Citation Impact
Citing Papers
Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4
2003
TRP channel activation by reversible covalent modification
2006 StandoutNobel
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity
2003 StandoutScienceNobel
Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons
2008 StandoutNobel
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
2011 StandoutNobel
Reconstituting Organ-Level Lung Functions on a Chip
2010 StandoutScience
The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist
2008 StandoutScience
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007 StandoutNobel
TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling
2009
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
2005 StandoutScience
Salt Intake Augments Hypotensive Effects of Transient Receptor Potential Vanilloid 4
2008
N-Oleoyldopamine, a Novel Endogenous Capsaicin-like Lipid That Produces Hyperalgesia
2003
Arresting a Transient Receptor Potential (TRP) Channel
2010 StandoutNobel
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
2003 StandoutNobel
Differential Regulation of TRPV1, TRPV3, and TRPV4 Sensitivity through a Conserved Binding Site on the Ankyrin Repeat Domain
2009
Adenosine receptor activation and nociception
1998
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
2002 Standout
The TRPV4 Cation Channel Mediates Stretch-evoked Ca2+ Influx and ATP Release in Primary Urothelial Cell Cultures
2009
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed
2005
Molecular Determinants of Permeation through the Cation Channel TRPV4
2002
Modulation of Synaptic Transmission by Nociceptin/Orphanin FQ and Nocistatin in the Spinal Cord Dorsal Horn of Mutant Mice Lacking the Nociceptin/Orphanin FQ Receptor
2001
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Knockdown of spinal metabotropic glutamate receptor 1 (mGluR1) alleviates pain and restores opioid efficacy after nerve injury in rats
2001
Increased Basal Activity Is a Key Determinant in the Severity of Human Skeletal Dysplasia Caused by TRPV4 Mutations
2011
TRPV3 and TRPV4 Mediate Warmth-evoked Currents in Primary Mouse Keratinocytes
2004
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Hypothalamic regulation of sleep and circadian rhythms
2005 StandoutNature
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding
2007
Peripheral gating of pain signals by endogenous lipid mediators
2014
Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor
1997
A Role of the Transient Receptor Potential Domain of Vanilloid Receptor I in Channel Gating
2007
TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia
2004
WNK kinases influence TRPV4 channel function and localization
2006
Transient Receptor Potential Channels in Endothelium: Solving the Calcium Entry Puzzle?
2003
The TRPV4 channel: structure-function relationship and promiscuous gating behaviour
2003
Descending control of pain
2002 Standout
Forward Genetic Analysis Reveals Multiple Gating Mechanisms of TRPV4
2010
Adenosine in the spinal cord and periphery: release and regulation of pain
2003
Transient receptor potential ion channels as participants in thermosensation and thermoregulation
2006
TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP
2009 StandoutNobel
The complexities of the cardiovascular actions of cannabinoids
2004
Prolonged Kappa Opioid Receptor Phosphorylation Mediated by G-protein Receptor Kinase Underlies Sustained Analgesic Tolerance
2004 StandoutNobel
Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors
2004
ThermoTRP channels and beyond: mechanisms of temperature sensation
2003 StandoutNobel
Orphanin FQ (nociceptin) modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli, and blocks the substance P-induced facilitation of N-methyl-d-aspartate-evoked responses
1999
Protease‐activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice
2006
Transient Receptor Potential Vanilloid 4 Is Essential in Chemotherapy-Induced Neuropathic Pain in the Rat
2004
Pro-resolving lipid mediators are leads for resolution physiology
2014 StandoutNature
Pore region of TRPV3 ion channel is specifically required for heat activation
2008 StandoutNobel
2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3
2004
Opposite thermosensor in fruitfly and mouse
2003 StandoutNatureNobel
Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)
2005
Anandamide and vanilloid TRPV1 receptors
2003
Cough and airway disease: The role of ion channels
2017
Heat-evoked Activation of TRPV4 Channels in a HEK293 Cell Expression System and in Native Mouse Aorta Endothelial Cells
2002
