996 StandoutNobel
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo
1988
Involvement of the pumilio gene in the transport of an abdominal signal in the Drosophila embryo
1987 StandoutNatureNobel
Morphogen gradient interpretation
2001 StandoutNatureNobel
Works of David Gubb being referenced
Splice‐activated UAS hairpin vector gives complete RNAi knockout of single or double target transcripts in drosophila melanogaster
2002
The balance between isoforms of the Prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs
1999
The Drosophila Immune Defense against Gram-Negative Infection Requires the Death Protein dFADD
2002 StandoutNobel
Pattern formation in the embryo and imaginal discs of Drosophila: What are the links?
1991
Characterization of the Necrotic Protein That Regulates the Toll-mediated Immune Response in Drosophila
2003
Prickle Mediates Feedback Amplification to Generate Asymmetric Planar Cell Polarity Signaling
2002
A selective screen to recover chromosomal deletions and duplications in Drosophila melanogaster.
1988
Genetic and cytogenetic analysis of the 43A-E region containing the segment polarity gene costa and the cellular polarity genes prickle and spiny-legs in Drosophila melanogaster.
1993
INTERACTIONS BETWEEN WHITE GENES CARRIED BY A LARGE TRANSPOSING ELEMENT AND THE ZESTE 1 ALLELE IN DROSOPHILA MELANOGASTER
1986
Further studies onengrailed mutants inDrosophila melanogaster
1985
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
A preliminary genetic analysis of TE146, a very large transposing element of Drosophila melanogaster
1985
Drosophila necroticmutations mirror disease-associated variants of human serpins
2003
The necrotic Gene in Drosophila Corresponds to One of a Cluster of Three Serpin Transcripts Mapping at 43A1.2
2000
A genetic analysis of the determination of cuticular polarity during development inDrosophila melanogaster
1982
Intron‐delay and the precision of expression of homoeotic gene products in Drosophila
1986
The genetic analysis of a large transposing element of Drosophila melanogaster
1984
Genes controlling cellular polarity in Drosophila
1993
The Drosophila tissue polarity gene starry night encodes a member of the protocadherin family
1999