Standout Papers
Citation Impact
Citing Papers
Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis
2012
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers
2016
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
2018 StandoutScienceNobel
Accurate computational design of multipass transmembrane proteins
2018 StandoutScienceNobel
Stimulation of Piezo1 by mechanical signals promotes bone anabolism
2019
Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu 5 ) X-ray Structures
2018
Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers
2019
A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel
2018
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Synthetic strategies in combinatorial chemistry
1997
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Piezo1-dependent regulation of urinary osmolarity
2016
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Amino acid distributions in integral membrane protein structures
2001
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Modular click chemistry libraries for functional screens using a diazotizing reagent
2019 StandoutNatureNobel
The β-Thalassemias
1999 Standout
Piezo1 incorporates mechanical force signals into the genetic program that governs lymphatic valve development and maintenance
2019
Cytogenetics in acute leukemia
2003
Force-induced conformational changes in PIEZO1
2019 NatureNobel
Liquid-Phase Parallel Synthesis of Ureas
2001
A Computationally Designed Water-Soluble Variant of a G-Protein-Coupled Receptor: The Human Mu Opioid Receptor
2013
Comprehensive survey of combinatorial libraries with undisclosed biological activity: 1992–1997
1998
A protein-conducting channel in the endoplasmic reticulum
1991 StandoutNobel
Redesigning an integral membrane K+ channel into a soluble protein
2005
Liquid phase parallel synthesis of guanidines
1999
Multipass membrane protein structure prediction using Rosetta
2005 StandoutNobel
Combinatorial synthesis of libraries of indole derivatives
2001
Inhibition of α-helix-mediated protein–protein interactions using designed molecules
2013
Model of thec‐subunit oligomer in the membrane domain of F‐ATPases
1997 StandoutNobel
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Robust Generation of Lead Compounds for Protein–Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists
2010
Identifying Recent Adaptations in Large-Scale Genomic Data
2013
Structural biology in fragment-based drug design
2010
Improving Site‐Directed RNA Editing In Vitro and in Cell Culture by Chemical Modification of the GuideRNA
2014
Piezos thrive under pressure: mechanically activated ion channels in health and disease
2017 StandoutNobel
On the industrial applications of MCRs: molecular diversity in drug discovery and generic drug synthesis
2010
SAR by NMR: Putting the Pieces Together
2006
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Structures of Bacterial Photosynthetic Reaction Centers
1991 Nobel
De novo design of a pentameric coiled‐coil: decoding the motif for tetramer versus pentamer formation in water‐soluble phospholamban*
2005
Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction
2019
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel
2020
Fragment-based lead discovery: a chemical update
2006
The Missing Diversity in Human Genetic Studies
2019 Standout
Solid-phase synthesis of 2,3-disubstituted indoles: discovery of a novel, high-affinity, selective h5-HT2A antagonist
2000
A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes
2002 StandoutNobel
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
2018
Nopp 140 shuttles on tracks between nucleolus and cytoplasm
1992 StandoutNobel
Rational design of `water-soluble' bacteriorhodopsin variants
2002 StandoutNobel
Recent Developments in Fragment-Based Drug Discovery
2008
Constructing genomic maps of positive selection in humans: Where do we go from here?
2009
Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels
2016
A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals
1997 StandoutNobel
A Red Carpet for Iron Metabolism
2017
Multicomponent domino reactions for the synthesis of biologically active natural products and drugs
2000 Standout
Touch, Tension, and Transduction – The Function and Regulation of Piezo Ion Channels
2016
Use of a Perfluoroalkylsulfonyl (PFS) Linker in a “Traceless” Synthesis of Biaryls through Suzuki Cleavage
2001
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002 StandoutNobel
Recent progress in fragment-based lead discovery
2009
Solid-supported reagents in organic synthesis
1999
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
2006 StandoutNobel
Structure of the δ-opioid receptor bound to naltrindole
2012 StandoutNatureNobel
Structure–activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry
2001
Transmembrane Structure of an Inwardly Rectifying Potassium Channel
1999
Comprehensive survey of chemical libraries yielding enzyme inhibitors, receptor agonists and antagonists, and other biologically active agents: 1992 through 1997
1997
Piezo channels
2017
Genetics of HIV-1infection: chemokine receptor CCR5 polymorphism and its consequences
1999
Recent advances in selective opioid receptor agonists and antagonists
2003
Evidence for Gradients of Human Genetic Diversity Within and Among Continents
2004 StandoutNobel
The Structure and Insertion of Integral Proteins in Membranes
1990
Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves
2016
The Human Condition—A Molecular Approach
2014 StandoutNobel
The Molecular Architecture of Odor and Pheromone Sensing in Mammals
2000 StandoutNobel
Modeling α‐helical transmembrane domains: The calculation and use of substitution tables for lipid‐facing residues
1993
A decade of fragment-based drug design: strategic advances and lessons learned
2007
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Synthesis of Trisubstituted Indoles on the Solid Phase via Palladium-Mediated Heteroannulation of Internal Alkynes
1997
A new approach to the solid-phase Suzuki coupling reaction
1997
Preparation of tricyclic nitrogen heterocycles via tandem four-component condensation/intramolecular Diels-Alder reaction
1999
Synthetic Approaches to the Neuraminidase Inhibitors Zanamivir (Relenza) and Oseltamivir Phosphate (Tamiflu) for the Treatment of Influenza
2009
Fluorous Synthesis: Fluorous Protocols for the Ugi and Biginelli Multicomponent Condensations
1997
Click chemistry on solid support: synthesis of a new REM resin and application for the preparation of tertiary amines
2004
Piezo1 links mechanical forces to red blood cell volume
2015 StandoutNobel
Traceless Solid-Phase Organic Synthesis
2002
Structure of the reaction center from Rhodobacter sphaeroides R-26: the cofactors.
