Citation Impact
Citing Papers
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
Principles for designing proteins with cavities formed by curved β sheets
2017 StandoutScienceNobel
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
Chemical warfare agents
2008
Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases
2012 StandoutNobel
Evolutionary History of a Specialized P450 Propane Monooxygenase
2008 StandoutNobel
Catalytic mechanisms for phosphotriesterases
2012
Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
1998 StandoutNature
Progress in the development of enzyme-based nerve agent bioscavengers
2013
Pseudo-catalytic scavenging: Searching for a suitable reactivator of phosphorylated butyrylcholinesterase
2010
Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro
2014
Demonstration of in vivo stability and lack of immunogenicity of a polyethyleneglycol-conjugated recombinant CHO-derived butyrylcholinesterase bioscavenger using a homologous macaque model
2010
Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II
2000
Enzyme-Linked Immunosorbent Assay
2000
Species Difference of Esterase Expression and Hydrolase Activity in Plasma
2012
Degradation of nerve agents by an organophosphate-degrading agent (OpdA)
2008
In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP)
2013
A De Novo Protein Binding Pair By Computational Design and Directed Evolution
2011 StandoutNobel
Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase
2014
Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity
1993
Management of acute organophosphorus pesticide poisoning
2007 Standout
Catalytic bioscavengers in nerve agent poisoning: A promising approach?
2015
Increased Diels-Alderase activity through backbone remodeling guided by Foldit players
2012 StandoutNobel
Neurological aspects of organophosphate poisoning
1992
Catalytic Versatility and Backups in Enzyme Active Sites: The Case of Serum Paraoxonase 1
2012
Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents
2011
Aging-Resistant Organophosphate Bioscavenger Based on Polyethylene Glycol-Conjugated F338A Human Acetylcholinesterase
2008
Computational Enzyme Design
2013 StandoutNobel
Contribution of Aromatic Moieties of Tyrosine 133 and of the Anionic Subsite Tryptophan 86 to Catalytic Efficiency and Allosteric Modulation of Acetylcholinesterase
1995
Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection
2016
The Role of Oximes in the Management of Organophosphorus Pesticide Poisoning
2003
Acetylcholinesterase: Converting a vulnerable target to a template for antidotes and detection of inhibitor exposure
2006
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Structure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and Serotonin
2012 StandoutNobel
Pro-2-PAM therapy for central and peripheral cholinesterases
2010
Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
2015 StandoutNobel
The Role of Phosphotriesterases in the Detoxication of Organophosphorus Compounds
1999
New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases
2011 StandoutNobel
Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers
2010
VX Hydrolysis by Human Serum Paraoxonase 1: A Comparison of Experimental and Computational Results
2011
Esterase metabolism of cholinesterase inhibitors using rat liver in vitro
2011
Enzyme promiscuity: evolutionary and mechanistic aspects
2006
Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation
2010
Current and emerging strategies for organophosphate decontamination: special focus on hyperstable enzymes
2016
Control of nerve agent-induced seizures is critical for neuroprotection and survival☆ ☆The animals used in these studies were handled in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals, proposed by the Committee to Revise the Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources, National Research Council, and published by National Academy Press, 1996, and the Animal Welfare Act of 1966, as amended. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as reflecting the views of the Department of the Army or the Department of Defense.
