Standout Papers
- Specific RNA Residue Interactions Required for Enzymatic Functions of Tetrahymena Telomerase (1996)
- Lack of telomere shortening during senescence inParamecium. (1994)
- Altering specific telomerase RNA template residues affects active site function. (1995)
- The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein (1999)
- The Telomere and Telomerase: How do they Interact? (2007)
- Ku is associated with the telomere in mammals (1999)
Citation Impact
Citing Papers
Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA
2003
Accelerated telomere shortening in response to life stress
2004 StandoutNobel
Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
2009
Rapid Inhibition of Cancer Cell Growth Induced by Lentiviral Delivery and Expression of Mutant-Template Telomerase RNA and Anti-telomerase Short-Interfering RNA
2004 StandoutNobel
Developmentally regulated initiation of DNA synthesis by telomerase: evidence for factor-assisted de novo telomere formation
1997
Mouse Embryonic Stem Cells, but Not Somatic Cells, Predominantly Use Homologous Recombination to Repair Double-Strand DNA Breaks
2010
Hallmarks of Cancer: The Next Generation
2011 Standout
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Assembly and regulation of telomerase
1999
Three telomerases with completely non-telomeric template replacements are catalytically active
2000
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
Adding to the ends: what makes telomerase processive and how important is it?
2004
Spontaneous tumor development in bone marrow-rescued DNA-PKcs3A/3A mice due to dysfunction of telomere leading strand deprotection
2015
Telomeres: No end in sight
1994 StandoutNobel
Chromosome first aid
1991 StandoutNobel
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
2007 StandoutNobel
A novel specificity for the primer-template pairing requirement in Tetrahymena telomerase
1998
Processive Utilization of the Human Telomerase Template
2004 StandoutNobel
A conserved secondary structure for telomerase RNA
1991 StandoutNobel
The ends and the middle: putting chromosomes together
1994
An alternative pathway for yeast telomere maintenance rescues est1− senescence
1993 StandoutNobel
Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility
2003
The end of the (DNA) line.
2000 StandoutNobel
Tying up loose ends: nonhomologous end-joining in Saccharomyces cerevisiae
2000
Telomere states and cell fates
2000 StandoutNatureNobel
The Human Rap1 Protein Complex and Modulation of Telomere Length
2004
Purification of tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme
1995 StandoutNobel
Defying death after DNA damage
2000 Nature
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
1997 StandoutNobel
Chromosomal stability and the DNA double-stranded break connection
2001
TIN2 Binds TRF1 and TRF2 Simultaneously and Stabilizes the TRF2 Complex on Telomeres
2004
Telomeres in T and B cells
2002
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
Yeast telomerase is specialized for C/A-rich RNA templates
2003
A novel pseudoknot element is essential for the action of a yeast telomerase
2003 StandoutNobel
Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro
2002
The roles of telomeres and telomerase in cell life span
1996
Human telomerase contains two cooperating telomerase RNA molecules
2001
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
2005 StandoutNobel
Telomerase RNA structure and function: implications for dyskeratosis congenita
2004 StandoutNobel
DNA Ligase IV-Dependent NHEJ of Deprotected Mammalian Telomeres in G1 and G2
2002
Runaway telomere elongation caused by telomerase RNA gene mutations
1995 StandoutNatureNobel
Secondary Structure of Vertebrate Telomerase RNA
2000 StandoutNobel
Telomere Maintenance Requires the RAD51D Recombination/Repair Protein
2004
Human Telomerase RNA Template Sequence Is a Determinant of Telomere Repeat Extension Rate
2005
Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability
2001
Protection of mammalian telomeres
2002
Human telomerase RNA-protein interactions
2001
Recognition of a chromosome truncation site associated with α-thalassaemia by human telomerase
1991 Nature
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
Stem cells in tumor angiogenesis
2010
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Roles for RNA in Telomerase Nucleotide and Repeat Addition Processivity
2003
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells
2001
Structure of the Human Telomerase RNA Pseudoknot Reveals Conserved Tertiary Interactions Essential for Function
2005
Switching and Signaling at the Telomere
2001 StandoutNobel
De novo telomere addition by Tetrahymena telomerase invitro
1997
Telomere Length, Telomere-binding Proteins, and DNA Damage Signaling
2000 StandoutNobel
Telomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70
2002
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 StandoutNobel
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Phosphorylation of H2AX at Short Telomeres in T Cells and Fibroblasts
2004 StandoutNobel
A role for a novel ‘trans-pseudoknot’ RNA–RNA interaction in the functional dimerization of human telomerase
2003 StandoutNobel
Shelterin: the protein complex that shapes and safeguards human telomeres
2005 Standout
Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis
2002 StandoutNobel
Mutational analysis of the Tetrahymena telomerase RNA: identification of residues affecting telomerase activity in vitro
1998
Repair of telomeric DNA prior to replicative senescence
2000
The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase
2001
Specific telomerase RNA residues distant from the template are essential for telomerase function
1998 StandoutNobel
Two types of telomeric chromatin in Tetrahymena thermophila 1 1Edited by T. Richmond
1998
Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein
2003
The telomerase reverse transcriptase: components and regulation
1998
Analysis of the structure of human telomerase RNA in vivo
2002
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
1990 StandoutNatureNobel
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein
2004 StandoutNobel
Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G‐strand overhang
2000
Transformation of Tetrahymena thermophila with a mutated circular ribosomal DNA plasmid vector.