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Structure–functional intimacies of transient receptor potential channels
2009
Targeting TRP channels for pain relief
2013
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
Pharmacological Characterization of Morphine‐Induced In Vivo Release of Cholecystokinin in Rat Dorsal Horn
1999
Tolerance to μ‐opioid agonists in human neuroblastoma SH‐SY5Y cells as determined by changes in guanosine‐5′‐O‐(3‐[35S]‐thio)triphosphate binding
1997
Molecular mechanisms of opiate and cocaine addiction
1997
Biochemistry and pharmacology of endovanilloids
2007
A 3.5-nm Structure of Rat TRPV4 Cation Channel Revealed by Zernike Phase-contrast Cryoelectron Microscopy
2010
TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells
2004
Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments
2004
Heat Sensitization in Skin and Muscle Nociceptors Expressing Distinct Combinations of TRPV1 and TRPV2 Protein
2007
4-(2-Pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists
2003
TRPV channels as temperature sensors
2003
Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels
2008
Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice
2003
Functional TRPV4 channels are expressed in human airway smooth muscle cells
2004
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
2011 StandoutNatureNobel
Pharmacology of nociceptin and its receptor: a novel therapeutic target
2000
Nocistatin, a peptide reversing acute and chronic morphine tolerance
2001
Characterization of the mouse cold‐menthol receptor TRPM8 and vanilloid receptor type‐1 VR1 using a fluorometric imaging plate reader (FLIPR) assay
2004
TRP channels as cellular sensors
2003 StandoutNature
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Inhibition of nociceptin‐induced allodynia in conscious mice by prostaglandin D2
1997
Camphor Activates and Strongly Desensitizes the Transient Receptor Potential Vanilloid Subtype 1 Channel in a Vanilloid-Independent Mechanism
2005
Altered Thermal Selection Behavior in Mice Lacking Transient Receptor Potential Vanilloid 4
2005
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
TRP channels: a TR(I)P through a world of multifunctional cation channels
2005
Activation of TRPV1 by the Satiety Factor Oleoylethanolamide
2003
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
TRPV channels as thermosensory receptors in epithelial cells
2005
TRPV4 and the mammalian kidney
2005
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
2003 Nature
TRP channels: An overview
2005
Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
2004 StandoutNobel
Effects of supraspinal orphanin FQ/nociceptin
2000
The menthol receptor TRPM8 is the principal detector of environmental cold
2007 StandoutNatureNobel
Arterial Response to Shear Stress Critically Depends on Endothelial TRPV4 Expression
2007
Endovanilloids
2004
Systemic and Site-Specific Effects of A-425619, a Selective TRPV1 Receptor Antagonist, on Wide Dynamic Range Neurons in CFA-Treated and Uninjured Rats
2005
PIEZO2 in sensory neurons and urothelial cells coordinates urination
2020 StandoutNatureNobel
Bidirectional actions of nociceptin/orphanin FQ on Aδ-fibre-evoked responses in rat superficial spinal dorsal horn in vitro
2001
Sensing with TRP channels
2005
The role of Drosophila Piezo in mechanical nociception
2012 StandoutNatureNobel
A TRPV family ion channel required for hearing in Drosophila
2003 Nature
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines
2008
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Nociceptin/orphanin FQ: role in nociceptive information processing
1999
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
2005 StandoutNature
Acid‐sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones
2004
Phosphorylation-Dependent Desensitization by Anandamide of Vanilloid Receptor-1 (TRPV1) Function in Rat Skeletal Muscle Arterioles and in Chinese Hamster Ovary Cells Expressing TRPV1
2005
Transient Receptor Potential Cation Channels in Disease
2007 Standout
Temperature Sensitivity of Dopaminergic Neurons of the Substantia Nigra Pars Compacta: Involvement of Transient Receptor Potential Channels
2005
Current understanding of mammalian TRP homologues
2002
Hypotonicity Induces TRPV4-Mediated Nociception in Rat
2003
Pain-associated signals, acidosis and lysophosphatidic acid, modulate the neuronal K2P2.1 channel
2008
Pharmacology of Vanilloid Transient Receptor Potential Cation Channels
2009
Warm Temperatures Activate TRPV4 in Mouse 308 Keratinocytes
2003
Intracerebroventricular administration of nocistatin reduces inflammatory hyperalgesia in rats
1999
Effects of Skin Surface Temperature on Epidermal Permeability Barrier Homeostasis
