Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity
2013 StandoutNobel
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
2016 StandoutScience
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Structure of the Quaternary Complex of Interleukin-2 with Its α, ß, and γ c Receptors
2005 Science
Crystal Structure of the Entire Ectodomain of gp130
2010
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Rationally Designed Integrin β3 Mutants Stabilized in the High Affinity Conformation
2008 StandoutNobel
A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy
2022 StandoutNobel
Accurate de novo design of heterochiral protein–protein interactions
2024 StandoutNobel
A structure‐based benchmark for protein–protein binding affinity
2011
Modulation of Integrin Activation by an Entropic Spring in the β-Knee
2010 StandoutNobel
Allosteric functioning of dimeric class C G‐protein‐coupled receptors
2005
Interleukin-6 and its receptor: from bench to bedside
2006
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Constitutive Activation and Uncoupling of the Atrial Natriuretic Peptide Receptor by Mutations at the Dimer Interface
2004
Intrinsically unstructured proteins and their functions
2005 Standout
Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis
2015
Structure and function of interleukin-17 family cytokines
2011
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Structure and Mechanism of Receptor Sharing by the IL-10R2 Common Chain
2010
Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor
2005
The pro- and anti-inflammatory properties of the cytokine interleukin-6
2011 Standout
GPL, a Novel Cytokine Receptor Related to GP130 and Leukemia Inhibitory Factor Receptor
2003
Allotopic antagonism of the non-peptide atrial natriuretic peptide (ANP) antagonist HS-142-1 on natriuretic peptide receptor NPR-A
2002
The rational designed antagonist derived from the complex structure of interleukin-6 and its receptor affectively blocking interleukin-6 might be a promising treatment in multiple myeloma
2006
A cytokine-mediated link between innate immunity, inflammation, and cancer
2007 Standout
Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer
2009 StandoutNobel
The Structure of the Interleukin-15α Receptor and Its Implications for Ligand Binding
2005
Multifarious Determinants of Cytokine Receptor Signaling Specificity
2014
Characterization of the Signaling Capacities of the Novel gp130-like Cytokine Receptor
2004
Improving de novo protein binder design with deep learning
2023 StandoutNobel
Compensatory Energetic Mechanisms Mediating the Assembly of Signaling Complexes Between Interleukin-2 and its α, β, and γc Receptors
2004
Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging
2012 Standout
Crystal Structure of Hormone-bound Atrial Natriuretic Peptide Receptor Extracellular Domain
2004
Targeting Interleukin-6: All the Way to Treat Autoimmune and Inflammatory Diseases
2012
Coupling of folding and binding for unstructured proteins
2002
The IL-6/sIL-6R complex as a novel target for therapeutic approaches
2007
Engineering interferons and interleukins for cancer immunotherapy
2022
Crystal structure and association behaviour of the GluR2 amino‐terminal domain
2009
Structure of the Human MutSα DNA Lesion Recognition Complex
2007 StandoutNobel
Natriuretic Peptide Receptor A Activation Stabilizes a Membrane-distal Dimer Interface
2003
IL-6 in Inflammation, Immunity, and Disease
2014 Standout
Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors
2007
Orientational Constraints of the gp130 Intracellular Juxtamembrane Domain for Signaling
2002
Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands
2015
The IL-10R2 Binding Hot Spot on IL-22 is Located on the N-terminal Helix and is Dependent on N-linked Glycosylation
2004
The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution
2010
Structure of the Ultra-High-Affinity Colicin E2 DNase–Im2 Complex
2012 StandoutNobel
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity
2017 StandoutNobel
STATs in cancer inflammation and immunity: a leading role for STAT3
2009 Standout
A functional role of the membrane‐proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor
2002
Modulating the selectivity of near-IR fluorescent probes toward various metal ions by judicious choice of aqueous buffer solutions
2011
Development of an IL-6 Inhibitor Based on the Functional Analysis of Murine IL-6Rα1
2009
The Class II cytokine receptor (CRF2) family: overview and patterns of receptor–ligand interactions
2004
Mapping of a Region within the N Terminus of Jak1 Involved in Cytokine Receptor Interaction
2001
Survey of the year 2003 commercial optical biosensor literature
2004
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
The human interleukin‐6 (IL‐6) receptor exists as a preformed dimer in the plasma membrane
2003
Interferons α and λ Inhibit Hepatitis C Virus Replication With Distinct Signal Transduction and Gene Regulation Kinetics
2006 StandoutNobel
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
2008 Nature
Molecular recognition of BMP-2 and BMP receptor IA
2004
Fluorescent and colorimetric sensors for detection of lead, cadmium, and mercury ions
2011 Standout
Convergent Mechanisms for Recognition of Divergent Cytokines by the Shared Signaling Receptor gp130
2003 StandoutNobel
The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila
2005 StandoutNobel
Programmable design of orthogonal protein heterodimers
2018 StandoutNatureNobel
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
2017 StandoutNobel
Conformational Changes Mediate Interleukin-10 Receptor 2 (IL-10R2) Binding to IL-10 and Assembly of the Signaling Complex
