Citation Impact
Citing Papers
Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59
2012 StandoutNobel
Genetic Dissection of the Amyloid Precursor Protein in Developmental Function and Amyloid Pathogenesis
2010 StandoutNobel
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
2002
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
1998 StandoutNature
Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism
1995
A Critical Function for β-Amyloid Precursor Protein in Neuronal Migration Revealed by In Utero RNA Interference
2007
Apoptosis in the nervous system
2000 StandoutNature
The Amyloid-β Pathway in Alzheimer’s Disease
2021
Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein
1997 Nature
Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport
2004 StandoutNobel
Lessons from signature-tagged mutagenesis on the infectious mechanisms of pathogenic bacteria
2004
A review of neurohormone GPCRs present in the fruitfly Drosophila melanogaster and the honey bee Apis mellifera
2006
Alternative isoform regulation in human tissue transcriptomes
2008 StandoutNature
Mechanisms of Neuronal Degeneration in Alzheimer's Disease
1996
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
2000 StandoutNature
Laminins and human disease
2000
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid
1992 Standout
Structural and biochemical studies of retroviral proteases
2000
Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
1992 Nature
Neuropathological Diagnosis of Alzheimer’s Disease: A Perspective from Longitudinal Clinicopathological Studies
1997
Natural Selection for Kinetic Stability Is a Likely Origin of Correlations between Mutational Effects on Protein Energetics and Frequencies of Amino Acid Occurrences in Sequence Alignments
2006
Autophagy regulates lipid metabolism
2009 StandoutNature
Analysis of NPR-1 Reveals a Circuit Mechanism for Behavioral Quiescence in C. elegans
2013
Glycosylation in Cellular Mechanisms of Health and Disease
2006 Standout
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor
1993
Role of Endoplasmic Reticulum, Endosomal–Lysosomal Compartments, and Microtubules in Amyloid Precursor Protein Metabolism of Human Neurons
1999
Zinc takes the center stage: its paradoxical role in Alzheimer’s disease
2003
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Aggregation of Secreted Amyloid β-Protein into Sodium Dodecyl Sulfate-stable Oligomers in Cell Culture
1995
Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization
1995
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
Tyrosine Phosphorylation of the β-Amyloid Precursor Protein Cytoplasmic Tail Promotes Interaction with Shc
2002
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Immunohistochemical localization of beta‐amyloid precursor protein sequences in Alzheimer and normal brain tissue by light and electron microscopy
1992
Exon mutations uncouple 5′ splice site selection from U1 snRNA pairing
1990 StandoutNobel
RNA travel: Tracks from DNA to cytoplasm
1993 StandoutNobel
Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation
2004 StandoutNobel
The Levels of Soluble versus Insoluble Brain Aβ Distinguish Alzheimer's Disease from Normal and Pathologic Aging
1999
Toward a framework for sulfoproteomics: Synthesis and characterization of sulfotyrosine‐containing peptides
2007
Autophagy in Human Health and Disease
2013 Standout
Amyloidogenic Processing of Human Amyloid Precursor Protein in Hippocampal Neurons Devoid of Cathepsin D
1996
Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease
1995
Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide
1993
Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study
2005
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene
1992
Axonal Transection in the Lesions of Multiple Sclerosis
1998 Standout
Alzheimer's Disease
2010 Standout
Insights into social insects from the genome of the honeybee Apis mellifera
2006 StandoutNature
Generation of Amyloidogenic C-terminal Fragments during Rapid Axonal Transport in Vivo of β-Amyloid Precursor Protein in the Optic Nerve
1995
Hierarchy for 5′ splice site preference determined in vivo
1990
Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions
1992
Basolateral Secretion of Amyloid Precursor Protein in Madin-Darby Canine Kidney Cells Is Disturbed by Alterations of Intracellular pH and by Introducing a Mutation Associated with Familial Alzheimer's Disease
1995
Insoluble wild–type and protease–resistant mutant prion protein in brains of patients with inherited prion disease
1996 StandoutNobel
Regulation by HIV Rev depends upon recognition of splice sites
1989 StandoutNobel
Amyloid β-peptide is produced by cultured cells during normal metabolism
1992 StandoutNature
Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments
1992 Nature
α1‐Antichymotrypsin Binding to Alzheimer Aβ Peptides Is Sequence Specific and Induces Fibril Disaggregation In Vitro
1993
Neurofibrillary Tangles Mediate the Association of Amyloid Load With Clinical Alzheimer Disease and Level of Cognitive Function
2004
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
1999 StandoutNature
Antibacterial drug discovery in the resistance era
2016 StandoutNature
Regulation of Alternative Splicing
1990
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
1999 StandoutNature
Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor
1993 Science
Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
1992 StandoutNature
Framing β–amyloid
1992
The Alzheimer's disease sphinx: a riddle with plaques and tangles.
