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Citing Papers
Patients with hippocampal amnesia cannot imagine new experiences
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Interactions of PGH Synthase Isozymes‐1 and ‐2 with NSAIDsa
1994
Induction of cyclooxygenase-2 is responsible for interleukin-1 beta-dependent prostaglandin E2 synthesis by human lung fibroblasts.
1995
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1
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1995
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Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
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1991
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1998
Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
1993
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1995
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1995
Rapid worldwide depletion of predatory fish communities
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1994
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1994
The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide
1987
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
1991 Standout
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1999
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2
2000 StandoutNobel
Glucocorticoid inhibition of interleukin-1-induced interleukin-6 production by human lung fibroblasts: evidence for transcriptional and post-transcriptional regulatory mechanisms.
1994
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1995
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1997
Comparison of Hydroperoxide Initiator Requirements for the Cyclooxygenase Activities of Prostaglandin H Synthase-1 and −2
1995
Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide.
1995
Prostacyclin synthesis in ovine pulmonary artery is developmentally regulated by changes in cyclooxygenase-1 gene expression.
1994
Pregnancy Maintenance and Parturition: The Role of Prostaglandin in Manipulating the Immune and Inflammatory Response
1994
Activation of Cytosolic Phospholipase A2 by Platelet-derived Growth Factor Is Essential for Cyclooxygenase-2-dependent Prostaglandin E2 Synthesis in Mouse Osteoblasts Cultured with Interleukin-1
1997
An Alternatively Spliced C. elegans ced-4 RNA Encodes a Novel Cell Death Inhibitor
1996 StandoutNobel
Human peritoneal mesothelial cell prostaglandin synthesis: Induction of cyclooxygenase mRNA by peritoneal macrophage-derived cytokines
1994
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1996
Genome‐wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis
2012
Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages
1992
Persistent and transcriptionally-dependent increase in protein phosphorylation in long-term facilitation ofAplysia sensory neurons
1989 StandoutNatureNobel
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
1994 Nature
c-Kit Ligand Mediates Increased Expression of Cytosolic Phospholipase A2, Prostaglandin Endoperoxide Synthase-1, and Hematopoietic Prostaglandin D2 Synthase and Increased IgE-dependent Prostaglandin D2 Generation in Immature Mouse Mast Cells
1995
Angiotensin II attenuates renal cortical cyclooxygenase-2 expression
1999
Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones
2005
Two-Photon Calcium Imaging Reveals an Odor-Evoked Map of Activity in the Fly Brain
2003 StandoutNobel
Frequency of gamma oscillations routes flow of information in the hippocampus
2009 StandoutNatureNobel
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
2013 Standout
Conversion of Prostaglandin G/H Synthase-1 into an Enzyme Sensitive to PGHS-2-selective Inhibitors by a Double His513→ Arg and Ile523→ Val Mutation
1997
Gene Switching and the Stability of Odorant Receptor Gene Choice
2004 StandoutNobel
Transcriptional Regulation of Prostaglandin Synthase 2 Gene Expression by Platelet-derived Growth Factor and Serum
1996
Differential expression of prostaglandin h synthase isozymes during multistage carcinogenesis in mouse epidermis
1995
Interleukin-1β-induced Cyclooxygenase-2 Expression Requires Activation of Both c-Jun NH2-terminal Kinase and p38 MAPK Signal Pathways in Rat Renal Mesangial Cells
1998
Odors Detected by Mice Deficient in Cyclic Nucleotide-Gated Channel Subunit A2 Stimulate the Main Olfactory System
2004
Induction of Cyclooxygenase-2 by the Activated MEKK1 → SEK1/MKK4 → p38 Mitogen-activated Protein Kinase Pathway
1998
A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor
1988
Representation of Odorants by Receptor Neuron Input to the Mouse Olfactory Bulb
2001
Expression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissues
1993
The Effects of Treatment with Recombinant Human Growth Hormone on Body Composition and Metabolism in Adults with Growth Hormone Deficiency
1989 Standout
Molecular‐feature domains with posterodorsal–anteroventral polarity in the symmetrical sensory maps of the mouse olfactory bulb: mapping of odourant‐induced Zif268 expression
2002
Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)
1996 Standout
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2
1996 Standout
Induction of cyclo‐oxygenase‐2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone
1994 Nobel
Anti-inflammatory drugs and their mechanism of action
1998 Nobel
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
1995 StandoutNobel
Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2.
