Citation Impact
Citing Papers
Nonclassic Functions of Human Topoisomerase I: Genome-Wide and Pharmacologic Analyses
2007
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors
1996
ICE-related proteases in apoptosis
1996
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
1995
Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6
1991
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
1996 StandoutNatureNobel
Caspases and caspase inhibitors
1997
Molecular Ordering of Apoptotic Mammalian CED-3/ICE-like Proteases
1996
Dual-specificity protein kinases: will any hydroxyl do?
1992
A Sequential Two-Step Mechanism for the Production of the Mature p17:p12 Form of Caspase-3 in Vitro
1997
Distinct Effects of Topoisomerase I and RNA Polymerase I Inhibitors Suggest a Dual Mechanism of Nucleolar/Nucleoplasmic Partitioning of Topoisomerase I
2004
The generation of diversity and pattern in animal development
1992 StandoutNobel
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Genetic analysis of chemoresistance in primary murine lymphomas
2000
When Checkpoints Fail
1997 StandoutNobel
Control of Apoptosis by Proteases
1997
Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
1993 StandoutNobel
The Large Subunit of the DNA Replication Complex C (DSEB/RF-C140) Cleaved and Inactivated by Caspase-3 (CPP32/YAMA) during Fas-induced Apoptosis
1997
A kinase from fission yeast responsible for blocking mitosis in S phase
1995 Nature
Caspase-mediated Cleavage of DNA Topoisomerase I at Unconventional Sites during Apoptosis
1999
Proteolytic cleavage during chemotherapy-induced apoptosis
1996
Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants
1998 Nature
The biochemistry of apoptosis
2000 StandoutNature
Spodoptera frugiperda Caspase-1, a Novel Insect Death Protease That Cleaves the Nuclear Immunophilin FKBP46, Is the Target of the Baculovirus Antiapoptotic Protein p35
1997
Programmed cell death in invertebrates
1996
Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death
1996 Standout
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Death substrates come alive
1997
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
1994 StandoutScience
Caspase structure, proteolytic substrates, and function during apoptotic cell death
1999
Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression
2009 StandoutNobel
A License to Kill
1996
Apoptosis
2002 Standout
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
Granzyme B Directly and Efficiently Cleaves Several Downstream Caspase Substrates: Implications for CTL-Induced Apoptosis
1998
Apoptosis without caspases: an inefficient molecular guillotine?
1999
ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis
1996
Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesterase
2002
Programmed population control by cell–cell communication and regulated killing
2004 StandoutNatureNobel
How Chemoproteomics Can Enable Drug Discovery and Development
2012
drICE is an essential caspase required for apoptotic activity in Drosophila cells
1997
Actin cleavage in various tumor cells is not a critical requirement for executing apoptosis
1998
twine, a cdc25 homolog that functions in the male and female germline of drosophila
1992 StandoutNobel
Two tumour necrosis factor receptors: structure and function
1995
Specific Cleavage of α-Fodrin during Fas- and Tumor Necrosis Factor-induced Apoptosis Is Mediated by an Interleukin-1β-converting Enzyme/Ced-3 Protease Distinct from the Poly(ADP-ribose) Polymerase Protease
1996
CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint
1997 StandoutNobel
WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine‐zipper domains
1993
Expression cloning of an activin receptor, a predicted transmembrane serine kinase
1991
Identification of a Cysteine Protease Closely Related to Interleukin‐1β‐Converting Enzyme
1996
Repair of and checkpoint response to topoisomerase I-mediated DNA damage
2003
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes
2008 Nature
Dentatorubral Pallidoluysian Atrophy (DRPLA) Protein Is Cleaved by Caspase-3 during Apoptosis
1997
Regulation of Protein Phosphatase 2A Activity by Caspase-3 during Apoptosis
1998
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Hidden Markov models of biological primary sequence information.
1994 StandoutNobel
SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.
1993
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
2002 StandoutNobel
Chemical Topology: Complex Molecular Knots, Links, and Entanglements
2011 StandoutNobel
Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes
1991 Science
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Cytokinetic failure and asynchronous nuclear division in BHK cells overexpressing a truncated protein-tyrosine-phosphatase.