1994
Lecanemab in Early Alzheimer’s Disease
2022 Standout
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells
1993
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.
1988
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
1996 StandoutScience
An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants
1994 StandoutScience
Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons
1996
A Century of Alzheimer's Disease
2006 StandoutScience
Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative.
1994
Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives
1992 Science
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
1993 Standout
A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau
1991 Science
Synthesis of Sulfotyrosine‐Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc‐Based Solid‐Phase Strategy
2015 StandoutNobel
Proteolytic Release of Membrane-Bound Angiotensin-Converting Enzyme: Role of the Juxtamembrane Stalk Sequence
1996
Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes
2019 StandoutNobel
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
The cerebrospinal-fluid soluble form of Alzheimer's amyloid β is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex
1993
Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.
1993
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
2005 StandoutScience
Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease
1997
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
1993 StandoutNatureNobel
Angiotensin-converting enzyme and male fertility
1998 StandoutNobel
Evidence that production and release of amyloid beta-protein involves the endocytic pathway
1994
Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.
1995
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
1996 StandoutNature
Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing
1992 StandoutScience
Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells
1997
Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.
1993
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
2004 StandoutNobel
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of David E. Lowery being referenced
Characterization of high affinity binding between laminin and Alzheimer's disease amyloid precursor proteins.
1992
High affinity interactions between the Alzheimer's beta-amyloid precursor proteins and the basement membrane form of heparan sulfate proteoglycan
1991
Type A Allatostatins from Drosophila melanogaster and Diplotera puncata Activate Two Drosophila Allatostatin Receptors, DAR-1 and DAR-2, Expressed in CHO Cells
2001
Identification of Actinobacillus pleuropneumoniae virulence genes using signature-tagged mutagenesis in a swine infection model
2000
Identification of Pasteurella multocida virulence genes in a septicemic mouse model using signature-tagged mutagenesis
2000
Alzheimer's disease: β-amyloid precursor protein expression in plaques varies among cytoarchitectonic areas of the medial temporal lobe
1991
Differential Activation of “Social” and “Solitary” Variants of the Caenorhabditis elegans G Protein-coupled Receptor NPR-1 by Its Cognate Ligand AF9
2003
Expression patterns of β‐amyloid precursor protein (β‐APP) in neural and nonneural human tissues from alzheimer's disease and control subjects
1991
Cloning and Functional Expression of the First Drosophila melanogaster Sulfakinin Receptor DSK-R1
2002
Comparison of in vitro and in vivo splice site selection in kappa-immunoglobulin precursor mRNA.
1988
Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.
1991
Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease.
1990
Subcellular localization of amyloid precursor protein in senile plaques of Alzheimer's disease.
1992
Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus
1991
In vitro splicing of kappa immunoglobulin precursor mRNA.
1987
Equilibrium and kinetic measurements of the conformational transition of thioredoxin in urea
1986
Alzheimer's amyloid precursor protein produced by recombinant baculovirus expression. Proteolytic processing and protease inhibitory properties.
1991
Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor
1992 Science
Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.
1990