2003
Directed evolution of hydrolases for prevention of G-type nerve agent intoxication
2011
Sofosbuvir Inhibits Hepatitis E Virus Replication In Vitro and Results in an Additive Effect When Combined With Ribavirin
2015 StandoutNobel
Comparison of kinetic parameters for acetylthiocholine, soman, ketamine and fasciculin towards acetylcholinesterase in liposomes and in solution
1990
Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases
2008
Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: A kinetic analysis
2009
Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning
1997
Cholinesterases as scavengers for organophosphorus compounds: Protection of primate performance against soman toxicity
1993
Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent Sarin
2010
Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase
2019 StandoutNobel
The Cholinesterases: From Genes to Proteins
1994
A comprehensive evaluation of novel oximes in creation of butyrylcholinesterase-based nerve agent bioscavengers
2016
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Asymmetric fluorogenic organophosphates for the development of active organophosphate hydrolases with reversed stereoselectivity
2006
Novel oximes as blood–brain barrier penetrating cholinesterase reactivators
2010
The Histidine 115-Histidine 134 Dyad Mediates the Lactonase Activity of Mammalian Serum Paraoxonases
2006
The Stoichiometry of Protection against Soman and VX Toxicity in Monkeys Pretreated with Human Butyrylcholinesterase
1997
CHOLINESTERASES, A TARGET OF PHARMACOLOGY AND TOXICOLOGY
2011
Design of activated serine–containing catalytic triads with atomic-level accuracy
2014 StandoutNobel
Structure, Activities and Biomedical Applications of Human Butyrylcholinesterase
2009
Identification and characterization of novel catalytic bioscavengers of organophosphorus nerve agents
2012
Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase
2006
Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples
2008
Acetylcholinesterase Inhibitors: Pharmacology and Toxicology
2013 Standout
Bivalent Ligands Derived from Huperzine A as Acetylcholinesterase Inhibitors
2007
Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study
2014
HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants
2016
Crystal structure of diisopropylfluorophosphatase from Loligo vulgaris
2001
Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks
2002 StandoutNobel
The Effects of Fresh Frozen Plasma on Cholinesterase Levels and Outcomes in Patients with Organophosphate Poisoning
2004
Organophosphates⧸Nerve Agent Poisoning: Mechanism of Action, Diagnosis, Prophylaxis, And Treatment
2004
Oxime-assisted Acetylcholinesterase Catalytic Scavengers of Organophosphates That Resist Aging
2011 StandoutNobel
Combined Serum Paraoxonase Knockout/Apolipoprotein E Knockout Mice Exhibit Increased Lipoprotein Oxidation and Atherosclerosis
2000 Standout
Pharmacokinetics and immunologic consequences of exposing macaques to purified homologous butyrylcholinesterase
2002
Stereoselectivity of soman detoxication by organophosphorus acid anhydrases from Escherichia coli
1993 StandoutNobel
Paraoxonase prevents accumulation of lipoperoxides in low‐density lipoprotein
1991 Standout
Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro
2015 StandoutNobel
Neurosensory mechanotransduction
2008 StandoutNobel
Evolved Stereoselective Hydrolases for Broad-Spectrum G-Type Nerve Agent Detoxification
2012
In search of a catalytic bioscavenger for the prophylaxis of nerve agent toxicity
2010
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
MEC-2 and MEC-6 in the Caenorhabditis elegans Sensory Mechanotransduction Complex: Auxiliary Subunits that Enable Channel Activity
2008
Self-reported Exposure to Neurotoxic Chemical Combinations in the Gulf War<subtitle>A Cross-sectional Epidemiologic Study</subtitle>
1997 Standout
Rapid Diagnostic Assay for Intact Influenza Virus Using a High Affinity Hemagglutinin Binding Protein
2017 StandoutNobel
Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase
2016 StandoutNobel
Complex View on Poisoning with Nerve Agents and Organophosphates
2005
Inhibitory Potency against Human Acetylcholinesterase and Enzymatic Hydrolysis of Fluorogenic Nerve Agent Mimics by Human Paraoxonase 1 and Squid Diisopropyl Fluorophosphatase
2008
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers
2017 StandoutNobel
In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications
2004 StandoutNobel
Cholinesterase reactivators and bioscavengers for pre‐ and post‐exposure treatments of organophosphorus poisoning
2017
Destruction and Detection of Chemical Warfare Agents
2011
In the light of directed evolution: Pathways of adaptive protein evolution
2009 StandoutNobel
Atherosclerosis: Basic Mechanisms
1995 Standout
Sequence–Structure–Binding Relationships Reveal Adhesion Behavior of the Car9 Solid-Binding Peptide: An Integrated Experimental and Simulation Study
2020 StandoutNobel
Recent advances in the treatment of organophosphorous poisonings.