1996
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
2003 Standout
Prostaglandin synthase 2
1996 Standout
Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10
2011 StandoutNobel
Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in Human Breast Cancer
1998
Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.
1994
Transforming growth factor β1 augments mitogen‐induced prostaglandin synthesis and expression of the TIS10/prostaglandin synthase 2 gene both in swiss 3T3 cells and in murine embryo fibroblasts
1994
Death and the cell
1986
v-src Induces Prostaglandin Synthase 2 Gene Expression by Activation of the c-Jun N-terminal Kinase and the c-Jun Transcription Factor
1995
Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester.
1994
Interleukin-1-Induced Prostaglandin E2 Biosynthesis in Human Synovial Cells Involves the Activation of Cytosolic Phospholipase A2 and Cyclooxygenase-2
1994
Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.
1994
Transcriptional induction of prostaglandin G/H synthase-2 by basic fibroblast growth factor.
1995
Comparative pharmacology of endothelium‐derived relaxing factor, nitric oxide and prostacyclin in platelets
1987
Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells
1989 StandoutNatureNobel
The Catalytic Outcomes of the Constitutive and the Mitogen Inducible Isoforms of Prostaglandin H2 Synthase Are Markedly Affected by Glutathione and Glutathione Peroxidase(s)
1995
Analysis of Training-Induced Changes in Ethyl Acetate Odor Maps Using a New Computational Tool to Map the Glomerular Layer of the Olfactory Bulb
2005
Arginine 120 of Prostaglandin G/H Synthase-1 Is Required for the Inhibition by Nonsteroidal Anti-inflammatory Drugs Containing a Carboxylic Acid Moiety
1995
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
1994
PGH synthase isoenzyme selectivity: The potential for safer nonsteroidal antiinflammatory drugs
1993
Inhibition of Cyclooxygenase-2 Rapidly Reverses Inflammatory Hyperalgesia and Prostaglandin E2 Production
1997
The Struggle to Govern the Commons
2003 StandoutScienceNobel
TGF-beta1 inhibits both endotoxin-induced prostaglandin synthesis and expression of the TIS10/prostaglandin synthase 2 gene in murine macrophages
1994
Endothelin stimulates prostaglandin endoperoxide synthase-2 mRNA expression and protein synthesis through a tyrosine kinase-signaling pathway in rat mesangial cells.
1994
Cigarette exposure induces changes in maternal vascular function in a pregnant mouse model
2010
Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis.
1992 StandoutNobel
Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells.
1994
Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells.
1993
Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus
2000
Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin.
1996 StandoutNobel
Axonal Ephrin-As and Odorant Receptors
2003 StandoutNobel
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Cyclooxygenases: Structural, Cellular, and Molecular Biology
2000 Standout
Olfactory Fingerprints for Major Histocompatibility Complex-Determined Body Odors II: Relationship among Odor Maps, Genetics, Odor Composition, and Behavior
2002
Differentiation‐associated expression of prostaglandin G/H synthase in monocytic cells
1993
Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene.
1992
Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.
1995 StandoutNobel
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.
1994 Standout
Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.
1996 StandoutNobel
Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2.
1993
Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages.
1994
Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
2014 StandoutScienceNobel
Steroid Receptors and the Mechanism of the Specificity of Glucocorticoid Responsiveness of Somatic Cell Hybrids between Hepatoma Tissue Culture Cells and Mouse Fibroblasts
1974
Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals
2007 StandoutNobel
Glucocorticoid Therapy for Immune-Mediated Diseases: Basic and Clinical Correlates
1993
The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum.
1994
COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex.
1996
Physiological and Molecular Basis of Thyroid Hormone Action
2001 Standout
Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase.
1994
THE MEDIAL TEMPORAL LOBE
2004 Standout
Transcriptional induction of cyclooxygenase-2 gene by okadaic acid inhibition of phosphatase activity in human chondrocytes: Co-stimulation of AP-1 and CRE nuclear binding proteins
1998
Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis
1984
Retinoids suppress epidermal growth factor-induced transcription of cyclooxygenase-2 in human oral squamous carcinoma cells.
1997
v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element.
1994
Regulated expression of human growth hormone genes in mouse cells
1982 StandoutNobel
Stimulation of prostaglandin e2 production by interleukin-1α and transforming growth factor α in osteoblastic MC3T3-E1 cells
1994
The mouse olfactory receptor gene family
2004 StandoutNobel
Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.
