Citation Impact
Citing Papers
Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance
2007
Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair
2008
Asymmetric Synthesis of Fluorinated Flavanone Derivatives by an Organocatalytic Tandem Intramolecular Oxa‐Michael Addition/Electrophilic Fluorination Reaction by Using Bifunctional Cinchona Alkaloids
2009
Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines
2010
Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay
2006
Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery
2005
The Catalytic Intermolecular Orthoarylation of Phenols
2003
Inhibition of cathepsin G by 4H-3,1-benzoxazin-4-ones
1997
Clinical Implications of Thiopurine Methyltransferase-Optimization of Drug Dosage and Potential Drug Interactions
1998
Mechanochemistry: opportunities for new and cleaner synthesis
2011 Standout
DNA cleavage assay for the identification of topoisomerase I inhibitors
2008
Indolocarbazole natural products: occurrence, biosynthesis, and biological activity
2006
Brønsted Acid Catalyzed Asymmetric SN2‐Type O‐Alkylations
2013 StandoutNobel
Molecular drug design, synthesis and structure elucidation of a new specific target peptide based metallo drug for cancer chemotherapy as topoisomerase I inhibitor
2012
Bisindenoisoquinoline Bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity
2006
Structural biology in fragment-based drug design
2010
Defective Mre11-dependent Activation of Chk2 by Ataxia Telangiectasia Mutated in Colorectal Carcinoma Cells in Response to Replication-dependent DNA Double Strand Breaks
2006
Covalent organic frameworks (COFs): from design to applications
2012 Standout
Screening of the Pan-African Natural Product Library Identifies Ixoratannin A-2 and Boldine as Novel HIV-1 Inhibitors
2015 StandoutNobel
Genetically programmed chiral organoborane synthesis
2017 StandoutNatureNobel
Synthesis of Biologically Relevant Biflavanoids – A Review
2007
Early Effects of Topoisomerase I Inhibition on RNA Polymerase II Along Transcribed Genes in Human Cells
2006
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
2016 StandoutNobel
Topoisomerase I inhibitors: camptothecins and beyond
2006 Standout
Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: Versatile intermediates for the design and synthesis of topoisomerase I inhibitors
2006
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Fast, greener and scalable direct coupling of organolithium compounds with no additional solvents
2016 StandoutNobel
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
Repair of Topoisomerase I‐Mediated DNA Damage
2006
Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA−Enzyme−Inhibitor Complex As Determined by X-ray Crystallographic Analysis
2005
Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products
2010 Standout
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Practical synthesis of a potent indolocarbazole-based, DNA topoisomerase inhibitor
2001
Boron Chemicals in Diagnosis and Therapeutics
2013
Iron Catalysis in Organic Synthesis
2015 Standout
3d Transition Metals for C–H Activation
2018 Standout
Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles
2006
Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters
2007
First Atropo-Divergent Total Synthesis of the Antimalarial Korupensamines A and B by the “Lactone Method”
2000
Oxidative aryl coupling reactions: a biomimetic approach to configurationally unstable or axially chiral biaryl natural products and related bioactive compounds
2001
Room-Temperature Ionic Liquids: Solvents for Synthesis and Catalysis. 2
2011 Standout
New Mechanistic and Functional Insights into DNA Topoisomerases
2013
Metal-Initiated Amination of Alkenes and Alkynes
1998 Standout
Oxidative Coupling between Two Hydrocarbons: An Update of Recent C–H Functionalizations
2015 Standout
Hydroamination: Direct Addition of Amines to Alkenes and Alkynes
2008 Standout
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
A Comprehensive History of Arynes in Natural Product Total Synthesis
