Standout Papers
- Programmed DNA destruction by miniature CRISPR-Cas14 enzymes (2018)
- New CRISPR–Cas systems from uncultivated microbes (2016)
- Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection (2016)
- A scoutRNA Is Required for Some Type V CRISPR-Cas Systems (2020)
- A Functional Mini-Integrase in a Two-Protein Type V-C CRISPR System (2019)
- RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes (2017)
Citation Impact
Citing Papers
Inter‐viral conflicts that exploit host CRISPR immune systems of S ulfolobus
2013
Protein interaction networks revealed by proteome coevolution
2019 StandoutScienceNobel
Reductive evolution and unique predatory mode in the CPR bacterium Vampirococcus lugosii
2021
Nucleic acid detection with CRISPR-Cas13a/C2c2
2017 StandoutScience
Identification of Genes Differentially Expressed in Benign versus Malignant Thyroid Tumors
2008
Recruitment of CRISPR-Cas systems by Tn7-like transposons
2017
Machine learning predicts new anti-CRISPR proteins
2020 StandoutNobel
A rooted phylogeny resolves early bacterial evolution
2021 Science
Type IV pili trigger episymbiotic association of Saccharibacteria with its bacterial host
2022
Structures of the CRISPR genome integration complex
2017 StandoutScienceNobel
Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome
2019
Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer
2009 Standout
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer
2015 Standout
Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system
2016
HH-suite3 for fast remote homology detection and deep protein annotation
2019
Acquisition and Adaptation of Ultra-small Parasitic Reduced Genome Bacteria to Mammalian Hosts
2020
Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle
2023 StandoutNobel
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a
2019 StandoutNobel
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28
2017
The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a
2017
Small GTP-Binding Proteins
1992
Glutamate and its receptors in cancer
2014
CRISPR-Based Technologies: Impact of RNA-Targeting Systems
2018
CRISPR-Cas3 induces broad and unidirectional genome editing in human cells
2019
Asymmetric positioning of Cas1–2 complex and Integration Host Factor induced DNA bending guide the unidirectional homing of protospacer in CRISPR-Cas type I-E system
2016
Immediate-early genes, kindling and long-term potentiation
1989
Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations
2018
Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9
2017
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Protein Complexes in Bacteria
2015
Implications of Follicular Neoplasms, Atypia, and Lesions Suspicious for Malignancy Diagnosed by Fine-Needle Aspiration of Thyroid Nodules
2002
Cas3-Derived Target DNA Degradation Fragments Fuel Primed CRISPR Adaptation
2016
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
Thyroid fine needle aspiration cytology: a review of the National Cancer Institute state of the science symposium
2010
Pervasive generation of oppositely oriented spacers during CRISPR adaptation
2014
Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a
2017
Is Hashimoto's Thyroiditis a Risk Factor for Papillary Thyroid Cancer?
2007
Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein
2018
Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities
2017
Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble
2019 StandoutNobel
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
1996 StandoutNatureNobel
Detection and characterization of spacer integration intermediates in type I-E CRISPR–Cas system
2014
DNA Targeting by a Minimal CRISPR RNA-Guided Cascade
2016 StandoutNobel
A CRISPR toolbox to study virus–host interactions
2017
ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons
1989
Diversity, classification and evolution of CRISPR-Cas systems
2017
Diversity and evolution of class 2 CRISPR–Cas systems
2017
A decade of discovery: CRISPR functions and applications
2017
Foreign DNA capture during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Transcriptional regulator-mediated activation of adaptation genes triggers CRISPR de novo spacer acquisition
2015
RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System
2017 StandoutNobel
RNA Guide Complementarity Prevents Self-Targeting in Type VI CRISPR Systems
2018
Massively parallel determination and modeling of endonuclease substrate specificity
2014 StandoutNobel
Inhibition of CRISPR-Cas9 with Bacteriophage Proteins
2016
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Priming in the Type I-F CRISPR-Cas system triggers strand-independent spacer acquisition, bi-directionally from the primed protospacer
2014
Discovery and Characterization of Cas9 Inhibitors Disseminated across Seven Bacterial Phyla
2019
CRISPR–Cas adaptation: insights into the mechanism of action
2016
Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product
1992 StandoutNobel
Anti-CRISPR: discovery, mechanism and function
2017
Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: A synopsis of the National Cancer Institute Thyroid Fine‐Needle Aspiration State of the Science Conference
2008 Standout
Targeted isolation and cultivation of uncultivated bacteria by reverse genomics
2019
Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration
2019 Nature
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
A thermostable Cas9 with increased lifetime in human plasma
2017 StandoutNobel
The next generation of CRISPR–Cas technologies and applications
2019
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a
2019 StandoutNobel
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
The Bethesda System for Reporting Thyroid Cytopathology
2009 Standout
Protecting genome integrity during CRISPR immune adaptation
2016 StandoutNobel
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
1994 StandoutNobel
An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites
1995 StandoutNobel
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Adaptation in CRISPR-Cas Systems
2016 StandoutNobel
CRISPR adaptation biases explain preference for acquisition of foreign DNA
2015 Nature
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
The Design and In Vivo Evaluation of Engineered I-OnuI-Based Enzymes for HEG Gene Drive
2013
The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit
2017
Inhibition of Type III CRISPR-Cas Immunity by an Archaeal Virus-Encoded Anti-CRISPR Protein
2019
Role of repeat fine‐needle aspiration biopsy (FNAB) in the management of thyroid nodules
2003
Clinical Utility of Thyroglobulin Antibody (TgAb) Measurements for Patients with Differentiated Thyroid Cancers (DTC)
