Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9
2017 StandoutNobel
Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
2015 StandoutScienceNobel
1 Developmental roles and clinical significance of Hedgehog signaling
2003
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Sonic Hedgehog–Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System
2000
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1
2001
The Whereabouts of a Morphogen: Direct Evidence for Short- and Graded Long-Range Activity of Hedgehog Signaling Peptides
2001
Cooperation of BMP7 and SHH in the Induction of Forebrain Ventral Midline Cells by Prechordal Mesoderm
1997
Requirement for LIM Homeobox Gene Isl1 in Motor Neuron Generation Reveals a Motor Neuron– Dependent Step in Interneuron Differentiation
1996
Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
1995 Standout
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
1999 StandoutNature
Some distal limb structures develop in mice lacking Sonic hedgehog signaling
2001
Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb
2000 Standout
Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation
1995
Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan
1999
Sonic Hedgehog (SHH) specifies muscle pattern at tissue and cellular chick level, in the chick limb bud
1999
Hedgehog and Patched in Neural Development and Disease
1998
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
2000 Standout
Hedgehog Signalling Is Required for Maintenance of myf5 and myoD Expression and Timely Terminal Differentiation in Zebrafish Adaxial Myogenesis
2001
Developmental basis of limblessness and axial patterning in snakes
1999 Nature
Control of Muscle Cell-Type Specification in the Zebrafish Embryo by Hedgehog Signalling
1999
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes
2017
Sertoli cell signaling by Desert hedgehog regulates the male germline
1996
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Determination of Neuroepithelial Cell Fate: Induction of the Oligodendrocyte Lineage by Ventral Midline Cells and Sonic Hedgehog
1996
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
The world according to bedgebog
1997
Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage
1995
Temporal and Spatial Effects of Sonic Hedgehog Signaling in Chick Eye Morphogenesis
2001
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Limbs are moving: where are they going?
1998
An Acylatable Residue of Hedgehog Is Differentially Required in Drosophila and Mouse Limb Development
2001
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
1996 StandoutNature
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
1995
Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish
1996 Nature
The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors
1998 StandoutNobel
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Sonic hedgehog signaling by the Patched–Smoothened receptor complex
1999
Identification of a Tetrameric Hedgehog Signaling Complex
2000
Induction of oligodendrocyte progenitors in the trunk neural tube by ventralizing signals: effects of notochord and floor plate grafts, and of sonic hedgehog
1996
Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
1995
Biochemical evidence that Patched is the Hedgehog receptor
1996 StandoutNature
Alkaline phosphatase fusions of ligands or receptors as in situ probes for staining of cells, tissues, and embryos
2000
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
2010 StandoutNature
A freely diffusible form of Sonic hedgehog mediates long-range signalling
2001 Nature
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells
2016
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Mouse Dispatched homolog1 Is Required for Long-Range, but Not Juxtacrine, Hh Signaling
2002
Analysis of Epithelial–Mesenchymal Interactions in the Initial Morphogenesis of the Mammalian Tooth
1998
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
1999 Standout
Hedgehog Signal Transduction via Smoothened Association with a Cytoplasmic Complex Scaffolded by the Atypical Kinesin, Costal-2
2003
The role of the notochord and floor plate in inductive interactions
1995
The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types
2000
FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate
1998
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
Identification of erythroferrone as an erythroid regulator of iron metabolism
2014
Analysis of the zebrafishsmoothenedmutant reveals conserved and divergent functions of hedgehog activity
2001
Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog
1997
Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
2002 Nature
Asymmetric Inheritance of Centrosome-Associated Primary Cilium Membrane Directs Ciliogenesis after Cell Division
2013
A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube
2000
New players and puzzles in the Hedgehog signaling pathway
1998
C. elegans patched-3 is an essential gene implicated in osmoregulation and requiring an intact permease transporter domain
2011
Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain
1996
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog
1999 Standout
Transducing Hedgehog: the story so far
1998
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
BMPs as Mediators of Roof Plate Repulsion of Commissural Neurons
1999
Recent advances in hedgehog signalling
1997
Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1
1997
A thermostable Cas9 with increased lifetime in human plasma
2017 StandoutNobel
Induction of midbrain dopaminergic neurons by Sonic hedgehog
1995
How is myogenesis initiated in the embryo?
