Standout Papers
Citation Impact
Citing Papers
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
2008 StandoutScienceNobel
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
2003
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
2002 StandoutScienceNobel
Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4
2008 StandoutNobel
Induction of human neuronal cells by defined transcription factors
2011 StandoutNatureNobel
β-Arrestin Scaffolding of Phosphatidylinositol 4-Phosphate 5-Kinase Iα Promotes Agonist-stimulated Sequestration of the β2-Adrenergic Receptor
2008 StandoutNobel
Requirement for a functional Rb-1 gene in murine development
1992 Nature
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
1996
Classical and new roles of β-arrestins in the regulation of G-PROTEIN-COUPLED receptors
2001 StandoutNobel
Multipotent cell lineages in early mouse development depend on SOX2 function
2003 Standout
Subunit counting in membrane-bound proteins
2007
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
A Novel Mutation Avoidance Mechanism Dependent on S. cerevisiae RAD27 Is Distinct from DNA Mismatch Repair
1997
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways
2009 StandoutNobel
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
1997 Nature
Targeted disruption ofSHIPleads to hemopoietic perturbations, lung pathology, and a shortened life span
1998
Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization
2003 StandoutNobel
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Differential Roles for Sox15 and Sox2 in Transcriptional Control in Mouse Embryonic Stem Cells
2005 StandoutNobel
Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway
2000 StandoutNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4
1998 Standout
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
2001 StandoutNatureNobel
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
2013 StandoutNobel
Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors
2010 Standout
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
2003 StandoutNature
Expanding roles for β-arrestins as scaffolds and adapters in GPCR signaling and trafficking
2001 StandoutNobel
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
The role of cytoskeletal proteins in cardiomyopathies
1998
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
1998 StandoutNobel
Seven-transmembrane receptors
2002 StandoutNobel
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
1997 StandoutNature
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
1996 StandoutNature
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
2003
Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes
2005 StandoutNatureNobel
Crystal Structure of β-Arrestin at 1.9 Å
2001
Dosage‐dependent switch from G protein‐coupled to G protein‐independent signaling by a GPCR
2006 StandoutNobel
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture
1994 StandoutScienceNobel
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells.
1994
Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
2008 StandoutScienceNobel
Altered CXCR2 Signaling in β-Arrestin-2-Deficient Mouse Models
2005
Quality Control by DNA Repair
1999 StandoutScienceNobel
RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.
1993
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
β-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
2006 StandoutNobel
Transgenic Gαq overexpression induces cardiac contractile failure in mice
1997
The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
2002 StandoutNobel
G Protein-Coupled Receptors: Functional and Mechanistic Insights Through Altered Gene Expression
1998 StandoutNobel
β-Arrestins and Cell Signaling
2007 StandoutNobel
beta -Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
2001
A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.
1993
β-Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of β2 adrenergic receptor Gαs signaling in 3T3-L1 adipocytes
2002
β-Arrestin is a necessary component of Wnt/β-catenin signaling in vitro and in vivo
2007
Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice.
1994
Increased Frequency of Surface IgA-Positive Plasma Cells in the Intestinal Lamina Propria and Decreased IgA Excretion in Hyper IgA (HIGA) Mice, a Murine Model of IgA Nephropathy with Hyperserum IgA
2000 StandoutNobel
Multifaceted roles of β-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling
2003 StandoutNobel
Double knockouts. Production of mutant cell lines in cardiovascular research.
1993
Fbx15 Is a Novel Target of Oct3/4 but Is Dispensable for Embryonic Stem Cell Self-Renewal and Mouse Development
2003 StandoutNobel
Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene
2001
β-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53
2007
Hematopoietic commitment during embryonic stem cell differentiation in culture.
1993
Altering mice by homologous recombination using embryonic stem cells.
1994 StandoutNobel
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
2001 StandoutScienceNobel
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.
1996
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference
2003 StandoutNobel
Works of David A. Conner being referenced
A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease
2001
A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
1995
Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
1998 Nature
Mutations in the cardiac myosin binding protein–C gene on chromosome 11 cause familial hypertrophic cardiomyopathy
1995
β-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
2001 StandoutNobel
Altered hepatic transport of immunoglobulin A in mice lacking the J chain.
1995
Impaired lymphatic contraction associated with immunosuppression
2011
Production of Homozygous Mutant ES Cells with a Single Targeting Construct
1992
Production of homozygous mutant ES cells with a single targeting construct.
1992
A Mouse Model of Familial Hypertrophic Cardiomyopathy
1996 Science
β-Arrestin1 Knockout Mice Appear Normal but Demonstrate Altered Cardiac Responses to β-Adrenergic Stimulation
1997