Citation Impact
Citing Papers
2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults
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Long-term Effects of a Lifestyle Intervention on Weight and Cardiovascular Risk Factors in Individuals With Type 2 Diabetes Mellitus
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Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
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In vivo gene editing in dystrophic mouse muscle and muscle stem cells
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Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance
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Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice
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Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice
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Lifestyle Change and Mobility in Obese Adults with Type 2 Diabetes
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Carnitine Insufficiency Caused by Aging and Overnutrition Compromises Mitochondrial Performance and Metabolic Control
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The promise and challenge of therapeutic genome editing
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Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.
1996
Specific Effects of Biliopancreatic Diversion on the Major Components of Metabolic Syndrome
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Mechanism of free fatty acid-induced insulin resistance in humans.
1996
Regional uptake of meal fatty acids in humans
2003
The unfolded protein response in human skeletal muscle is not involved in the onset of glucose tolerance impairment induced by a fat-rich diet
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Contributions of Insulin-Resistance and Insulin-Secretory Defects to the Pathogenesis of Type 2 Diabetes Mellitus
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Clinical and pathophysiological consequences of abdominal adiposity and abdominal adipose tissue depots
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Impact of a Weight Management Program on Health-Related Quality of Life in Overweight Adults With Type 2 Diabetes
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Metabolic Syndrome and Cardiovascular Mortality in Older Type 2 Diabetic Patients: A Longitudinal Study
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Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-α
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Leg Muscle Mass and Composition in Relation to Lower Extremity Performance in Men and Women Aged 70 to 79: The Health, Aging and Body Composition Study
2002
Adipose tissue as a buffer for daily lipid flux
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Sarcopenia: Diagnosis and treatment
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Inflammation and metabolic disorders
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The importance of diagnostic criteria in the association between the metabolic syndrome and cardiovascular disease in obese subjects
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Weight management through lifestyle modification for the prevention and management of type 2 diabetes: rationale and strategies. A statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American Society for Clinical Nutrition
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SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism
2011
Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-β agonist
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Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes
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Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity
1999
Epidemiology of the Metabolic Syndrome
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Acute effects of gastric bypass versus gastric restrictive surgery on β-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes
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Hormonal mechanisms of weight loss and diabetes resolution after bariatric surgery
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The metabolic syndrome: similar deleterious impact on all-cause mortality in hypertensive and normotensive subjects
2008
The association of regional fat depots withhypertension in older persons of white and African American ethnicity
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A Randomized Study on the Effect of Weight Loss on Obstructive Sleep Apnea Among Obese Patients With Type 2 Diabetes<subtitle>The Sleep AHEAD Study</subtitle><alt-title>Effect of Weight Loss on Obstructive Sleep Apnea</alt-title>
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Plasma Acylcarnitine Profiles Suggest Incomplete Long-Chain Fatty Acid β-Oxidation and Altered Tricarboxylic Acid Cycle Activity in Type 2 Diabetic African-American Women
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Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women
2004
The metabolic syndrome and its components and the long-term risk of death in patients with coronary heart disease
2006
Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes
1999
Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials
2003
Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus.
1998
Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease
2004
The metabolic syndrome
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Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
2008 Standout
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
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Bariatric Surgery
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Is mitochondrial dysfunction a cause of insulin resistance?
2008
Glucoregulatory Relevance of Small Intestinal Nutrient Sensing in Physiology, Bariatric Surgery, and Pharmacology
2015
Impact of Abdominal Visceral and Subcutaneous Adipose Tissue on Cardiometabolic Risk Factors: The Jackson Heart Study
2010
A motivation-focused weight loss maintenance program is an effective alternative to a skill-based approach
2010
Alterations in Muscle Attenuation following Detraining and Retraining in Resistance-Trained Older Adults
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In Situ Evidence That Peripheral Insulin Resistance in Adolescents with Poorly Controlled Type 1 Diabetes Is Associated with Impaired Suppression of Lipolysis: A Microdialysis Study
2003
Relationship between Generalized and Upper Body Obesity to Insulin Resistance in Asian Indian Men1
1999
Adjustable Gastric Banding and Conventional Therapy for Type 2 Diabetes
2008
Four‐Year Weight Losses in the Look AHEAD Study: Factors Associated With Long‐Term Success
2011
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
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Can Diabetes Be Surgically Cured? Long-Term Metabolic Effects of Bariatric Surgery in Obese Patients with Type 2 Diabetes Mellitus
2013
Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus
2003
Safety of Drug Therapies Used for Weight Loss and Treatment of Obesity
2006
Exercise without weight loss is an effective strategy for obesity reduction in obese individuals with and without Type 2 diabetes
2005
Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 5-Year Outcomes
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Accumulated versus Continuous Exercise for Health Benefit
2008
A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM
1995
Waist Circumference, Body Mass Index, and Survival in Systolic Heart Failure: The Obesity Paradox Revisited
2011
Skeletal muscle is a major site of lactate uptake and release during hyperinsulinemia
1992
Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice
2015
Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity
2014
Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM
1996
Why might South Asians be so susceptible to central obesity and its atherogenic consequences? The adipose tissue overflow hypothesis
2007
Adipose Tissue Quantification by Imaging Methods: A Proposed Classification
2003
Relationship between Abdominal Fat Compartments and Glucose and Lipid Metabolism in Early Postmenopausal Women1
2001
Tipping the metabolic scales towards increased longevity in mammals
2015
Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle
2004
Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus.