1996
Prostate Development Requires Sonic Hedgehog Expressed by the Urogenital Sinus Epithelium
1999
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Patterning activities of vertebrate hedgehog proteins in the developing eye and brain
1995
Sonic hedgehog signaling is essential for hair development
1998
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
1996 Standout
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Manifestation of the Limb Prepattern: Limb Development in the Absence of Sonic Hedgehog Function
2001
Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling
1997
Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog
1998 Standout
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing
1995
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
1996 StandoutNature
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities
2004 Standout
Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling
1999
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
2002 Standout
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
1997
Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity
1996
Stage-Specific Effects ofSonic HedgehogExpression in the Epidermis
1998
Modulation of Early but Not Later Stages of Programmed Cell Death in Embryonic Avian Spinal Cord by Sonic Hedgehog
1999
Slow muscle induction by Hedgehog signalling in vitro
2000
Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog
1998
Axonal Ephrin-As and Odorant Receptors
2003 StandoutNobel
Autoregulation ofShhexpression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development
2000
RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
2010
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Control of somite patterning by Sonic hedgehog and its downstream signal response genes
1998
Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina
1997
Characterization of two patched receptors for the vertebrate hedgehog protein family
1998
Sonic hedgehog regulates the growth and patterning of the cerebellum
1999
Hox10 and Hox11 Genes Are Required to Globally Pattern the Mammalian Skeleton
2003 StandoutScienceNobel
THE SPECIFICATION OF DORSAL CELL FATES IN THE VERTEBRATE CENTRAL NERVOUS SYSTEM
1999
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
1998 StandoutScience
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.
1996
The chemistry of Cas9 and its CRISPR colleagues
2017 StandoutNobel
Midline signalling is required for Pax gene regulation and patterning of the eyes
1995
Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage
1995
CRISPR-Cas: biology, mechanisms and relevance
2016 StandoutNobel
The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction
1998
Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation
2001
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
Gli proteins encode context-dependent positive and negative functions: implications for development and disease
1999
Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway
2000
Small molecule modulation of Smoothened activity
2002 Standout
N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons
2001
RNA-dependent RNA targeting by CRISPR-Cas9
2018 StandoutNobel
The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium
2000
Control of chick tectum territory along dorsoventral axis by Sonic hedgehog
2000
Hedgehog Proteins Stimulate Chondrogenic Cell Differentiation and Cartilage Formation
2000
Sonic hedgehog is required for survival of both myogenic and chondrogenic somitic lineages
1998
A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
1997
Pharmacogenomic and Structural Analysis of Constitutive G Protein–Coupled Receptor Activity
2006
Sonic hedgehogRegulates Proliferation and Inhibits Differentiation of CNS Precursor Cells
1999
Sonic Hedgehog Control of Size and Shape in Midbrain Pattern Formation
2001 Science
Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
1998
Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases
2019
Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb
1998
Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
1996
A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve
1999
Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog
1998
Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
1998
Regulation of pancreas development by hedgehog signaling
2000
Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1
2000
Hedgehog signals regulate multiple aspects of gastrointestinal development
2000
hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila
1996
Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
1999
Systemic Iron Homeostasis
2013
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro
1997
Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome
1996 StandoutScience
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb
1996
A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice
2016
Regulation of patched by sonic hedgehog in the developing neural tube.
1996 Standout
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
2000 StandoutScienceNobel
The Hedgehog Signaling Pathway in Cancer
2006
Sonic hedgehog is a survival factor for hypaxial muscles during mouse development
2001
Transient establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic hedgehog activity
1999 Nobel
Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors
1999
Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
1996 StandoutScience
Sonic hedgehog controls epaxial muscle determination through Myf5 activation
1999
Diversity and Pattern in the Developing Spinal Cord
1996 Science
Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo
2001
A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling
2000
The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members
2008
Morphogen gradient interpretation
2001 StandoutNatureNobel
Works of David Bumcrot being referenced
Somite Differentiation: Sonic signals somites
1995
Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications
2015
Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway
2007 Nature
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
2002
A Role forIndian hedgehogin Extraembryonic Endoderm Differentiation in F9 Cells and the Early Mouse Embryo
1997
Comparative biological responses to human Sonic, Indian, and Desert hedgehog
2001
Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein
1995
RNAi therapeutics: a potential new class of pharmaceutical drugs
2006
Delivery and Specificity of CRISPR/Cas9 Genome Editing Technologies for Human Gene Therapy
2015
Sonic Hedgehog Promotes the Survival of Specific CNS Neuron Populations and Protects These Cells from Toxic InsultIn Vitro
1997
Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo
1995
Proteolytic Processing Yields Two Secreted Forms of Sonic hedgehog
1995
An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe−/− mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia
2012
Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb
1997
Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
1995 Nature
Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.
1995
Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult In vitro.
1997