Citation Impact
Citing Papers
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
2002 Standout
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei
2004 Standout
Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad
2013
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Jasmonate Response Locus JAR1 and Several Related Arabidopsis Genes Encode Enzymes of the Firefly Luciferase Superfamily That Show Activity on Jasmonic, Salicylic, and Indole-3-Acetic Acids in an Assay for Adenylation
2002
Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47
2003 StandoutScience
SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing
2012 Standout
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
2019 StandoutNobel
Evolutionary History of a Specialized P450 Propane Monooxygenase
2008 StandoutNobel
The biosynthesis of coenzyme a in bacteria
2001
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Promiscuous protein biotinylation by Escherichia coli biotin protein ligase
2004
Structural aspects of non-ribosomal peptide biosynthesis
2004
Molecular mechanisms of antibiotic resistance
2014 Standout
Multimodular biocatalysts for natural product assembly
2001
Mapping the Limits of Substrate Specificity of the Adenylation Domain of TycA
2009
Crystal structure of the surfactin synthetase-activating enzyme Sfp: a prototype of the 4'-phosphopantetheinyl transferase superfamily
1999
PKS and NRPS release mechanisms
2009
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
2011 Standout
The Enzymology of Combinatorial Biosynthesis
2003
Fluorine in Medicinal Chemistry
2015
Activity of OP0595/β-lactam combinations against Gram-negative bacteria with extended-spectrum, AmpC and carbapenem-hydrolysing β-lactamases
2015
Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
2015 StandoutNobel
Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis
1999
Antimicrobial activity of ceftaroline combined with avibactam tested against bacterial organisms isolated from acute bacterial skin and skin structure infections in United States medical centers (2010–2012)
2014
The Science of Antibiotic Discovery
2020 Standout
The Subsystems Approach to Genome Annotation and its Use in the Project to Annotate 1000 Genomes
2005 Standout
The Biosynthesis of the Aromatic Myxobacterial Electron Transport Inhibitor Stigmatellin Is Directed by a Novel Type of Modular Polyketide Synthase
2002
Evolution of antimicrobial resistance among Enterobacteriaceae (focus on extended spectrum β-lactamases and carbapenemases)
2013
Protein Chemistry on the Surface of Living Cells
2004
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Protein–Protein Interactions in Multienzyme Megasynthetases
2008
Cloning, Expression, and Characterization of a Human 4′-Phosphopantetheinyl Transferase with Broad Substrate Specificity
2003
Combinatorial biosynthesis of antimicrobials and other natural products
2001
Natural Product Hybrids as New Leads for Drug Discovery
2003 Standout
Protein Function Microarrays Based on Self‐Immobilizing and Self‐Labeling Fusion Proteins
2005
Biosynthesis of Natural Products on Modular Peptide Synthetases
2001
Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome
2007
β-Lactams and β-Lactamase Inhibitors: An Overview
2016 Standout
Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15
2001
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways
2008
Activity of MK-7655 combined with imipenem against Enterobacteriaceae and Pseudomonas aeruginosa
2013
Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies
2015
Cryptosporidium parvum: the first protist known to encode a putative polyketide synthase
2002
Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery
2020 StandoutNobel
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
A resurgence of β-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens
2015
Antibacterial drug discovery in the resistance era
2016 StandoutNature
Ribozyme catalysis: not different, just worse
2005 StandoutNobel
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
2006 Standout
The Biosynthetic Logic of Polyketide Diversity
2009 Standout
Dissecting the Mechanism and Assembly of a Complex Virulence Mycobacterial Lipid
2005
Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties
2007 StandoutNobel
3d Transition Metals for C–H Activation
2018 Standout
Enantioselective Palladium(II)‐Catalyzed Oxidative Aminofluorination of Unactivated Alkenes with Et4NF⋅3 HF as a Fluoride Source
2019
Ribosomal Synthesis of N-Methyl Peptides
2008 StandoutNobel
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
2009 StandoutScience
Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms
2006
Enantioselective Palladium(II)‐Catalyzed Oxidative Aminofluorination of Unactivated Alkenes with Et4NF⋅3 HF as a Fluoride Source
2019
Non-Heme Fe(IV)–Oxo Intermediates
2007 Standout
