Citation Impact
Citing Papers
AB INITIO QUANTUM CHEMICAL AND MIXED QUANTUM MECHANICS/MOLECULAR MECHANICS (QM/MM) METHODS FOR STUDYING ENZYMATIC CATALYSIS
2005
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation
2005
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation Kinetics
2010 Science
Iron(IV)hydroxide p K a and the Role of Thiolate Ligation in C–H Bond Activation by Cytochrome P450
2013 Science
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
Origins of catalysis by computationally designed retroaldolase enzymes
2010 StandoutNobel
Computational Thermostabilization of an Enzyme
2005 StandoutScienceNobel
Protein stability promotes evolvability
2006 StandoutNobel
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
Preliminary Characterization and Crystal Structure of a Thermostable Cytochrome P450 from Thermus thermophilus
2002
Protein Conformational Switches: From Nature to Design
2012
Intermediates in the reaction of substrate‐free cytochrome P450cam with peroxy acetic acid
2000
Construction of heme enzymes: four approaches
2002
Self-assembled nanoscale biosensors based on quantum dot FRET donors
2003
An A245T Mutation Conveys on Cytochrome P450eryF the Ability to Oxidize Alternative Substrates
2000
The development of mechanistic enzymology in the 20th century
2001
Dynamic personalities of proteins
2007 StandoutNature
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
2007 StandoutNobel
MECHANISTIC ENZYMOLOGY OF OXYGEN ACTIVATION BY THE CYTOCHROMES P450
2002
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
Spectroscopic studies of peroxyacetic acid reaction intermediates of cytochrome P450cam and chloroperoxidase
2002
Diversity of P450 enzymes in the biosynthesis of natural products
2012
Analyzing protein functions in four dimensions.
2000
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Crystal Structure of the F87W/Y96F/V247L Mutant of Cytochrome P-450cam with 1,3,5-Trichlorobenzene Bound and Further Protein Engineering for the Oxidation of Pentachlorobenzene and Hexachlorobenzene
2002
Two-state reactivity mechanisms of hydroxylation and epoxidation by cytochrome P-450 revealed by theory
2002
Substrate Binding Is the Rate-limiting Step in Thromboxane Synthase Catalysis
2001
Accurate design of co-assembling multi-component protein nanomaterials
2014 StandoutNatureNobel
A Large Scale Test of Computational Protein Design: Folding and Stability of Nine Completely Redesigned Globular Proteins
2003 StandoutNobel
The High-Valent Compound of Cytochrome P450: The Nature of the Fe−S Bond and the Role of the Thiolate Ligand as an Internal Electron Donor
2000
Multiple mechanisms and multiple oxidants in P450-catalyzed hydroxylations
2002
NMR Study on the Structural Changes of Cytochrome P450cam upon the Complex Formation with Putidaredoxin
2003
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Cytochrome P450cin (CYP176A), Isolation, Expression, and Characterization
2002
Cryoradiolysis for the study of P450 reaction intermediates
2002
Principles for designing ideal protein structures
2012 StandoutNatureNobel
Substrate Recognition and Molecular Mechanism of Fatty Acid Hydroxylation by Cytochrome P450 from Bacillus subtilis
2003
Definite coordination arrangement of organometallic palladium complexes accumulated on the designed interior surface of apo-ferritin
2010 StandoutNobel
Crystal Structure of the Dioxygen-bound Heme Oxygenase from Corynebacterium diphtheriae
2004
Kinetic Characterization of Compound I Formation in the Thermostable Cytochrome P450 CYP119
2002
Conformational States of Cytochrome P450cam Revealed by Trapping of Synthetic Molecular Wires
2004
Computational Design and Characterization of a Monomeric Helical Dinuclear Metalloprotein
2003
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
High-throughput screening of enzyme libraries
2000
Characterization of the oxygenated intermediate of the thermophilic cytochrome P450 CYP119
2001
Computational de novo Design, and Characterization of an A2B2 Diiron Protein
2002
Crystal Structures and Molecular Mechanism of a Light-Induced Signaling Switch: The Phot-LOV1 Domain from Chlamydomonas reinhardtii
2003
Crystal structures of cytochrome P450nor and its mutants (Ser286→Val, Thr) in the ferric resting state at cryogenic temperature: a comparative analysis with monooxygenase cytochrome P450s
