Citation Impact
Citing Papers
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
2007
Multisite Protein Kinase A and Glycogen Synthase Kinase 3β Phosphorylation Leads to Gli3 Ubiquitination by SCF βTrCP
2006
High burden and pervasive positive selection of somatic mutations in normal human skin
2015 StandoutScience
A Novel Somatic Mouse Model to Survey Tumorigenic Potential Applied to the Hedgehog Pathway
2006
Small-molecule modulators of the Sonic Hedgehog signaling pathway
2009
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
2017 Standout
A Role for Runx Transcription Factor Signaling in Dorsal Root Ganglion Sensory Neuron Diversification
2006
c-Myc Enhances Sonic Hedgehog-Induced Medulloblastoma Formation from Nestin-Expressing Neural Progenitors in Mice
2003
Orchestrating ontogenesis: variations on a theme by sonic hedgehog
2006
Targeted Expression of GLI1 in the Mammary Gland Disrupts Pregnancy-induced Maturation and Causes Lactation Failure
2007
The complexities of skeletal biology
2003 StandoutNature
Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons
2007
Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin
2004 StandoutNobel
Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
2009 Standout
The Requirement of Nkx2-1 in the Temporal Specification of Cortical Interneuron Subtypes
2008
The third dimension bridges the gap between cell culture and live tissue
2007 Standout
In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
2005 Nature
Mechanisms and Functional Implications of Adult Neurogenesis
2008 Standout
Long non-coding RNAs in nervous system function and disease
2010
Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation
2013
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Hedgehog signalling in the mouse requires intraflagellar transport proteins
2003 StandoutNature
Dynamics of Lgr6 + Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis
2015
TGFβ signalling in context
2012 Standout
Developmental biology informs cancer
2003
The Hedgehog's tale: developing strategies for targeting cancer
2011
Malignant astrocytic glioma: genetics, biology, and paths to treatment
2007 Standout
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
The Graded Response to Sonic Hedgehog Depends on Cilia Architecture
2007
Chapter 9 The Primary Cilium
2008
Communicating with Hedgehogs
2005
Vertebrate Smoothened functions at the primary cilium
2005 StandoutNature
Inactivation of a Gαs–PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis
2015
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
2005
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Reinforcement Learning, Fast and Slow
2019 StandoutNobel
Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase
2010 StandoutNobel
Pancreatic Adenocarcinoma
2014 Standout
Cancer genes and the pathways they control
2004 Standout
A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA
2011 Standout
WNT signaling in bone homeostasis and disease: from human mutations to treatments
2013 Standout
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
2008 Standout
The Hedgehog Signalling Pathway in the Gastrointestinal Tract: Implications for Development, Homeostasis, and Disease
2005
Piezo2 is the principal mechanotransduction channel for proprioception
2015 StandoutNobel
Fibroblast growth factor signalling: from development to cancer
2010 Standout
Dopamine neurons share common response function for reward prediction error
2016
Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
2010
A distributional code for value in dopamine-based reinforcement learning
2020 StandoutNatureNobel
Sonic Hedgehog Signaling Confers Ventral Telencephalic Progenitors with Distinct Cortical Interneuron Fates
2010
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
2012
Neural Stem Cells and the Origin of Gliomas
2005
Mosaic Removal of Hedgehog Signaling in the Adult SVZ Reveals That the Residual Wild-Type Stem Cells Have a Limited Capacity for Self-Renewal
2007
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
2013 Standout
C. elegans patched-3 is an essential gene implicated in osmoregulation and requiring an intact permease transporter domain
2011
Malignant Gliomas in Adults
2008 Standout
Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification
2003
Building strong bones: molecular regulation of the osteoblast lineage
2011
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
2010 StandoutNature
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
2011 Standout
Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease
2011 StandoutNobel
Multimodal imaging of mouse development: Tools for the postgenomic era
2006
Loss of Tgif Function Causes Holoprosencephaly by Disrupting the Shh Signaling Pathway
2012
Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches
2003
Stem Cells and Cancer
2004 Standout
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis
2007 Standout
Hedgehog–Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer
2003
Adipocyte differentiation from the inside out
2006 Standout
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
2008
Pattern formation: old models out on a limb
2003
Transient Inhibition of the Hedgehog Pathway in Young Mice Causes Permanent Defects in Bone Structure
2008
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1+/−p53−/− mice
2004
Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres
2014
Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells
2011
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
2008 Standout
GREAT improves functional interpretation of cis-regulatory regions
2010 Standout
Genetic Fate Mapping Reveals That the Caudal Ganglionic Eminence Produces a Large and Diverse Population of Superficial Cortical Interneurons
2010
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations
2011
A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex
2011 Standout
Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells
2007
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development
2010 StandoutNobel
Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications
2019 Standout
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
2005
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development
2012 StandoutNobel
Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells
2009
The Organocatalytic Approach to Enantiopure 2H‐ and 3H‐Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
2016 StandoutNobel
The extracellular matrix: A dynamic niche in cancer progression
2012 Standout
Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development
2005
Multiple roles ofHoxa11andHoxd11in the formation of the mammalian forelimb zeugopod
2003 StandoutNobel
Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2
2006 StandoutNobel
Electrosprayed nanoparticles and electrospun nanofibers based on natural materials: applications in tissue regeneration, drug delivery and pharmaceuticals
2014 Standout
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways fromDrosophilato vertebrates
2005
The Origins of Medulloblastoma Subtypes
2008
Wound Healing: A Cellular Perspective
2018 Standout
Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation
2006
Neural Circuitry of Reward Prediction Error
2017
Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents
2009
Induction of Sonic Hedgehog Mediators by Transforming Growth Factor-β: Smad3-Dependent Activation of Gli2 and Gli1 Expression In vitro and In vivo
2007
Cilia and Hedgehog responsiveness in the mouse
2005
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
2014
Works of Daniel Stephen being referenced
Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei
2011
Gli1 is important for medulloblastoma formation in Ptc1+/− mice
2005
All Mouse Ventral Spinal Cord Patterning by Hedgehog Is Gli Dependent and Involves an Activator Function of Gli3
2004
Patterning of ventral telencephalon requires positive function of Gli transcription factors
2009
Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling
2008
Gli2, but notGli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
2002
Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1.
2002