2012 Standout
2-(Diethylamino)thieno[1,3]oxazin-4-ones as Stable Inhibitors of Human Leukocyte Elastase
1999
DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition
2009 Standout
Enantiospecific Synthesis of Heterocycles from α-Amino Acids
1996
Molecular Determinants of Topoisomerase I Poisoning by Lamellarins: Comparison with Camptothecin and Structure−Activity Relationships
2005
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
C−H Activation for the Construction of C−B Bonds
2009 Standout
Mitsunobu and Related Reactions: Advances and Applications
2009
Practical Methodologies for the Synthesis of Indoles
2006 Standout
Synthesis and Biological Evaluation of Bisindenoisoquinolines as Topoisomerase I Inhibitors
2006
Synthesis and Functionalization of Indoles Through Palladium-catalyzed Reactions
2005 Standout
Phosphine Organocatalysis
2018 Standout
Practical synthesis of the rebeccamycin aglycone and related analogs by oxidative cyclization of bisindolylmaleimides with a Wacker-type catalytic system
2001
Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
2012 Standout
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
An Automated Microfluidic System for Online Optimization in Chemical Synthesis
2010
Total Synthesis of Michellamines A−C, Korupensamines A−D, and Ancistrobrevine B
1999
Design, Synthesis, and Biological Evaluation of 14-Substituted Aromathecins as Topoisomerase I Inhibitors
2008
A novel one pot route to flavones under dual catalysis, an organo- and a Lewis acid catalyst
2011
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
An Evolutionary View of the Mechanism for Immune and Genome Diversity
2012 StandoutNobel
Iridium-catalyzed C–H coupling reaction of heteroaromatic compounds with bis(pinacolato)diboron: regioselective synthesis of heteroarylboronates
2002
Direct and Versatile Synthesis of Red‐Shifted Azobenzenes
2016 StandoutNobel
Aryl−Aryl Bond Formation by Transition-Metal-Catalyzed Direct Arylation
2007 Standout
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex
2006 Nobel
Investigation of the Lactam Side Chain Length Necessary for Optimal Indenoisoquinoline Topoisomerase I Inhibition and Cytotoxicity in Human Cancer Cell Cultures
2007
Directed ortho Metalation Strategies. Effective Regioselective Routes to 1,2-, 2,3-, and 1,2,3-Substituted Naphthalenes
2014
Total Synthesis and Biological Evaluation of 22-Hydroxyacuminatine
2006
Regioselective Cross‐Dehydrogenative Coupling of Chromones and Non‐Activated Arenes
2012
Supported Ionic Liquids. New Recyclable Materials for the L ‐Proline‐Catalyzed Aldol Reaction
2006
Total Synthesis of (+)-Decursivine
2011
The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives
2009
Artificial Molecular Machines
2015 Standout
Drugging Topoisomerases: Lessons and Challenges
2012
Concise Synthesis of Anti-HIV-1 Active (+)-Inophyllum B and (+)-Calanolide A by Application of (−)-Quinine-Catalyzed Intramolecular Oxo-Michael Addition
2004
Amide rotamers of N-acetyl-1,3-dimethyltetrahydroisoquinolines: synthesis, variable temperature NMR spectroscopy and molecular modelling
2003
A Systematic Study of Nitrated Indenoisoquinolines Reveals a Potent Topoisomerase I Inhibitor
2006
Palladium‐Catalyzed, tert‐Butyllithium‐Mediated Dimerization of Aryl Halides and Its Application in the Atropselective Total Synthesis of Mastigophorene A
2016 StandoutNobel
Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
2011 Standout
Bulbine-Knipholone, a New, Axially Chiral Phenylanthraquinone fromBulbine abyssinica (Asphodelaceae): Isolation, Structural Elucidation, Synthesis, and Antiplasmodial Activity
2002
Advances in Synthetic Applications of Hypervalent Iodine Compounds
2016 Standout
Regiospecific Synthesis of Mono-N-substituted Indolopyrrolocarbazoles
2005
Synthesis of granulatimide bis-imide analogues
2005
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Highly convergent synthesis of a rebeccamycin analog with benzothioeno(2,3-a)pyrrolo(3,4-c)carbazole as the aglycone
2005
Rebeccamycin analogues as anti-cancer agents