2006
gp130 dimerization in the absence of ligand: Preformed cytokine receptor complexes
2006
Survey of the year 2001 commercial optical biosensor literature
2002
Quantitative analysis of the activation mechanism of the multicomponent growth-factor receptor Ret
2006
Mutations Designed to Destabilize the Receptor-Bound Conformation Increase MICA-NKG2D Association Rate and Affinity
2007 StandoutNobel
Symbiotic Control in Mechanical Bond Formation
2016 StandoutNobel
Efficacy, safety and tolerability of tocilizumab in patients with systemic juvenile idiopathic arthritis
2012
Effects of β-cyclodextrin and di-O-methyl-β-cyclodextrin on the percutaneous absorption of butylparaben, indomethacin and sulfanilic acid
1986
JAK2 activation by growth hormone and other cytokines
2015
Intramolecular transport of small-molecule cargo in a nanoscale device operated by light
2016 StandoutNobel
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
2003 Standout
Allosteric Regulation of Unidirectional Spring-like Motion of Double-Stranded Helicates
2016
Density Variant Glycan Microarray for Evaluating Cross-Linking of Mucin-like Glycoconjugates by Lectins
2012 StandoutNobel
Elucidation of the Interleukin-15 Binding Site on Its Alpha Receptor by NMR
2007
A solvent-driven molecular spring
2012
Unraveling Viral Interleukin-6 Binding to gp130 and Activation of STAT-Signaling Pathways Independently of the Interleukin-6 Receptor
2009
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
Cyclodextrin Drug Carrier Systems
1998 Standout
Insights into Cytokine–Receptor Interactions from Cytokine Engineering
2014
Natriuretic Peptides, Their Receptors, and Cyclic Guanosine Monophosphate-Dependent Signaling Functions
2005 Standout
Forced Homo- and Heterodimerization of All gp130-Type Receptor Complexes Leads to Constitutive Ligand-independent Signaling and Cytokine-independent Growth
2010
Therapeutic Targeting of the Interleukin-6 Receptor
2011
Structure of the extracellular domains of the human interleukin-6 receptor α-chain
2002
Four functionally distinct C-type natriuretic peptides found in fish reveal evolutionary history of the natriuretic peptide system
2003
Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand
2003
Three Decades of β-Lactamase Inhibitors
2010 Standout
Contributions of Amino Acid Side Chains to the Kinetics and Thermodynamics of the Bivalent Binding of Protein L to Ig κ Light Chain
2004 StandoutNobel
Mechanistic Diversity of Cytokine Receptor Signaling Across Cell Membranes
2004
Supramolecular Helical Systems: Helical Assemblies of Small Molecules, Foldamers, and Polymers with Chiral Amplification and Their Functions
2016 Standout
Artificial Molecular Machines
2015 Standout
Rotaxane-Based Molecular Muscles
2014 StandoutNobel
Switchable Reporter Enzymes Based on Mutually Exclusive Domain Interactions Allow Antibody Detection Directly in Solution
2013
Endometriosis
2020 Standout
Role of Structural Plasticity in Signal Transduction by the Cryptochrome Blue-Light Photoreceptor
2005 StandoutNobel
Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor
2003
Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma–associated herpesvirus
2001
Ligand/Receptor Signaling Threshold (LIST) Model Accounts for gp130‐Mediated Embryonic Stem Cell Self‐Renewal Responses to LIF and HIL‐6
2002
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
Forced Dimerization of gp130 Leads to Constitutive STAT3 Activation, Cytokine-independent Growth, and Blockade of Differentiation of Embryonic Stem Cells
2006
The Structure of Interleukin-2 Complexed with Its Alpha Receptor
2005 Science
Circumventing the Problems Caused by Protein Diversity in Microarrays: Implications for Protein Interaction Networks
2006
Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells
2005
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Stability of 100 Homo and Heterotypic Coiled−Coil a−a‘ Pairs for Ten Amino Acids (A, L, I, V, N, K, S, T, E, and R)
2006
Although IL-6 Trans-Signaling Is Sufficient To Drive Local Immune Responses, Classical IL-6 Signaling Is Obligate for the Induction of T Cell-Mediated Autoimmunity
2010
Design Strategies for Water-Soluble Small Molecular Chromogenic and Fluorogenic Probes
2013 Standout
Structural Biology of Shared Cytokine Receptors
2007
Development of Pseudorotaxanes and Rotaxanes: From Synthesis to Stimuli-Responsive Motions to Applications
2015
Works of Dar‐Chone Chow being referenced
Structural Insight into the Kinetics and ΔCp of Interactions between TEM-1 β-Lactamase and β-Lactamase Inhibitory Protein (BLIP)
2008
Fine Mapping of the Sequence Requirements for Binding of β-Lactamase Inhibitory Protein (BLIP) to TEM-1 β-Lactamase Using a Genetic Screen for BLIP Function
2009
Thermodynamic Investigation of the Role of Contact Residues of β-Lactamase-inhibitory Protein for Binding to TEM-1 β-Lactamase
2007
Concentration-Dependent Enhancement of 1 -Dodecylazacycloheptan-2-one on the Percutaneous Penetration Kinetics of Triamcinolone Acetonide
1984
In Vitro Reconstitution of Recognition and Activation Complexes between Interleukin-6 and gp130
2001
Hexameric Structure and Assembly of the Interleukin-6/IL-6 α-Receptor/gp130 Complex
2003 Science
Small Molecule Inhibition of the Steroid Receptor Coactivators, SRC-3 and SRC-1
2011
Allosteric Activation of a Spring-Loaded Natriuretic Peptide Receptor Dimer by Hormone
2001 Science
Structure of an Extracellular gp130 Cytokine Receptor Signaling Complex
2001 Science
Thermodynamic Analysis of the Binding of Oxidized and Reduced FMN Cofactor to Vibrio harveyi NADPH-FMN Oxidoreductase FRP Apoenzyme
2006