Citation Impact
Citing Papers
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
2011 Standout
In vitro and In vivo Radiosensitization with AZD6244 (ARRY-142886), an Inhibitor of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase 1/2 Kinase
2009
Combined MEK and PI3K Inhibition in a Mouse Model of Pancreatic Cancer
2014
Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment
2018 StandoutNobel
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo , pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models
2007
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer
2015 Standout
PEGylation and HAylation via catechol: α-Amine-specific reaction at N-terminus of peptides and proteins
2016
Comparative Binding of Disulfide-Bridged PEG-Fabs
2012
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition
2009
From basic research to clinical development of MEK1/2 inhibitors for cancer therapy
2010
Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution
2024 StandoutNobel
Mutant-selective degradation by BRAF-targeting PROTACs
2021
Living Radical Polymerization by the RAFT Process – A Third Update
2012 Standout
Nano-based smart pesticide formulations: Emerging opportunities for agriculture
2018 Standout
Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study
2009
PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins
2013
Reactive astrocytes: cellular and molecular cues to biological function
1997 Standout
Selective Staudinger Modification of Proteins Containing p‐Azidophenylalanine
2005
Cell cycle proteins as promising targets in cancer therapy
2017 Standout
Pathological roles of MAPK signaling pathways in human diseases
2010 Standout
Multi-input chemical control of protein dimerization for programming graded cellular responses
2019 StandoutNobel
Design strategies for bioorthogonal smart probes
2014 StandoutNobel
Clinical experience of MEK inhibitors in cancer therapy
2006
Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning
2018 Standout
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
2015 StandoutNature
A computationally engineered RAS rheostat reveals RAS–ERK signaling dynamics
2016 StandoutNobel
A novel neoglycopeptide linkage compatible with native chemical ligation
2006 StandoutNobel
BrafV600E cooperates with Pten loss to induce metastatic melanoma
2009
Network medicine: a network-based approach to human disease
2010 Standout
Clk post-transcriptional control denoises circadian transcription both temporally and spatially
2015 StandoutNobel
Lung cancer: current therapies and new targeted treatments
2016 Standout
Cancer-associated cachexia
2018 Standout
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
2016 Standout
The Pharmacology of PEGylation: Balancing PD with PK to Generate Novel Therapeutics
2008
Cell-free nucleic acids as biomarkers in cancer patients
2011 Standout
Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo
1992
Targeting apoptosis in cancer therapy
2020 Standout
Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study
2012
Drug repurposing: progress, challenges and recommendations
2018 Standout
Therapeutic strategies for inhibiting oncogenic BRAF signaling
2008
The essence of senescence: Figure 1.
2010 Standout
Targeting RAS–ERK signalling in cancer: promises and challenges
2014
Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach
2018 Standout
Designing hydrogels for controlled drug delivery
2016 Standout
Integrated analysis of breast cancer cell lines reveals unique signaling pathways
2009
Non-kinase targets of protein kinase inhibitors
2017
Recombinant gelatin hydrogels for the sustained release of proteins
2007
PROTAC targeted protein degraders: the past is prologue
2022 Standout
Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
2012
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
2021
Bio-reversible polyPEGylation
2009
Pancreatic Cancer
2010 Standout
Regulation of RAF protein kinases in ERK signalling
2015
Prospects for MEK inhibitors for treating cancer
2014
Role of cysteine residues in thermal inactivation of fungal Cel6A cellobiohydrolases
2013 StandoutNobel
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015 StandoutNature
A FRET‐Based Fluorogenic Phosphine for Live‐Cell Imaging with the Staudinger Ligation
2008 StandoutNobel
p90RSKs mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes
2013
The Role of Thiols and Disulfides on Protein Stability
2009
T Cell Immunoglobulin Mucin-3 Crystal Structure Reveals a Galectin-9-Independent Ligand-Binding Surface
2007 StandoutNobel
Human growth hormone expressed in tobacco cells as an arabinogalactan-protein fusion glycoprotein has a prolonged serum life
2010
Small‐Molecule Inhibitors of the ERK Signaling Pathway: Towards Novel Anticancer Therapeutics
2010
Site-specific polymer modification of therapeutic proteins
2005
Apoptosis Induction by MEK Inhibition in Human Lung Cancer Cells Is Mediated by Bim
2010
MEK Inhibition in the Treatment of Advanced Melanoma
2013
Improved pharmacokinetics and immunogenicity profile of organophosphorus hydrolase by chemical modification with polyethylene glycol
2010
Expression, Refolding, Purification, Molecular Characterization, Crystallization, and Preliminary X-ray Analysis of the Receptor Binding Domain of Human B7-2
2002
The history and future of targeting cyclin-dependent kinases in cancer therapy
2015 Standout
A New Reagent for Stable Thiol-Specific Conjugation
2013
PolyPEGylation of Protein using Semitelechelic and Mid-functional Poly(PEGMA)s synthesized by RAFT polymerization
2011
Monitoring Protein−Polymer Conjugation by a Fluorogenic Cu(I)-Catalyzed Azide−Alkyne 1,3-Dipolar Cycloaddition
2009
A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins
2014
Atom Transfer Radical Polymerization (ATRP): Current Status and Future Perspectives
2012 Standout
The MAPK pathway across different malignancies: A new perspective
2014 Standout
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Controlled/living radical polymerization: Features, developments, and perspectives
2007 Standout
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury.
1995
Polydopamine Surface Chemistry: A Decade of Discovery
2018 Standout
Strong negative feedback from Erk to Raf confers robustness to MAPK signalling
2011
Synthesis of Uniform Protein−Polymer Conjugates
2005
Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development
2014 StandoutNobel
Engineering of temperature- and light-switchable Cas9 variants
2013 StandoutNobel
Evolving Approaches to Patients with Advanced Differentiated Thyroid Cancer
2013
Imaging Cell Surface Glycans with Bioorthogonal Chemical Reporters
2007 StandoutNobel
Diminishing catalyst concentration in atom transfer radical polymerization with reducing agents
2006 Standout
Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag
2011 StandoutNobel
Allylic Selenosulfide Rearrangement: A Method for Chemical Ligation to Cysteine and Other Thiols
2006
Ribosome Biogenesis: Emerging Evidence for a Central Role in the Regulation of Skeletal Muscle Mass
2014 Standout
In Situ Preparation of Protein−“Smart” Polymer Conjugates with Retention of Bioactivity
2005
Hydrogels in drug delivery: Progress and challenges
2008 Standout
Connexin Mutations in X-Linked Charcot-Marie-Tooth Disease
1993 StandoutScience
Works of Darin Smith being referenced
Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor
2007
Refolding and Characterization of Recombinant Human Soluble CTLA-4 Expressed in Escherichia coli
1999
A Long-Acting, Mono-PEGylated Human Growth Hormone Analog Is a Potent Stimulator of Weight Gain and Bone Growth in Hypophysectomized Rats
2007
Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling
2014
Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli
1991
Design of homogeneous, monopegylated erythropoietin analogs with preserved in vitro bioactivity
2006
Site-Specific Protein PEGylation: Application to Cysteine Analogs of Recombinant Human Granulocyte Colony-Stimulating Factor.
2005
A Long-Acting, Highly Potent Interferon α-2 Conjugate Created Using Site-Specific PEGylation
2005
Site-Specific PEGylation of Engineered Cysteine Analogues of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor
2005