Citation Impact
Citing Papers
An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy
2015
Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O 2 activation
2019 StandoutNobel
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
RN927C, a Site-Specific Trop-2 Antibody–Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models
2016
Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer
2012 Standout
Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer
2014
Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
2021 StandoutNobel
Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes
2014
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody–drug conjugate in development for the treatment of HER2-positive cancer
2012
Targeted glycan degradation potentiates the anticancer immune response in vivo
2020 StandoutNobel
A Phase II Study of Trastuzumab Emtansine in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer Who Were Previously Treated With Trastuzumab, Lapatinib, an Anthracycline, a Taxane, and Capecitabine
2012
A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy
2016
De novo design of immunoglobulin-like domains
2022 StandoutNobel
Going beyond the liver: Progress and challenges of targeted delivery of siRNA therapeutics
2015
Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis
2017
Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development
2015
LC–MS/MS method for the simultaneous determination of Lys-MCC-DM1, MCC-DM1 and DM1 as potential intracellular catabolites of the antibody-drug conjugate trastuzumab emtansine (T-DM1)
2017
Antibody-drug conjugates for cancer therapy: The technological and regulatory challenges of developing drug-biologic hybrids
2015
Targeting VEGF signalling via the neuropilin co-receptor
2012
Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells
2022 StandoutNobel
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
2019 Standout
Gut biogeography of the bacterial microbiota
2015 Standout
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
2017 Standout
Characterization of Cysteine-Linked Conjugation Profiles of Immunoglobulin G1 and Immunoglobulin G2 Antibody–Drug Conjugates
2015
Ageing as a risk factor for neurodegenerative disease
2019 Standout
Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges
2012
CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity
2019 StandoutNobel
The immune contexture in cancer prognosis and treatment
2017 Standout
Cancer stem cells revisited
2017 Standout
Challenges and opportunities for non-antibody scaffold drugs
2015
Tau in physiology and pathology
2015 Standout
Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
2018 Standout
Drawing lessons from the clinical development of antibody-drug conjugates
2018
Site-specific antibody drug conjugates for cancer therapy
2013
Environmental factors influencing the development and spread of antibiotic resistance
2017 Standout
Bacterial spore structures and their protective role in biocide resistance
2012
Effects of antibody, drug and linker on the preclinical and clinical toxicities of antibody-drug conjugates
2016
The role of short-chain fatty acids in microbiota–gut–brain communication
2019 Standout
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
2019
Alzheimer's disease
2016 Standout
Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool
2013
The blood–brain barrier
2016
PROTAC targeted protein degraders: the past is prologue
2022 Standout
Strategies and challenges for the next generation of antibody–drug conjugates
2017 Standout
Emerging Strategies for Developing Next-Generation Protein Therapeutics for Cancer Treatment
2016
Design of amyloidogenic peptide traps
2024 StandoutNobel
The gut microbiota — masters of host development and physiology
2013 Standout
De novo design of buttressed loops for sculpting protein functions
2024 StandoutNobel
A Bioorthogonal Reaction of N‐Oxide and Boron Reagents
2015 StandoutNobel
Microbial adhesins to gastrointestinal mucus
2011
Multispecific drugs herald a new era of biopharmaceutical innovation
2020 Nature
BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease
2014
Peripheral immune system in aging and Alzheimer’s disease
2018
Bispecific antibodies: a mechanistic review of the pipeline
2019
New developments for antibody-drug conjugate-based therapeutic approaches
2016
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
2020 Standout
Nuclear Tau, a Key Player in Neuronal DNA Protection
2010
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy
2023 StandoutNobel
Computational design of a synthetic PD-1 agonist
2021 StandoutNobel
Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?
2016
pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures
2015 Standout
RadicalS-Adenosylmethionine Enzymes
2014
High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice
2015
Neuronal and Vascular Interactions
2015
Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier
2014
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
2020 Standout
Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis
2019
Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A
2016 StandoutNobel
Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues
2015
Capacity limits of asialoglycoprotein receptor-mediated liver targeting
2017
Transferrin' bispecific antibodies across the blood–brain barrier
2014
Introduction to the human gut microbiota
2017 Standout
PEGylation Does Not Significantly Change the Initial Intravenous or Subcutaneous Pharmacokinetics or Lymphatic Exposure of Trastuzumab in Rats but Increases Plasma Clearance after Subcutaneous Administration
2015
Antibody Conjugates: From Heterogeneous Populations to Defined Reagents
2015
Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core
2015
Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development
2014
Computational Evolution of Threonine-Rich β-Hairpin Peptides Mimicking Specificity and Affinity of Antibodies
2019 StandoutNobel
Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents
2021 StandoutNobel
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
A Pictet-Spengler ligation for protein chemical modification
2012 StandoutNobel
Modular repeat protein sculpting using rigid helical junctions
2020 StandoutNobel
Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box
2015 Standout
Marine natural products
2018 Standout
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
Natural product and natural product derived drugs in clinical trials
2014 Standout
Formylglycine, a Post-Translationally Generated Residue with Unique Catalytic Capabilities and Biotechnology Applications
2014 StandoutNobel
Strain-specific diversity of mucus-binding proteins in the adhesion and aggregation properties of Lactobacillus reuteri
2010
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Tutorial on Monoclonal Antibody Pharmacokinetics and Its Considerations in Early Development
2018
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
2021 StandoutNobel
Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models
2015
Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development
2014 StandoutNobel
Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates
2017
A Polar Sulfamide Spacer Significantly Enhances the Manufacturability, Stability, and Therapeutic Index of Antibody–Drug Conjugates
2018
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Improving the Serum Stability of Site-Specific Antibody Conjugates with Sulfone Linkers
2014
Drugs and Drug Candidates from Marine Sources: An Assessment of the Current “State of Play”
2016
PK Assays for Antibody–Drug Conjugates: Case Study with Ado-Trastuzumab Emtansine
2013
Works of Daniela Bumbaca being referenced
Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (T-DM1)
2014
Maximizing tumour exposure to anti‐neuropilin‐1 antibody requires saturation of non‐tumour tissue antigenic sinks in mice
2011
Genome‐based identification and characterization of a putative mucin‐binding protein from the surface of Streptococcus pneumoniae
2006
Catabolic Fate and Pharmacokinetic Characterization of Trastuzumab Emtansine (T-DM1): an Emphasis on Preclinical and Clinical Catabolism
2012
Quantitative cumulative biodistribution of antibodies in mice
2014
Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor
2016
A strategy for risk mitigation of antibodies with fast clearance
2012
Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics
2012
Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies
2015
Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4
2011
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
2014
Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody–Drug Conjugates in Rats
2011
Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
2014
Abstract A135: T-DM1-induced thrombocytopenia results from impaired platelet production in a HER2-independent manner.
2011
Structure of a protein–DNA complex essential for DNA protection in spores of Bacillus species
2008