2011
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
2017 StandoutNobel
Fine-needle aspiration of the thyroid and correlation with histopathology in a contemporary series of 240 patients
2003
Cryo-EM structure of a type IV secretion system
2022 StandoutNatureNobel
The host-encoded RNase E endonuclease as the crRNA maturation enzyme in a CRISPR–Cas subtype III-Bv system
2018
The role of Rab3A in neurotransmitter release
1994 StandoutNatureNobel
Foreign DNA acquisition by the I-F CRISPR–Cas system requires all components of the interference machinery
2015
Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR–Cas Systems
2018
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System
2015 StandoutNobel
Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers
2017 Nature
NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation
1991
Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems
2015
Clinical and Cytological Features Predictive of Malignancy in Thyroid Follicular Neoplasms
2009
The Bethesda Thyroid Fine-Needle Aspiration Classification System: Year 1 at an Academic Institution
2009
Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Taskforce
2006 Standout
Thyroid Nodules with Atypia or Follicular Lesions of Undetermined Significance (Bethesda Category III): Importance of Ultrasonography and Cytological Subcategory
2014
The Cytological, Clinical, and Pathological Features of the Cribriform-Morular Variant of Papillary Thyroid Carcinoma and Mutation Analysis of CTNNB1 and BRAF Genes
2009
Targeted RNA Knockdown by a Type III CRISPR-Cas Complex in Zebrafish
2020
A New Group of Phage Anti-CRISPR Genes Inhibits the Type I-E CRISPR-Cas System of Pseudomonas aeruginosa
2014
Structural basis of Type IV CRISPR RNA biogenesis by a Cas6 endoribonuclease
2019
Small GTP-Binding Proteins
2001 Standout
Symbiosis between Candidatus Patescibacteria and Archaea Discovered in Wastewater-Treating Bioreactors
2022
Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6
2018 StandoutScience
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
1995 StandoutScience
Type IV secretion systems: Advances in structure, function, and activation
2020
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Saccharibacteria (TM7) in the Human Oral Microbiome
2019
Widespread but Poorly Understood Bacteria: Candidate Phyla Radiation
2022
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
Remarkable Mechanisms in Microbes to Resist Phage Infections
2014
RNA-dependent RNA targeting by CRISPR-Cas9
2018 StandoutNobel
Adapting to new threats: the generation of memory by CRISPR‐Cas immune systems
2014
Trans -Splicing in Trypanosomes: Machinery and Its Impact on the Parasite Transcriptome
2011
Tapping natural reservoirs of homing endonucleases for targeted gene modification
2011
Molecular recordings by directed CRISPR spacer acquisition
2016 Science
CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
1997 Standout
Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.
1994
Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms
1991
Growth Factors and Cancer
1991 StandoutScience
Molecular Targets of Lithium Action
2001
Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition
2015
Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions.
1991
PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures
2018
Insights Obtained by Culturing Saccharibacteria With Their Bacterial Hosts
2020
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Degenerate target sites mediate rapid primed CRISPR adaptation
2014
Mechanisms and clinical importance of bacteriophage resistance
2021
Cultivation of a vampire: ‘ Candidatus Absconditicoccus praedator’
2021
Nerve growth factor as a paradigm for other polypeptide growth factors
1986 StandoutNobel
Works of David Burstein being referenced
Analysis of five complete genome sequences for members of the class Peribacteria in the recently recognized Peregrinibacteria bacterial phylum
2016
Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires
2016
Major bacterial lineages are essentially devoid of CRISPR-Cas viral defence systems
2016
Anti-Glutamate Receptor 2 as a New Potential Diagnostic Probe for Prostatic Adenocarcinoma
2012
Native homing endonucleases can target conserved genes in humans and in animal models
2011
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes
2017 StandoutNobel
Differential GC Content between Exons and Introns Establishes Distinct Strategies of Splice-Site Recognition
2012
Dissociation of c-fos from ODC expression and neuronal differentiation in a PC12 subline stably transfected with an inducible N-ras oncogene
1988
Novel Microbial Diversity and Functional Potential in the Marine Mammal Oral Microbiome
2017
Genome-Scale Identification of Legionella pneumophila Effectors Using a Machine Learning Approach
2009
Cellular swirls in fine needle aspirates of papillary thyroid carcinoma: a new diagnostic criterion
2006
The distinction of CPR bacteria from other bacteria based on protein family content
2019
CoPAP: Coevolution of Presence–Absence Patterns
2013
Retroelement-guided protein diversification abounds in vast lineages of Bacteria and Archaea
2017
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Large-scale comparative analysis of splicing signals and their corresponding splicing factors in eukaryotes
2007
Expression of p63 in papillary thyroid carcinoma and in Hashimoto’s thyroiditis: a pathobiologic link?
2003
Thyroid Cytology and the Risk of Malignancy in Thyroid Nodules: Importance of Nuclear Atypia in Indeterminate Specimens
2001
Activated N‐ras gene induces neuronal differentiation of PC12 rat pheochromocytoma cells
1986
Oncogene N-ras mediates selective inhibition of c-fos induction by nerve growth factor and basic fibroblast growth factor in a PC12 cell line.
1990
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
Regulation of protein kinase C activity in neuronal differentiation induced by the N-ras oncogene in PC-12 cells.
1990
Lithium ion inhibits nerve growth factor-induced neurite outgrowth and phosphorylation of nerve growth factor-modulated microtubule-associated proteins.
1985
Potential for microbial H2 and metal transformations associated with novel bacteria and archaea in deep terrestrial subsurface sediments
2017
Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal
2013
DNA motifs determining the efficiency of adaptation into the Escherichia coli CRISPR array
2013
Genomic resolution of a cold subsurface aquifer community provides metabolic insights for novel microbes adapted to high CO 2 concentrations
2016