1987
Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives
1999
Solid phase cross-coupling reaction of aryl(halo)silanes with 4-iodobenzoic acid
2001
Nobel lecture. The photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis.
1989 Nobel
Features of MotA proton channel structure revealed by tryptophan-scanning mutagenesis.
1995
Solid phase synthesis of 5,6,7,8-tetrahydro-1H-imidazo[4,5-g]quinoxalin-6-ones
2000
Novel applications of resin bound α-amino acids for the synthesis of benzodiazepines (via Wang resin) and ketopiperazines (via hydroxymethyl resin)
2000
Inherited Thrombophilia: Part 1
1996
Soluble Polymer Bound Cleavage Reagents: A Multipolymer Strategy for the Cleavage of Tertiary Amines from REM Resin
2000
Screening of Protein–Protein Interaction Modulators via Sulfo-Click Kinetic Target-Guided Synthesis
2011
Solid phase synthesis of 2-substituted benzofurans via the palladium-catalysed heteroannulation of acetylenes
1997
Combinatorial Synthesis of Small Organic Molecules
1996
The Solid Phase Synthesis of Tri-Substituted Indoles
1997
Remarkable three-step-one-pot solution phase preparation of novel imidazolines utilizing a UDC (Ugi/de-Boc/cyclize) strategy
1999
Solid support synthesis of polysubstituted tetrahydroquinolines via three-component condensation catalyzed by Yb(OTf)3
1998
A solid phase traceless synthesis of benzimidazoles with three combinatorial steps
1999
Solid phase synthesis of chiral 2-amino-benzimidazoles
2001
Solid-phase cross-coupling reaction of aryl(fluoro)silanes with 4-iodobenzoic acid
2000
Yoda1 analogue (D ooku1) which antagonizes Y oda1‐evoked activation of P iezo1 and aortic relaxation
2018
Structure-guided examination of the mechanogating mechanism of PIEZO2
2019
A new “traceless” solid-phase synthesis strategy: Synthesis of a benzimidazole library
1999
Solid Phase Heterocyclic Chemistry
2001
Fluorous Synthesis: A Fluorous-Phase Strategy for Improving Separation Efficiency in Organic Synthesis
1997 Science
Transmembrane Protein Structure: Spin Labeling of Bacteriorhodopsin Mutants
1990 Science
Traceless solid phase synthesis of 2,3-disubstituted indoles
1998
Combinatorial Liquid-Phase Synthesis of Structurally Diverse Benzimidazole Libraries
2000
Crystal Structure of DNA Photolyase from Escherichia coli
1995 StandoutScienceNobel
The family of G‐protein‐coupled receptors
1995
Geographic Distribution of the 20210 G to A Prothrombin Variant
1998
Synthesis of an Aziridinomitosene Analog
1996
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Solution phase combinatorial synthesis of arylpiperazines
1997
Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery
2000 StandoutScience
Risk Factors for Pregnancy Associated Venous Thromboembolism
1997
Aryl-aryl cross coupling on a solid support using zinc organic reagents and palladium catalysis
1996
A concise and efficient solid-phase synthesis of 2-amino-4(3H)-quinazolinones
2000
A combinatorial approach towards 2-acyl-3-amino-indole derivatives
2000
The Suzuki-Miyaura cross coupling reactions on solid support. Link to solution phase directed ortho metalation. The Leznoff acetal linker approach to biaryl and heterobiaryl aldehydes
1998
Traceless Solid-Phase Synthesis of Substituted Benzimidazoles via a Base-Cleavable Linker
2000
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
2018 StandoutNobel
In situclick chemistry: a powerful means for lead discovery
2006 StandoutNobel
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Combinatorial Synthesis of Heterocycles: Solid-Phase Synthesis of 2-Amino-4(1H)-quinazolinone Derivatives
2000
Molecular Shape Diversity of Combinatorial Libraries: A Prerequisite for Broad Bioactivity
2003
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation
2000
The synthesis of unusual tetrahydropyrimidine amino acids
1993
Two subunits of the canine signal peptidase complex are homologous to yeast SEC11 protein.