1989 StandoutNobel
Telomere length predicts replicative capacity of human fibroblasts.
1992 StandoutNobel
Functional Regions of Human Telomerase Reverse Transcriptase and Human Telomerase RNA Required for Telomerase Activity and RNA-Protein Interactions
2001
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
1989 StandoutScienceNobel
A Quantitative Assay for Telomere Protection in Saccharomyces cerevisiae
2002
A molecular switch underlies a human telomerase disease
2002 StandoutNobel
Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules
2004 StandoutNobel
TELOMERES AND THEIR CONTROL
2000 StandoutNobel
Identification of Kluyveromyces lactis Telomerase: Discontinuous Synthesis along the 30-Nucleotide-Long Templating Domain
1998 StandoutNobel
Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang.
1996 Nobel
Mutant Telomere Sequences Lead to Impaired Chromosome Separation and a Unique Checkpoint Response
2004 StandoutNobel
The DNA of ciliated protozoa
1994
Functional Interaction between Poly(ADP-Ribose) Polymerase 2 (PARP-2) and TRF2: PARP Activity Negatively Regulates TRF2
2004
A Mammalian Telomerase-Associated Protein
1997 Science
S Phase of the Cell Cycle
1989 Science
Ciliate Telomerase Biochemistry
1999
Telomere fusions caused by mutating the terminal region of telomeric DNA
2000 StandoutNobel
Telomerase in Yeast
1995 StandoutScienceNobel
Telomeres and telomerase
2004 StandoutNobel
Dynamics of Telomeric DNA Turnover in Yeast
2002 StandoutNobel
Polymerization Defects within Human Telomerase Are Distinct from Telomerase RNA and TEP1 Binding
2000
Short Telomeres Result in Organismal Hypersensitivity to Ionizing Radiation in Mammals
2000
Telomerase in kinetoplastid parasitic protozoa
1999 StandoutNobel
A Single Telomerase RNA Is Sufficient for the Synthesis of Variable Telomeric DNA Repeats in Ciliates of the Genus Paramecium
1996
Functional analysis of the pseudoknot structure in human telomerase RNA
2005 StandoutNobel
T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang
2001
Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro.
1997 StandoutNobel
A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation
2001 StandoutNobel
Effects of Reverse Transcriptase Inhibitors on Telomere Length and Telomerase Activity in Two Immortalized Human Cell Lines
1996 StandoutNobel
Identification of Functional Domains and Dominant Negative Mutations in Vertebrate Telomerase RNA Using an in VivoReconstitution System
2001
Template Boundary in a Yeast Telomerase Specified by RNA Structure
2000 StandoutScienceNobel
Protection of Telomeres by the Ku Protein in Fission Yeast
2000 Nobel
A Sense of the End
2000 Science
Structure and function of telomeres
1991 StandoutNatureNobel
A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains
1997 StandoutNobel
Immunosenescence phenotypes in the telomerase knockout mouse
2002
Telomere Dysfunction Triggers Developmentally Regulated Germ Cell Apoptosis
2001 StandoutNobel
Flexible Positioning of the Telomerase-Associated Nuclease Leads to Preferential Elimination of Nontelomeric DNA
1998
Works of David Gilley being referenced
Ku acts in a unique way at the mammalian telomere to prevent end joining
2000
Autonomous replication and addition of telomerelike sequences to DNA microinjected into Paramecium tetraurelia macronuclei.
1988
Ku is associated with the telomere in mammals
1999 StandoutNobel
Autonomous Replication and Addition of Telomerelike Sequences to DNA Microinjected into Paramecium tetraurelia Macronuclei
1988
Lack of telomere shortening during senescence inParamecium.
1994 StandoutNobel
Altering specific telomerase RNA template residues affects active site function.
1995 StandoutNobel
Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood
2004
Specific RNA Residue Interactions Required for Enzymatic Functions of Tetrahymena Telomerase
1996 StandoutNobel
DNA-PKcs is critical for telomere capping
2001
The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein
1999 StandoutNobel
Transformation of Paramecium by microinjection of a cloned serotype gene.
1987