Citation Impact
Citing Papers
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination
2003 StandoutNobel
Down-regulation of Delta by proteolytic processing
2002
Hallmarks of Cancer: The Next Generation
2011 Standout
Notch signals control the fate of immature progenitor cells in the intestine
2005 Nature
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Hypoxia Requires Notch Signaling to Maintain the Undifferentiated Cell State
2005
Selective Formation of Covalent Protein Heterodimers with an Unnatural Amino Acid
2011
Calicheamicin-conjugated humanized anti-CD33 monoclonal antibody (gemtuzumab zogamicin, CMA-676) shows cytocidal effect on CD33-positive leukemia cell lines, but is inactive on P-glycoprotein-expressing sublines
2000
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
A secreted Delta1‐Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling
2002
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Deregulated NOTCH Signaling in Acute T-Cell Lymphoblastic Leukemia/Lymphoma: New Insights, Questions, and Opportunities
2005
The evolving role of natural products in drug discovery
2005 Standout
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4+ T cells
2000
Gemtuzumab ozogamicin (Mylotarg®) as single-agent treatment for frail patients 61 years of age and older with acute myeloid leukemia: final results of AML-15B, a phase 2 study of the European Organisation for Research and Treatment of Cancer and Gruppo Italiano Malattie Ematologiche dell'Adulto Leukemia Groups
2005
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis
2006
Applying the principles of stem-cell biology to cancer
2003
Administration of mylotarg 4 days after beginning of a chemotherapy including intermediate-dose aracytin and mitoxantrone (MIDAM regimen) produces a high rate of complete hematologic remission in patients with CD33+ primary resistant or relapsed acute myeloid leukemia
2005
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
2000
The Notch Ligands, Jagged and Delta, Are Sequentially Processed by α-Secretase and Presenilin/γ-Secretase and Release Signaling Fragments
2003
Tension-tuned receptors for synthetic mechanotransduction and intercellular force detection
2023
A role for mitochondria in NLRP3 inflammasome activation
2010 StandoutNature
Osteoblastic cells regulate the haematopoietic stem cell niche
2003 StandoutNature
Cancer Statistics, 2006
2006 Standout
Regulation of αβ/γδ T Cell Lineage Commitment and Peripheral T Cell Responses by Notch/RBP-J Signaling
2004 StandoutNobel
Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
2007 StandoutNature
The role of Notch in tumorigenesis: oncogene or tumour suppressor?
2003
Thicker Than Blood
2003
In vitro and in vivo expansion of hematopoietic stem cells
2004
Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells
2008
Early Phase I/II Trials with Gemtuzumab Ozogamicin (Mylotarg®) in Acute Myeloid Leukemia
2002
The C-terminal PDZ-Ligand of JAGGED1 Is Essential for Cellular Transformation
2003
Kuz and TACE can activate Notch independent of ligand
2008
Antibody targeted drugs as cancer therapeutics
2006
Isolation of rare circulating tumour cells in cancer patients by microchip technology
2007 StandoutNature
Notch Signaling – Constantly on the Move
2007
Notch regulation of lymphocyte development and function
2004
Notch and the Immune System
2003
Follicular B helper T cells in antibody responses and autoimmunity
2005
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
Notch signalling: a simple pathway becomes complex
2006 Standout
Structural basis for autoinhibition of Notch
2007
Antibody-targeted chemotherapy with immunoconjugates of calicheamicin
2003
A role for Wnt signalling in self-renewal of haematopoietic stem cells
2003 StandoutNature
Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3
2008
Uncertainty in the niches that maintain haematopoietic stem cells
2008
Identification and expansion of human colon-cancer-initiating cells
2006 StandoutNature
Notch and the Immune System
1999
Safety and efficacy of gemtuzumab ozogamicin in pediatric patients with advanced CD33+ acute myeloid leukemia
2005
The many facets of Notch ligands
2008
HOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo
2002
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
MicroRNA expression profiles classify human cancers
2005 StandoutNatureNobel
Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors
2003
Antibody–cytotoxic agent conjugates for cancer therapy
2005
Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination
1999 Standout
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Identification of human brain tumour initiating cells
2004 StandoutNature
Wnt signalling in stem cells and cancer
2005 StandoutNature
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
Identification of stem cells in small intestine and colon by marker gene Lgr5
2007 StandoutNature
Granulocyte–Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML
2004
Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities
2003