1992
Racial Differences in Adipocyte Size and Relationship to the Metabolic Syndrome in Obese Women
2004
Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes
2005
Glucose uptake and insulin action in human adipose tissue—influence of BMI, anatomical depot and body fat distribution
2002
Strength and Muscle Quality in a Well‐Functioning Cohort of Older Adults: The Health, Aging and Body Composition Study
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Pharmacotherapy for NASH: Current and emerging
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Acute or Chronic Upregulation of Mitochondrial Fatty Acid Oxidation Has No Net Effect on Whole-Body Energy Expenditure or Adiposity
2010
Metabolic Syndrome and Risk of Cardiovascular Disease: A Meta-Analysis
2006
Risk of Myocardial Infarction and Heart Failure Among Metabolically Healthy But Obese Individuals
2013
The future of obesity reduction: beyond weight loss
2009
Weight and Type 2 Diabetes after Bariatric Surgery: Systematic Review and Meta-analysis
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Cellular mechanisms of insulin resistance
2000 Standout
High prevalence of metabolic syndrome among young women with premature coronary artery disease
2005
Abnormal hepatic apolipoprotein B metabolism in type 2 diabetes
2010
Sarcopenic obesity: definition, cause and consequences
2008
Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes
2007
13C and 31P NMR Studies on the Effects of Increased Plasma Free Fatty Acids on Intramuscular Glucose Metabolism in the Awake Rat
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Mechanisms of NAFLD development and therapeutic strategies
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What interventions should we add to weight reducing diets in adults with obesity? A systematic review of randomized controlled trials of adding drug therapy, exercise, behaviour therapy or combinations of these interventions
2004
The influence of physical activity on abdominal fat: a systematic review of the literature
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Adipokines in inflammation and metabolic disease
2011 Standout
Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance
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Changes in body weight and serum lipid profile in obese patients treated with orlistat in addition to a hypocaloric diet: a systematic review of randomized clinical trials
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Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease
2004
Molecular and cellular mechanisms of liver fibrosis and its regression
2020
Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism.
1990
Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease
2011
Metabolic Syndrome: Risk factor distribution and 18-year mortality in the Multiple Risk Factor Intervention Trial
2006
Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance
2006
Genetic Epidemiology of Insulin Resistance and Visceral Adiposity The IRAS Family Study Design and Methods
2003
The metabolic syndrome
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Sources of hepatic triglyceride accumulation during high‐fat feeding in the healthy rat
2008
Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance.
1998
Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomised clinical trial
2013
Benefits of Modest Weight Loss in Improving Cardiovascular Risk Factors in Overweight and Obese Individuals With Type 2 Diabetes
2011
POSTPRANDIAL HEPATIC GLYCOGEN SYNTHESIS IN LIVER TRANSPLANT RECIPIENTS1
2000
Intensive Lifestyle Intervention Improves Physical Function Among Obese Adults With Knee Pain: Findings From the Look AHEAD Trial
2010
Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion
2004
Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects.
