Standout Papers
Citation Impact
Citing Papers
Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs
2018 StandoutNobel
The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25
2006 StandoutNobel
MicroRNA Gene Expression Deregulation in Human Breast Cancer
2005 Standout
Sequence Variations of MicroRNAs in Human Cancer: Alterations in Predicted Secondary Structure Do Not Affect Processing
2006
Developmental Decline in Neuronal Regeneration by the Progressive Change of Two Intrinsic Timers
2013 StandoutScienceNobel
Characterization of MicroRNA Expression Levels and Their Biological Correlates in Human Cancer Cell Lines
2007 StandoutNobel
A microRNA expression signature of human solid tumors defines cancer gene targets
2006 Standout
Genetic Unmasking of an Epigenetically Silenced microRNA in Human Cancer Cells
2007
miR-15 and miR-16 induce apoptosis by targeting BCL2
2005 Standout
A Polycistronic MicroRNA Cluster, miR-17-92 , Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation
2005
Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells
2005 Science
The Human let-7a-3 Locus Contains an Epigenetically Regulated MicroRNA Gene with Oncogenic Function
2007
Systematic analysis of dynamic miRNA-target interactions during C. elegans development
2009 StandoutNobel
A Genomewide Search for Ribozymes Reveals an HDV-Like Sequence in the Human CPEB3 Gene
2006 StandoutScienceNobel
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb
2005
MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation
2005
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
2024 StandoutNobel
A 3′-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis
2011
Systematic identification of microRNA functions by combining target prediction and expression profiling
2006
MicroRNA function in animal development
2005
Interaction between Zucchini Yellow Mosaic Potyvirus RNA-Dependent RNA Polymerase and Host Poly-(A) Binding Protein
2000
Solution structure of a let-7 miRNA: lin-41 mRNA complex from C. elegans
2008
mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein–enriched transcripts
2008 StandoutNobel
The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs
2009 Nature
The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2
2009
Mammalian microRNAs: a small world for fine-tuning gene expression
2006
The Caenorhabditis elegans pumilio homolog, puf-9, is required for the 3′UTR-mediated repression of the let-7 microRNA target gene, hbl-1
2007
The p53/miR-34 axis in development and disease
2014
A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity
2008 StandoutNobel
Spatial preferences of microRNA targets in 3' untranslated regions
2007
MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer
2009
Regulatory Mutations of mir-48, a C. elegans let-7 Family MicroRNA, Cause Developmental Timing Defects
2005
How microRNAs control cell division, differentiation and death
2005
Targeting microRNAs in cancer: rationale, strategies and challenges
2010
Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?
2005
A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans
2010
Small non-coding RNAs in animal development
2008
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence
2012 StandoutNatureNobel
Functional proteins from a random-sequence library
2001 StandoutNatureNobel
nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans
2009 StandoutNobel
The Diverse Functions of MicroRNAs in Animal Development and Disease
2006 Standout
Post‐embryonic expression of C. elegans microRNAs belonging to the lin‐4 and let‐7 families in the hypodermis and the reproductive system
2005
The tumor suppressor microRNA let-7 represses the HMGA2 oncogene
2007
Misexpression of the Caenorhabditis elegans miRNA let-7 Is Sufficient to Drive Developmental Programs
2006 StandoutNobel
Potent effect of target structure on microRNA function
2007 StandoutNobel
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Growth of the plant cell wall
2005 Standout
Function, mechanism and regulation of bacterial ribonucleases
1999
Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54
2006
The let-7 microRNA Directs Vulval Development through a Single Target
2015
Slicer function of Drosophila Argonautes and its involvement in RISC formation
2005
The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells
2009
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
2011 StandoutNatureNobel
LNA-modified oligonucleotides mediate specific inhibition of microRNA function
2006