2000
Cryogenic absorption spectra of hydroperoxo‐ferric heme oxygenase, the active intermediate of enzymatic heme oxygenation
2002
The coming of age of de novo protein design
2016 StandoutNatureNobel
Reaction of Neuronal Nitric-oxide Synthase with Oxygen at Low Temperature
1998
The catalytic pathway of horseradish peroxidase at high resolution
2002 StandoutNature
Crystal structures of cyanide complexes of P450cam and the oxygenase domain of inducible nitric oxide synthase—structural models of the short-lived oxygen complexes
2002
Kemp elimination catalysts by computational enzyme design
2008 StandoutNatureNobel
Copper–Nitrene Complexes in Catalytic CH Amination
2008
CdSe nanocrystal based chem-/bio- sensors
2007 StandoutNobel
De novo design of bioactive protein switches
2019 StandoutNatureNobel
The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-Å Resolution
2004
Synthetic active site analogues of heme–thiolate proteins Characterization and identification of intermediates of the catalytic cycles of cytochrome P450cam and chloroperoxidase
2001
P450 BM3: the very model of a modern flavocytochrome
2002
Tyrosine Radical Formation in the Reaction of Wild Type and Mutant Cytochrome P450cam with Peroxy Acids
2004
Structure of the Bound Dioxygen Species in the Cytochrome Oxidase Reaction of Cytochrome cd1Nitrite Reductase
2001
Crystal Structure of a Thermophilic Cytochrome P450 from the Archaeon Sulfolobus solfataricus
2000
Advances in kinetic protein crystallography
2005
Computational protein design
2001
Complex reactions catalyzed by cytochrome P450 enzymes
2006
On the role of the axial ligand in heme proteins: a theoretical study
2004
Calculation of the electronic structure and spectra of model cytochrome P450 compound I
2001
Emerging themes in the computational design of novel enzymes and protein–protein interfaces
2012
Oxidation and electronic state dependence of proton transfer in the enzymatic cycle of cytochrome P450eryF
2002
Design of functional metalloproteins
2009 Nature
Mutation effects of a conserved threonine (Thr243) of cytochrome P450nor on its structure and function
2000
Roles of the axial push effect in cytochrome P450cam studied with the site-directed mutagenesis at the heme proximal site
2000
Crystallography with Online Optical and X-ray Absorption Spectroscopies Demonstrates an Ordered Mechanism in Copper Nitrite Reductase
2008
Computational design of receptor and sensor proteins with novel functions
2003 Nature
Structural Studies of an Engineered Zinc Biosensor Reveal an Unanticipated Mode of Zinc Binding
2005
Putidaredoxin-Cytochrome P450cam Interaction
1999
Non‐natural Olefin Cyclopropanation Catalyzed by Diverse Cytochrome P450s and Other Hemoproteins
2014 StandoutNobel
What makes a P450 tick?
2013
Oxidizing species in the mechanism of cytochrome P450
2002
How Does Ethene Inactivate Cytochrome P450 En Route to Its Epoxidation? A Density Functional Study
2001
Construction of a fluorescent biosensor family
2002
De novo proteins from designed combinatorial libraries
2004
Oxidizing intermediates in cytochrome P450 model reactions
2004
Crystal Structures of the Ferric, Ferrous, and Ferrous–NO Forms of the Asp140Ala Mutant of Human Heme Oxygenase-1: Catalytic Implications
2003
Reactive Intermediates in Cytochrome P450 Catalysis
2013
Cryotrapped Reaction Intermediates of Cytochrome P450 Studied by Radiolytic Reduction with Phosphorus-32
2001
Proton nuclear magnetic resonance study of the binary complex of cytochrome P450cam and putidaredoxin: interaction and electron transfer rate analysis
1999
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Formation and Decay of Hydroperoxo-Ferric Heme Complex in Horseradish Peroxidase Studied by Cryoradiolysis
2002
Crystallographic Study on the Dioxygen Complex of Wild-type and Mutant Cytochrome P450cam
2005
Models and mechanisms of O‐O bond activation by cytochrome P450
2004
Fatty Acid Hydroperoxide Lyase: A Plant Cytochrome P450 Enzyme Involved in Wound Healing and Pest Resistance
2001
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
2001
Motif‐directed flexible backbone design of functional interactions
2009 StandoutNobel
Medium Polarization and Hydrogen Bonding Effects on Compound I of Cytochrome P450: What Kind of a Radical Is It Really?
