Citation Impact
Citing Papers
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
2020 StandoutScience
Chemical Structure in Relation to Biological Activities of Vitamin B6
1958
The development of mechanistic enzymology in the 20th century
2001
Pyridoxal phosphate-dependent enzymes
1995
Phosphate Recognition in Structural Biology
2006
Hydrolytic Stability of Hydrazones and Oximes
2008
Rack‐induced bonding in blue‐copper proteins
1994
Controlling reaction specificity in pyridoxal phosphate enzymes
2011
JLigand: a graphical tool for the CCP4 template-restraint library
2012
Allosteric regulation of substrate channeling and catalysis in the tryptophan synthase bienzyme complex
2012
Substitution of glutamic acid 109 by aspartic acid alters the substrate specificity and catalytic activity of the .beta.-subunit in the tryptophan synthase bienzyme complex from Salmonella typhimurium
1992
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
1996 StandoutNature
Why ion pair reversal by protein engineering is unlikely to succeed
1988 StandoutNatureNobel
Nature of the primary photochemical events in rhodopsin and bacteriorhodopsin
1990
Crystal structure of photosystem II from Synechococcus elongatus at 3.8 Å resolution
2001 StandoutNature
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
Simple yet functional phosphate-loop proteins
2018 StandoutNobel
Picosecond solvation dynamics of coumarin 153: The importance of molecular aspects of solvation
1987
Glutamic Acid Decarboxylase
1960
Arginine Decarboxylase from Escherichia coli
1968
Spectrophotometric study of the enzyme-substrate complex of phosphorylase b
1968
The Enzymatic Oxidation of Pyridoxine and Pyridoxamine Phosphates
1961
Structural and Functional Aspects of Domain Motions in Proteins
1984 StandoutNobel
Base or copper promoted annulation reactions of α-aminohydrazones
1997
Oxidative deamination and oxygenation of a cu II Schiff base complex
1990
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
GLUTAMIC ASPARTIC TRANSAMINASE
1957
Crystallization and properties of glutamate decarboxylase from Escherichia coli strain W
1967 StandoutNobel
Antibody–antigen flexibility
1987 StandoutNatureNobel
Properties and catalytic activities of vitamin B6 N-oxide
1969
Synthesis of analogs of pyridoxal 5'-phosphate
1969 StandoutNobel
Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing
1996 StandoutScienceNobel
Femtosecond to nanosecond solvation dynamics in pure water and inside the γ-cyclodextrin cavity
1995
Interaction of muscle glycogen phosphorylase with pyridoxal 5′-methylenephosphonate
1974 StandoutNobel
Advanced Glycation End Products
2006 Standout
Evidence for a Rate-determining Proton Abstraction in the Serine Deaminase Reaction of the β2 Subunit of Tryptophan Synthetase
1974
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
1976 Standout
Molar absorptivity and A1cm1% values for proteins at selected wavelengths of the ultraviolet and visible regions. VIII
1973
METAL IONS IN BIOLOGICAL SYSTEMS
1953
Ultrafast solvation dynamics at binding and active sites of photolyases
2010 StandoutNobel
Biosynthetic Arginine Decarboxylase from Escherichia coli
1973
Synthesis of functionalised pyrazolones and imidazolines/imidazoles through divergent cyclisation reactions
2001
Chiroptical Molecular Switches
2000 StandoutNobel
On the Role of Pyridoxal 5'-Phosphate in Phosphorylase. I. Absence of Classical Vitamin B6—dependent Enzymatic Activities in Muscle Glycogen Phosphorylase*
1965 StandoutNobel
Threonine Synthetase Mechanism: Studies with Isotopic Hydrogen
1960
STEREOCHEMISTRY AND THE MECHANISM OF ENZYMATIC REACTIONS
1953
Pyridoxal- and metal ion-catalyzed oxidative deamination of alpha amino acids
1987
Glutamic Acid Decarboxylase
1960
Immune Versus Natural Selection: Antibody Aldolases with Enzymic Rates But Broader Scope
1997 StandoutScienceNobel
PROPERTIES OF CRYSTALLINE PHOSPHORYLASE b
1958 StandoutNobel
Carbohydrate-Mediated Purification of Petrochemicals
2015 StandoutNobel
THE SITE OF BINDING OF PYRIDOXAL-5′-PHOSPHATE TO HEAR GLUTAMIC-ASPARTIC TRANSAMINASE
1962 StandoutNobel
The isolation of pyridoxal-5-phosphate from crystalline muscle phosphorylase
1957
Pyridoxamine-Pyruvate Transaminase. II. Characteristics of the Enzyme*
1963
Spectrophotometric Determination of Pyridoxal in the Presence of Pyridoxamine and Pyridoxine.