2003
Staurosporine and Rebeccamycin Aglycones Are Assembled by the Oxidative Action of StaP, StaC, and RebC on Chromopyrrolic Acid
2006
Access to Flavones via a Microwave-Assisted, One-Pot Sonogashira−Carbonylation−Annulation Reaction
2009
Update 1 of: Synthesis and Functionalization of Indoles Through Palladium-Catalyzed Reactions
2011
Nitrated Indenoisoquinolines as Topoisomerase I Inhibitors: A Systematic Study and Optimization
2007
Advances in Copper Complexes as Anticancer Agents
2013 Standout
On the Binding of Indeno[1,2-c]isoquinolines in the DNA−Topoisomerase I Cleavage Complex
2005
Recent Applications of Palladium‐Catalyzed Coupling Reactions in the Pharmaceutical, Agrochemical, and Fine Chemical Industries
2009
Synthesis and reactivity of substituted 3-([(Trifluoromethyl)sulfonyl]oxy)-1H-indole-2-carboxylate in palladium-catalyzed reactions
1998
Human Immunodeficiency Virus Type 1 cDNA Integration: New Aromatic Hydroxylated Inhibitors and Studies of the Inhibition Mechanism
1998
Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics
1999 StandoutScience
Cytotoxicity of the traditional chinese medicine (TCM) plumbagin in its copper chemistry
2009
Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation
2009 Standout
Asymmetric Enamine Catalysis
2007 StandoutNobel
Lamellarins and Related Pyrrole-Derived Alkaloids from Marine Organisms
2007 Standout
Synthetic Studies on Indolocarbazoles: Total Synthesis of Staurosporine Aglycon
2011
Isolation and Synthesis of Biologically Active Carbazole Alkaloids
2002 Standout
Construction of Covalent Organic Framework for Catalysis: Pd/COF-LZU1 in Suzuki–Miyaura Coupling Reaction
2011 Standout
Aryl−Aryl Bond Formation One Century after the Discovery of the Ullmann Reaction
2002 Standout
Defining Self-Assembling Linear Oligo(dioxaborole)s
2007
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Metal-Free Multicomponent Syntheses of Pyridines
2014 Standout
Works of David E. Zembower being referenced
Diethyldithiocarbamate S-methylation: evidence for catalysis by human liver thiol methyltransferase and thiopurine methyltransferase.
1993
Indolocarbazole poisons of human topoisomerase I: Regioisomeric analogues of ED-110
1999
Peptide boronic acids Versatile synthetic ligands for affinity chromatography of serine proteinases*
1996
Robustaflavone, a potential non-nucleoside anti-hepatitis B agent
1998
Enantiospecific syntheses of .alpha.-(fluoromethyl)tryptophan analogs: interactions with tryptophan hydroxylase and aromatic L-amino acid decarboxylase
1993
In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI
1998
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G
1992
Efficient reversed-phase purification of a hydrophobic reaction product following Mitsunobu-mediated glycosylation
2002
Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex
2005
Development of a Scalable Synthetic Process for DG-051B, A First-in-Class Inhibitior of LTA4H
2009
Development of a Scalable Process for DG-041, a Potent EP3 Receptor Antagonist, via Tandem Heck Reactions
2007
Structural Analogues of the Calanolide Anti-HIV Agents. Modification of the trans-10,11-Dimethyldihydropyran-12-ol Ring (Ring C)
1997
Automated Process Research. An Example of Accelerated Optimization of the Friedel−Crafts Acylation Reaction, a Key Step for the Synthesis of Anti-HIV (+)-Calanolide A
2000
Synthesis of (+)-calanolide A, an anti-HIV agent, Via enzyme-catalyzed resolution of the aldol products
1996
Robustaflavone, a naturally occurring biflavanoid, is a potent non-nucleoside inhibitor of hepatitis B virus replication in vitro
1997
Structural analogues of the michellamine anti-HIV agents. Importance of the tetrahydroisoquinoline rings for biological activity
1997
Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography
2009
Total Synthesis of Robustaflavone, a Potential Anti-Hepatitis B Agent
1998
Synthesis of 5-Alkyl- and 5-Aryl-L-Tryptophan Analogues via Palladium-Catalyzed Cross-Coupling of an Iodinated Cyclic Tryptophan Tautomer
1994