Citation Impact
Citing Papers
Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
2011
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
A bacterium that degrades and assimilates poly(ethylene terephthalate)
2016 StandoutScience
Fast molecular tracking maps nanoscale dynamics of plasma membrane lipids
2010 StandoutNobel
Targeting bile-acid signalling for metabolic diseases
2008
XBP1s Is an Anti-lipogenic Protein
2016
XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum
2010
Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation
2014
Cell type-selective secretome profiling in vivo
2020 StandoutNobel
A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer
2018
Lipid-like materials for low-dose, in vivo gene silencing
2010
Energy balance regulation by thyroid hormones at central level
2013
Beyond the Sympathetic Tone: The New Brown Fat Activators
2013
Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis
2008
mTOR Signaling in Growth Control and Disease
2012 Standout
Hepatic Bax Inhibitor-1 Inhibits IRE1α and Protects from Obesity-associated Insulin Resistance and Glucose Intolerance
2009
Adipose tissue browning and metabolic health
2013
Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum
2010
Brown and beige fat: development, function and therapeutic potential
2013 Standout
Intestinal homeostasis and its breakdown in inflammatory bowel disease
2011 StandoutNature
Identification and characterization of new family members in the tautomerase superfamily: Analysis and implications
2014
New insights into ER stress-induced insulin resistance
2012
Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance
2013
Mice with a Targeted Deletion of the Type 2 Deiodinase Are Insulin Resistant and Susceptible to Diet Induced Obesity
2011
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
2014 StandoutNature
ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development
2014
Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis
2018
Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease
2009
The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response
2009
Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice
2011
The IRE1α-XBP1 Pathway of the Unfolded Protein Response Is Required for Adipogenesis
2009
mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion
2017
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
2012 Standout
Selective versus Total Insulin Resistance: A Pathogenic Paradox
2008 Nobel
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
2012
Dissociating fatty liver and diabetes
2012
Evolution of Inflammation in Nonalcoholic Fatty Liver Disease: The Multiple Parallel Hits Hypothesis
2010 Standout
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
2009
Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation
2008
The changing landscape of atherosclerosis
2021 StandoutNature
BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α
2009
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
2009
Bile acids and nonalcoholic fatty liver disease
2016
Regulated portals of entry into the cell
2003 StandoutNature
Bile acid sequestrants
2011
Effects of codon usage versus putative 5′-mRNA structure on the expression of Fusarium solani cutinase in the Escherichia coli cytoplasm
2002
Coordination of hypothalamic and pituitary T3 production regulates TSH expression
2013
Physiological IRE-1-XBP-1 and PEK-1 Signaling in Caenorhabditis elegans Larval Development and Immunity
2011
The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption
2002
Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1
2010
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis
2009
The endoplasmic reticulum stress response in immunity and autoimmunity
2008
IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level
2010
Non-alcoholic fatty liver disease
2021 Standout
Diet–microbiota interactions as moderators of human metabolism
2016 StandoutNature
The role of the gut microbiota in NAFLD
2016
Farnesoid X Receptor Deficiency Induces Nonalcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Knockout Mice Fed a High-Fat Diet
2008
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
Unraveling the Regulation of Hepatic Metabolism by Insulin
2017
Insulin action and resistance in obesity and type 2 diabetes
2017
The Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance
2012
Fructose induced lipogenesis: from sugar to fat to insulin resistance
2010
Quantification of Cation–π Interactions in Protein–Ligand Complexes: Crystal‐Structure Analysis of Factor Xa Bound to a Quaternary Ammonium Ion Ligand
2005
The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis
2016
Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes
2009
Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
2016
The evolving role of lipid rafts and caveolae in G protein‐coupled receptor signaling: implications for molecular pharmacology
2004
Caveolae: From Cell Biology to Animal Physiology
2002
Therapeutic Landscape for NAFLD in 2020
2020
Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance
2009
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
2010
Direct observation of the nanoscale dynamics of membrane lipids in a living cell
2008 StandoutNatureNobel
Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease
2016
Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells
2013
Toward Genetic Prediction of Nonalcoholic Fatty Liver Disease Trajectories: PNPLA3 and Beyond
2020
GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice
2009
What We Talk About When We Talk About Fat
2014 Standout
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
2008 Standout
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators
2008
The unfolded protein response transducer IRE1α prevents ER stress‐induced hepatic steatosis
2011
Association of non-alcoholic fatty liver disease with major adverse cardiovascular events: A systematic review and meta-analysis
2016
Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis
2016
The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling
2012
Energy Metabolism in the Liver
2014 Standout
Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes
2008
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
In vivo plasma membrane organization: results of biophysical approaches
2004
Hepatic FoxOs Regulate Lipid Metabolism via Modulation of Expression of the Nicotinamide Phosphoribosyltransferase Gene
2011
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice
2000
The role of ER stress in lipid metabolism and lipotoxicity
2016
A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells
2012
Animal Models in the Study of the Unfolded Protein Response
2011
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome
2009
Template-directed synthesis of a genetic polymer in a model protocell
2008 StandoutNatureNobel
Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis
2010
Vascular permeability, vascular hyperpermeability and angiogenesis
2008
Severe Cholestasis Induced by Cholic Acid Feeding in Knockout Mice of Sister of P–Glycoprotein
2003
Gut microbiota in human metabolic health and disease
2020 Standout
Insulin signaling to hepatic lipid metabolism in health and disease
2011
Gut Microbiota in Health and Disease
2010 Standout
The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α
2011
Brown Adipose Tissue Growth and Development
2013
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Thyroid Hormone-Related Regulation of Gene Expression in Human Fatty Liver
2009
Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system
2016 StandoutNobel
Endoplasmic Reticulum Stress in Immunity
2014
A CHOP-regulated microRNA controls rhodopsin expression
2011
Insulin Receptor Isoforms in Physiology and Disease: An Updated View
2017
Actin, a Central Player in Cell Shape and Movement
2009 StandoutScience
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance
2011
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes
2006 StandoutNobel
Dual and opposing roles of the unfolded protein response regulated by IRE1α and XBP1 in proinsulin processing and insulin secretion
2011
Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template
2012 StandoutNobel
Regulation of basal cellular physiology by the homeostatic unfolded protein response
2010
Type 2 deiodinase at the crossroads of thyroid hormone action
2011
Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress
2010
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
Computational Prediction of the Heterodimeric and Higher-Order Structure of gpE1/gpE2 Envelope Glycoproteins Encoded by Hepatitis C Virus
2017 StandoutNobel
Lipotoxicity and the gut-liver axis in NASH pathogenesis
2017
Inflammatory Bowel Disease
2010 Standout
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
2010 Nobel
Thyroid Hormone Regulation of Metabolism
2014 Standout
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation
2008
MicroRNA Regulation of Atherosclerosis
2016
Human Fatty Liver Disease: Old Questions and New Insights
2011 StandoutScience
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation
2010
The Metabolic Syndrome
2008 Standout
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis
2010
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
2011
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines
2023 StandoutNobel
SUMO modification regulates the transcriptional activity of XBP1
2010
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Lipocalin-2 Deficiency Impairs Thermogenesis and Potentiates Diet-Induced Insulin Resistance in Mice
2010
The relationship between membrane fluidity and permeabilities to water, solutes, ammonia, and protons.
1995
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Mechanisms of Endocytosis
2009 Standout
Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption
2004 StandoutScience
Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Expression
2009
Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress
2015 StandoutNobel
Works of David E. Cohen being referenced
MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis
2010 Science
Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue
2009
Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice
2003
Hepatic Overexpression of Murine Abcb11 Increases Hepatobiliary Lipid Secretion and Reduces Hepatic Steatosis
2004
Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse
2003
MicroRNAs in Metabolism and Metabolic Diseases
2011
Structure of human phosphatidylcholine transfer protein in complex with its ligand
2002
Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins
2019
Structure and function of phosphatidylcholine transfer protein (PC-TP)/StarD2
2007
Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling
2017
Biliary lipids and cholesterol gallstone disease
2008
Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis
2008
Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease
2013
Homozygous disruption of Pctp modulates atherosclerosis in apolipoprotein E-deficient mice
2006
Dissociation of Adaptive Thermogenesis from Glucose Homeostasis in Microbiome-Deficient Mice
2020
Microvascular Hyperpermeability in Caveolin-1 (−/−) Knock-out Mice
2002
Rationale and design of a prospective clinical trial program to evaluate the glucose-lowering effects of colesevelam HCl in patients with type 2 diabetes mellitus
2007
Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease
2016
The Arrestin Domain-Containing 3 Protein Regulates Body Mass and Energy Expenditure
2011
Decreased Expression of ARV1 Results in Cholesterol Retention in the Endoplasmic Reticulum and Abnormal Bile Acid Metabolism*
2010
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue
2012
CONTROL: A randomized phase 2 study of obeticholic acid and atorvastatin on lipoproteins in nonalcoholic steatohepatitis patients
2019
Biochemical characterization of l-DOPA 2,3-dioxygenase, a single-domain type I extradiol dioxygenase from lincomycin biosynthesis
2008
Impaired biliary lipid secretion in obese Zucker rats: leptin promotes hepatic cholesterol clearance
2001
Quasielastic light scattering evidence for vesicular secretion of biliary lipids
1989
Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis
1999
High-Level Expression and Mutagenesis of Recombinant Human Phosphatidylcholine Transfer Protein Using a Synthetic Gene: Evidence for a C-Terminal Membrane Binding Domain
2000
Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2
2008
Disruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutrality
2011
Phosphatidylcholine Transfer Protein Interacts with Thioesterase Superfamily Member 2 to Attenuate Insulin Signaling
2013
Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1
2008 Science
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance
2012
Adenovirus-Mediated Expression of Caveolin-1 in Mouse Liver Increases Plasma High-Density Lipoprotein Levels
2001
Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice
2001