2012
Reactivation of Tabun-inhibited Acetylcholinesterase Investigated by Two Oximes and Mutagenesis
2012
Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre
1996
Zr-based metal–organic frameworks: design, synthesis, structure, and applications
2016 Standout
The Cation−π Interaction
1997 Standout
Binding of a Designed Substrate Analogue to Diisopropyl Fluorophosphatase: Implications for the Phosphotriesterase Mechanism
2006
Progress in Medical Defense Against Nerve Agents
1989
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
Translation of in vitro to in vivo pyridinium oxime potential in tabun poisoning / Translacija učinkovitosti piridinijevih oksima kod trovanja tabunom iz in vitro sustava u in vivo primjenu
2015
In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species
2011
Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
2010 Standout
Protein- and Peptide-Directed Syntheses of Inorganic Materials
2008
Production of a recombinant antibody fragment in whole insect larvae
2007
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Biomaterials for Mediation of Chemical and Biological Warfare Agents
2003
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)
2018 Standout
Gold Nanoparticles in Chemical and Biological Sensing
2012 Standout
Serum Albumin is as Efficient as Paraxonase in the Detoxication of Paraoxon at Toxicologically Relevant Concentrations
2008
Imidazole Aldoximes Effective in Assisting Butyrylcholinesterase Catalysis of Organophosphate Detoxification
2014 StandoutNobel
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
2004 StandoutNobel
Stereoselective Hydrolysis of Organophosphate Nerve Agents by the Bacterial Phosphotriesterase
2010
Magnetic Electrochemical Sensing Platform for Biomonitoring of Exposure to Organophosphorus Pesticides and Nerve Agents Based on Simultaneous Measurement of Total Enzyme Amount and Enzyme Activity
2011
Nerve agent stereoisomers: analysis, isolation and toxicology
1988
In vitro and in vivo efficacy of PEGylated diisopropyl fluorophosphatase (DFPase)
2011
De Novo Computational Design of Retro-Aldol Enzymes
2008 StandoutScienceNobel
Reaction Products of Acetylcholinesterase and VX Reveal a Mobile Histidine in the Catalytic Triad
1999
Origin of the Catalytic Power of Acetylcholinesterase: Computer Simulation Studies
1998 StandoutNobel
Aging Mechanism of Soman Inhibited Acetylcholinesterase
2012
Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes
2015
Engineering V-Type Nerve Agents Detoxifying Enzymes Using Computationally Focused Libraries
2013 StandoutNobel
Engineered recombinant human paraoxonase 1 (rHuPON1) purified fromEscherichia coliprotects against organophosphate poisoning
2008
Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes
2012
Works of David E. Lenz being referenced
Effect of carboxylesterase inhibition on carbamate protection against soman toxicity.
1988
Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates.
1991
The Role of Glutamate-199 in the Aging of Cholinesterase
1993
Direct detection of stereospecific soman hydrolysis by wild‐type human serum paraoxonase
2007
Butyrylcholinesterase as a therapeutic drug for protection against percutaneous VX
2010
Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: A mini review
2006
Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure
2010
A Gas Chromatographic-Mass Spectrometric Approach to Examining Stereoselective Interaction of Human Plasma Proteins with Soman*
2008
Monoclonal antibodies against soman: characterization of soman stereoisomers
1992
Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman
2005
Purification and characterization of functional human paraoxonase-1 expressed in Trichoplusia ni larvae
2010
Organophosphate skin decontamination using immobilized enzymes
1999
(07) In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia™) as a potential nerve agent bioscavenger
2005
Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys
2005
Role of immunogen design in induction of soman-specific monoclonal antibodies
2004
Hypothesis for Synergistic Toxicity of Organophosphorus Poisoning-induced Cholinergic Crisis and Anaphylactoid Reactions
1996
Partial characterization of an enzyme that hydrolyzes sarin, soman, tabun, and diisopropyl phosphorofluoridate (DFP)
1989
Post-exposure therapy with human butyrylcholinesterase following percutaneous VX challenge in guinea pigs
2011
Efficacy and physiological effects of human butyrylcholinesterase as a post-exposure therapy against percutaneous poisoning by VX in the guinea-pig
2010
In silico analyses of substrate interactions with human serum paraoxonase 1
2008
A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters
2008
DNA aptamers developed against a soman derivative cross‐react with the methylphosphonic acid core but not with flanking hydrophobic groups
2008
Catalytic antibodies hydrolysing organophosphorus esters
1993
Computational modeling of human paraoxonase 1: preparation of protein models, binding studies, and mechanistic insights
2010
Specific soman-hydrolyzing enzyme activity in a clonal neuronal cell culture
1988
Behavioral decrements persist in rhesus monkeys trained on a serial probe recognition task despite protection against soman lethality by butyrylcholinesterase
1994
Bioscavenger for Protection From Toxicity of Organophosphorus Compounds
2006
Analysis of active‐site amino‐acid residues of human serum paraoxonase using competitive substrates
2005
Structure/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model
2004
Development of an immunoassay for diagnosis of exposure to toxic organophosphorus compounds
2001
On the nature of the serum enzyme catalyzing paraoxon hydrolysis
1973
Structural and stereochemical specificity of mouse monoclonal antibodies to the organophosphorous cholinesterase inhibitor soman.
1985
Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents
2010
Dramatic Differences in Organophosphorus Hydrolase Activity between Human and Chimeric Recombinant Mammalian Paraoxonase-1 Enzymes
2009
The effects of blood flow and detoxification on in vivo cholinesterase inhibition by soman in rats
1987
Kinetic properties of soluble and membrane-bound acetylcholinesterase from electric eel
1984
Antibody quantitation using an immunoadsorbent and the unlabeled antibody enzyme method
1976
Rapid Production of Recombinant Proteins Utilizing the PERLXpress Platform
2006
Inhibition of rat cerebrum acetylcholinesterase isoenzymes after acute administration of soman
1981