2000
3d Transition Metals for C–H Activation
2018 Standout
A Density Functional Study of O−O Bond Cleavage for a Biomimetic Non-Heme Iron Complex Demonstrating an FeV-Intermediate
2002
Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
2011 StandoutScienceNobel
A Theoretical Study of the Dynamic Behavior of Alkane Hydroxylation by a Compound I Model of Cytochrome P450
2001
Water as an Active Constituent in Cell Biology
2007 Standout
Electronic Structure and Reactivity of Low-Spin Fe(III)−Hydroperoxo Complexes: Comparison to Activated Bleomycin
2002
A Role for Highly Conserved Carboxylate, Aspartate-140, in Oxygen Activation and Heme Degradation by Heme Oxygenase-1
2001
Kinetic Isotope Effects in a C−H Bond Dissociation by the Iron-Oxo Species of Cytochrome P450
2000
Infrared Spectroscopic and Mutational Studies on Putidaredoxin-Induced Conformational Changes in Ferrous CO-P450cam,
2003
In the light of directed evolution: Pathways of adaptive protein evolution
2009 StandoutNobel
Toward High-Resolution de Novo Structure Prediction for Small Proteins
2005 StandoutScienceNobel
Roles of the Proximal Heme Thiolate Ligand in Cytochrome P450cam
2001
Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase
2018 StandoutNobel
Computational protein engineering
1998
P450BM3‐Axial Mutations: A Gateway to Non‐Natural Reactivity
2014 StandoutNobel
A Fluorescence Resonance Energy Transfer Sensor Based on Maltose Binding Protein
2003
Design of Protein Catalysts
2013
Selective C–H oxidation catalyzed by metalloporphyrins
2011
Does the Hydroperoxo Species of Cytochrome P450 Participate in Olefin Epoxidation with the Main Oxidant, Compound I? Criticism from Density Functional Theory Calculations
2003
Structural Aspects of Ligand Binding to and Electron Transfer in Bacterial and Fungal P450s
2004
A theoretical study of electronic factors affecting hydroxylation by model ferryl complexes of cytochrome P-450 and horseradish peroxidase
1999
Molecular Recognition in (+)-α-Pinene Oxidation by Cytochrome P450cam
2002
Crystallographic and Spectroscopic Characterization of a Nonheme Fe(IV)=O Complex
2003 Science
Molecular Mechanism of the Electron Transfer Reaction in Cytochrome P450cam−Putidaredoxin: Roles of Glutamine 360 at the Heme Proximal Site
2002
What Factors Affect the Regioselectivity of Oxidation by Cytochrome P450? A DFT Study of Allylic Hydroxylation and Double Bond Epoxidation in a Model Reaction
2002
Genome Mining in Streptomyces. Discovery of an Unprecedented P450-Catalyzed Oxidative Rearrangement That Is the Final Step in the Biosynthesis of Pentalenolactone
2011
Metastable Water Clusters in the Nonpolar Cavities of the Thermostable Protein Tetrabrachion
2007
Nanosecond Photoreduction of Cytochrome P450cam by Channel-Specific Ru-diimine Electron Tunneling Wires
2003
Structure and Spectra of Ferrous Dioxygen and Reduced Ferrous Dioxygen Model Cytochrome P450
1998
Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes
2009
Stereospecific Alkane Hydroxylation by Non-Heme Iron Catalysts: Mechanistic Evidence for an FeVO Active Species
2001
Heme Enzyme Structure and Function
2014
Proton-Transfer Dynamics in the Activation of Cytochrome P450eryF
2002
Hydroxylation of Camphor by Reduced Oxy-Cytochrome P450cam: Mechanistic Implications of EPR and ENDOR Studies of Catalytic Intermediates in Native and Mutant Enzymes
2001
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
Protein Side-Chain Motion and Hydration in Proton-Transfer Pathways. Results for Cytochrome P450cam
2003
Challenges in the computational design of proteins
2009
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Enzyme-like proteins by computational design
2001
pH-Sensitive Quantum Dots
2006
Design of a Novel Globular Protein Fold with Atomic-Level Accuracy
2003 StandoutScienceNobel
From simple to supramolecular cytochrome P450 mimics
2000
Progress in Modeling of Protein Structures and Interactions
2005 StandoutScienceNobel
Construction and optimization of a family of genetically encoded metabolite sensors by semirational protein engineering
2005
Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters
2008 StandoutNobel
Protein Design: Toward Functional Metalloenzymes
2014
Engineering Novel Metalloproteins: Design of Metal-Binding Sites into Native Protein Scaffolds
2001
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Protein Design by Directed Evolution
2008
Molecular engineering of cytochrome P450 and myoglobin for selective oxygenations