2006
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
TRPV3 is a calcium-permeable temperature-sensitive cation channel
2002 Nature
Invertebrate TRP proteins as functional models for mammalian channels
2004
Modulation of the Ca 2 Permeable Cation Channel TRPV4 by Cytochrome P450 Epoxygenases in Vascular Endothelium
2005
Nocistatin: a novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor
2000
Evidence for a Functional Role of Endothelial Transient Receptor Potential V4 in Shear Stress–Induced Vasodilatation
2006
TRPV2 Is a Component of Osmotically Sensitive Cation Channels in Murine Aortic Myocytes
2003
Cell Signaling and the Genesis of Neuropathic Pain
2004
Selective Suppression of Inhibitory Synaptic Transmission by Nocistatin in the Rat Spinal Cord Dorsal Horn
2000
TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity
2005
Transient Receptor Potential Channels in Cardiovascular Function and Disease
2006
The TRP Superfamily of Cation Channels
2005
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin
2006
Spinal Morphine/Clonidine Antinociceptive Synergism is Regulated by Protein Kinase C, but not Protein Kinase A Activity
1998
Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms
2018
Structure–function relationship of the TRP channel superfamily
2006
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
2005 StandoutScienceNobel
TRPV4 calcium entry channel: a paradigm for gating diversity
2004
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4
2009 StandoutNobel
Newly emerging Ca2+ entry channel molecules that regulate the vascular tone
2004
TRPA1 mediates formalin-induced pain
2007 StandoutNobel
The orphan opioid receptor and its endogenous ligand — nociceptin/orphanin FQ
1997
AN INTRODUCTION TO TRP CHANNELS
2005 Standout
TRP ION CHANNELS AND TEMPERATURE SENSATION
2006 StandoutNobel
Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: Comparison of ORL1 receptor mRNA expression with125I-[14Tyr]-orphanin FQ binding
1999
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Impaired osmotic sensation in mice lacking TRPV4
2003
Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions
2006
Homo- and heteromeric assembly of TRPV channel subunits
2005
The Role of Hypocretins (Orexins) in Sleep Regulation and Narcolepsy
2002
Emerging Targets in Photopharmacology
2016 StandoutNobel
The Molecular and Behavioral Pharmacology of the Orphanin FQ/Nociceptin Peptide and Receptor Family
2001
Structural insight into TRPV5 channel function and modulation
2019 StandoutNobel
Heat-Evoked Activation of the Ion Channel, TRPV4
2002
Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat
1999
Vanilloid and TRP channels: a family of lipid-gated cation channels
2002
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Works of Darren Smart being referenced
Cannabinoid activation of recombinant and endogenous vanilloid receptors
2001
Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology
2001
Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices
1998
‘Entourage’ effects of N‐acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide‐induced vanilloid receptor activation and upon anandamide metabolism
2002
Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain
2004
Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX 1 ) receptors, with downstream 5-HT 2C receptor involvement
2001
Characterisation of μ-opioid receptors on SH-SY5Y cells using naloxonazine and β-funaltrexamine
1994
The Effects of Local and Intravenous Anesthetics on Recombinant Rat VR1 Vanilloid Receptors
2003
Discovery of small molecule antagonists of TRPV1
2004
Activation of vanilloid receptor 1 by resiniferatoxin mobilizes calcium from inositol 1,4,5‐trisphosphate‐sensitive stores
2003
The stimulatory effects of opioids and their possible role in the development of tolerance
1996
TRPV1 and CB1 receptor‐mediated effects of the endovanilloid/endocannabinoid N‐arachidonoyl‐dopamine on primary afferent fibre and spinal cord neuronal responses in the rat
2004
Evidence for biological effects of exogenous LPA on rat primary afferent and spinal cord neurons
2004
Comparison of the effects of [Phe1Ψ(CH2‐NH)Gly2]Nociceptin (1–13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors
1999
Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development
2006
Orexins and the treatment of obesity
2002
Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives
2002
Cannabinoid modulation of sensory neurotransmission via cannabinoid and vanilloid receptors: Roles in regulation of cardiovascular function
2002
Nociceptin induced inhibition of K+ evoked glutamate release from rat cerebrocortical slices
1996