SyrB2 in syringomycin E biosynthesis is a nonheme Fe II α-ketoglutarate- and O 2 -dependent halogenase
2005
Biosynthesis of Nonribosomal Peptides
2004
Autophagy Negatively Regulates Cell Death by Controlling NPR1-Dependent Salicylic Acid Signaling during Senescence and the Innate Immune Response inArabidopsis
2009 StandoutNobel
Homologation of the Fischer Indolization: A Quinoline Synthesis via Homo‐Diaza‐Cope Rearrangement
2020 StandoutNobel
A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells
2012 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Structural Aspects of Ligand Binding to and Electron Transfer in Bacterial and Fungal P450s
2004
Molecular Mechanisms Underlying Nonribosomal Peptide Synthesis: Approaches to New Antibiotics
2005
Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution
2005 StandoutNobel
Polymer Brushes via Surface-Initiated Controlled Radical Polymerization: Synthesis, Characterization, Properties, and Applications
2009 Standout
Precise Modulation of CO2 Sorption in Ti8Ce2–Oxo Clusters: Elucidating Lewis Acidity of the Ce Metal Sites and Structural Flexibility
2024 StandoutNobel
In Vitro Activity of Aztreonam-Avibactam against a Global Collection of Gram-Negative Pathogens from 2012 and 2013
2015
Chemistry and Biology of the Tetrahydroisoquinoline Antitumor Antibiotics
2002 Standout
Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
2010 Standout
Ribosomal Synthesis of Dehydroalanine-Containing Peptides
2006 StandoutNobel
Microarray Analysis of the Mycobacterium tuberculosis Transcriptional Response to the Acidic Conditions Found in Phagosomes
2002
Overcoming Resistance to β-Lactam Antibiotics
2013
In Vitro Activities of Ceftazidime-Avibactam and Aztreonam-Avibactam against 372 Gram-Negative Bacilli Collected in 2011 and 2012 from 11 Teaching Hospitals in China
2013
Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1
2021 StandoutNobel
Diketopiperazines as Advanced Intermediates in the Biosynthesis of Ecteinascidins
2000
Natural Products Version 2.0: Connecting Genes to Molecules
2010
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections
2019
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
Upregulation of the Phthiocerol Dimycocerosate Biosynthetic Pathway by Rifampin-Resistant,rpoBMutant Mycobacterium tuberculosis
2012 StandoutNobel
Polyketide and Nonribosomal Peptide Antibiotics: Modularity and Versatility
2004 Science
A Fluorogenic Trehalose Probe for Tracking Phagocytosed Mycobacterium tuberculosis
2020 StandoutNobel
Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling
2007 StandoutNobel
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of theMycobacterium tuberculosisvirulence factor Sulfolipid-1
2007 StandoutNobel
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Efficacy of a Ceftazidime-Avibactam Combination in a Murine Model of Septicemia Caused by Enterobacteriaceae Species Producing AmpC or Extended-Spectrum β-Lactamases
2014
A C 35 Carotenoid Biosynthetic Pathway
2003 StandoutNobel
In Vitro Susceptibility of Characterized β-Lactamase-Producing Strains Tested with Avibactam Combinations
2014
Ribosomal Synthesis of Unnatural Peptides
2005 StandoutNobel
Confinement-Controlled, Either syn- or anti-Selective Catalytic Asymmetric Mukaiyama Aldolizations of Propionaldehyde Enolsilanes
2021 StandoutNobel
Challenges of Antibacterial Discovery
2011
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Structure and Chemistry of Cytochrome P450
2005 Standout
Works of David E. Ehmann being referenced
Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor
2012
Biochemical characterization of an inhibitor of Escherichia coli UDP-N-acetylmuramyl-l-alanine ligase
2003
Aminoacyl-SNACs as small-molecule substrates for the condensation domains of nonribosomal peptide synthetases
2000
Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pKa: Antibacterial Agents with an Improved Safety Profile
2012
Chain Termination Steps in Nonribosomal Peptide Synthetase Assembly Lines: Directed Acyl-S-Enzyme Breakdown in Antibiotic and Siderophore Biosynthesis
2001
Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48
2014
Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases
2013
The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase: Sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates
2000
Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II: Broad-Spectrum Antibacterial Agents with Reduced hERG Activity
2011
Selectivity of the Yersiniabactin Synthetase Adenylation Domain in the Two-Step Process of Amino Acid Activation and Transfer to a Holo-Carrier Protein Domain
2000
Lysine Biosynthesis in Saccharomyces cerevisiae: Mechanism of α-Aminoadipate Reductase (Lys2) Involves Posttranslational Phosphopantetheinylation by Lys5
1999
Chain Termination Steps in Nonribosomal Peptide Synthetase Assembly Lines: Directed Acyl-S-Enzyme Breakdown in Antibiotic and Siderophore Biosynthesis
2001