1996
Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association
2021 Standout
The Metabolic Syndrome and Cardiovascular Risk
2010 Standout
Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 3-Year Outcomes
2014 Standout
Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial
2011
Insulin action and resistance in obesity and type 2 diabetes
2017
Diabetes and Atherosclerosis
2002 Standout
Fructose induced lipogenesis: from sugar to fat to insulin resistance
2010
Roux-en-Y Gastric Bypass vs Intensive Medical Management for the Control of Type 2 Diabetes, Hypertension, and Hyperlipidemia
2013
Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance
2017
Metformin hydrochloride in the treatment of type 2 diabetes mellitus: A clinical review with a focus on dual therapy
2003
The Utility of Physical Activity in the Management of Global Cardiometabolic Risk
2009
Liver, Muscle, and Adipose Tissue Insulin Action Is Directly Related to Intrahepatic Triglyceride Content in Obese Subjects
2008
Effect of a Free Prepared Meal and Incentivized Weight Loss Program on Weight Loss and Weight Loss Maintenance in Obese and Overweight Women
2010
Dose-Dependent Effects of Testosterone on Regional Adipose Tissue Distribution in Healthy Young Men
2004
Long-term effects of weight-reducing diets in hypertensive patients
2011
Weight Loss to Treat Urinary Incontinence in Overweight and Obese Women
2009 Standout
Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes
2012 Standout
Visceral Fat Is an Independent Predictor of All‐cause Mortality in Men
2006
Metabolic syndrome update
2015
Influence of Pro12Ala peroxisome proliferator-activated receptor γ2 polymorphism on glucose response to exercise training in type 2 diabetes
2005
Gastric Bypass vs Sleeve Gastrectomy for Type 2 Diabetes Mellitus
2011
Obesity, visceral fat and Crohnʼs disease
2010
Long-term effects of weight-reducing drugs in hypertensive patients
2009
Internet delivered behavioral obesity treatment
2010
Comparison of Usefulness of Body Mass Index Versus Metabolic Risk Factors in Predicting 10-Year Risk of Cardiovascular Events in Women
2007
Is visceral obesity the cause of the metabolic syndrome?
2006
Is weight loss the optimal target for obesity-related cardiovascular disease risk reduction?
2008
Increased Fat Intake, Impaired Fat Oxidation, and Failure of Fat Cell Proliferation Result in Ectopic Fat Storage, Insulin Resistance, and Type 2 Diabetes Mellitus
2002
Type 2 Diabetes and Weight Loss following Biliopancreatic Diversion for Obesity
2006
Lipin, a lipodystrophy and obesity gene
2005
Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance
2007
The Obesity Paradox in Men Versus Women With Systolic Heart Failure
2012
A Two-Year Randomized Trial of Obesity Treatment in Primary Care Practice
2011
Reduced glycogen synthase activity in skeletal muscle from obese patients with and without Type 2 (non-insulin-dependent) diabetes mellitus
1991
Long‐term changes in blood pressure following orlistat and sibutramine treatment: a meta‐analysis
2009
Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance
2008 Standout
Impact of metabolic syndrome on the outcome of patients with stable coronary artery disease: 2-year follow-up of the MASS II study
2008
Association of an Intensive Lifestyle Intervention With Remission of Type 2 Diabetes
2012
Long-term effects of weight-reducing drugs in hypertensive patients
2013
Metabolic Syndrome and Risk of Incident Cardiovascular Events and Death
2007 Standout
Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle
2000
Visceral and Intrahepatic Fat Are Associated with Cardiometabolic Risk Factors Above Other Ectopic Fat Depots: The Framingham Heart Study
2018
Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle
2007
Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle
2018
Relationship Between Hepatic/Visceral Fat and Hepatic Insulin Resistance in Nondiabetic and Type 2 Diabetic Subjects
2007
Strength, But Not Muscle Mass, Is Associated With Mortality in the Health, Aging and Body Composition Study Cohort
2006
The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones
2003
Associations of Muscle Strength and Fitness with Metabolic Syndrome in Men
2004
Sarcopenia: Its assessment, etiology, pathogenesis, consequences and future perspectives
2008
Mechanisms of fatty acid-induced inhibition of glucose uptake.
1994 Standout
Systematic review of long-term weight loss studies in obese adults: clinical significance and applicability to clinical practice
2005
Both Subcutaneous and Visceral Adipose Tissue Correlate Highly with Insulin Resistance in African Americans
2004
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Impaired adipose tissue lipid storage, but not altered lipolysis, contributes to elevated levels of NEFA in type 2 diabetes. Degree of hyperglycemia and adiposity are important factors
2016
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
2007 Standout
The Obese Without Cardiometabolic Risk Factor Clustering and the Normal Weight With Cardiometabolic Risk Factor Clustering
2008
Leisure-time physical activity and high-risk fat: a longitudinal population-based twin study
2009
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Body Fat Distribution, Adipocyte Size, and Metabolic Characteristics of Nondiabetic Adults
2009
Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat
1998
Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter
2010
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
2013
Lipid-induced insulin resistance: unravelling the mechanism
2010
Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects
2012
Relation of regional fat distribution to insulin sensitivity in postmenopausal women
2000
Surgical Removal of Omental Fat Does Not Improve Insulin Sensitivity and Cardiovascular Risk Factors in Obese Adults
2010
Role of Body Fat Distribution and the Metabolic Complications of Obesity
2008
Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes
2017
Abdominal Obesity, Muscle Composition, and Insulin Resistance in Premenopausal Women
2002
The Hallmarks of Aging
2013 Standout
Comparison of Cardioprotective Benefits of Vigorous Versus Moderate Intensity Aerobic Exercise
2005
Effect of Exercise and Pharmacological Interventions on Visceral Adiposity: A Systematic Review and Meta-analysis of Long-term Randomized Controlled Trials
2019
Gender differences in regional fatty acid metabolism before and after meal ingestion.