2004
Electronic Structure of Activated Bleomycin: Oxygen Intermediates in Heme versus Non-Heme Iron
2000
Rate-Limiting Steps in Cytochrome P450 Catalysis
2002
Searching for the Second Oxidant in the Catalytic Cycle of Cytochrome P450: A Theoretical Investigation of the Iron(III)-Hydroperoxo Species and Its Epoxidation Pathways
2002
Cytochrome P450CAM Enzymatic Catalysis Cycle: A Quantum Mechanics/Molecular Mechanics Study
2004
Redox cycling and kinetic analysis of single molecules of solution-phase nitrite reductase
2011 StandoutNobel
Olefin Cis-Dihydroxylation versus Epoxidation by Non-Heme Iron Catalysts: Two Faces of an FeIII−OOH Coin
2002
De Novo Computational Design of Retro-Aldol Enzymes
2008 StandoutScienceNobel
Synthetic models for the active site of cytochrome P450
2002
Revisiting the Mechanism of P450 Enzymes with the Radical Clocks Norcarane and Spiro[2,5]octane
2002
Catalysis by a De Novo Zinc-Mediated Protein Interface: Implications for Natural Enzyme Evolution and Rational Enzyme Engineering
2012
Theoretical Perspective on the Structure and Mechanism of Cytochrome P450 Enzymes
2005
Oxygen Activation and Electron Transfer in Flavocytochrome P450 BM3
2003
Evaluation of Norcarane as a Probe for Radicals in Cytochome P450- and Soluble Methane Monooxygenase-Catalyzed Hydroxylation Reactions
2002
The Elusive Oxidant Species of Cytochrome P450 Enzymes: Characterization by Combined Quantum Mechanical/Molecular Mechanical (QM/MM) Calculations
2002
Peripheral heme substituents control the hydrogen-atom abstraction chemistry in cytochromes P450
2003
Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy
2016 StandoutNobel
Multi-State Epoxidation of Ethene by Cytochrome P450: A Quantum Chemical Study
2001
Protein topology and stability define the space of allowed sequences
2002 StandoutNobel
Crystallographic Structure Determination of Unstable Species
2000
Oxygenase Pathways: Oxo, Peroxo, and Superoxo
2001 Science
Cytochrome P450nor: A nitric oxide reductase—Structure, spectra, and mechanism
2002
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
A Theoretical Study on the Mechanism of Camphor Hydroxylation by Compound I of Cytochrome P450
2003
De novo design of catalytic proteins
2004
Terpene synthases are widely distributed in bacteria
2014 StandoutNobel
Review: Protein Design—Where We Were, Where We Are, Where We're Going
2001
Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
2014 StandoutNobel
Spectroscopic Properties and Electronic Structure of Low-Spin Fe(III)−Alkylperoxo Complexes: Homolytic Cleavage of the O−O Bond
2001
Phe393 Mutants of Cytochrome P450 BM3 with Modified Heme Redox Potentials Have Altered Heme Vinyl and Propionate Conformations
2004
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
Role of the Heme Active Site and Protein Environment in Structure, Spectra, and Function of the Cytochrome P450s
2000
A simple physical model for binding energy hot spots in protein–protein complexes
2002 StandoutNobel
Structure and Chemistry of Cytochrome P450
2005 Standout
Oxidative Aliphatic C-H Fluorination with Fluoride Ion Catalyzed by a Manganese Porphyrin
2012 Science
Artificial Metalloenzymes and Metallopeptide Catalysts for Organic Synthesis
2013
Fluorescence Resonance Energy Transfer Between Quantum Dot Donors and Dye-Labeled Protein Acceptors
2003 StandoutNobel
Works of David E. Benson being referenced
Complex Formation of Cytochrome P450cam with Putidaredoxin
2002
Analysis of allosteric signal transduction mechanisms in an engineered fluorescent maltose biosensor
2005
Design of Bioelectronic Interfaces by Exploiting Hinge-Bending Motions in Proteins
2001 Science
Construction of a Novel Redox Protein by Rational Design: Conversion of a Disulfide Bridge into a Mononuclear Iron−Sulfur Center
1998
Rational design of nascent metalloenzymes
2000
The development of new biotechnologies using metalloprotein design
1998
Resonance Raman Investigations of Cytochrome P450cam Complexed with Putidaredoxin
1997
Protein Design Provides Lead(II) Ion Biosensors for Imaging Molecular Fluxes around Red Blood Cells
2008
Converting a Maltose Receptor into a Nascent Binuclear Copper Oxygenase by Computational Design
2002
The Catalytic Pathway of Cytochrome P450cam at Atomic Resolution
2000 Science
A Modular Nanoparticle-Based System for Reagentless Small Molecule Biosensing
2005
Reduced Oxy Intermediate Observed in D251N Cytochrome P450cam
1997