Arming antibodies: prospects and challenges for immunoconjugates
2005
Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33‐positive acute myeloid leukemia in first recurrence
2005
Notch2 Is Preferentially Expressed in Mature B Cells and Indispensable for Marginal Zone B Lineage Development
2003
Internalization and cell cycle-dependent killing of leukemic cells by Gemtuzumab Ozogamicin: rationale for efficacy in CD33-negative malignancies with endocytic capacity
2003
Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice
2002
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
1999 StandoutNature
Cancer Therapy with Radiolabeled and Drug/Toxin-conjugated Antibodies
2005
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity
2008 StandoutNobel
Notch-dependent control of myelopoiesis is regulated by fucosylation
2008
RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development
2010 StandoutNobel
The Role of Apoptosis in the Regulation of Hematopoietic Stem Cells
2000
Isolating gene-corrected stem cells without drug selection
2005 StandoutNobel
Fringe Glycosyltransferases Differentially Modulate Notch1 Proteolysis Induced by Delta1 and Jagged1
2004
Antitumor Antibiotics: Bleomycin, Enediynes, and Mitomycin
2005 Standout
REGULATION OF LYMPHOID DEVELOPMENT, DIFFERENTIATION, AND FUNCTION BY THE NOTCH PATHWAY
2005
Hematopoietic Stem and Progenitor Cells: Clinical and Preclinical Regeneration of the Hematolymphoid System
2002
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
2006 StandoutNature
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity
2009 StandoutNobel
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
1999
Notch signalling via RBP-J promotes myeloid differentiation
2000
Human Notch-1 Inhibits NF-κB Activity in the Nucleus Through a Direct Interaction Involving a Novel Domain
2001
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
The roles of receptor and ligand endocytosis in regulating Notch signaling
2005
HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo
2003
Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
A Pictet-Spengler ligation for protein chemical modification
2012 StandoutNobel
DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur
2007
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development
2004
Concise Review: Notch Signaling in Stem Cell Systems
2006
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Neural Cell Adhesion Molecule Contributes to Hemopoiesis‐Supporting Capacity of Stromal Cell Lines
2005
Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
2003
pH-Operated Nanopistons on the Surfaces of Mesoporous Silica Nanoparticles
2010 StandoutNobel
Notch Signaling: Cell Fate Control and Signal Integration in Development
1999 StandoutScience
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Cure of SCID mice bearing human B-lymphoma xenografts by an anti-CD74 antibody-anthracycline drug conjugate.
2003
Polysialic acid governs T-cell development by regulating progenitor access to the thymus
2009 StandoutNobel
Quantum dot/antibody conjugates for in vivo cytometric imaging in mice
2015 StandoutNobel
Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome
2002
STEM CELL NICHE: Structure and Function
2005
Telomerase Regulation, Cell Cycle, and Telomere Stability in Primitive Hematopoietic Cells
1997
MOLECULAR GENETICS OF T CELL DEVELOPMENT
2004
A cell nanoinjector based on carbon nanotubes
2007 StandoutNobel
Telomerase Regulation, Cell Cycle, and Telomere Stability in Primitive Hematopoietic Cells
1997
Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling
1999 Science
Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation
2001
Induction of Antigen-Specific Regulatory T Cells following Overexpression of a Notch Ligand by Human B Lymphocytes
2003
Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis
2003 StandoutNobel
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
1998 StandoutScience
Works of David Flowers being referenced
Regulation of colony forming cell generation by flt‐3 ligand
1996
Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
2000
Multidrug resistance protein attenuates gemtuzumab ozogamicin–induced cytotoxicity in acute myeloid leukemia cells
2003
Selective Ablation of Acute Myeloid Leukemia Using Antibody-Targeted Chemotherapy: A Phase I Study of an Anti-CD33 Calicheamicin Immunoconjugate
1999
The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells
1998
An Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia. Choice of Linker
2001
Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1
2000
Selective Ablation of Acute Myeloid Leukemia Using Antibody-Targeted Chemotherapy: A Phase I Study of an Anti-CD33 Calicheamicin Immunoconjugate
1999
Gemtuzumab Ozogamicin, A Potent and Selective Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia
2001
Multidrug-resistance phenotype and clinical responses to gemtuzumab ozogamicin
2001
Immobilization of Notch ligand, Delta-1, is required for induction of Notch signaling
2000
The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells
1998