1992 StandoutNobel
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity
1991
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
1995 StandoutScience
Dismantling Cell–Cell Contacts during Apoptosis Is Coupled to a Caspase-dependent Proteolytic Cleavage of β-Catenin
1997
Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).
1991
Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres
2006 StandoutNobel
Interaction of the Baculovirus Anti-apoptotic Protein p35 with Caspases. Specificity, Kinetics, and Characterization of the Caspase/p35 Complex
1998
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.
1996
Cancer Cell Cycles
1996 StandoutScience
Rfc5, a small subunit of replication factor C complex, couples DNA replication and mitosis in budding yeast.
1996
Functional and Physical Interaction between Rad24 and Rfc5 in the Yeast Checkpoint Pathways
1998
Tumor Cell Death Induced by Topoisomerase-Targeting Drugs
2001
Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner.
1991
Rfc4 Interacts with Rpa1 and Is Required for Both DNA Replication and DNA Damage Checkpoints in Saccharomyces cerevisiae
2001
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
Death Receptors: Signaling and Modulation
1998 StandoutScience
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.
1996
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.
1994 StandoutNobel
The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types
2002 StandoutNobel
The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.
1994
PROTEOLYTIC ACTIVITIES THAT MEDIATE APOPTOSIS
1998
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
New Biarsenical Ligands and Tetracysteine Motifs for Protein Labeling in Vitro and in Vivo: Synthesis and Biological Applications
2002 StandoutNobel
The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.
1996
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis
1997
Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak
1997
A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.
1993
MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis
1998
Caspases: the executioners of apoptosis
1997 Standout
Addiction Modules and Programmed Cell Death and Antideath in Bacterial Cultures
1999
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia
1998 StandoutNobel
E1B 19K Inhibits Fas-mediated Apoptosis through FADD-dependent Sequestration of FLICE
1998
Mitochondria and Apoptosis
1998 StandoutScience
Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function.
1996
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
1999 Standout
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.
1991
MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment
1999
Role of a Complex Containing Rad17, Mec3, and Ddc1 in the Yeast DNA Damage Checkpoint Pathway
1999
Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways
1996 Science
Fas Is Expressed in Human Atherosclerotic Intima and Promotes Apoptosis of Cytokine-Primed Human Vascular Smooth Muscle Cells
1997
Rad53 FHA Domain Associated with Phosphorylated Rad9 in the DNA Damage Checkpoint
1998 Science
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.
1996
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.
1996
Involvement of caspase-dependent activation of cytosolic phospholipase A2in tumor necrosis factor-induced apoptosis
1997
Caspases: Enemies Within
1998 StandoutScience
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Repair of DNA–polypeptide crosslinks by human excision nuclease
2006 StandoutNobel
mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans
2011 StandoutNobel
Modulation of Caspase-8 and FLICE-Inhibitory Protein Expression as a Potential Mechanism of Epstein-Barr Virus Tumorigenesis in Burkitt’s Lymphoma
1999
Cell Cycle Checkpoints: Preventing an Identity Crisis
1996 StandoutScience
Chemical Glycoproteomics
2016 StandoutNobel
Works of David Beidler being referenced
Camptothecin induction of a time- and concentration-dependent decrease of topoisomerase I and its implication in camptothecin activity.
1995
Overexpression of Bcl-xL Promotes Chemotherapy Resistance of Mammary Tumors in a Syngeneic Mouse Model
1999
The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis
1995
CrmA-inhibitable Cleavage of the 70-kDa Protein Component of the U1 Small Nuclear Ribonucleoprotein during Fas- and Tumor Necrosis Factor-induced Apoptosis
1995
Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor
2010
Spk1, a New Kinase from Saccharomyces cerevisiae, Phosphorylates Proteins on Serine, Threonine, and Tyrosine
1991
Identification of antisense RNA transcripts from a human DNA topoisomerase I pseudogene.
1992