1995
Lipids, Lipoproteins, and Exercise
2002
NASH: a mitochondrial disease
2005
The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study
2006 Standout
Skeletal Muscle Fatty Acid Handling in Insulin Resistant Men
2011
Splanchnic lipolysis in human obesity
2004
Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic Model of Human Hepatic Glucose Metabolism
2012
Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency
2005
Physical Activity, Including Walking, and Cognitive Function in Older Women
2004
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
1999
31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus.
1992
Insulin Resistance: A Metabolic Pathway to Chronic Liver Disease *
2005
Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training
2005
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Insulin Signaling and Glucose Transport in Insulin Resistant Skeletal Muscle
1998
Obesity, Regional Body Fat Distribution, and the Metabolic Syndrome in Older Men and Women
2005
Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle
2012
Ethnic influences on the relations between abdominal subcutaneous and visceral adiposity, liver fat, and cardiometabolic risk profile: the International Study of Prediction of Intra-Abdominal Adiposity and Its Relationship With Cardiometabolic Risk/Intra-Abdominal Adiposity
2012
Prevention of fat-induced insulin resistance by salicylate
2001
Effect of 2 weeks of sprint interval training on health-related outcomes in sedentary overweight/obese men
2010
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
2004
Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms
2005
One‐year Weight Losses in the Look AHEAD Study: Factors Associated With Success
2009
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
2009
Sarcopenia != Dynapenia
2008
Clinical significance of the metabolic syndrome in the absence of established hypertension and diabetes: A community-based study
2007
Weight Loss Prevents Urinary Incontinence in Women With Type 2 Diabetes: Results From the Look AHEAD Trial
2012
Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance
2008
Intramyocellular lipids and insulin resistance
2004
Randomized Trial of a Multifaceted Commercial Weight Loss Program
2007
Body Fat Distribution and Insulin Resistance in Healthy Asian Indians and Caucasians
2001
Role of the glucosamine pathway in fat-induced insulin resistance.
1997
Waist circumference and abdominal adipose tissue distribution: influence of age and sex
2005
Adjustable Gastric Band Surgery or Medical Management in Patients With Type 2 Diabetes: A Randomized Clinical Trial
2015
Effect of thiazolidinediones on body weight in patients with diabetes mellitus
2003
Factors associated with percent change in visceral versus subcutaneous abdominal fat during weight loss: findings from a systematic review
2008
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
2003 Standout
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
2009 Standout
Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state
2005
Long-term rates of cardiovascular events in patients with the metabolic syndrome according to severity of coronary-angiographic alterations
2008
Bariatric surgery: an IDF statement for obese Type 2 diabetes
2011
Morphometric documentation of abnormal intramyocellular fat storage and reduced glycogen in obese patients with Type II diabetes
2001
Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans
2012
Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease
2014
Roux-en-Y Gastric Bypass Surgery or Lifestyle With Intensive Medical Management in Patients With Type 2 Diabetes
2014
Pathophysiology of Human Visceral Obesity: An Update
2013 Standout
Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction
2006
Diagnosis and Management of the Metabolic Syndrome
2005 Standout
2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults
2013 Standout
Visceral Adiposity Index
2010
Obesity Accelerates the Progression of Coronary Atherosclerosis in Young Men
2002
Regional Adiposity and Insulin Resistance
2004
Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients.