1962
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
2017 StandoutNobel
Pyridoxal Phosphate Enzymes: Mechanistic, Structural, and Evolutionary Considerations
2004
Mechanism of mutual activation of the tryptophan synthase alpha and beta subunits. Analysis of the reaction specificity and substrate-induced inactivation of active site and tunnel mutants of the beta subunit.
1991
Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure
1984
A Pictet-Spengler ligation for protein chemical modification
2012 StandoutNobel
Manganese Cluster in Photosynthesis: Where Plants Oxidize Water to Dioxygen
1996
NMR Crystallography of a Carbanionic Intermediate in Tryptophan Synthase: Chemical Structure, Tautomerization, and Reaction Specificity
2016
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Direct α-Arylation of α-Amino Carbonyl Compounds with Indoles Using Visible Light Photoredox Catalysis
2012
Aerobic Copper-Catalyzed Organic Reactions
2013 Standout
The nature of the hydrated excess proton in water
1999 StandoutNature
Arginine Decarboxylase from Escherichia coli
1969 StandoutNobel
Proline-Catalyzed Direct Asymmetric Aldol Reactions
2000 StandoutNobel
THE REACTION OF SODIUM BOROHYDRIDE WITH MUSCLE PHOSPHORYLASE1
1958 StandoutNobel
Ultrafast Dynamics of Flavins in Five Redox States
2008 StandoutNobel
Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase
2016 StandoutNobel
Enzymatic Transamination of Pyridoxamine
1962
The Mechanism of Tryptophan Binding to Tryptophan Synthase from Escherichia coli
1981
SERINE DEAMINATION BY THE B PROTEIN OF ESCHERICHIA COLI TRYPTOPHAN SYNTHETASE
1964
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Pyridoxal-Catalyzed Decarboxylation of Amino Acids*
1962
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Protonation States of the Tryptophan Synthase Internal Aldimine Active Site from Solid-State NMR Spectroscopy: Direct Observation of the Protonated Schiff Base Linkage to Pyridoxal-5′-Phosphate
2014
Reconstitution of apophosphorylase with pyridoxal 5'-phosphate analogs
1969 StandoutNobel
Highly Efficient ReversibleZ−EPhotoisomerization of a Bridged Azobenzene with Visible Light through Resolved S1(nπ*) Absorption Bands
2009
The Reduction of Flavins by Borohydride: 3,4‐Dihydroflavin
1969
THE ABSOLUTE STEREOCHEMICAL COURSE OF CITRIC ACID BIOSYNTHESIS
1963 StandoutNobel
Computer simulations of enzyme catalysis: Finding out what has been optimized by evolution
1998 StandoutNobel
Tertiary Structure Around the Guanosine-Binding Site of the Tetrahymena Ribozyme
1992 ScienceNobel
The Relation of Spectral Changes and Tritium Exchange Reactions to the Mechanism of Tryptophanase-catalyzed Reactions
1967
Is the mechanism of the proline-catalyzed enantioselective aldol reaction related to biochemical processes ?
