Citation Impact
Citing Papers
The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways
2007
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ
2013 StandoutNobel
Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)
2010 StandoutNobel
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism
2013 Science
Cutting Edge: Roles of Caspase-8 and Caspase-10 in Innate Immune Responses to Double-Stranded RNA
2006
UAF1 Is a Subunit of Multiple Deubiquitinating Enzyme Complexes
2008
The Deubiquitinating Enzyme BAP1 Regulates Cell Growth via Interaction with HCF-1
2009
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The Long Form of FLIP Is an Activator of Caspase-8 at the Fas Death-inducing Signaling Complex
2002
Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin pools
2011
Drosophila Dscam Is Required for Divergent Segregation of Sister Branches and Suppresses Ectopic Bifurcation of Axons
2002
RNA recognition and signal transduction by RIG‐I‐like receptors
2008
Phosphorylation of ETS1 by Src Family Kinases Prevents Its Recognition by the COP1 Tumor Suppressor
2014 StandoutNobel
Necroptosis as an alternative form of programmed cell death
2010
Toll‐like Receptor and RIG‐1‐like Receptor Signaling
2008
Mechanisms of NOD-like Receptor-Associated Inflammasome Activation
2013
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
2010 Standout
Wnt Signals and Frizzled Activity Orient Anterior-Posterior Axon Outgrowth in C. elegans
2006
The CD95(APO-1/Fas) DISC and beyond
2003
Caspases: pharmacological manipulation of cell death
2005 Standout
An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains
2011
c‐IAP1 and UbcH5 promote K11‐linked polyubiquitination of RIP1 in TNF signalling
2010
Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
2009
A Vast Repertoire of Dscam Binding Specificities Arises from Modular Interactions of Variable Ig Domains
2007 StandoutNobel
CUL4A Abrogation Augments DNA Damage Response and Protection against Skin Carcinogenesis
2009
Axon guidance: Starting and stopping with Slit
1999
Function and regulation of cullin–RING ubiquitin ligases
2005 Standout
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
Activation and regulation of the inflammasomes
2013 Standout
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins
2009
Pattern Recognition Receptors and Inflammation
2010 Standout
E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation
2006
Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction
2011
The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
2008
Apoptotic mechanisms in the control of erythropoiesis
2004
PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunit
2007
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
2002
Mechanisms of inflammasome activation: recent advances and novel insights
2015
Immune Signaling by RIG-I-like Receptors
2011
Modulation of K11-Linkage Formation by Variable Loop Residues within UbcH5A
2011
The Deubiquitinating Enzyme Ataxin-3, a Polyglutamine Disease Protein, Edits Lys63 Linkages in Mixed Linkage Ubiquitin Chains
2008
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase
2005 StandoutNobel
Breaking the chains: structure and function of the deubiquitinases
2009 Standout
Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex
2011
The P53 pathway: what questions remain to be explored?
2006
Caspase Functions in Cell Death and Disease
2013 Standout
Deubiquitylation and regulation of the immune response
2008
Interdimer processing mechanism of procaspase-8 activation
2003
3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome
2013
Evidence for Bidentate Substrate Binding as the Basis for the K48 Linkage Specificity of Otubain 1
2009
Inflammasomes: mechanism of assembly, regulation and signalling
2016 Standout
C. elegans Slit Acts in Midline, Dorsal-Ventral, and Anterior-Posterior Guidance via the SAX-3/Robo Receptor
2001
BMPs as Mediators of Roof Plate Repulsion of Commissural Neurons
1999
Superresolution Imaging of Chemical Synapses in the Brain
2010
Analytical glycobiology at high sensitivity: current approaches and directions
2012
The Logic of the 26S Proteasome
2017
The NAIP/NLRC4 inflammasomes
2015
Mechanisms and Functions of Inflammasomes
2014 Standout
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Mammalian COP9 signalosome
2009
Mechanism and Consequences for Paralog-Specific Sumoylation of Ubiquitin-Specific Protease 25
2008
Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes
2003 Standout
An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets
2005
The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation
2014
Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity
2013
Newly described pattern recognition receptors team up against intracellular pathogens
2013
Key Role of Ubc5 and Lysine-63 Polyubiquitination in Viral Activation of IRF3
2009
Optical Pooled Screens in Human Cells
2019
Drosophila Neurexin IV Interacts with Roundabout and Is Required for Repulsive Midline Axon Guidance
2010
Shigella Type III Secretion Protein MxiI Is Recognized by Naip2 to Induce Nlrc4 Inflammasome Activation Independently of Pkcδ
2014
BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination
2010
The p53 pathway: positive and negative feedback loops
2005 Standout
Ubiquitylation in innate and adaptive immunity
2009 Nature