2000
Contribution of muscle and liver to glucose-fatty acid cycle in humans
1993
Baseline characteristics of the randomised cohort from the Look AHEAD (Action for Health in Diabetes) study
2006
Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans
2004
Reduction in Obesity and Related Comorbid Conditions after Diet-Induced Weight Loss or Exercise-Induced Weight Loss in Men
2000
Dual Metabolic Defects Are Required to Produce Hypertriglyceridemia in Obese Subjects
2011
Bariatric surgery: an IDF statement for obese Type 2 diabetes
2011
The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases
2010
Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy Adults
2011 Standout
Influence of Body Fat Content and Distribution on Variation in Metabolic Risk
2006
Insulin Sensitivity, Insulin Secretion, and Abdominal Fat
2003
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Hepatic ATGL knockdown uncouples glucose intolerance from liver TAG accumulation
2012
Long-term non-pharmacological weight loss interventions for adults with type 2 diabetes mellitus
2005
Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
2009 Standout
Type 2 diabetes: principles of pathogenesis and therapy
2005 Standout
Single-cell analysis of insulin-regulated fatty acid uptake in adipocytes
2010
Association of Bioavailable, Free, and Total Testosterone With Insulin Resistance
2004
Insulin Resistance Is Associated With Reduced Mitochondrial Oxidative Capacity Measured by 31P-Magnetic Resonance Spectroscopy in Participants Without Diabetes From the Baltimore Longitudinal Study of Aging
2016
The Effects of Central Adiposity on Growth Hormone (GH) Response to GH-Releasing Hormone-Arginine Stimulation Testing in Men
2008
Multiple metabolic effects of CGRP in conscious rats: role of glycogen synthase and phosphorylase
1993
Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance
2007
Dialogue between E. coli free radical pathways and the mitochondria of C. elegans
2015 StandoutNobel
Pharmacological and surgical treatment of obesity.
2004
Revisiting the diacylglycerol‐induced insulin resistance hypothesis
2012
Carbohydrate Metabolism in Non-Insulin-Dependent Diabetes Mellitus
1992
The case of visceral fat: argument for the defense
2004
Translating Lifestyle Intervention to Practice in Obese Patients With Type 2 Diabetes
2004
Assessing Adiposity
2011
The Atherogenic Lipoprotein Profile Associated With Obesity and Insulin Resistance Is Largely Attributable to Intra-Abdominal Fat
2003
Central Role of the Adipocyte in the Metabolic Syndrome
2001
Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene
2009
Skeletal Muscle Insulin Resistance in Normoglycemic Subjects With a Strong Family History of Type 2 Diabetes Is Associated With Decreased Insulin-Stimulated Insulin Receptor Substrate-1 Tyrosine Phosphorylation
2001
Insulin Regulates Adipocyte Lipolysis via an Akt-Independent Signaling Pathway
2010
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice
2008 StandoutNobel
Long-term non-pharmacological weight loss interventions for adults with prediabetes
2005
Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle
2007
A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle
2005
Metabolic Effects of Bariatric Surgery in Patients With Moderate Obesity and Type 2 Diabetes
2013
Myocardial Infarction and Ischemic Heart Disease in Overweight and Obesity With and Without Metabolic Syndrome
2013
Normal insulin sensitivity and IMCL content in overweight humans are associated with higher fasting lipid oxidation
2002
Acylcarnitines: potential implications for skeletal muscle insulin resistance
2014
Motivational Interviewing Improves Weight Loss in Women With Type 2 Diabetes
2007
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis*
1997 Standout
The effects of 24 weeks of moderate- or high-intensity exercise on insulin resistance
2005
Minireview: Lipid Droplets in Lipogenesis and Lipolysis
2008
Adiposity and Incidence of Heart Failure Hospitalization and Mortality
2009
American Association of Clinical Endocrinologists and American College of Endocrinology Comprehensive Clinical Practice Guidelines For Medical Care of Patients with Obesity
2016
The Multifaceted Roles of Adipose Tissue—Therapeutic Targets for Diabetes and Beyond: The 2015 Banting Lecture
2016
Acylcarnitines
2012
Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice
2000
Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes
2002
Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance
2010
Pharmacologic Therapy for Type 2 Diabetes Mellitus
1999
A systematic review and meta‐analysis on the effects of exercise training versus hypocaloric diet: distinct effects on body weight and visceral adipose tissue
2016
Synthesis Rate of Muscle Proteins, Muscle Functions, and Amino Acid Kinetics in Type 2 Diabetes
2002
Clinical Implications of Obesity With Specific Focus on Cardiovascular Disease
2004
Abdominal adiposity and insulin resistance in obese men
2002
Systemic and regional free fatty acid metabolism in type 2 diabetes
2001
Treatment of Obesity in Mitigating Metabolic Risk
2020
Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome
2000 Standout
Skeletal Muscle Mitochondria in Insulin Resistance: Differences in Intermyofibrillar Versus Subsarcolemmal Subpopulations and Relationship to Metabolic Flexibility
2010
The Genetic Basis of Type 2 Diabetes Mellitus: Impaired Insulin Secretion versus Impaired Insulin Sensitivity
1998
Increased mitochondrial content rescues in vivo muscle oxidative capacity in long‐term high‐fat‐diet‐fed rats
2009
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
1999 Standout
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role ofPGC1andNRF1
2003 Standout
Effects of a High vs Moderate Volume of Aerobic Exercise on Adiposity Outcomes in Postmenopausal Women
2015
Partial Disruption of Lipolysis Increases Postexercise Insulin Sensitivity in Skeletal Muscle Despite Accumulation of DAG
2016
Postprandial leg and splanchnic fatty acid metabolism in nonobese men and women
1996
Mitochondrial Dysfunction and Type 2 Diabetes
2005 StandoutScience
Exercise and the metabolic syndrome with weight regain
2010
The Science of Obesity Management: An Endocrine Society Scientific Statement
2018
Metabolic Syndrome Increases the Risk of Ischemic Stroke in Women
2007
Pigment Epithelium–Derived Factor Regulates Lipid Metabolism via Adipose Triglyceride Lipase
2011
Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus.
