Citation Impact
Citing Papers
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
2023 StandoutNobel
Adipocyte-specific Disruption of Fat-specific Protein 27 Causes Hepatosteatosis and Insulin Resistance in High-fat Diet-fed Mice
2014
Sirtuins as regulators of metabolism and healthspan
2012 Standout
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
2017 StandoutNobel
Genetic determinants of hepatic steatosis in man
2011
Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease
2016
Lipid-like materials for low-dose, in vivo gene silencing
2010
Lipid lowering with PCSK9 inhibitors
2014
Genetic control ofde novolipogenesis: role in diet-induced obesity
2010
Targeting PCSK9 for Therapeutic Gains
2015
Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia not Adequately Controlled with Current Lipid-Lowering Therapy: Design and Rationale of the ODYSSEY FH Studies
2014
mRNA-based therapeutics — developing a new class of drugs
2014 StandoutNobel
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
2013
Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines
2023 StandoutNobel
Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery
2021 StandoutNobel
Targeting Ferroptosis to Iron Out Cancer
2019 Standout
A Role for Phosphatidic Acid in the Formation of “Supersized” Lipid Droplets
2011
A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
2015 Nobel
Molecular biology of PCSK9: its role in LDL metabolism
2007
Translating molecular discoveries into new therapies for atherosclerosis
2008 Nature
Delivery materials for siRNA therapeutics
2013 Standout
The changing landscape of atherosclerosis
2021 StandoutNature
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
2017 StandoutNature
Targeting the Proprotein Convertase Subtilisin/Kexin Type 9 for the Treatment of Dyslipidemia and Atherosclerosis
2013
An ionizable lipid toolbox for RNA delivery
2021 StandoutNobel
mTOR at the nexus of nutrition, growth, ageing and disease
2020 Standout
Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery
2021 StandoutNobel
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
2021 StandoutNobel
Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes
2015 StandoutNobel
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
How to improve R&D productivity: the pharmaceutical industry's grand challenge
2010 Standout
Non-viral vectors for gene-based therapy
2014 Standout
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
2017 StandoutNobel
Epidemiology and Natural History of Non-Alcoholic Steatohepatitis
2009
Inhibiting Monoacylglycerol Acyltransferase 1 Ameliorates Hepatic Metabolic Abnormalities but Not Inflammation and Injury in Mice
2014
Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors
2020 StandoutNobel
Dynamics and functions of lipid droplets
2018 Standout
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature
RNAi-based therapeutic strategies for metabolic disease
2011
Age-induced hypercholesterolemia in the rat relates to reduced elimination but not increased intestinal absorption of cholesterol
2007
New Therapies for Reducing Low-Density Lipoprotein Cholesterol
2014
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
2020 Standout
A Spectrum of PCSK9 Alleles Contributes to Plasma Levels of Low-Density Lipoprotein Cholesterol
2006
Adeno-associated virus vector as a platform for gene therapy delivery
2019 Standout
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
2018 Standout
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
COPII — a flexible vesicle formation system
2013 StandoutNobel
Mechanisms and regulation of cholesterol homeostasis
2019
Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease
2006 Standout
Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells
2014
Molecular Characterization of Loss-of-Function Mutations in PCSK9 and Identification of a Compound Heterozygote
2006
Bile acids and lipoprotein metabolism: Effects of cholestyramine and chenodeoxycholic acid on human hepatic mRNA expression
2007
A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing
2018
Degradation from the outside in: Targeting extracellular and membrane proteins for degradation through the endolysosomal pathway
2021 StandoutNobel
Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events
2015 Standout
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
2020 StandoutNobel
Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease
2014
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Nuclear receptor PPARγ-regulated monoacylglycerol O -acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis
2012
Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing
2014
Forecasting the Future of Cardiovascular Disease in the United States
2011 Standout
The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
2017 Standout
The Multifaceted Roles of Adipose Tissue—Therapeutic Targets for Diabetes and Beyond: The 2015 Banting Lecture
2016
Ionizable lipid nanoparticles for in utero mRNA delivery
2021 StandoutNobel
Mechanisms of Diabetic Complications
2013 Standout
Human Fatty Liver Disease: Old Questions and New Insights
2011 StandoutScience
Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device
2021 StandoutNobel
Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis
2016 Standout
Lowering LDL--Not Only How Low, But How Long?
2006 ScienceNobel
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines
2023 StandoutNobel
Cholesterol Synthesis Inhibition Elicits an Integrated Molecular Response in Human Livers Including Decreased ACAT2
2008 StandoutNobel
Treatment of erythropoietin deficiency in mice with systemically administered siRNA
2012 StandoutNobel
In Vivo Base Editing of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) as a Therapeutic Alternative to Genome Editing
2017
Endothelial Function and Dysfunction
2007 Standout
Works of David E. Curtis being referenced
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice
2006
Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy
2009
Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9
2005