1986
Synthesis and properties of α and ε pyridoxyl lysines and their phosphorylated derivatives
1971 StandoutNobel
Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
2013 Standout
Thiamin Diphosphate Catalysis: Enzymic and Nonenzymic Covalent Intermediates
2008
Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag
2011 StandoutNobel
Asymmetric Enamine Catalysis
2007 StandoutNobel
On Low-Barrier Hydrogen Bonds and Enzyme Catalysis
1995 StandoutScienceNobel
Microwave Spectrum of CH2DCH : CH2; Equilibrium Conformation of Propylene
1958 StandoutNobel
Light-Triggered Proton and Electron Transfer in Flavin Cofactors
2008
Energy considerations show that low-barrier hydrogen bonds do not offer a catalytic advantage over ordinary hydrogen bonds
1996 StandoutNobel
Frozen Density Functional Free Energy Simulations of Redox Proteins: Computational Studies of the Reduction Potential of Plastocyanin and Rusticyanin
2003 StandoutNobel
Low-Barrier Hydrogen Bonds and Enzymic Catalysis
1994 StandoutScience
Kinetic and Stereochemical Evidence for the Involvement of Only One Proline Molecule in the Transition States of Proline-Catalyzed Intra- and Intermolecular Aldol Reactions
2002 StandoutNobel
Chemical properties of Escherichia coli lysine decarboxylase including a segment of its pyridoxal 5'-phosphate binding site
1974 StandoutNobel
The Catalytic Mechanism of Tryptophan Synthase from Escherichia coli
1983
Biomass Recalcitrance: Engineering Plants and Enzymes for Biofuels Production
2007 StandoutScience
Works of David E. Metzler being referenced
Role of an Active Site Residue Analyzed by Combination of Mutagenesis and Coenzyme Analog
1993
Quantitative description of absorption spectra of a pyridoxal phosphate-dependent enzyme using lognormal distribution curves
1987
Spectroscopic studies of quinonoid species from pyridoxal 5'-phosphate
1988
Synthesis of vitamin b6derivatives. II. 3‐Hydroxy‐4‐hydroxymethyl‐2‐methyl‐5‐pyridine acetic acid and related substances
1966
Spectra of 3-hydroxypyridines. Band-shape analysis and evaluation of tautomeric equilibriums
1973
Shapes of spectral bands of visual pigments
1978
Synthesis of vitamin B6derivatives I. Preparation of some isopyridoxamine derivatives from isopyridoxal
1966
The oxidation of a reduced pyridine nucleotide analog by flavins
1960
Reaction of apoaspartate aminotransferase with analogs of pyridoxal phosphate
1969
Equilibria and absorption spectra of tryptophanase
1991
NMR observation of exchangeable protons of pyridoxal phosphate and histidine residues in cytosolic aspartate aminotransferase.
1991
A novel reaction of the coenzyme of glutamate decarboxylase with L-serine O-sulfate
1982
Structures of Thiamine in Basic Solution1
1957
Band Shapes of the Electronic Spectra of Complex Molecules
1969
Crystalline enzyme.substrate complexes of asparate aminotransferase
1978
Water-Soluble Vitamins Part II
1956
Spectra and Ionization Constants of the Vitamin B6 Group and Related 3-Hydroxypyridine Derivatives1
1955
PHOTOCHEMICAL DEGRADATION OF FLAVINS‐IV. STUDIES OF THE ANAEROBIC PHOTOLYSIS OF RIBOFLAVIN*
1967
DEAMINATION OF SERINE
1952
Covalently modified peptides isolated from aspartate aminotransferase after reaction with pyridoxal 5'-sulfate
1982
Metals and Enzyme Activity.
1959
Equilibria between Pyridoxal and Amino Acids and their Imines1
1957
2-(Hydroxymethyl) aspartic acid: synthesis, crystal structure, and reaction with a transaminase
1980
The Reversible Catalytic Cleavage of Hydroxyamino Acids by Pyridoxal and Metal Salts1
1954
Circular dichroism of L-glutamic acid decarboxylase
1967
Synthesis of vitamin B6 derivatives. III. 3‐ (4‐formyl‐3‐hydroxy‐2‐methyl‐5‐pyridyl)propionic acid, an analog of pyridoxal phosphate
1967
DEAMINATION OF SERINE
1952
Catalytic Racemization of Amino Acids by Pyridoxal and Metal Salts
1952
Schiff bases and geminal diamines derived from pyridoxal 5'-phosphate and diamines
1989
Equilibriums and absorption spectra of Schiff bases
1980
Metal Chelates of Imines Derived from Pyridoxal and Amino Acids1
1961
REVERSIBLE CATALYTIC CLEAVAGE OF HYDROXYAMINO ACIDS BY PYRIDOXAL AND METAL SALTS
1953
Transamination of Pyridoxamine and Amino Acids with Glyoxylic Acid1
1954
Some Transamination Reactions Involving Vitamin B61
1952
Refinement and Comparisons of the Crystal Structures of Pig Cytosolic Aspartate Aminotransferase and Its Complex with 2-Methylaspartate
1997
Chemistry of the inactivation of cytosolic aspartate aminotransferase by serine O-sulfate
1982
A General Mechanism for Vitamin B6-catalyzed Reactions1
1954
Tautomerism in Pyridoxal Phosphate and in Enzymatic Catalysis
1979