1995
Pharmacotherapy for weight loss in adults with type 2 diabetes mellitus
2005
Cardiorespiratory Fitness Is Inversely Associated With the Incidence of Metabolic Syndrome
2005
Visceral Adipose Tissue Is an Independent Correlate of Glucose Disposal in Older Obese Postmenopausal Women1
2000
“Deficiency” of Mitochondria in Muscle Does Not Cause Insulin Resistance
2013
Conventional Knockout of Tbc1d1 in Mice Impairs Insulin- and AICAR-Stimulated Glucose Uptake in Skeletal Muscle
2013
Adipocytokines Attenuate the Association Between Visceral Adiposity and Diabetes in Older Adults
2004
31P-Magnetization Transfer Magnetic Resonance Spectroscopy Measurements of In Vivo Metabolism
2012
All-Cause Mortality Associated With Specific Combinations of the Metabolic Syndrome According to Recent Definitions
2007
Adipose Tissue Expandability in the Maintenance of Metabolic Homeostasis
2008
Liver Fat Is Increased in Type 2 Diabetic Patients and Underestimated by Serum Alanine Aminotransferase Compared With Equally Obese Nondiabetic Subjects
2007
Exercise Is Required for Visceral Fat Loss in Postmenopausal Women with Type 2 Diabetes
2005
Hormone Replacement Therapy, Insulin Sensitivity, and Abdominal Obesity in Postmenopausal Women
2002
Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
2014
The Metabolic Syndrome
2008 Standout
Liver ATP Synthesis Is Lower and Relates to Insulin Sensitivity in Patients With Type 2 Diabetes
2011
Exercise and Physical Activity in the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
2003 Standout
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
1999
Perioperative Safety in the Longitudinal Assessment of Bariatric Surgery
2009
Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet
2011 StandoutNobel
Exercise and Hypertension
2004 Standout
Long-term pharmacotherapy for obesity and overweight
2003
Abdominal Visceral and Subcutaneous Adipose Tissue Compartments
2007 Standout
Estimation of skeletal muscle mass by bioelectrical impedance analysis
2000
Influence of Metabolic Syndrome and General Obesity on the Risk of Ischemic Stroke
2006
Sarcopenia: European consensus on definition and diagnosis
2010 Standout
Abdominal Obesity and the Metabolic Syndrome: Contribution to Global Cardiometabolic Risk
2008
Liver Fat in the Metabolic Syndrome
2007
NFATc3 and NFATc4 Are Required for Cardiac Development and Mitochondrial Function
2003
Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss
2005
The Metabolic Syndrome: Time for a Critical Appraisal
2005 Standout
The Finnish Diabetes Prevention Study (DPS)
2003
Alterations in Postprandial Hepatic Glycogen Metabolism in Type 2 Diabetes
2004
Relation Between the Metabolic Syndrome and Ischemic Stroke or Transient Ischemic Attack
2005
Effects of Gastric Bypass Surgery in Patients With Type 2 Diabetes and Only Mild Obesity
2012
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents
2014
Cardiac Adiposity and Global Cardiometabolic Risk New Concept and Clinical Implication
2008
Visceral Adiposity and the Risk of Impaired Glucose Tolerance
2003
Three-Year Outcomes of Bariatric Surgery vs Lifestyle Intervention for Type 2 Diabetes Mellitus Treatment
2015
Insulin Resistance Is Accompanied by Increased Fasting Glucagon and Delayed Glucagon Suppression in Individuals With Normal and Impaired Glucose Regulation
2016
Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial.