1990 StandoutNobel
Facile substitution of resin-bound indoles via the Mannich reaction
1998
Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair
2018
Regulation of Hepcidin by Erythropoiesis: The Story So Far
2016
Thioamides as Useful Synthons in the Synthesis of Heterocycles
2002 Standout
Identification of novel PIEZO1 variants using prenatal exome sequencing and correlation to ultrasound and autopsy findings of recurrent hydrops fetalis
2018
A general and efficient solid phase synthesis of quinazoline-2,4-diones
1997
Solid phase synthesis of styrylquinazolinones
2000
GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large
2006 StandoutNobel
Comprehensive Survey of Combinatorial Library Synthesis: 2000
2001
A Distributional Model of Bound Ligand Conformational Strain: From Small Molecules up to Large Peptidic Macrocycles
2023
Venous thrombosis: a multicausal disease
1999 Standout
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
A Genomic Perspective on Protein Families
1997 StandoutScience
The “One-Bead-One-Compound” Combinatorial Library Method
1997
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Positive Natural Selection in the Human Lineage
2006 Science
Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
2006 StandoutScienceNobel
Dispersed Polaron Simulations of Electron Transfer in Photosynthetic Reaction Centers
1989 StandoutScienceNobel
Direct release of nitriles from solid phase
2001
Targeted Investigation of the Neandertal Genome by Array-Based Sequence Capture
2010 StandoutScienceNobel
OPM: Orientations of Proteins in Membranes database
2006
Rapid microwave-assisted Suzuki coupling on solid-phase
1996
Works of David C. Rees being referenced
The role of ligand efficiency metrics in drug discovery
2014
FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group
2000
Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis
2015
Amide bond replacements incorporated into CCK-B selective "dipeptoids"
1992
The Hemoglobin E Syndromes
1998
Highly selective .kappa.-opioid analgesics. 2. Synthesis and structure activity relationships of novel N-(2-aminocyclohexyl)arylacetamide derivatives
1989
Group Efficiency: A Guideline for Hits‐to‐Leads Chemistry
2008
Sickle Cell Disease
2017
Highly selective .kappa.-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted cyclohexyl]arylacetamide derivatives
1990
Evidence for a single origin of factor V Leiden
1996
Regression of extramedullary haemopoiesis and augmentation of fetal haemoglobin concentration during hydroxyurea therapy in β thalassaemia
1998
The conductance of red blood cells from sickle cell patients: ion selectivity and inhibitors
2012
Solid Phase Synthesis of Tertiary Amines on Amide REM Resins: Grignard and Metal Hydride Compatible Resins
2000
Molecular Analysis of the β-Globin Gene Cluster in the Niokholo Mandenka Population Reveals a Recent Origin of the βS Senegal Mutation
2002
Sickle-cell disease
2010 Standout
THE BACTERIAL PHOTOSYNTHETIC REACTION CENTER AS A MODEL FOR MEMBRANE PROTEINS
1989
The rise of fragment-based drug discovery
2009
CI‐977, a novel and selective agonist for the κ‐opioid receptor
1990
World distribution of factor V Leiden
1995 Standout
Fragment-based lead discovery: leads by design
2005
Global distribution of the CCR5 gene 32-basepair deletion
1997
The design of a dipeptide library for screening at peptide receptor sites
1993
Amide bond replacements : incorporation of a 2,5,5-trisubstituted imidazoline into dipeptides and into a CCK-4 derivative.
1991
Solid Phase Synthesis
1998
Hydrophobic Organization of Membrane Proteins
1989 Science
Solid-phase organic reactions III: A review of the literature Nov 96–Dec 97
1998
A left-hand beta-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila.
1996
Solid-phase organic reactions II: A review of the literature Nov 95–Nov 96
1997
Resin-immobilised benzyl and aryl vinyl sulfones: New versatile traceless linkers for solid-phase organic synthesis
1997
Structural homology of reaction centers from Rhodopseudomonas sphaeroides and Rhodopseudomonas viridis as determined by x-ray diffraction.
1986 StandoutNobel
Applications of Solid-Phase Synthesis to Drug Discovery
1997
Solid-phase organic reactions: A review of the recent literature
1996
Synthesis of an array of amides by aluminium chloride assisted cleavage of resin-bound esters
1996
Synthesis of Tertiary Amines Using a Polystyrene (REM) Resin
1997
A novel linker strategy for solid-phase synthesis
1996
The synthesis of 1,6-disubstituted indanes which mimic the orientation of amino acid side-chains in a protein alpha-helix motif.
1992
Total synthesis of (.+-.)-limaspermine derivatives using organoiron chemistry
1982