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA
2011 StandoutNobel
A Whole-Genome RNAi Screen for C. elegans miRNA Pathway Genes
2007 StandoutNobel
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Lin28: A MicroRNA Regulator with a Macro Role
2010
Epigenetics in Cancer
2008 Standout
MicroRNAs as oncogenes
2005
A genetic interactome of the let-7 microRNA in C. elegans
2015
MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease
2008
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
2007 StandoutNature
An elegant miRror: microRNAs in stem cells, developmental timing and cancer
2009
Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans
2011
A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors
2006
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
2005
miR-58 family and TGF-β pathways regulate each other inCaenorhabditis elegans
2015
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity
2008 StandoutNobel
U1 snRNP regulates cancer cell migration and invasion in vitro
2020 Standout
Oncomirs — microRNAs with a role in cancer
2006 Standout
Ribosomal protein RPS-14 modulates let-7 microRNA function in Caenorhabditis elegans
2009
Extensive post-transcriptional regulation of microRNAs and its implications for cancer
2006
A Genome-Wide Map of Conserved MicroRNA Targets in C. elegans
2006
MicroRNAs in cell proliferation, cell death, and tumorigenesis
2006
LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans
2009
Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans
2010
Poliovirus RNA Replication Requires Genome Circularization through a Protein–Protein Bridge
2001
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
2008 Standout
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
2013 Standout
LIN-42, the Caenorhabditis elegans PERIOD homolog, Negatively Regulates MicroRNA Transcription
2014
Genomics of microRNA
2006
MicroRNA signatures in human cancers
2006 Standout
Deletion of microRNA-80 Activates Dietary Restriction to Extend C. elegans Healthspan and Lifespan
2013
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
2006
MicroRNAs Both Promote and Antagonize Longevity in C. elegans
2010
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
The Developmental Timing Regulator AIN-1 Interacts with miRISCs and May Target the Argonaute Protein ALG-1 to Cytoplasmic P Bodies in C. elegans
2005
MicroRNAs in Stress Signaling and Human Disease
2012
MicroRNA expression profiles classify human cancers
2005 StandoutNatureNobel
Gene regulation by microRNAs
2006
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
2006 Standout
let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells
2007 Standout
The chemical repertoire of natural ribozymes
2002 StandoutNatureNobel
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
2006 Standout
MicroRNA deregulation in human thyroid papillary carcinomas
2006
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells
2009
Camels and zebrafish, viruses and cancer: a microRNA update
2005
A New Role for the GARP Complex in MicroRNA-Mediated Gene Regulation
2013
The microRNA pathway controls germ cell proliferation and differentiation in C. elegans
2012
Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
2007 StandoutNobel
Non‐coding RNAs in cancer initiation and progression and as novel biomarkers
2011
The mir-51 Family of microRNAs Functions in Diverse Regulatory Pathways in Caenorhabditis elegans
2012
Parallels among positive-strand RNA viruses, reverse-transcribing viruses and double-stranded RNA viruses
2006
Inference of miRNA targets using evolutionary conservation and pathway analysis
2007
The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation
2008
The let-7 MicroRNA Family Members mir-48, mir-84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans
2005 StandoutNobel
Functional Genomic Analysis of the let-7 Regulatory Network in Caenorhabditis elegans
2013
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Autophagy modulates miRNA‐mediated gene silencing and selectively degrades AIN‐1/GW182 in C. elegans
2013
The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans
2011
RNA–protein analysis using a conditional CRISPR nuclease
2013 StandoutNobel
Initiation of viral RNA-dependent RNA polymerization
2004
Alphavirus RNA Genome Repair and Evolution: Molecular Characterization of Infectious Sindbis Virus Isolates Lacking a Known Conserved Motif at the 3′ End of the Genome
2000
Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons
2003
3′ Nontranslated RNA Signals Required for Replication of Hepatitis C Virus RNA
2003
MicroRNA functions in animal development and human disease
2005
microRNAs exhibit high frequency genomic alterations in human cancer
2006
Dengue Virus Utilizes a Novel Strategy for Translation Initiation When Cap-Dependent Translation Is Inhibited
2006
A role for Dicer in immune regulation
2006 StandoutNobel
Expression of Hepatitis C Virus Proteins Induces Distinct Membrane Alterations Including a Candidate Viral Replication Complex
2002
The role of microRNA genes in papillary thyroid carcinoma
2005 Standout
Let-7 expression defines two differentiation stages of cancer
2007
The Temporal Patterning MicroRNA let-7 Regulates Several Transcription Factors at the Larval to Adult Transition in C. elegans
2005
Sizing up miRNAs as cancer genes
2005
Does graft-versus-host disease influence the tempo of immunologic recovery after allogeneic human marrow transplantation? An observation on 56 long-term survivors
1978
Biochemistry and Evolution of Anaerobic Energy Metabolism in Eukaryotes
2012
Requirements at the 3′ End of the Sindbis Virus Genome for Efficient Synthesis of Minus-Strand RNA
2005 StandoutNobel
Specific suppressor cells in graft–host tolerance of HLA-identical marrow transplantation
1981 StandoutNatureNobel
Human let-7a miRNA blocks protein production on actively translating polyribosomes
2006
MicroRNA Expression Abnormalities in Pancreatic Endocrine and Acinar Tumors Are Associated With Distinctive Pathologic Features and Clinical Behavior
2006
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Distance constraints between microRNA target sites dictate efficacy and cooperativity
2007
Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1
2015
The regulation of genes and genomes by small RNAs
2007 StandoutNobel
In Vivo Addition of Poly(A) Tail and AU-Rich Sequences to the 3′ Terminus of the Sindbis Virus RNA Genome: a Novel 3′-End Repair Pathway
1999
In Vitro Selection of Functional Nucleic Acids
1999 StandoutNobel
Minimal Template Requirements for Initiation of Minus-Strand Synthesis In Vitro by the RNA-Dependent RNA Polymerase of Turnip Yellow Mosaic Virus
1998
Myogenic factors that regulate expression of muscle-specific microRNAs
2006
let-7 MicroRNA Functions as a Potential Growth Suppressor in Human Colon Cancer Cells
2006
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
Micro-RNA Regulation of the Mammalian lin-28 Gene during Neuronal Differentiation of Embryonal Carcinoma Cells
2005
MicroRNA-Cancer Connection: The Beginning of a New Tale
2006
microRNA Functions
2007 Standout
Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation
2007 Science
Proteomic and functional analysis of Argonaute‐containing mRNA–protein complexes in human cells
2007
Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets
2009 StandoutNobel
Works of David Brown being referenced
Development of a Lung Cancer Therapeutic Based on the Tumor Suppressor MicroRNA-34
2010
The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells
2007
Identification of Novel Genes in Arabidopsis Involved in Secondary Cell Wall Formation Using Expression Profiling and Reverse Genetics
2005
RAS Is Regulated by the let-7 MicroRNA Family
2005 Standout
Libraries for genomic SELEX
1997
Regression of murine lung tumors by the let-7 microRNA
2009
Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice
2011
A H2O‐Producing NADH Oxidase from the Protozoan Parasite Giardia Duodenalis
1996
Thelet-7microRNA reduces tumor growth in mouse models of lung cancer
2008
miR-10a overexpression is associated with NPM1 mutations and MDM4 downregulation in intermediate-risk acute myeloid leukemia
2011
An optimized isolation and labeling platform for accurate microRNA expression profiling
2005
Anaerobic bacterial metabolism in the ancient eukaryote Giardia duodenalis
1998
From oligonucleotide shapes to genomic SELEX: Novel biological regulatory loops
1997
Requirements for Assembly of Poliovirus Replication Complexes and Negative-Strand RNA Synthesis
2001
In Vitro Selection of RNA Specifically Cleaved by Bacteriophage T4 RegB Endonuclease
1996
Congenital Aplasia of the Thymus Gland (DiGeorge's Syndrome)
1968
RNA replication by Q beta replicase: a working model.
1996
Cell-Dependent Role for the Poliovirus 3′ Noncoding Region in Positive-Strand RNA Synthesis
2004
Replication-competent picornaviruses with complete genomic RNA 3' noncoding region deletions
1997