2007
LIPOLYSIS:Contribution from Regional Fat
1997
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
2003 StandoutScience
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Mitochondrial dysfunction and insulin resistance: an update
2014
The Sphingosine-1-Phosphate Analog FTY720 Reduces Muscle Ceramide Content and Improves Glucose Tolerance in High Fat-Fed Male Mice
2012
Wnt10b Deficiency Promotes Coexpression of Myogenic and Adipogenic Programs in Myoblasts
2005
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
2000
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T 1 -weighted MRI
2023 StandoutNobel
Adipocytokines and the Metabolic Complications of Obesity
2008
Deletion of Pten in Pancreatic β-Cells Protects Against Deficient β-Cell Mass and Function in Mouse Models of Type 2 Diabetes
2010 StandoutNobel
Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin
2002 Standout
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
1997
Effect of insulin on glycerol production in obese adolescents
1998
Fasting for 72 h increases intramyocellular lipid content in nondiabetic, physically fit men
2002
The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux
2016
Association of early-onset coronary heart disease in South Asian men with glucose intolerance and hyperinsulinemia.
1993
Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance
2007
Works of David E. Kelley being referenced
Role of Reduced Suppression of Glucose Production and Diminished Early Insulin Release in Impaired Glucose Tolerance
1992
Waist Circumference and Cardiometabolic Risk: A Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Association
2007
Waist circumference and cardiometabolic risk: a consensus statement from Shaping America’s Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Association
2007
Metabolic consequences of weight loss on glucose metabolism and insulin action in type 2 diabetes
2000
Higher liver fat content among Japanese in Japan compared with non-Hispanic whites in the United States
2009
Metabolic Changes Following a 1-Year Diet and Exercise Intervention in Patients With Type 2 Diabetes
2009
Exercise training increases intramyocellular lipid and oxidative capacity in older adults
2004
The Chronic Inflammatory Hypothesis for the Morbidity Associated with Morbid Obesity: Implications and Effects of Weight Loss
2004
Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus.
1990
Adipose tissue distribution is different in type 2 diabetes
2009
Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus.
1994
Effects of Obesity on Substrate Utilization during Exercise
2002
Obstructive Sleep Apnea Among Obese Patients With Type 2 Diabetes
2009
Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation
2017
Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus
2000
The acute versus the chronic response to exercise
2001
Increased Levels of Plasma Acylcarnitines in Obesity and Type 2 Diabetes and Identification of a Marker of Glucolipotoxicity
2010
Skeletal muscle utilization of free fatty acids in women with visceral obesity.
1995
Skeletal muscle triglyceride: Marker or mediator of obesity-induced insulin resistance in type 2 diabetes mellitus?
2002
Intramuscular lipid content is increased in obesity and decreased by weight loss
2000
Relationship of Adiposity to Subclinical Atherosclerosis in Obese Patients with Type 2 Diabetes
2003
Effects of Weight Loss and Physical Activity on Muscle Lipid Content and Droplet Size
2004
Effect of Laparoscopic Roux-En Y Gastric Bypass on Type 2 Diabetes Mellitus
2003
Impaired postprandial glucose utilization in non-insulin-dependent diabetes mellitus
1994
Skeletal muscle lipid concentration quantified by magnetic resonance imaging
2004
Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance
2003
High-performance liquid chromatography-based methods of enzymatic analysis: electron transport chain activity in mitochondria from human skeletal muscle
2004
Metabolic Flexibility in Response to Glucose Is Not Impaired in People With Type 2 Diabetes After Controlling for Glucose Disposal Rate
2008
Differential Effect of Weight Loss on Adipocyte Size Subfractions in Patients With Type 2 Diabetes
2009
The Look AHEAD Study: A Description of the Lifestyle Intervention and the Evidence Supporting It
2006
Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity
2004
Glucose Transport and Phosphorylation in Skeletal Muscle in Obesity: Insight from a Muscle-Specific Positron Emission Tomography Model
2003
Changes in Adipose Tissue Depots and Metabolic Markers Following a 1-Year Diet and Exercise Intervention in Overweight and Obese Patients With Type 2 Diabetes
2014
Effects of exercise on glucose homeostasis in Type 2 diabetes mellitus
2001
Interaction between glucose and free fatty acid metabolism in human skeletal muscle.
1993
Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load.
1988
The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle.