A quantitative analysis software tool for mass spectrometry–based proteomics
2008
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
Post-translational modification of p53 in tumorigenesis
2004
Multiple Functions of Jab1 Are Required for Early Embryonic Development and Growth Potential in Mice
2004 StandoutNobel
Structural basis for specific recognition of Lys 63‐linked polyubiquitin chains by tandem UIMs of RAP80
2009
F-Spondin Is Required for Accurate Pathfinding of Commissural Axons at the Floor Plate
1999
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
2002
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas
2010 StandoutScience
A decade of caspases
2003
Regulation of death receptor signaling by the ubiquitin system
2009
Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation
2011
Mechanisms of caspase activation
2003
Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation
2009
Fast Alkene Functionalization In Vivo by Photoclick Chemistry: HOMO Lifting of Nitrile Imine Dipoles
2009
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Axonal Ephrin-As and Odorant Receptors
2003 StandoutNobel
The application of targeted mass spectrometry‐based strategies to the detection and localization of post‐translational modifications
2014
Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5
2015
The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon
2009
Diversity of gene expression in adenocarcinoma of the lung
2001
The Role of Ubiquitin in NF-κB Regulatory Pathways
2009
The protein structures that shape caspase activity, specificity, activation and inhibition
2004
Two Adjacent Trimeric Fas Ligands Are Required for Fas Signaling and Formation of a Death-Inducing Signaling Complex
2003
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Transcriptional control of human p53-regulated genes
2008 Standout
Neural Science
2000 StandoutNobel
Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes
2014 StandoutNobel
F-spondin is a contact-repellent molecule for embryonic motor neurons
2001
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Regulation of Fas-associated Death Domain Interactions by the Death Effector Domain Identified by a Modified Reverse Two-hybrid Screen
2002
TLRs and innate immunity
2008 StandoutNobel
The future of immune checkpoint therapy
2015 StandoutScienceNobel
K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody
2010
Molecular and Immunological Significance of Chimpanzee Major Histocompatibility Complex Haplotypes for Hepatitis C Virus Immune Response and Vaccination Studies
2002 StandoutNobel
Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development
2012 StandoutNobel
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
The Ubiquitin Code
2012 Standout
Recognition of Bacteria by Inflammasomes
2012
Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation
2013
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
2002
BLIMP1 regulates cell growth through repression of p53 transcription
2007
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Innate immunity to virus infection
2008
Ubiquitin in NF-κB Signaling
2009
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Chromatin Immunoprecipitation-Based Screen To Identify Functional Genomic Binding Sites for Sequence-Specific Transactivators
2005
Chemical Glycoproteomics
2016 StandoutNobel
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Liver-Derived CTL in Hepatitis C Virus Infection: Breadth and Specificity of Responses in a Cohort of Persons with Chronic Infection
1998 StandoutNobel
Works of David Arnott being referenced
A Deubiquitinase That Regulates Type I Interferon Production
2007 Science
Human De-Etiolated-1 Regulates c-Jun by Assembling a CUL4A Ubiquitin Ligase
2004 Science
B and T Lymphocyte Attenuator Regulates B Cell Receptor Signaling by Targeting Syk and BLNK
2009
Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines
2010
Improved Quantitative Mass Spectrometry Methods for Characterizing Complex Ubiquitin Signals
2010
Phosphorylation of NLRC4 is critical for inflammasome activation
2012 Nature
Mass Spectrometric Contributions to the Practice of Phosphorylation Site Mapping through 2003
2005
Death Receptor Recruitment of Endogenous Caspase-10 and Apoptosis Initiation in the Absence of Caspase-8
2001
Targeted mass spectrometric strategy for global mapping of ubiquitination on proteins
2007
Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling
2010
The ubiquitin ligase COP1 is a critical negative regulator of p53
2004 Nature
Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance
1999
Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas
1999
COP1 is a tumour suppressor that causes degradation of ETS transcription factors
2011 Nature
Preparation of Distinct Ubiquitin Chain Reagents of High Purity and Yield
2011
Biochemical Purification of a Mammalian Slit Protein as a Positive Regulator of Sensory Axon Elongation and Branching
1999
Selective Detection of Membrane Proteins Without Antibodies
2002
NLRP3 recruitment by NLRC4 during Salmonella infection
2016
Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1
2009
Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2
2008
Definition of specific peptide motifs for four major HLA-A alleles.
1994
Rapid removal of N-linked oligosaccharides using microwave assisted enzyme catalyzed deglycosylation
2006