Standout Papers
Citation Impact
Citing Papers
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
2002 StandoutScienceNobel
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA
2009 StandoutScienceNobel
PDE4 cAMP-specific phosphodiesterases
2001
The RACK1 Signaling Scaffold Protein Selectively Interacts with the cAMP-specific Phosphodiesterase PDE4D5 Isoform
1999
Improved molecular replacement by density- and energy-guided protein structure optimization
2011 StandoutNatureNobel
The 2.0 Å crystal structure of a heterotrimeric G protein
1996 Nature
Sturge–Weber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ
2013 Standout
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
1997 StandoutNobel
Structural studies of elongation and release factors
2008
The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht
1999 Standout
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
2001 Nature
Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
1997 Standout
A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation
1996
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
The Coiled-coil Region of the G Protein β Subunit
1997
Fluorescent BODIPY-GTP Analogs: Real-Time Measurement of Nucleotide Binding to G Proteins
2001
Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue
1997 Nature
Mapping of Effector Binding Sites of Transducin α-Subunit Using Gαt/Gαil Chimeras
1996
A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p
1997
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
2007
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
1997 StandoutNobel
Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form
1995 Nature
A short history ofSHELX
2007 Standout
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
A cryo-electron microscopic study of ribosome-bound termination factor RF2
2003 StandoutNatureNobel
C-terminal Mutation of G Protein β Subunit Affects Differentially Extracellular Signal-regulated Kinase and c-Jun N-terminal Kinase Pathways in Human Embryonal Kidney 293 Cells
1997
Stimulation of the GTPase Activity of Translation Elongation Factor G by Ribosomal Protein L7/12
2000
Receptor-Mediated Activation of Heterotrimeric G-Proteins: Current Structural Insights
2007
Placement of protein and RNA structures into a 5 Å-resolution map of the 50S ribosomal subunit
1999 StandoutNatureNobel
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Sites for Gα Binding on the G Protein β Subunit Overlap with Sites for Regulation of Phospholipase Cβ and Adenylyl Cyclase
1998 Nobel
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Phosducin induces a structural change in transducin βγ
1998
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Heterotrimeric G proteins
1996
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
1997 Standout
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins
2006
Purification of Recombinant G Proteins from Sf9 Cells by Hexahistidine Tagging of Associated Subunits
1995 Nobel
The Second Intracellular Loop of the m5 Muscarinic Receptor Is the Switch Which Enables G-protein Coupling
1998
Heterotrimeric C proteins: Organizers of transmembrane signals
1995
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Crystal Structure at 2.4 Å Resolution of the Complex of Transducin βγ and Its Regulator, Phosducin
1996
The Importance of Structural Transitions of the Switch II Region for the Functions of Elongation Factor Tu on the Ribosome
2001
Crystal Structure of Human RhoA in a Dominantly Active Form Complexed with a GTP Analogue
1998
Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2
1999 Nobel
Heterotrimeric G protein activation by G-protein-coupled receptors
2007
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp
1999 StandoutNatureNobel
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Structure of a β-TrCP1-Skp1-β-Catenin Complex
2003
A Domain on the G Protein β Subunit Interacts with Both Adenylyl Cyclase 2 and the Muscarinic Atrial Potassium Channel
1996
Structure and dynamics of the M3 muscarinic acetylcholine receptor
2012 StandoutNatureNobel
X-ray structure of the mammalian GIRK2–βγ G-protein complex
2013 NatureNobel
A Posttermination Ribosomal Complex Is the Guanine Nucleotide Exchange Factor for Peptide Release Factor RF3
2001
Integrins
2002 Standout
Sterol Resistance in CHO Cells Traced to Point Mutation in SREBP Cleavage–Activating Protein
1996 Nobel
TLP1: A Gene Encoding a Protein Component of Mammalian Telomerase Is a Novel Member of WD Repeats Family
1997
GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits
1996 Nobel
Mutational Analysis of Gβγ and Phospholipid Interaction with G Protein-coupled Receptor Kinase 2
2000
Phasing at resolution higher than the experimental resolution
2005
Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis
1997 Nobel
Limited Proteolysis and Amino Acid Replacements in the Effector Region ofThermus thermophilusElongation Factor Tu
1996
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
1998 StandoutNatureNobel
Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM
2008 StandoutNobel
Mechanism of GTP hydrolysis by G-protein alpha subunits.
1994 StandoutNobel
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
Crystal Structure of the Extracellular Segment of Integrin αVβ3
2001 Science
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
1999 Nobel
The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants
1997 Science
SCF and Cullin/RING H2-Based Ubiquitin Ligases
1999
Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain
1997
The Polycomb group in Caenorhabditis elegans and maternal control of germline development
1998
Targeting the Receptor-G q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy
1998 StandoutScienceNobel
Activation of the mitogen-activated protein kinase cascade by pertussis toxin-sensitive and -insensitive pathways in cultured ventricular cardiomyocytes
1995
Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors
2000
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities.
1997
Visualizing tmRNA Entry into a Stalled Ribosome
2003 StandoutScienceNobel
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State
2009 StandoutScienceNobel
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
G PROTEIN βγ SUBUNITS
1997
The Solution Structure and Dynamics of the Pleckstrin Homology Domain of G Protein-coupled Receptor Kinase 2 (β-Adrenergic Receptor Kinase 1)
1998
Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit
2011
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
2011 StandoutScienceNobel
G Protein Selectivity Is Regulated by Multiple Intracellular Regions of GPCRs
2003
Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G sα ·GTPγS
1997 ScienceNobel
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
RNAi in C. elegans : Soaking in the Genome Sequence
1998 StandoutScienceNobel
GTPase-Activating Proteins for Heterotrimeric G Proteins: Regulators of G Protein Signaling (RGS) and RGS-Like Proteins
2000
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
G PROTEIN MECHANISMS: Insights from Structural Analysis
1997
G proteins, effectors and GAPs: structure and mechanism
1997
Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
2011 StandoutNobel
Crystal Structure of the Adenylyl Cyclase Activator G s α
1997 ScienceNobel
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995 StandoutScienceNobel
Crystal Structure of the Ternary Complex of Phe-tRNA Phe , EF-Tu, and a GTP Analog
1995 Science
Works of David E. Coleman being referenced
Invasion of the Nucleotide Snatchers
1998
Structure of Giα1·GppNHp, Autoinhibition in a Gα Protein-Substrate Complex
1999
Crystallization and Preliminary Crystallographic Studies of Giα1 and Mutants of Giα1 in the GTP and GDP-bound States
1994 StandoutNobel
Direct phase determination for the molecular envelope of tryptophanyl-tRNA synthetase from Bacillus stearothermophilus by X-ray contrast variation
1990
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
The structure of the G protein heterotrimer Giα1β1γ2
1995 Nobel
How G proteins work: a continuing story.
1996
Structural and Biochemical Characterization of the GTPγS-, GDP·Pi-, and GDP-Bound Forms of a GTPase-Deficient Gly42 → Val Mutant of Giα1
1997 Nobel
Tertiary and Quaternary Structural Changes in G iα1 Induced by GTP Hydrolysis
1995 ScienceNobel
Crystal Structures of the G Protein Giα1 Complexed with GDP and Mg2+: A Crystallographic Titration Experiment
1998
How G proteins work: a continuing story
1996