1996
Role of muscle in triglyceride metabolism
1998
Metabolic flexibility
2004
Effects of Exercise on Mitochondrial Content and Function in Aging Human Skeletal Muscle
2006
Relative effects of calorie restriction and weight loss in noninsulin- dependent diabetes mellitus
1993
Effect of Laparoscopic Roux‐en‐Y Gastric Bypass on Type 2 Diabetes Mellitus
2004
Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
1999
Weight Loss-Induced Plasticity of Glucose Transport and Phosphorylation in the Insulin Resistance of Obesity and Type 2 Diabetes
2003
Enhanced Fat Oxidation Through Physical Activity Is Associated With Improvements in Insulin Sensitivity in Obesity
2003
Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM
1990
Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM
1996
Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM
1997
Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes
2005
Influence of Hepatic Steatosis (Fatty Liver) on Severity and Composition of Dyslipidemia in Type 2 Diabetes
2006
Relationship between Serum Resistin Concentrations and Insulin Resistance in Nonobese, Obese, and Obese Diabetic Subjects
2004
Differential regulation of intracellular glucose metabolism by glucose and insulin in human muscle
1993
Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study
2001
Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat
1997
Changes Induced by Physical Activity and Weight Loss in the Morphology of Intermyofibrillar Mitochondria in Obese Men and Women
2006
Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity
2009
Duodenal‐jejunal bypass surgery induces hepatic lipidomic alterations associated with ameliorated hepatic steatosis in mice
2016
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
2002 Standout
Intracellular defects in glucose metabolism in obese patients with NIDDM
1992
Overexpression of muscle uncoupling protein 2 content in human obesity associates with reduced skeletal muscle lipid utilization
1998
Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content
2000
Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women
1995
Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss
1999
Plasma Fatty Acids, Adiposity, and Variance of Skeletal Muscle Insulin Resistance in Type 2 Diabetes Mellitus
2001
Mitochondrial Capacity in Skeletal Muscle Is Not Stimulated by Weight Loss Despite Increases in Insulin Action and Decreases in Intramyocellular Lipid Content
2008
Effects of insulin on skeletal muscle glucose storage, oxidation, and glycolysis in humans
1990
MUSCLE TRIGLYCERIDE AND INSULIN RESISTANCE
2002
Skeletal Muscle Triglyceride
2001
Effects of Moderate Weight Loss and Orlistat on Insulin Resistance, Regional Adiposity, and Fatty Acids in Type 2 Diabetes
2004
Effect of Exercise Intensity on Glucose and Insulin Metabolism in Obese Individuals and Obese NIDDM Patients
1996
The analog free testosterone assay: are the results in men clinically useful?
1998
Clinical Efficacy of Orlistat Therapy in Overweight and Obese Patients With Insulin-Treated Type 2 Diabetes
2002
Intracellular Defects in Glucose Metabolism in Obese Patients With NIDDM
1992
Efficacy and Safety of Acarbose in Insulin-Treated Patients With Type 2 Diabetes
1998
Interleukin-6 Regulation of AMP-Activated Protein Kinase
2006
Role of Orlistat in the Treatment of Obese Patients With Type 2 Diabetes: A 1-year randomized double-blind study
1998
Metabolic Syndrome Modifies the Cardiovascular Risk Associated With Angiographic Coronary Artery Disease in Women
2004
PET imaging reveals distinctive roles for different regional adipose tissue depots in systemic glucose metabolism in nonobese humans
2012
Association Between Regional Adipose Tissue Distribution and Both Type 2 Diabetes and Impaired Glucose Tolerance in Elderly Men and Women
2003
Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance
2000
Plasma Fatty Acids, Adiposity, and Variance of Skeletal Muscle Insulin Resistance in Type 2 Diabetes Mellitus
2001
Waist Circumference and Cardiometabolic Risk
2007
Skeletal Muscle Lipid Content and Insulin Resistance: Evidence for a Paradox in Endurance-Trained Athletes
2001
Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise
1996
Skeletal muscle triglycerides: an aspect of regional adiposity and insulin resistance.
2002
Clinical Importance of Obesity Versus the Metabolic Syndrome in Cardiovascular Risk in Women
2004
Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus.
1993
Interactions of Impaired Glucose Transport and Phosphorylation in Skeletal Muscle Insulin Resistance
2001
The Effect of Short Periods of Caloric Restriction on Weight Loss and Glycemic Control in Type 2 Diabetes
1998
Subcutaneous Abdominal Fat and Thigh Muscle Composition Predict Insulin Sensitivity Independently of Visceral Fat
1997
Skeletal Muscle Lipid Content and Oxidative Enzyme Activity in Relation to Muscle Fiber Type in Type 2 Diabetes and Obesity
2001
Effects of Physical Activity and Weight Loss on Skeletal Muscle Mitochondria and Relationship With Glucose Control in Type 2 Diabetes
2007