1992
Variability of position of the P2 glomerulus within a map of the mouse olfactory bulb
2001
How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions*
2000 Standout
Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA.
1977 StandoutNobel
Arachidonic Acid Oxygenation by COX-1 and COX-2
1999
Seppuku and Autoimmunity
1992 StandoutScienceNobel
Mechanisms of steroid resistance
1974
Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.
1993
Two-dimensional gel electrophoresis of proteins
1987
Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells.
1993
STUDIES ON BLOOD CAPILLARIES
1968 StandoutNobel
TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
1991 Standout
Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model
1985 StandoutNatureNobel
Protein Radicals in Enzyme Catalysis
1998 Standout
Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.
1993 Nobel
Interleukin‐1‐Induced Prostaglandin E2 Biosynthesis in Human Synovial Cells Involves the Activation of Cytosolic Phospholipase A2 and Cyclooxygenase‐2
1994
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2
2001 StandoutNobel
Pharmacological analysis of cyclooxygenase-1 in inflammation
1998
Fever and hypothermia in systemic inflammation: recent discoveries and revisions
2005
Apoptosis in AIDS
1993 StandoutScienceNobel
Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: up-regulation of interleukin 10 and down-regulation of interleukin 12 production.
1998
Lipopolysaccharide priming of alveolar macrophages for enhanced synthesis of prostanoids involves induction of a novel prostaglandin H synthase.
1992
Smells, brains and hormones
2006 Nature
Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2
1999
Deconstructing complexin function in activating and clamping Ca 2+ -triggered exocytosis by comparing knockout and knockdown phenotypes
2013 StandoutNobel
Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase.
1992
Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.
1991
Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production.
1994
Gene Profile of Electroconvulsive Seizures: Induction of Neurotrophic and Angiogenic Factors
2003
The mouse macrophage activation-associated marker protein, p71/73, is an inducible prostaglandin endoperoxide synthase (cyclooxygenase)
1993
NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein.
1990 StandoutNobel
Isoproterenol-induced desensitization of adenylate cyclase responsiveness in a cell-free system.
1979
Works of David A. Young being referenced
IGF-1 influences olfactory bulb maturation. Evidence from anti-IGF-1 antibody treatment of developing grafts in oculo
1995
Effects of hippocampal lesions on patterned motor learning in the rat
2002
Developmental and genetic influences on the p50 sensory gating phenotype
1996
Heritability of Inhibitory Gating of the P50 Auditory-Evoked Potential in Monozygotic and Dizygotic Twins
1996
The Comparative Role of Activator Protein 1 and Smad Factors in the Regulation of Timp-1 and MMP-1 Gene Expression by Transforming Growth Factor-β1
2003
Chronic hypoxia augments uterine artery distensibility and alters the circumferential wall stress-strain relationship during pregnancy
2006
Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs
2012
Advantages of separations on "giant" two-dimensional gels for detection of physiologically relevant changes in the expression of protein gene-products.
1984
Free fatty acid estimation by a semi-automated fluorimetric method
1973
Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo.
1994
Changes in the synthesis and phosphorylation of cellular proteins in chick fibroblasts transformed by two avian sarcoma viruses.
1984
Glucocorticoid-receptor complexes and the earliest steps in the action of glucocorticoids on thymus cells
1972
cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.
1992
A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.
1991
Persistent induction of cyclooxygenase in p60v-src-transformed 3T3 fibroblasts.
1990
Effects of fasting and insulin administration on polyribosome formation in rat epididymal fat cells.
1980
Increased permeability of the capillaries of the rat heart to the plasma albumin with asphyxiation and with perfusion
1966
Anti-inflammatory glucocorticoid action: inhibition of griPGHS, a new cyclooxygenase.
1993
Refractoriness of the cyclic AMP response to adenosine and prostaglandin E1 in thymic lymphocytes. Dependence on protein synthesis and energy-providing substrates
1978
Separate glucocorticoid, heavy metal, and heat shock domains in thymic lymphocytes.
1983
Nonlinear Models for Repeated Measurement Data
1997
Glucocorticoid-induced proteins in rat thymus cells.
1981
Electrophoretic separation of in vitro translation products on giant two-dimensional gels allows detailed analysis of cellular mRNAs.
1986
Olfactory Fingerprints for Major Histocompatibility Complex-Determined Body Odors
2001
Rapid preparation of large quantities of human haemoglobin with low phosphate content by counter-flow dialysis
1976